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Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.

Publication ,  Journal Article
Loomba, R; Huang, DQ; Sanyal, AJ; Anstee, QM; Trauner, M; Lawitz, EJ; Ding, D; Ma, L; Jia, C; Billin, A; Huss, RS; Chung, C; Goodman, Z ...
Published in: Gut
March 2023

OBJECTIVE: In retrospective studies, liver stiffness (LS) by vibration-controlled transient elastography (VCTE) is associated with the risk of liver decompensation in patients with non-alcoholic steatohepatitis (NASH), but prospective data in biopsy-confirmed cohorts with advanced fibrosis are limited. We aimed to establish thresholds for LS by VCTE that predict progression to cirrhosis among patients with bridging fibrosis and hepatic decompensation among patients with cirrhosis due to NASH. DESIGN: We used data from four randomised placebo-controlled trials of selonsertib and simtuzumab in participants with advanced fibrosis (F3-F4). The trials were discontinued due to lack of efficacy. Liver fibrosis was staged centrally at baseline and week 48 (selonsertib study) or week 96 (simtuzumab study). Associations between LS by VCTE with disease progression were determined using Cox proportional hazards regression analysis. RESULTS: Progression to cirrhosis occurred in 16% (103/664) of participants with bridging fibrosis and adjudicated liver-related events occurred in 4% (27/734) of participants with baseline cirrhosis. The optimal baseline LS thresholds were ≥16.6 kPa for predicting progression to cirrhosis, and ≥30.7 kPa for predicting liver-related events. Baseline LS ≥16.6 kPa (adjusted HR 3.99; 95% CI 2.66 to 5.98, p<0.0001) and a ≥5 kPa (and ≥20%) increase (adjusted HR 1.98; 95% CI 1.20 to 3.26, p=0.008) were independent predictors of progression to cirrhosis in participants with bridging fibrosis, while baseline LS ≥30.7 kPa (adjusted HR 10.13, 95% CI 4.38 to 23.41, p<0.0001) predicted liver-related events in participants with cirrhosis. CONCLUSION: The LS thresholds identified in this study may be useful for risk stratification of NASH patients with advanced fibrosis.

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Published In

Gut

DOI

EISSN

1468-3288

Publication Date

March 2023

Volume

72

Issue

3

Start / End Page

581 / 589

Location

England

Related Subject Headings

  • Retrospective Studies
  • Prospective Studies
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Elasticity Imaging Techniques
  • Disease Progression
  • 3210 Nutrition and dietetics
 

Citation

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Loomba, R., Huang, D. Q., Sanyal, A. J., Anstee, Q. M., Trauner, M., Lawitz, E. J., … Myers, R. P. (2023). Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. Gut, 72(3), 581–589. https://doi.org/10.1136/gutjnl-2022-327777
Loomba, Rohit, Daniel Q. Huang, Arun J. Sanyal, Quentin Mark Anstee, Michael Trauner, Eric J. Lawitz, Dora Ding, et al. “Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.Gut 72, no. 3 (March 2023): 581–89. https://doi.org/10.1136/gutjnl-2022-327777.
Loomba R, Huang DQ, Sanyal AJ, Anstee QM, Trauner M, Lawitz EJ, et al. Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. Gut. 2023 Mar;72(3):581–9.
Loomba, Rohit, et al. “Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis.Gut, vol. 72, no. 3, Mar. 2023, pp. 581–89. Pubmed, doi:10.1136/gutjnl-2022-327777.
Loomba R, Huang DQ, Sanyal AJ, Anstee QM, Trauner M, Lawitz EJ, Ding D, Ma L, Jia C, Billin A, Huss RS, Chung C, Goodman Z, Wong VW-S, Okanoue T, Romero-Gómez M, Abdelmalek MF, Muir A, Afdhal N, Bosch J, Harrison S, Younossi ZM, Myers RP. Liver stiffness thresholds to predict disease progression and clinical outcomes in bridging fibrosis and cirrhosis. Gut. 2023 Mar;72(3):581–589.

Published In

Gut

DOI

EISSN

1468-3288

Publication Date

March 2023

Volume

72

Issue

3

Start / End Page

581 / 589

Location

England

Related Subject Headings

  • Retrospective Studies
  • Prospective Studies
  • Non-alcoholic Fatty Liver Disease
  • Liver Cirrhosis
  • Liver
  • Humans
  • Gastroenterology & Hepatology
  • Elasticity Imaging Techniques
  • Disease Progression
  • 3210 Nutrition and dietetics