Igor Klem | Scholars@Duke

Igor Klem
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Cardiology, Medicine 2019

Contact Information

Duke Box 3943, Durham, NC 27710
Trent Drive, Duke Clinic, Orange Zone, Rm 4229, Durham, NC 27710
igor.klem@duke.edu (919) 668-3539

Background
Education, Training, & Certifications
- M.D., University of Vienna (Austria) 1997
Duke Appointment History
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 2016 - 2019
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2010 - 2016
- Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2007 - 2010
Research
Selected Grants
External Relationships
- Bayer Healthcare Pharmaceuticals
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Jenista, Elizabeth R., Christoph J. Jensen, David Wendell, Deneen Spatz, Stephen Darty, Han W. Kim, Michele Parker, et al. “Double spectral attenuated inversion recovery (DSPAIR)-an efficient fat suppression technique for late gadolinium enhancement at 3 tesla.” Nmr in Biomedicine 34, no. 10 (October 2021): e4580. https://doi.org/10.1002/nbm.4580.
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  - Mandawat, Aditya, Pairoj Chattranukulchai, Anant Mandawat, Alexander J. Blood, Sindhoor Ambati, Brenda Hayes, Wolfgang Rehwald, et al. “Progression of Myocardial Fibrosis in Nonischemic DCM and Association With Mortality and Heart Failure Outcomes.” Jacc Cardiovasc Imaging 14, no. 7 (July 2021): 1338–50. https://doi.org/10.1016/j.jcmg.2020.11.006.
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  - Zweerink, Alwin, Daniel J. Friedman, Igor Klem, Peter M. van de Ven, Caitlin Vink, P Stefan Biesbroek, Steen M. Hansen, et al. “Segment Length in Cine Strain Analysis Predicts Cardiac Resynchronization Therapy Outcome Beyond Current Guidelines.” Circ Cardiovasc Imaging 14, no. 7 (July 2021): e012350. https://doi.org/10.1161/CIRCIMAGING.120.012350.
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  - Klem, Igor, Michael Klein, Mohammad Khan, Eric Y. Yang, Faisal Nabi, Alexander Ivanov, Lubna Bhatti, et al. “Relationship of LVEF and Myocardial Scar to Long-Term Mortality Risk and Mode of Death in Patients With Nonischemic Cardiomyopathy.” Circulation 143, no. 14 (April 6, 2021): 1343–58. https://doi.org/10.1161/CIRCULATIONAHA.120.048477.
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  - Cavalier, Joanna S., and Igor Klem. “Using Cardiac Magnetic Resonance Imaging to Evaluate Patients with Chest Pain in the Emergency Department.” J Cardiovasc Imaging 29, no. 2 (April 2021): 91–107. https://doi.org/10.4250/jcvi.2021.0036.
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  - Kochav, Jonathan D., Jiwon Kim, Robert Judd, Han W. Kim, Igor Klem, John Heitner, Dipan Shah, et al. “Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation.” Jacc Cardiovasc Imaging 14, no. 4 (April 2021): 826–39. https://doi.org/10.1016/j.jcmg.2021.01.007.
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  - Beijnink, Casper W. H., Troels Thim, Dirk Jan van der Heijden, Igor Klem, Rasha Al-Lamee, Jacqueline L. Vos, Yvonne Koop, et al. “Instantaneous wave-free ratio guided multivessel revascularisation during percutaneous coronary intervention for acute myocardial infarction: study protocol of the randomised controlled iMODERN trial.” Bmj Open 11, no. 1 (January 15, 2021): e044035. https://doi.org/10.1136/bmjopen-2020-044035.
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  - Romano, Minna Moreira Dias, Henrique Turin Moreira, José Antônio Marin-Neto, Priscila Elias Baccelli, Fawaz Alenezi, Igor Klem, Benedito Carlos Maciel, Joseph Kisslo, André Schmidt, and Eric J. Velazquez. “Early impairment of myocardial deformation assessed by regional speckle-tracking echocardiography in the indeterminate form of Chagas disease without fibrosis detected by cardiac magnetic resonance.” Plos Negl Trop Dis 14, no. 11 (November 2020): e0008795. https://doi.org/10.1371/journal.pntd.0008795.
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  - Loungani, Rahul S., Michael R. Rehorn, L Kristin Newby, Jason N. Katz, Igor Klem, Robert J. Mentz, W Schuyler Jones, et al. “A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response.” Am Heart J 225 (July 2020): 3–9. https://doi.org/10.1016/j.ahj.2020.04.024.
