Ferdinand Kappes
Associate Professor of Biology at Duke Kunshan University
Current Appointments & Affiliations
- Associate Professor of Biology at Duke Kunshan University, DKU Faculty, Duke Kunshan University 2022
- Associate Professor of the Practice, DKU Visiting Faculty, Duke University 2022
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., University of Konstanz (Germany) 1999
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Guo, Haihong, Malte Prell, Hiltrud Königs, Nengwei Xu, Tanja Waldmann, Benita Hermans-Sachweh, Elisa Ferrando-May, Bernhard Lüscher, and Ferdinand Kappes. “Bacterial Growth Inhibition Screen (BGIS) identifies a loss-of-function mutant of the DEK oncogene, indicating DNA modulating activities of DEK in chromatin.” Febs Letters 595, no. 10 (May 2021): 1438–53. https://doi.org/10.1002/1873-3468.14070.Full Text
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Guo, Haihong, Nengwei Xu, Malte Prell, Hiltrud Königs, Benita Hermanns-Sachweh, Bernhard Lüscher, and Ferdinand Kappes. “Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function.” Febs Letters 595, no. 10 (May 2021): 1422–37. https://doi.org/10.1002/1873-3468.14072.Full Text
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Capitano, Maegan L., Nirit Mor-Vaknin, Anjan K. Saha, Scott Cooper, Maureen Legendre, Haihong Guo, Rafael Contreras-Galindo, et al. “Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.” The Journal of Clinical Investigation 129, no. 6 (May 2019): 2555–70. https://doi.org/10.1172/jci127460.Full Text
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Ganz, Magdalena, Christopher Vogel, Christina Czada, Vera Jörke, Eva Christina Gwosch, Rebecca Kleiner, Agnieszka Pierzynska-Mach, et al. “The oncoprotein DEK affects the outcome of PARP1/2 inhibition during mild replication stress.” Plos One 14, no. 8 (January 2019): e0213130. https://doi.org/10.1371/journal.pone.0213130.Full Text Open Access Copy
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Albuquerque Oliveira, Ana Cecília de, Ferdinand Kappes, Danyelly Bruneska Gondim Martins, and José Luiz de Lima Filho. “The unique DEK oncoprotein in women's health: A potential novel biomarker.” Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 106 (October 2018): 142–48. https://doi.org/10.1016/j.biopha.2018.06.082.Full Text
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Bütepage, Mareike, Christian Preisinger, Alexander von Kriegsheim, Anja Scheufen, Eva Lausberg, Jinyu Li, Ferdinand Kappes, et al. “Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription.” Scientific Reports 8, no. 1 (April 2018): 6748. https://doi.org/10.1038/s41598-018-25137-w.Full Text
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Smith, Eric A., Eric F. Krumpelbeck, Anil G. Jegga, Malte Prell, Marie M. Matrka, Ferdinand Kappes, Kenneth D. Greis, Abdullah M. Ali, Amom R. Meetei, and Susanne I. Wells. “The nuclear DEK interactome supports multi-functionality.” Proteins 86, no. 1 (January 2018): 88–97. https://doi.org/10.1002/prot.25411.Full Text
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Cifdaloz, Metehan, Lisa Osterloh, Osvaldo Graña, Erica Riveiro-Falkenbach, Pilar Ximénez-Embún, Javier Muñoz, Cristina Tejedo, et al. “Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.” Nature Communications 8, no. 1 (December 2017): 2249. https://doi.org/10.1038/s41467-017-02353-y.Full Text
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Smith, Eric A., Boris Gole, Nicholas A. Willis, Rebeca Soria, Linda M. Starnes, Eric F. Krumpelbeck, Anil G. Jegga, et al. “DEK is required for homologous recombination repair of DNA breaks.” Scientific Reports 7 (March 2017): 44662. https://doi.org/10.1038/srep44662.Full Text Open Access Copy
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Deutzmann, A., M. Ganz, F. Schönenberger, J. Vervoorts, F. Kappes, and E. Ferrando-May. “The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress.” Oncogene 34, no. 32 (August 2015): 4270–77. https://doi.org/10.1038/onc.2014.346.Full Text
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Logan, Gemma E., Nirit Mor-Vaknin, Till Braunschweig, Edgar Jost, Pia Verena Schmidt, David M. Markovitz, Ken I. Mills, Ferdinand Kappes, and Melanie J. Percy. “DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML).” Blood Cells, Molecules & Diseases 54, no. 1 (January 2015): 123–31. https://doi.org/10.1016/j.bcmd.2014.07.009.Full Text
