Igor Klem | Scholars@Duke

Igor Klem
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Cardiology, Medicine 2016

Contact Information

Duke Box 3943, Durham, NC 27710
Trent Drive, Duke Clinic, Orange Zone, Rm 4229, Durham, NC 27710
igor.klem@duke.edu (919) 668-3539

Background
Education, Training, & Certifications
- M.D., University of Vienna (Austria) 1997
Duke Appointment History
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2010 - 2016
- Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2007 - 2010
Research
Selected Grants
- Medical Images, HTML5, and Clinical Trial Remote Collaboration awarded by Heart Imaging Technologies, LLC 2017 - 2018
- Gadavist-enhanced CMRI to Detect Coronary Artery Disease (CAD) - GadaCAD2 awarded by Bayer Healthcare Pharmaceuticals Inc 2015 - 2017
- Delayed-Enhancement Cardiac MRI: Prognostic Implications and Improved Imaging awarded by National Institutes of Health 2010 - 2015
Publications & Artistic Works
Selected Publications
- Book Sections
  - Khouri, MG, Klem, I, Shenoy, C, Sulpher, J, and Dent, SF. "Screening and monitoring for cardiotoxicity during cancer treatment." In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 43-80. April 11, 2017. Full Text
- Journal Articles
  - Romano, S, Judd, RM, Kim, RJ, Kim, HW, Klem, I, Heitner, JF, Shah, DJ, Jue, J, and Farzaneh-Far, A. "Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection Fraction: A Multicenter Study." Radiology 286, no. 2 (February 2018): 452-460. Full Text
  - Romano, S, Judd, RM, Kim, RJ, Kim, HW, Klem, I, Heitner, JF, Shah, DJ, Jue, J, White, BE, Indorkar, R, Shenoy, C, and Farzaneh-Far, A. "Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients with Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late Gadolinium Enhancement." JACC. Cardiovascular imaging (January 12, 2018). Full Text
  - Kim, HW, Rehwald, WG, Jenista, ER, Wendell, DC, Filev, P, van Assche, L, Jensen, CJ, Parker, MA, Chen, E-L, Crowley, ALC, Klem, I, Judd, RM, and Kim, RJ. "Dark-Blood Delayed Enhancement Cardiac Magnetic Resonance of Myocardial Infarction." JACC. Cardiovascular imaging (December 8, 2017). Full Text Open Access Copy
  - Pueschner, A, Chattranukulchai, P, Heitner, JF, Shah, DJ, Hayes, B, Rehwald, W, Parker, MA, Kim, HW, Judd, RM, Kim, RJ, and Klem, I. "The Prevalence, Correlates, and Impact on Cardiac Mortality of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy." JACC. Cardiovascular imaging 10, no. 10 Pt B (October 2017): 1225-1236. Full Text
  - Ivanov, A, Dabiesingh, DS, Bhumireddy, GP, Mohamed, A, Asfour, A, Briggs, WM, Ho, J, Khan, SA, Grossman, A, Klem, I, Sacchi, TJ, and Heitner, JF. "Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging." Circulation. Cardiovascular imaging 10, no. 9 (September 2017). Full Text
  - Romano, S, Judd, RM, Kim, RJ, Kim, HW, Klem, I, Heitner, J, Shah, DJ, Jue, J, White, BE, Shenoy, C, and Farzaneh-Far, A. "Association of Feature-Tracking Cardiac Magnetic Resonance Imaging Left Ventricular Global Longitudinal Strain With All-Cause Mortality in Patients With Reduced Left Ventricular Ejection Fraction." Circulation 135, no. 23 (June 2017): 2313-2315. (Letter) Full Text
  - Huang, H, Nijjar, PS, Misialek, JR, Blaes, A, Derrico, NP, Kazmirczak, F, Klem, I, Farzaneh-Far, A, and Shenoy, C. "Accuracy of left ventricular ejection fraction by contemporary multiple gated acquisition scanning in patients with cancer: comparison with cardiovascular magnetic resonance." Journal of Cardiovascular Magnetic Resonance 19, no. 1 (March 24, 2017): 34-. Full Text
  - Ivanov, A, Kaczkowska, BA, Khan, SA, Ho, J, Tavakol, M, Prasad, A, Bhumireddy, G, Beall, AF, Klem, I, Mehta, P, Briggs, WM, Sacchi, TJ, and Heitner, JF. "Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals." PloS one 12, no. 1 (January 20, 2017): e0170056-. Full Text