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  - Klem, Igor, and Akash Goyal. “Left Ventricular Noncompaction: Meglio solo che mal accompagnati: Italian proverb: "Better Alone Than in Bad Company".” Jacc Cardiovasc Imaging 12, no. 11 Pt 1 (November 2019): 2152–54. https://doi.org/10.1016/j.jcmg.2019.03.012.
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  - Kimmick, Gretchen, Susan Dent, and Igor Klem. “Risk of Cardiomyopathy in Breast Cancer: How Can We Attenuate the Risk of Heart Failure from Anthracyclines and Anti-HER2 Therapies?” Curr Treat Options Cardiovasc Med 21, no. 6 (May 31, 2019): 30. https://doi.org/10.1007/s11936-019-0736-1.
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  - Loring, Zak, Brett D. Atwater, Xiaojuan Xia, Jimmy Axelsson, Igor Klem, Robin Nijveldt, Erik B. Schelbert, et al. “Low lead one ratio predicts clinical outcomes in left bundle branch block.” J Cardiovasc Electrophysiol 30, no. 5 (May 2019): 709–16. https://doi.org/10.1111/jce.13875.
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  - Heitner, John F., Annamalai Senthilkumar, J Kevin Harrison, Igor Klem, Michael H. Sketch, Alexandr Ivanov, Carine Hamo, et al. “Identifying the Infarct-Related Artery in Patients With Non-ST-Segment-Elevation Myocardial Infarction.” Circulation. Cardiovascular Interventions 12, no. 5 (May 2019): e007305. https://doi.org/10.1161/circinterventions.118.007305.
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  - Axelsson, Jimmy, Björn Wieslander, Robert Jablonowski, Igor Klem, Robin Nijveldt, Erik B. Schelbert, Peder Sörensson, et al. “Corrigendum to "Wieslander, et al., Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar" [J Electrocardiol 51(2018) 1071-1076].” J Electrocardiol 53 (March 2019): 115. https://doi.org/10.1016/j.jelectrocard.2019.01.082.
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  - Heitner, John F., Raymond J. Kim, Han W. Kim, Igor Klem, Dipan J. Shah, Dany Debs, Afshin Farzaneh-Far, et al. “Prognostic Value of Vasodilator Stress Cardiac Magnetic Resonance Imaging: A Multicenter Study With 48 000 Patient-Years of Follow-up.” Jama Cardiol 4, no. 3 (March 1, 2019): 256–64. https://doi.org/10.1001/jamacardio.2019.0035.
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  - Khan, Mohammad A., Eric Y. Yang, Yang Zhan, Robert M. Judd, Wenyaw Chan, Faisal Nabi, John F. Heitner, et al. “Association of left atrial volume index and all-cause mortality in patients referred for routine cardiovascular magnetic resonance: a multicenter study.” J Cardiovasc Magn Reson 21, no. 1 (January 7, 2019): 4. https://doi.org/10.1186/s12968-018-0517-0.
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  - Kim, Han W., Wolfgang G. Rehwald, Elizabeth R. Jenista, David C. Wendell, Peter Filev, Lowie van Assche, Christoph J. Jensen, et al. “Dark-Blood Delayed Enhancement Cardiac Magnetic Resonance of Myocardial Infarction.” Jacc Cardiovasc Imaging 11, no. 12 (December 2018): 1758–69. https://doi.org/10.1016/j.jcmg.2017.09.021.
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  - Zweerink, Alwin, Daniel J. Friedman, Igor Klem, Peter M. van de Ven, Caitlin Vink, P Stefan Biesbroek, Steen M. Hansen, et al. “Size Matters: Normalization of QRS Duration to Left Ventricular Dimension Improves Prediction of Long-Term Cardiac Resynchronization Therapy Outcome.” Circ Arrhythm Electrophysiol 11, no. 12 (December 2018): e006767. https://doi.org/10.1161/CIRCEP.118.006767.
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  - Axelsson, Jimmy, Björn Wieslander, Robert Jablonowski, Igor Klem, Robin Nijveldt, Erik B. Schelbert, Peder Sörensson, et al. “Ejection fraction in left bundle branch block is disproportionately reduced in relation to amount of myocardial scar.” J Electrocardiol 51, no. 6 (November 2018): 1071–76. https://doi.org/10.1016/j.jelectrocard.2018.09.009.
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  - Romano, Simone, Robert M. Judd, Raymond J. Kim, Han W. Kim, Igor Klem, John F. Heitner, Dipan J. Shah, et al. “Feature-Tracking Global Longitudinal Strain Predicts Death in a Multicenter Population of Patients With Ischemic and Nonischemic Dilated Cardiomyopathy Incremental to Ejection Fraction and Late Gadolinium Enhancement.” Jacc Cardiovasc Imaging 11, no. 10 (October 2018): 1419–29. https://doi.org/10.1016/j.jcmg.2017.10.024.