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Matrka, Marie C., Robert F. Hennigan, Ferdinand Kappes, Monica L. DeLay, Paul F. Lambert, Bruce J. Aronow, and Susanne I. Wells. “DEK over-expression promotes mitotic defects and micronucleus formation.” Cell Cycle (Georgetown, Tex.) 14, no. 24 (January 2015): 3939–53. https://doi.org/10.1080/15384101.2015.1044177.Full Text
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Treude, Fabian, Ferdinand Kappes, Dirk Fahrenkamp, Gerhard Müller-Newen, Federico Dajas-Bailador, Oliver H. Krämer, Bernhard Lüscher, and Jörg Hartkamp. “Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis.” Oncotarget 5, no. 10 (May 2014): 2988–98. https://doi.org/10.18632/oncotarget.1634.Full Text
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Contreras-Galindo, Rafael, Mark H. Kaplan, Shirley He, Angie C. Contreras-Galindo, Marta J. Gonzalez-Hernandez, Ferdinand Kappes, Derek Dube, et al. “HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses.” Genome Research 23, no. 9 (September 2013): 1505–13. https://doi.org/10.1101/gr.144303.112.Full Text
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Broxmeyer, Hal E., Nirit Mor-Vaknin, Ferdinand Kappes, Maureen Legendre, Anjan K. Saha, Xuan Ou, Heather O’Leary, Maegan Capitano, Scott Cooper, and David M. Markovitz. “Concise review: role of DEK in stem/progenitor cell biology.” Stem Cells (Dayton, Ohio) 31, no. 8 (August 2013): 1447–53. https://doi.org/10.1002/stem.1443.Full Text
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Saha, Anjan K., Ferdinand Kappes, Amruta Mundade, Anja Deutzmann, David M. Rosmarin, Maureen Legendre, Nicolas Chatain, et al. “Intercellular trafficking of the nuclear oncoprotein DEK.” Proceedings of the National Academy of Sciences of the United States of America 110, no. 17 (April 2013): 6847–52. https://doi.org/10.1073/pnas.1220751110.Full Text
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Privette Vinnedge, Lisa M., Ferdinand Kappes, Nicolas Nassar, and Susanne I. Wells. “Stacking the DEK: from chromatin topology to cancer stem cells.” Cell Cycle (Georgetown, Tex.) 12, no. 1 (January 2013): 51–66. https://doi.org/10.4161/cc.23121.Full Text
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Patel, Rajiv M., Laura L. Walters, Ferdinand Kappes, Rohit Mehra, Douglas R. Fullen, David M. Markovitz, and Linglei Ma. “DEK expression in Merkel cell carcinoma and small cell carcinoma.” Journal of Cutaneous Pathology 39, no. 8 (August 2012): 753–57. https://doi.org/10.1111/j.1600-0560.2012.01941.x.Full Text
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Broxmeyer, Hal E., Ferdinand Kappes, Nirit Mor-Vaknin, Maureen Legendre, John Kinzfogl, Scott Cooper, Giao Hangoc, and David M. Markovitz. “DEK regulates hematopoietic stem engraftment and progenitor cell proliferation.” Stem Cells and Development 21, no. 9 (June 2012): 1449–54. https://doi.org/10.1089/scd.2011.0451.Full Text
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Kappes, Ferdinand, Michael S. Khodadoust, Limin Yu, David S. L. Kim, Douglas R. Fullen, David M. Markovitz, and Linglei Ma. “DEK expression in melanocytic lesions.” Human Pathology 42, no. 7 (July 2011): 932–38. https://doi.org/10.1016/j.humpath.2010.10.022.Full Text
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Kappes, Ferdinand, Tanja Waldmann, Veena Mathew, Jindan Yu, Ling Zhang, Michael S. Khodadoust, Arul M. Chinnaiyan, et al. “The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.” Genes & Development 25, no. 7 (April 2011): 673–78. https://doi.org/10.1101/gad.2036411.Full Text
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Mor-Vaknin, Nirit, Ferdinand Kappes, Amalie E. Dick, Maureen Legendre, Catalina Damoc, Seagal Teitz-Tennenbaum, Roland Kwok, Elisa Ferrando-May, Barbara S. Adams, and David M. Markovitz. “DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen.” Arthritis and Rheumatism 63, no. 2 (February 2011): 556–67. https://doi.org/10.1002/art.30138.Full Text
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Fahrer, Jörg, Oliver Popp, Maria Malanga, Sascha Beneke, David M. Markovitz, Elisa Ferrando-May, Alexander Bürkle, and Ferdinand Kappes. “High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length.” Biochemistry 49, no. 33 (August 2010): 7119–30. https://doi.org/10.1021/bi1004365.Full Text
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Khodadoust, Michael S., Monique Verhaegen, Ferdinand Kappes, Erica Riveiro-Falkenbach, Juan C. Cigudosa, David S. L. Kim, Arul M. Chinnaiyan, David M. Markovitz, and María S. Soengas. “Melanoma proliferation and chemoresistance controlled by the DEK oncogene.” Cancer Research 69, no. 16 (August 2009): 6405–13. https://doi.org/10.1158/0008-5472.can-09-1063.Full Text
