HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses.

Journal Article (Journal Article;Review)

Immunoevasive viruses which effect antigen presentation by class I major histocompatibility complex (MHC) molecules have helped to broaden our understanding of the intracellular transport and processing of HLA-G and HLA-C in the placenta. Cellular infection with herpes simplex virus (HSV) and human cytomegalovirus (HCMV) are each associated with the downregulation of surface expression of HLA-A and -B, albeit by remarkably distinct mechanisms. Investigations on the effects of HSV and HCMV infection on HLA-G and HLA-C in the trophoblast have revealed both hypothesized similarities and surprising differences between trophoblast and classical class I products.

Full Text

Duke Authors

Cited Authors

  • Schust, DJ; Tortorella, D; Ploegh, HL

Published Date

  • February 1999

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 37 - 46

PubMed ID

  • 10092549

International Standard Serial Number (ISSN)

  • 1044-579X

Digital Object Identifier (DOI)

  • 10.1006/scbi.1998.0106


  • eng

Conference Location

  • England