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Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study.

Publication ,  Journal Article
Sood, MR; Abdelmoneim, SS; Dontineni, N; Ivanov, A; Lee, E; Rubin, M; Vittoria, M; Meykler, M; Ramachandran, V; Sacchi, T; Brener, S; Klem, I ...
Published in: Vasc Health Risk Manag
2022

BACKGROUND: Aortic distensibility (AD) is an important determinant of cardiovascular (CV) morbidity and mortality. There is scant data on the association between AD measured within the descending thoracic aorta and CV outcomes. OBJECTIVE: We evaluated the association of AD at the descending thoracic aorta (AD desc) with the primary outcome of all-cause mortality, myocardial infarction (MI), stroke or coronary revascularization in patients referred for a cardiovascular magnetic resonance (CMR) study. METHODS: 928 consecutive patients [(mean age 60 ± 17; 33% with prior cardiovascular disease (CVD))] were evaluated. AD desc was measured at the cross-section of the descending thoracic aorta in the 4-chamber view (via steady-state free precession [SSFP] cine sequences) and was grouped into quintiles (with the 1st quintile corresponding to the least AD, i.e., the stiffest aorta). Cox proportional-hazards regression analysis were performed for the primary outcome. RESULTS: A total of 315 patients (34%) experienced the primary outcome during a median (25% IQR, 75% IQR) follow-up of 5.0 (0.56, 9.3) years. A decreased AD was significantly associated with hypertension, diabetes, renal disease, and dyslipidemia (p <0.0001). A primary outcome occurred in 43% of patients with AD desc ≤ median compared to 25% with AD desc > median, p <0.0001, and in 44% of patients with AD desc in the 1st quintile compared to 31% with AD desc in the other quintiles (p = 0.0004). Event free survival was incrementally reduced amongst quintiles (p <0.0001). However, AD desc ≤ median was not an independent predictor of the primary endpoint after multivariable adjustment in the overall population [adjusted HR 1.09 (95% CI:0.82-1.45), p = 0.518] or in the subgroup analysis of patients with or without prior CVD. CONCLUSION: In this real-world cohort of 928 patients referred for CMR, AD desc is not an independent predictor of CV outcomes.

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Published In

Vasc Health Risk Manag

DOI

EISSN

1178-2048

Publication Date

2022

Volume

18

Start / End Page

653 / 665

Location

New Zealand

Related Subject Headings

  • Stroke
  • Myocardial Infarction
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Disease Progression
  • Cardiovascular System & Hematology
  • Aorta
  • Aged
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sood, M. R., Abdelmoneim, S. S., Dontineni, N., Ivanov, A., Lee, E., Rubin, M., … Heitner, J. F. (2022). Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study. Vasc Health Risk Manag, 18, 653–665. https://doi.org/10.2147/VHRM.S359632
Sood, Michael R., Sahar S. Abdelmoneim, Nripen Dontineni, Alexander Ivanov, Ernest Lee, Michael Rubin, Michael Vittoria, et al. “Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study.Vasc Health Risk Manag 18 (2022): 653–65. https://doi.org/10.2147/VHRM.S359632.
Sood MR, Abdelmoneim SS, Dontineni N, Ivanov A, Lee E, Rubin M, et al. Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study. Vasc Health Risk Manag. 2022;18:653–65.
Sood, Michael R., et al. “Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study.Vasc Health Risk Manag, vol. 18, 2022, pp. 653–65. Pubmed, doi:10.2147/VHRM.S359632.
Sood MR, Abdelmoneim SS, Dontineni N, Ivanov A, Lee E, Rubin M, Vittoria M, Meykler M, Ramachandran V, Sacchi T, Brener S, Klem I, Heitner JF. Descending Aortic Distensibility and Cardiovascular Outcomes: A Cardiac Magnetic Resonance Imaging Study. Vasc Health Risk Manag. 2022;18:653–665.

Published In

Vasc Health Risk Manag

DOI

EISSN

1178-2048

Publication Date

2022

Volume

18

Start / End Page

653 / 665

Location

New Zealand

Related Subject Headings

  • Stroke
  • Myocardial Infarction
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Disease Progression
  • Cardiovascular System & Hematology
  • Aorta
  • Aged
  • Adult