  - Hamo, CE, Klem, I, Rao, SV, Songco, V, Najjar, S, Lakatta, EG, Raman, SV, Harrington, RA, and Heitner, JF. "The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction." PloS one 12, no. 1 (January 6, 2017): e0169108-. Full Text
  - Di Marco, A, Anguera, I, Schmitt, M, Klem, I, Neilan, TG, White, JA, Sramko, M, Masci, PG, Barison, A, Mckenna, P, Mordi, I, Haugaa, KH, Leyva, F, Rodriguez Capitán, J, Satoh, H, Nabeta, T, Dallaglio, PD, Campbell, NG, Sabaté, X, and Cequier, Á. "Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis." JACC. Heart failure 5, no. 1 (January 2017): 28-38. (Review) Full Text
  - Ivanov, A, Mohamed, A, Asfour, A, Ho, J, Khan, SA, Chen, O, Klem, I, Ramasubbu, K, Brener, SJ, and Heitner, JF. "Right atrial volume by cardiovascular magnetic resonance predicts mortality in patients with heart failure with reduced ejection fraction." PloS one 12, no. 4 (January 2017): e0173245-. Full Text
  - Ivanov, A, Bhumireddy, GP, Dabiesingh, DS, Khan, SA, Ho, J, Krishna, N, Dontineni, N, Socolow, JA, Briggs, WM, Klem, I, Sacchi, TJ, and Heitner, JF. "Importance of papillary muscle infarction detected by cardiac magnetic resonance imaging in predicting cardiovascular events." International journal of cardiology 220 (October 2016): 558-563. Full Text
  - Park, J-B, Kim, H-K, Jung, J-H, Klem, I, Yoon, YE, Lee, S-P, Park, E-A, Hwang, H-Y, Lee, W, Kim, K-H, Kim, Y-J, Cho, G-Y, Kim, K-B, Sohn, D-W, and Ahn, H. "Prognostic Value of Cardiac MR Imaging for Preoperative Assessment of Patients with Severe Functional Tricuspid Regurgitation." Radiology 280, no. 3 (September 2016): 723-734. Full Text
  - Klem, I. "Expanding CT Application to Myocardial Tissue Characterization." JACC. Cardiovascular imaging 9, no. 7 (July 2016): 846-848. Full Text
  - Leeters, IPM, Davis, A, Zusterzeel, R, Atwater, B, Risum, N, Søgaard, P, Klem, I, Nijveldt, R, Wagner, GS, Gorgels, APM, and Kisslo, J. "Left ventricular regional contraction abnormalities by echocardiographic speckle tracking in combined right bundle branch with left anterior fascicular block compared to left bundle branch block." Journal of electrocardiology 49, no. 3 (May 2016): 353-361. Full Text
  - Ahmad, IG, Abdulla, RK, Klem, I, Margulis, R, Ivanov, A, Mohamed, A, Judd, RM, Borges-Neto, S, Kim, RJ, and Heitner, JF. "Comparison of stress cardiovascular magnetic resonance imaging (CMR) with stress nuclear perfusion for the diagnosis of coronary artery disease." Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 23, no. 2 (April 2016): 287-297. Full Text
  - Åkerlund, S, Wieslander, B, Turesson, M, Nijveldt, R, Klem, I, Almer, J, Engblom, H, Wagner, GS, Atwater, BD, and Ugander, M. "Specificity for each of the 46 criteria of the Selvester QRS score for electrocardiographic myocardial scar sizing in left bundle branch block." Journal of electrocardiology 48, no. 5 (September 2015): 769-776. Full Text
  - Wieslander, B, Nijveldt, R, Klem, I, Lokhnygina, Y, Pura, J, Wagner, GS, Ugander, M, and Atwater, BD. "Evaluation of Selvester QRS score for use in presence of conduction abnormalities in a broad population." American heart journal 170, no. 2 (August 2015): 346-352. Full Text
  - Kim, EK, Chattranukulchai, P, and Klem, I. "Cardiac Magnetic Resonance Scar Imaging for Sudden Cardiac Death Risk Stratification in Patients with Non-Ischemic Cardiomyopathy." Korean journal of radiology 16, no. 4 (July 2015): 683-695. (Review) Full Text
  - Kim, HW, Van Assche, L, Jennings, RB, Wince, WB, Jensen, CJ, Rehwald, WG, Wendell, DC, Bhatti, L, Spatz, DM, Parker, MA, Jenista, ER, Klem, I, Crowley, ALC, Chen, E-L, Judd, RM, and Kim, RJ. "Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk." Circulation research 117, no. 3 (July 2015): 254-265. Full Text Open Access Copy