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  - Wieslander, Björn, Xiaojuan Xia, Robert Jablonowski, Jimmy Axelsson, Igor Klem, Robin Nijveldt, Charles Maynard, et al. “The ability of the electrocardiogram in left bundle branch block to detect myocardial scar determined by cardiovascular magnetic resonance.” J Electrocardiol 51, no. 5 (September 2018): 779–86. https://doi.org/10.1016/j.jelectrocard.2018.05.019.
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  - Romano, Simone, Robert M. Judd, Raymond J. Kim, Han W. Kim, Igor Klem, John F. Heitner, Dipan J. Shah, Jennifer Jue, and Afshin Farzaneh-Far. “Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection Fraction: A Multicenter Study.” Radiology 286, no. 2 (February 2018): 452–60. https://doi.org/10.1148/radiol.2017170529.
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  - Chandy, Elizabeth, Alexander Ivanov, Devindra S. Dabiesingh, Alexandra Grossman, Prasanthi Sunkesula, Lakshmi Velagapudi, Virna L. Sales, et al. “Systemic involvement in ACS: Using CMR imaging to compare the aortic wall in patients with and without acute coronary syndrome.” Plos One 13, no. 12 (2018): e0203514. https://doi.org/10.1371/journal.pone.0203514.
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  - Pueschner, Andreas, Pairoj Chattranukulchai, John F. Heitner, Dipan J. Shah, Brenda Hayes, Wolfgang Rehwald, Michele A. Parker, et al. “The Prevalence, Correlates, and Impact on Cardiac Mortality of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy.” Jacc Cardiovasc Imaging 10, no. 10 Pt B (October 2017): 1225–36. https://doi.org/10.1016/j.jcmg.2017.06.013.
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  - Ivanov, Alexander, Devindra S. Dabiesingh, Geetha P. Bhumireddy, Ambreen Mohamed, Ahmed Asfour, William M. Briggs, Jean Ho, et al. “Prevalence and Prognostic Significance of Left Ventricular Noncompaction in Patients Referred for Cardiac Magnetic Resonance Imaging.” Circulation. Cardiovascular Imaging 10, no. 9 (September 2017). https://doi.org/10.1161/circimaging.117.006174.
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  - Klem, Igor, Einar Heiberg, Lowie Van Assche, Michele A. Parker, Han W. Kim, John D. Grizzard, Håkan Arheden, and Raymond J. Kim. “Sources of variability in quantification of cardiovascular magnetic resonance infarct size - reproducibility among three core laboratories.” J Cardiovasc Magn Reson 19, no. 1 (August 11, 2017): 62. https://doi.org/10.1186/s12968-017-0378-y.
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  - Romano, Simone, Robert M. Judd, Raymond J. Kim, Han W. Kim, Igor Klem, John Heitner, Dipan J. Shah, et al. “Association of Feature-Tracking Cardiac Magnetic Resonance Imaging Left Ventricular Global Longitudinal Strain With All-Cause Mortality in Patients With Reduced Left Ventricular Ejection Fraction.” Circulation 135, no. 23 (June 6, 2017): 2313–15. https://doi.org/10.1161/CIRCULATIONAHA.117.027740.
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  - Huang, Hans, Prabhjot S. Nijjar, Jeffrey R. Misialek, Anne Blaes, Nicholas P. Derrico, Felipe Kazmirczak, Igor Klem, Afshin Farzaneh-Far, and Chetan Shenoy. “Accuracy of left ventricular ejection fraction by contemporary multiple gated acquisition scanning in patients with cancer: comparison with cardiovascular magnetic resonance.” Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance 19, no. 1 (March 24, 2017): 34. https://doi.org/10.1186/s12968-017-0348-4.
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  - Di Marco, Andrea, Ignasi Anguera, Matthias Schmitt, Igor Klem, Tomas G. Neilan, James A. White, Marek Sramko, et al. “Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis.” Jacc Heart Fail 5, no. 1 (January 2017): 28–38. https://doi.org/10.1016/j.jchf.2016.09.017.
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  - Hamo, Carine E., Igor Klem, Sunil V. Rao, Vincent Songco, Samer Najjar, Edward G. Lakatta, Subha V. Raman, Robert A. Harrington, and John F. Heitner. “The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction.” Plos One 12, no. 1 (2017): e0169108. https://doi.org/10.1371/journal.pone.0169108.
