The current landscape of immunotherapy for pediatric brain tumors.

Journal Article (Journal Article;Review)

Pediatric central nervous system tumors are the most common solid malignancies in childhood, and aggressive therapy often leads to long-term sequelae in survivors, making these tumors challenging to treat. Immunotherapy has revolutionized prospects for many cancer types in adults, but the intrinsic complexity of treating pediatric patients and the scarcity of clinical studies of children to inform effective approaches have hampered the development of effective immunotherapies in pediatric settings. Here, we review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.

Full Text

Duke Authors

Cited Authors

  • Hwang, EI; Sayour, EJ; Flores, CT; Grant, G; Wechsler-Reya, R; Hoang-Minh, LB; Kieran, MW; Salcido, J; Prins, RM; Figg, JW; Platten, M; Candelario, KM; Hale, PG; Blatt, JE; Governale, LS; Okada, H; Mitchell, DA; Pollack, IF

Published Date

  • January 2022

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • 11 - 24

PubMed ID

  • 35121998

Electronic International Standard Serial Number (EISSN)

  • 2662-1347

Digital Object Identifier (DOI)

  • 10.1038/s43018-021-00319-0

Language

  • eng

Conference Location

  • England