  - Chen, O, Sharma, A, Ahmad, I, Bourji, N, Nestoiter, K, Hua, P, Hua, B, Ivanov, A, Yossef, J, Klem, I, Briggs, WM, Sacchi, TJ, and Heitner, JF. "Correlation between pericardial, mediastinal, and intrathoracic fat volumes with the presence and severity of coronary artery disease, metabolic syndrome, and cardiac risk factors." European heart journal cardiovascular Imaging 16, no. 1 (January 2015): 37-46. Full Text
  - Ivanov, A, Yossef, J, Mohamed, A, Socolow, J, Gulkarov, I, Worku, B, Chattranukulchai, P, Tortolani, A, Sacchi, T, Ghosn, MG, Shah, DJ, Grizzard, JD, Biederman, RW, Klem, I, and Heitner, J. "Evaluating change of function after revascularization in patients with multi vessel coronary artery disease, severely reduced left ventricular systolic function and no scar on CMR imaging." Journal of Cardiovascular Magnetic Resonance 17, no. Suppl 1 (2015): P169-P169. Full Text
  - Klem, I, Heiberg, E, van Assche, L, Wagner, G, Parker, M, Kim, HW, Grizzard, JD, Arheden, H, and Kim, R. "Sources of variability in quantification of CMR infarct size and their impact on sample size calculations - reproducibility among three core laboratories." Journal of Cardiovascular Magnetic Resonance 17, no. Suppl 1 (2015): P84-P84. Full Text
  - Simprini, LA, Afroz, A, Cooper, MA, Klem, I, Jensen, C, Kim, RJ, Srichai, MB, Heitner, JF, Sood, M, Chandy, E, Shah, DJ, Lopez-Mattei, J, Biederman, RW, Grizzard, JD, Fuisz, A, Ghafourian, K, Farzaneh-Far, A, and Weinsaft, J. "Routine cine-CMR for prosthesis-associated mitral regurgitation: a multicenter comparison to echocardiography." The Journal of heart valve disease 23, no. 5 (September 2014): 575-582.
  - Heitner, JF, Klem, I, Rasheed, D, Chandra, A, Kim, HW, Van Assche, LMR, Parker, M, Judd, RM, Jollis, JG, and Kim, RJ. "Stress cardiac MR imaging compared with stress echocardiography in the early evaluation of patients who present to the emergency department with intermediate-risk chest pain." Radiology 271, no. 1 (April 2014): 56-64. Full Text
  - Oldan, JD, Klem, I, and Borges-Neto, S. "Pulmonary venous stenosis on ventilation-perfusion scintigraphy: a correlation with dynamic magnetic resonance pulmonary angiography." Clinical nuclear medicine 39, no. 3 (March 2014): 292-294. Full Text
  - Oldan, JD, Klem, I, and Borges-Neto, S. "Pulmonary venous stenosis on ventilation-perfusion scintigraphy: a correlation with dynamic magnetic resonance pulmonary angiography." Clinical nuclear medicine 39, no. 3 (January 1, 2014): -294-.
  - Jenista, ER, Rehwald, WG, Chen, E-L, Kim, HW, Klem, I, Parker, MA, and Kim, RJ. "Motion and flow insensitive adiabatic T2 -preparation module for cardiac MR imaging at 3 Tesla." Magn Reson Med 70, no. 5 (November 2013): 1360-1368. Full Text Link to Item
  - Jenista, ER, Rehwald, WG, Chen, EL, Kim, HW, Klem, I, Parker, MA, and Kim, RJ. "Motion and flow insensitive adiabatic T2-preparation module for cardiac MR imaging at 3 tesla." Magnetic Resonance in Medicine 70, no. 5 (November 1, 2013): 1360-1368. Full Text
  - Klem, I, Weinsaft, JW, Bahnson, TD, Hegland, D, Kim, HW, Hayes, B, Parker, MA, Judd, RM, and Kim, RJ. "Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation." J Am Coll Cardiol 60, no. 5 (July 31, 2012): 408-420. Full Text Link to Item
  - Greulich, S, Bruder, O, Parker, M, Schumm, J, Grün, S, Schneider, S, Klem, I, Sechtem, U, and Mahrholdt, H. "Comparison of exercise electrocardiography and stress perfusion CMR for the detection of coronary artery disease in women." Journal of Cardiovascular Magnetic Resonance 14, no. 1 (2012). Full Text
  - Heitner, J, Bhumireddy, GP, Crowley, AL, Weinsaft, J, Haq, SA, Klem, I, Kim, RJ, and Jollis, JG. "Clinical application of cine-MRI in the visual assessment of mitral regurgitation compared to echocardiography and cardiac catheterization." PLoS One 7, no. 7 (2012): e40491-. Full Text Link to Item