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  - Ivanov, Alexander, Ambreen Mohamed, Ahmed Asfour, Jean Ho, Saadat A. Khan, Onn Chen, Igor Klem, Kumudha Ramasubbu, Sorin J. Brener, and John F. Heitner. “Right atrial volume by cardiovascular magnetic resonance predicts mortality in patients with heart failure with reduced ejection fraction.” Plos One 12, no. 4 (2017): e0173245. https://doi.org/10.1371/journal.pone.0173245.
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  - Ivanov, Alexander, Beata A. Kaczkowska, Saadat A. Khan, Jean Ho, Morteza Tavakol, Ashok Prasad, Geetha Bhumireddy, et al. “Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals.” Plos One 12, no. 1 (2017): e0170056. https://doi.org/10.1371/journal.pone.0170056.
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  - Ivanov, A., G. P. Bhumireddy, D. S. Dabiesingh, S. A. Khan, J. Ho, N. Krishna, N. Dontineni, et al. “Importance of papillary muscle infarction detected by cardiac magnetic resonance imaging in predicting cardiovascular events.” Int J Cardiol 220 (October 1, 2016): 558–63. https://doi.org/10.1016/j.ijcard.2016.06.201.
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  - Park, Jun-Bean, Hyung-Kwan Kim, Ji-Hyun Jung, Igor Klem, Yeonyee E. Yoon, Seung-Pyo Lee, Eun-Ah Park, et al. “Prognostic Value of Cardiac MR Imaging for Preoperative Assessment of Patients with Severe Functional Tricuspid Regurgitation.” Radiology 280, no. 3 (September 2016): 723–34. https://doi.org/10.1148/radiol.2016151556.
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  - Klem, Igor. “Expanding CT Application to Myocardial Tissue Characterization.” Jacc Cardiovasc Imaging 9, no. 7 (July 2016): 846–48. https://doi.org/10.1016/j.jcmg.2016.01.019.
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  - Leeters, Irene P. M., Ashlee Davis, Robbert Zusterzeel, Brett Atwater, Niels Risum, Peter Søgaard, Igor Klem, et al. “Left ventricular regional contraction abnormalities by echocardiographic speckle tracking in combined right bundle branch with left anterior fascicular block compared to left bundle branch block.” J Electrocardiol 49, no. 3 (May 2016): 353–61. https://doi.org/10.1016/j.jelectrocard.2016.02.002.
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  - Ahmad, Ijaz G., Raushan K. Abdulla, Igor Klem, Roman Margulis, Alexander Ivanov, Ambreen Mohamed, Robert M. Judd, Salvatore Borges-Neto, Raymond J. Kim, and John F. Heitner. “Comparison of stress cardiovascular magnetic resonance imaging (CMR) with stress nuclear perfusion for the diagnosis of coronary artery disease.” J Nucl Cardiol 23, no. 2 (April 2016): 287–97. https://doi.org/10.1007/s12350-015-0242-0.
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  - Kim, H. W., D. Labib, D. J. Shah, A. Farzaneh-Far, J. Heitner, J. D. Grizzard, A. L. Crowley, et al. “Prevalence of unrecognized myocardial scarring in patients with normal contractile function across four U.S. hospitals.” Journal of Cardiovascular Magnetic Resonance 18 (January 1, 2016): 1–2. https://doi.org/10.1186/1532-429X-18-S1-O131.
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  - Labib, D., H. W. Kim, D. J. Shah, A. Farzaneh-Far, J. Heitner, I. Klem, A. L. Crowley, et al. “Prevalence of regional and whole-heart viability in patients with myocardial akinesis consecutively enrolled from 4 US hospitals.” Journal of Cardiovascular Magnetic Resonance 18 (January 1, 2016): 1–2. https://doi.org/10.1186/1532-429X-18-S1-Q33.
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  - Mandawat, A., A. L. Crowley, J. Heitner, A. Ivanov, D. J. Shah, F. Nabi, A. Farzaneh-Far, et al. “Prevalence of dysfunctional but viable myocardium in patients with ischemic cardiomyopathy-results from clinical scans performed in 2010-2014 at four U.S. hospitals.” Journal of Cardiovascular Magnetic Resonance 18 (January 1, 2016): 1–2. https://doi.org/10.1186/1532-429X-18-S1-O1.
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  - Åkerlund, Sofia, Björn Wieslander, Madeleine Turesson, Robin Nijveldt, Igor Klem, Jakob Almer, Henrik Engblom, Galen S. Wagner, Brett D. Atwater, and Martin Ugander. “Specificity for each of the 46 criteria of the Selvester QRS score for electrocardiographic myocardial scar sizing in left bundle branch block.” J Electrocardiol 48, no. 5 (September 2015): 769–76. https://doi.org/10.1016/j.jelectrocard.2015.07.018.
