The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.

Journal Article (Review;Journal Article)

The protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms (not in yeast). It is expressed in more than a million copies/nucleus of rapidly proliferating mammalian cells. DEK has two DNA binding modules of which one includes a SAP box, a sequence motif that DEK shares with a number of other chromatin proteins. DEK has no apparent affinity to specific DNA sequences, but preferentially binds to superhelical and cruciform DNA, and induces positive supercoils into closed circular DNA. The available evidence strongly suggests that DEK could function as an architectural protein in chromatin comparable to the better known classic architectural chromatin proteins, the high-mobility group or HMG proteins.

Full Text

Duke Authors

Cited Authors

  • Waldmann, T; Scholten, I; Kappes, F; Hu, HG; Knippers, R

Published Date

  • December 2004

Published In

Volume / Issue

  • 343 / 1

Start / End Page

  • 1 - 9

PubMed ID

  • 15563827

Electronic International Standard Serial Number (EISSN)

  • 1879-0038

International Standard Serial Number (ISSN)

  • 0378-1119

Digital Object Identifier (DOI)

  • 10.1016/j.gene.2004.08.029


  • eng