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Kappes, F., J. Fahrer, M. S. Khodadoust, A. Tabbert, C. Strasser, N. Mor-Vaknin, M. Moreno-Villanueva, A. Bürkle, D. M. Markovitz, and E. Ferrando-May. “DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.” Molecular and Cellular Biology 28, no. 10 (May 2008): 3245–57. https://doi.org/10.1128/mcb.01921-07.Full Text
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Devany, Matthew, Ferdinand Kappes, Kuan-Ming Chen, David M. Markovitz, and Hiroshi Matsuo. “Solution NMR structure of the N-terminal domain of the human DEK protein.” Protein Science : A Publication of the Protein Society 17, no. 2 (February 2008): 205–15. https://doi.org/10.1110/ps.073244108.Full Text
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Mor-Vaknin, Nirit, Antonello Punturieri, Kajal Sitwala, Neil Faulkner, Maureen Legendre, Michael S. Khodadoust, Ferdinand Kappes, et al. “The DEK nuclear autoantigen is a secreted chemotactic factor.” Molecular and Cellular Biology 26, no. 24 (December 2006): 9484–96. https://doi.org/10.1128/mcb.01030-06.Full Text
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Tabbert, Anja, Ferdinand Kappes, Rolf Knippers, Josef Kellermann, Friedrich Lottspeich, and Elisa Ferrando-May. “Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform.” Proteomics 6, no. 21 (November 2006): 5758–72. https://doi.org/10.1002/pmic.200600197.Full Text
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Grasemann, Corinna, Sandrine Gratias, Harald Stephan, Andreas Schüler, Alexander Schramm, Ludger Klein-Hitpass, Harald Rieder, et al. “Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.” Oncogene 24, no. 42 (September 2005): 6441–49. https://doi.org/10.1038/sj.onc.1208792.Full Text
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Böhm, Friederike, Ferdinand Kappes, Ingo Scholten, Nicole Richter, Hiroshi Matsuo, Rolf Knippers, and Tanja Waldmann. “The SAF-box domain of chromatin protein DEK.” Nucleic Acids Research 33, no. 3 (January 2005): 1101–10. https://doi.org/10.1093/nar/gki258.Full Text
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Waldmann, Tanja, Ingo Scholten, Ferdinand Kappes, Hong Gang Hu, and Rolf Knippers. “The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin.” Gene 343, no. 1 (December 2004): 1–9. https://doi.org/10.1016/j.gene.2004.08.029.Full Text
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Kappes, Ferdinand, Catalina Damoc, Rolf Knippers, Michael Przybylski, Lorenzo A. Pinna, and Claudia Gruss. “Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.” Molecular and Cellular Biology 24, no. 13 (July 2004): 6011–20. https://doi.org/10.1128/mcb.24.13.6011-6020.2004.Full Text
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Kappes, Ferdinand, Ingo Scholten, Nicole Richter, Claudia Gruss, and Tanja Waldmann. “Functional domains of the ubiquitous chromatin protein DEK.” Molecular and Cellular Biology 24, no. 13 (July 2004): 6000–6010. https://doi.org/10.1128/mcb.24.13.6000-6010.2004.Full Text
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Kulartz, Monika, Ekkehard Hiller, Ferdinand Kappes, Lorenzo A. Pinna, and Rolf Knippers. “Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin.” Biochemical and Biophysical Research Communications 315, no. 4 (March 2004): 1011–17. https://doi.org/10.1016/j.bbrc.2004.01.164.Full Text
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Kappes, F., K. Burger, M. Baack, F. O. Fackelmayer, and C. Gruss. “Subcellular localization of the human proto-oncogene protein DEK.” The Journal of Biological Chemistry 276, no. 28 (July 2001): 26317–23. https://doi.org/10.1074/jbc.m100162200.Full Text
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Preprints
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Ganz, Magdalena, Christopher Vogel, Christina Czada, Vera Jörke, Rebecca Kleiner, Agnieszka Pierzynska-Mach, Francesca Cella Zanacchi, et al. “The oncoprotein DEK affects the outcome of PARP1/2 inhibition during replication stress.” Cold Spring Harbor Laboratory, February 19, 2019. https://doi.org/10.1101/555003.Full Text
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- Teaching & Mentoring
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Recent Courses
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