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  - Wieslander, Björn, Robin Nijveldt, Igor Klem, Yuliya Lokhnygina, John Pura, Galen S. Wagner, Martin Ugander, and Brett D. Atwater. “Evaluation of Selvester QRS score for use in presence of conduction abnormalities in a broad population.” Am Heart J 170, no. 2 (August 2015): 346–52. https://doi.org/10.1016/j.ahj.2015.05.005.
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  - Kim, Han W., Lowie Van Assche, Robert B. Jennings, W Benjamin Wince, Christoph J. Jensen, Wolfgang G. Rehwald, David C. Wendell, et al. “Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk.” Circ Res 117, no. 3 (July 17, 2015): 254–65. https://doi.org/10.1161/CIRCRESAHA.117.305771.
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  - Kim, Eun Kyoung, Pairoj Chattranukulchai, and Igor Klem. “Cardiac Magnetic Resonance Scar Imaging for Sudden Cardiac Death Risk Stratification in Patients with Non-Ischemic Cardiomyopathy.” Korean J Radiol 16, no. 4 (July 2015): 683–95. https://doi.org/10.3348/kjr.2015.16.4.683.
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  - Ivanov, A., J. Yossef, A. Mohamed, J. Socolow, I. Gulkarov, B. Worku, P. Chattranukulchai, et al. “Evaluating change of function after revascularization in patients with multi vessel coronary artery disease, severely reduced left ventricular systolic function and no scar on CMR imaging (Accepted).” Journal of Cardiovascular Magnetic Resonance, February 3, 2015, 1–2. https://doi.org/10.1186/1532-429X-17-S1-P169.
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  - Klem, I., E. Heiberg, L. van Assche, G. Wagner, M. Parker, H. W. Kim, J. D. Grizzard, H. Arheden, and R. Kim. “Sources of variability in quantification of CMR infarct size and their impact on sample size calculations - reproducibility among three core laboratories (Accepted).” Journal of Cardiovascular Magnetic Resonance, February 3, 2015, 1–2. https://doi.org/10.1186/1532-429X-17-S1-P84.
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  - Chen, On, Abhishek Sharma, Ijaz Ahmad, Naji Bourji, Konstantin Nestoiter, Pauline Hua, Betty Hua, et al. “Correlation between pericardial, mediastinal, and intrathoracic fat volumes with the presence and severity of coronary artery disease, metabolic syndrome, and cardiac risk factors.” Eur Heart J Cardiovasc Imaging 16, no. 1 (January 2015): 37–46. https://doi.org/10.1093/ehjci/jeu145.
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  - Simprini, Lauren A., Anika Afroz, Mitchell A. Cooper, Igor Klem, Christoph Jensen, Raymond J. Kim, Monvadi B. Srichai, et al. “Routine cine-CMR for prosthesis-associated mitral regurgitation: a multicenter comparison to echocardiography.” J Heart Valve Dis 23, no. 5 (September 2014): 575–82.
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  - Heitner, John F., Igor Klem, Derek Rasheed, Abhinav Chandra, Han W. Kim, Lowie M. R. Van Assche, Michele Parker, Robert M. Judd, James G. Jollis, and Raymond J. Kim. “Stress cardiac MR imaging compared with stress echocardiography in the early evaluation of patients who present to the emergency department with intermediate-risk chest pain.” Radiology 271, no. 1 (April 2014): 56–64. https://doi.org/10.1148/radiol.13130557.
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  - Oldan, Jorge Daniel, Igor Klem, and Salvador Borges-Neto. “Pulmonary venous stenosis on ventilation-perfusion scintigraphy: a correlation with dynamic magnetic resonance pulmonary angiography.” Clin Nucl Med 39, no. 3 (March 2014): 292–94. https://doi.org/10.1097/RLU.0000000000000344.
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  - Oldan, J. D., I. Klem, and S. Borges-Neto. “Pulmonary venous stenosis on ventilation-perfusion scintigraphy: a correlation with dynamic magnetic resonance pulmonary angiography.” Clinical Nuclear Medicine 39, no. 3 (January 1, 2014): 294.
  - Jenista, Elizabeth R., Wolfgang G. Rehwald, Enn-Ling Chen, Han W. Kim, Igor Klem, Michele A. Parker, and Raymond J. Kim. “Motion and flow insensitive adiabatic T2 -preparation module for cardiac MR imaging at 3 Tesla.” Magn Reson Med 70, no. 5 (November 2013): 1360–68. https://doi.org/10.1002/mrm.24564.