  - Klem, I, Shah, DJ, White, RD, Pennell, DJ, van Rossum, AC, Regenfus, M, Sechtem, U, Schvartzman, PR, Hunold, P, Croisille, P, Parker, M, Judd, RM, and Kim, RJ. "Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection fraction and myocardial damage: an international, multicenter study." Circ Cardiovasc Imaging 4, no. 6 (November 2011): 610-619. Full Text Link to Item
  - Weinsaft, JW, Kim, HW, Crowley, AL, Klem, I, Shenoy, C, Van Assche, L, Brosnan, R, Shah, DJ, Velazquez, EJ, Parker, M, Judd, RM, and Kim, RJ. "LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed enhancement CMR." JACC Cardiovasc Imaging 4, no. 7 (July 2011): 702-712. Full Text Link to Item
  - Hirsch, A, Nijveldt, R, and Klem, I. "Imaging in acute coronary syndrome." Cardiology Research and Practice 1, no. 1 (2011). Full Text
  - Shenoy, C, Klem, I, Crowley, AL, Patel, MR, Winchester, MA, Owusu, C, and Kimmick, GG. "Cardiovascular complications of breast cancer therapy in older adults." Oncologist 16, no. 8 (2011): 1138-1143. (Review) Full Text Link to Item
  - Siegler, JC, Rehman, S, Bhumireddy, GP, Abdula, R, Klem, I, Brener, SJ, Lee, L, Dunbar, CC, Saul, B, Sacchi, TJ, and Heitner, JF. "The accuracy of the electrocardiogram during exercise stress test based on heart size." PLoS One 6, no. 8 (2011): e23044-. Full Text Link to Item
  - Heitner, JF, Bhumireddy, GP, Cawley, PJ, Klem, I, Patel, MR, Crowley, AL, Weinsaft, JW, Elliott, M, Parker, M, Brener, S, Judd, RM, and Kim, RJ. "The aorta wall of patients presenting to the emergency department with acute myocardial infarction by cardiac magnetic resonance." Atherosclerosis 212, no. 1 (September 2010): 166-170. Full Text Link to Item
  - Vavalle, J, Bashore, TM, and Klem, I. "Surprising finding of a primary pericardial mesothelioma." Int J Cardiovasc Imaging 26, no. 6 (August 2010): 625-627. Full Text Link to Item
  - Banko, LT, Haq, SA, Rainaldi, DA, Klem, I, Siegler, J, Fogel, J, Sacchi, TJ, and Heitner, JF. "Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening." Am J Cardiol 105, no. 10 (May 15, 2010): 1474-1479. Full Text Link to Item
  - Patel, MR, Cawley, PJ, Heitner, JF, Klem, I, Parker, MA, Jaroudi, WA, Meine, TJ, White, JB, Elliott, MD, Kim, HW, Judd, RM, and Kim, RJ. "Detection of myocardial damage in patients with sarcoidosis." Circulation 120, no. 20 (November 17, 2009): 1969-1977. Full Text Link to Item
  - Kim, HW, Klem, I, Shah, DJ, Wu, E, Meyers, SN, Parker, MA, Crowley, AL, Bonow, RO, Judd, RM, and Kim, RJ. "Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease." PLoS Med 6, no. 4 (April 21, 2009): e1000057-. Full Text Link to Item
  - Klem, I, and Kim, RJ. "Assessment of microvascular injury after acute myocardial infarction: importance of the area at risk." Nat Clin Pract Cardiovasc Med 5, no. 12 (December 2008): 756-757. Full Text Link to Item
  - Weinsaft, JW, Kim, HW, Shah, DJ, Klem, I, Crowley, AL, Brosnan, R, James, OG, Patel, MR, Heitner, J, Parker, M, Velazquez, EJ, Steenbergen, C, Judd, RM, and Kim, RJ. "Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction." J Am Coll Cardiol 52, no. 2 (July 8, 2008): 148-157. Full Text Link to Item
  - Klem, I, Greulich, S, Heitner, JF, Kim, H, Vogelsberg, H, Kispert, E-M, Ambati, SR, Bruch, C, Parker, M, Judd, RM, Kim, RJ, and Sechtem, U. "Value of cardiovascular magnetic resonance stress perfusion testing for the detection of coronary artery disease in women." JACC Cardiovasc Imaging 1, no. 4 (July 2008): 436-445. Full Text Link to Item
  - Kim, HW, Klem, I, and Kim, RJ. "Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance." Magn Reson Imaging Clin N Am 15, no. 4 (November 2007): 527-vi. Full Text Link to Item