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  - Klem, Igor, Jonathan W. Weinsaft, Tristram D. Bahnson, Don Hegland, Han W. Kim, Brenda Hayes, Michele A. Parker, Robert M. Judd, and Raymond J. Kim. “Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac defibrillator implantation.” Journal of the American College of Cardiology 60, no. 5 (July 2012): 408–20. https://doi.org/10.1016/j.jacc.2012.02.070.
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  - Greulich, Simon, Oliver Bruder, Michele Parker, Julia Schumm, Stefan Grün, Steffen Schneider, Igor Klem, Udo Sechtem, and Heiko Mahrholdt. “Comparison of exercise electrocardiography and stress perfusion CMR for the detection of coronary artery disease in women.” J Cardiovasc Magn Reson 14 (June 14, 2012): 36. https://doi.org/10.1186/1532-429X-14-36.
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  - Heitner, John, Geetha P. Bhumireddy, Anna Lisa Crowley, Jonathan Weinsaft, Salman A. Haq, Igor Klem, Raymond J. Kim, and James G. Jollis. “Clinical application of cine-MRI in the visual assessment of mitral regurgitation compared to echocardiography and cardiac catheterization.” Plos One 7, no. 7 (2012): e40491. https://doi.org/10.1371/journal.pone.0040491.
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  - Hirsch, A., R. Nijveldt, and I. Klem. “Imaging in acute coronary syndrome.” Cardiology Research and Practice 1, no. 1 (December 1, 2011). https://doi.org/10.4061/2011/461720.
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  - Klem, Igor, Dipan J. Shah, Richard D. White, Dudley J. Pennell, Albert C. van Rossum, Matthias Regenfus, Udo Sechtem, et al. “Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection fraction and myocardial damage: an international, multicenter study.” Circulation. Cardiovascular Imaging 4, no. 6 (November 2011): 610–19. https://doi.org/10.1161/circimaging.111.964965.
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  - Weinsaft, Jonathan W., Han W. Kim, Anna Lisa Crowley, Igor Klem, Chetan Shenoy, Lowie Van Assche, Rhoda Brosnan, et al. “LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed enhancement CMR.” Jacc Cardiovasc Imaging 4, no. 7 (July 2011): 702–12. https://doi.org/10.1016/j.jcmg.2011.03.017.
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  - Shenoy, Chetan, Igor Klem, Anna Lisa Crowley, Manesh R. Patel, Mark A. Winchester, Cynthia Owusu, and Gretchen G. Kimmick. “Cardiovascular complications of breast cancer therapy in older adults.” Oncologist 16, no. 8 (2011): 1138–43. https://doi.org/10.1634/theoncologist.2010-0348.
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  - Siegler, Jason C., Shafiq Rehman, Geetha P. Bhumireddy, Raushan Abdula, Igor Klem, Sorin J. Brener, Leonard Lee, et al. “The accuracy of the electrocardiogram during exercise stress test based on heart size.” Plos One 6, no. 8 (2011): e23044. https://doi.org/10.1371/journal.pone.0023044.
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  - Heitner, John F., Geetha P. Bhumireddy, Peter J. Cawley, Igor Klem, Manesh R. Patel, Anna Lisa Crowley, Jonathan W. Weinsaft, et al. “The aorta wall of patients presenting to the emergency department with acute myocardial infarction by cardiac magnetic resonance.” Atherosclerosis 212, no. 1 (September 2010): 166–70. https://doi.org/10.1016/j.atherosclerosis.2010.05.002.
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  - Vavalle, John, Thomas M. Bashore, and Igor Klem. “Surprising finding of a primary pericardial mesothelioma.” Int J Cardiovasc Imaging 26, no. 6 (August 2010): 625–27. https://doi.org/10.1007/s10554-010-9615-2.
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  - Banko, Lesan T., Salman A. Haq, Debroah A. Rainaldi, Igor Klem, Jason Siegler, Joshua Fogel, Terrence J. Sacchi, and John F. Heitner. “Incidence of caffeine in serum of patients undergoing dipyridamole myocardial perfusion stress test by an intensive versus routine caffeine history screening.” Am J Cardiol 105, no. 10 (May 15, 2010): 1474–79. https://doi.org/10.1016/j.amjcard.2009.12.072.
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  - Patel, Manesh R., Peter J. Cawley, John F. Heitner, Igor Klem, Michele A. Parker, Wael A. Jaroudi, Trip J. Meine, et al. “Detection of myocardial damage in patients with sarcoidosis.” Circulation 120, no. 20 (November 17, 2009): 1969–77. https://doi.org/10.1161/CIRCULATIONAHA.109.851352.
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  - Kim, Han W., Igor Klem, Dipan J. Shah, Edwin Wu, Sheridan N. Meyers, Michele A. Parker, Anna Lisa Crowley, Robert O. Bonow, Robert M. Judd, and Raymond J. Kim. “Unrecognized non-Q-wave myocardial infarction: prevalence and prognostic significance in patients with suspected coronary disease.” Plos Med 6, no. 4 (April 21, 2009): e1000057. https://doi.org/10.1371/journal.pmed.1000057.
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  - Klem, Igor, and Raymond J. Kim. “Assessment of microvascular injury after acute myocardial infarction: importance of the area at risk.” Nat Clin Pract Cardiovasc Med 5, no. 12 (December 2008): 756–57. https://doi.org/10.1038/ncpcardio1373.
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  - Weinsaft, Jonathan W., Han W. Kim, Dipan J. Shah, Igor Klem, Anna Lisa Crowley, Rhoda Brosnan, Olga G. James, et al. “Detection of left ventricular thrombus by delayed-enhancement cardiovascular magnetic resonance prevalence and markers in patients with systolic dysfunction.” J Am Coll Cardiol 52, no. 2 (July 8, 2008): 148–57. https://doi.org/10.1016/j.jacc.2008.03.041.
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  - Klem, Igor, Simon Greulich, John F. Heitner, Han Kim, Holger Vogelsberg, Eva-Maria Kispert, Srivani R. Ambati, et al. “Value of cardiovascular magnetic resonance stress perfusion testing for the detection of coronary artery disease in women.” Jacc Cardiovasc Imaging 1, no. 4 (July 2008): 436–45. https://doi.org/10.1016/j.jcmg.2008.03.010.
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  - Kim, Han W., Igor Klem, and Raymond J. Kim. “Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance.” Magn Reson Imaging Clin N Am 15, no. 4 (November 2007): 527–vi. https://doi.org/10.1016/j.mric.2007.08.008.
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  - Weinsaft, J. W., I. Klem, and R. M. Judd. “MRI for the Assessment of Myocardial Viability.” Magnetic Resonance Imaging Clinics of North America 15, no. 4 (November 1, 2007): 505–25. https://doi.org/10.1016/j.mric.2007.08.007.
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  - Bruch, Christian, Igor Klem, Günter Breithardt, Thomas Wichter, and Rainer Gradaus. “Diagnostic usefulness and prognostic implications of the mitral E/E' ratio in patients with heart failure and severe secondary mitral regurgitation.” Am J Cardiol 100, no. 5 (September 1, 2007): 860–65. https://doi.org/10.1016/j.amjcard.2007.03.108.
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  - Kim, Han W., Igor Klem, and Raymond J. Kim. “Detection of myocardial ischemia by stress perfusion cardiovascular magnetic resonance.” Cardiol Clin 25, no. 1 (February 2007): 57–vi. https://doi.org/10.1016/j.ccl.2007.02.002.
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  - Weinsaft, Jonathan W., Igor Klem, and Robert M. Judd. “MRI for the assessment of myocardial viability.” Cardiol Clin 25, no. 1 (February 2007): 35–v. https://doi.org/10.1016/j.ccl.2007.02.001.
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  - Sievers, Burkhard, Michael D. Elliott, Lynne M. Hurwitz, Timothy S. E. Albert, Igor Klem, Wolfgang G. Rehwald, Michele A. Parker, Robert M. Judd, and Raymond J. Kim. “Rapid detection of myocardial infarction by subsecond, free-breathing delayed contrast-enhancement cardiovascular magnetic resonance.” Circulation 115, no. 2 (January 16, 2007): 236–44. https://doi.org/10.1161/CIRCULATIONAHA.106.635409.
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  - Mahrholdt, H., I. Klem, and U. Sechtem. “Cardiovascular MRI for detection of myocardial viability and ischaemia.” Heart 93, no. 1 (January 2007): 122–29. https://doi.org/10.1136/hrt.2005.071290.
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  - Klem, Igor, John F. Heitner, Dipan J. Shah, Michael H. Sketch, Victor Behar, Jonathan Weinsaft, Peter Cawley, et al. “Improved detection of coronary artery disease by stress perfusion cardiovascular magnetic resonance with the use of delayed enhancement infarction imaging.” J Am Coll Cardiol 47, no. 8 (April 18, 2006): 1630–38. https://doi.org/10.1016/j.jacc.2005.10.074.