  - Kim, HW, Klem, I, and Kim, RJ. "Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance." Cardiol Clin 25, no. 1 (February 2007): 57-vi. (Review) Full Text Link to Item
  - Sievers, B, Elliott, MD, Hurwitz, LM, Albert, TSE, Klem, I, Rehwald, WG, Parker, MA, Judd, RM, and Kim, RJ. "Rapid detection of myocardial infarction by subsecond, free-breathing delayed contrast-enhancement cardiovascular magnetic resonance." Circulation 115, no. 2 (January 16, 2007): 236-244. Full Text Link to Item
  - Bruch, C, Klem, I, Breithardt, G, Wichter, T, and Gradaus, R. "Diagnostic Usefulness and Prognostic Implications of the Mitral E/E′ Ratio in Patients With Heart Failure and Severe Secondary Mitral Regurgitation." American Journal of Cardiology 100, no. 5 (2007): 860-865. Full Text
  - Mahrholdt, H, Klem, I, and Sechtem, U. "Cardiovascular MRI for detection of myocardial viability and ischaemia." Heart 93, no. 1 (2007): 122-129. Full Text
  - Weinsaft, JW, Klem, I, and Judd, RM. "MRI for the Assessment of Myocardial Viability." Magnetic Resonance Imaging Clinics of North America 15, no. 4 (2007): 505-525. Full Text
  - Weinsaft, JW, Klem, I, and Judd, RM. "MRI for the Assessment of Myocardial Viability." Cardiology Clinics 25, no. 1 (2007): 35-56. Full Text
  - Klem, I, Heitner, JF, Shah, DJ, Sketch, MH, Behar, V, Weinsaft, J, Cawley, P, Parker, M, Elliott, M, Judd, RM, and Kim, RJ. "Improved detection of coronary artery disease by stress perfusion cardiovascular magnetic resonance with the use of delayed enhancement infarction imaging." J Am Coll Cardiol 47, no. 8 (April 18, 2006): 1630-1638. Full Text Link to Item
  - Deluigi, CC, Meinhardt, G, Ursulescu, A, Klem, I, Fritz, P, and Mahrholdt, H. "Noninvasive characterization of left atrial mass." Circulation 113, no. 2 (2006): e19-e20. Full Text
  - Heitner, J, Lotfi, M, Harrison, JK, Cabell, C, Klem, I, Banko, L, Kim, RJ, and Califf, RM. "Where's the flap?." J Cardiovasc Magn Reson 8, no. 3 (2006): 549-550. Link to Item
  - Klem, I, Rehwald, WG, Heitner, JF, Wagner, A, Albert, T, Parker, MA, Chen, E-L, Kim, RJ, and Judd, RM. "Noninvasive assessment of blood flow based on magnetic resonance global coherent free precession." Circulation 111, no. 8 (March 1, 2005): 1033-1039. Full Text Link to Item
  - Heitner, JF, Klem, I, Alexander, K, Thomson, L, Meine, TJ, Patel, MR, Haq, SA, Shah, DJ, and Kim, RJ. "The case of the disappearing myxoma." J Cardiovasc Magn Reson 7, no. 5 (2005): 841-843. Link to Item
  - Klem, I, and Sechtem, U. "Is coronary magnetic resonance angiography already a clinically useful diagnostic tool?." Deutsche Medizinische Wochenschrift 129, no. 50 (December 10, 2004): 2733-2738. (Review) Full Text
  - Thompson, RB, Parsa, CJ, van den Bos, EJ, Davis, BH, Toloza, EM, Klem, I, Glower, DD, and Taylor, DA. "Video-assisted thoracoscopic transplantation of myoblasts into the heart." Ann Thorac Surg 78, no. 1 (July 2004): 303-307. Full Text Link to Item
  - Klem, I, and Sechtem, U. "Is coronary magnetic resonance angiography already a clinically useful diagnostic tool?." Deutsche Medizinische Wochenschrift 129, no. 50 (2004): 2733-2738. Full Text
  - Stöllberger, C, Chnupa, P, Abzieher, C, Länger, T, Finsterer, J, Klem, I, Hartl, E, Wehinger, C, and Schneider, B. "Mortality and Rate of Stroke or Embolism in Atrial Fibrillation during Long-Term Follow-Up in the Embolism in Left Atrial Thrombi (ELAT) Study." Clinical Cardiology 27, no. 1 (2004): 40-46.
  - Klem, I, Wehinger, C, Schneider, B, Hartl, E, Finsterer, J, and Stöllberger, C. "Diabetic atrial fibrillation patients: Mortality and risk for stroke or embolism during a 10-year follow-up." Diabetes/Metabolism Research and Reviews 19, no. 4 (2003): 320-328. Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Book Sections

Journal Articles