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  - Deluigi, Claudia C., Gabriel Meinhardt, Adrian Ursulescu, Igor Klem, Peter Fritz, and Heiko Mahrholdt. “Images in cardiovascular medicine. Noninvasive characterization of left atrial mass.” Circulation 113, no. 2 (January 17, 2006): e19–20. https://doi.org/10.1161/CIRCULATIONAHA.105.536755.
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  - Heitner, John, Mat Lotfi, J Kevin Harrison, Christopher Cabell, Igor Klem, Lesan Banko, Raymond J. Kim, and Robert M. Califf. “Where's the flap?” J Cardiovasc Magn Reson 8, no. 3 (2006): 549–50. https://doi.org/10.1080/10976640600584785.
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  - Klem, Igor, Wolfgang G. Rehwald, John F. Heitner, Anja Wagner, Timothy Albert, Michele A. Parker, Enn-Ling Chen, Raymond J. Kim, and Robert M. Judd. “Noninvasive assessment of blood flow based on magnetic resonance global coherent free precession.” Circulation 111, no. 8 (March 1, 2005): 1033–39. https://doi.org/10.1161/01.CIR.0000156332.56894.22.
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  - Heitner, John F., Igor Klem, Karen Alexander, Louise Thomson, Trip J. Meine, Manesh R. Patel, Salman A. Haq, Dipan J. Shah, and Raymond J. Kim. “The case of the disappearing myxoma.” J Cardiovasc Magn Reson 7, no. 5 (2005): 841–43. https://doi.org/10.1080/10976640500288156.
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  - Klem, I., and U. Sechtem. “[Is coronary magnetic resonance angiography already a clinically useful diagnostic tool?].” Dtsch Med Wochenschr 129, no. 50 (December 10, 2004): 2733–38. https://doi.org/10.1055/s-2004-836104.
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  - Thompson, Richard B., Cyrus J. Parsa, Ewout J. van den Bos, Bryce H. Davis, Eric M. Toloza, Igor Klem, Donald D. Glower, and Doris A. Taylor. “Video-assisted thoracoscopic transplantation of myoblasts into the heart.” Ann Thorac Surg 78, no. 1 (July 2004): 303–7. https://doi.org/10.1016/S0003-4975(03)01215-3.
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  - Stöllberger, Claudia, Pavel Chnupa, Christine Abzieher, Thomas Länger, Josef Finsterer, Igor Klem, Elisabeth Hartl, Cornelius Wehinger, and Barbara Schneider. “Mortality and rate of stroke or embolism in atrial fibrillation during long-term follow-up in the embolism in left atrial thrombi (ELAT) study.” Clin Cardiol 27, no. 1 (January 2004): 40–46. https://doi.org/10.1002/clc.4960270111.
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  - Klem, Igor, Cornelius Wehinger, Barbara Schneider, Elisabeth Hartl, Josef Finsterer, and Claudia Stöllberger. “Diabetic atrial fibrillation patients: mortality and risk for stroke or embolism during a 10-year follow-up.” Diabetes Metab Res Rev 19, no. 4 (July 2003): 320–28. https://doi.org/10.1002/dmrr.386.
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- Book Sections
  - Khouri, M. G., I. Klem, C. Shenoy, J. Sulpher, and S. F. Dent. “Screening and monitoring for cardiotoxicity during cancer treatment.” In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 43–80, 2017. https://doi.org/10.1007/978-3-319-43096-6_3.
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  - Jenista, E. R., D. C. Wendell, I. Klem, E. S. H. Ibrahim, and W. G. Rehwald. “Introduction to cardiovascular magnetic resonance imaging.” In Heart Mechanics: Magnetic Resonance Imaging-Mathematical Modeling, Pulse Sequences, and Image Analysis, 121–77, 2017. https://doi.org/10.1201/9781315119083.
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  - Grizzard, J. D., D. J. Shah, I. Klem, and R. J. Kim. “MR angiography of the lower extremity circulation with protocols.” In CT and MR Angiography of the Peripheral Circulation: Practical Approach with Clinical Protocols, 283–308, 2007.
  - Klem, I., J. D. Grizzard, D. J. Shah, R. M. Judd, and R. J. Kim. “MR angiography of the thoracic aorta with protocols.” In CT and MR Angiography of the Peripheral Circulation: Practical Approach with Clinical Protocols, 227–45, 2007.
- Conference Papers
  - Hamo, Carine E., Sahar S. Abdelmoneim, Seol Young Han, Elizabeth Chandy, Cornelia Muntean, Saadat A. Khan, Prasanthi Sunkesula, et al. “OUTpatient intravenous LASix Trial in reducing hospitalization for acute decompensated heart failure (OUTLAST).” In Plos One, 16:e0253014, 2021. https://doi.org/10.1371/journal.pone.0253014.
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