Feasibility of clinical evaluation of individuals with increased risk for HPV-associated oropharynx cancer.

Journal Article (Journal Article)

BACKGROUND: Human papillomavirus-associated oropharynx squamous cell carcinoma (HPV-OPSCC) has no known pre-malignant lesion. While vaccination offers future primary prevention, there is current interest in secondary prevention. The feasibility of clinical evaluation of individuals at increased risk for HPV-OPSCC is unclear. METHODS: Individuals with risk factors for HPV-OPSCC were enrolled in a prospective study (MOUTH). Participants positive for biomarkers associated with HPV-OPSCC were eligible for a clinical evaluation which comprised a head and neck examination and imaging with ultrasound and/or magnetic resonance imaging (MRI). This study was designed to evaluate feasibility of clinical evaluation in a screening study. RESULTS: Three hundred and eighty-four participants were eligible for clinical evaluation. Of the 384, 204 (53%) completed a head and neck examination or imaging. Of these, 66 (32%) completed MRI (n = 51) and/or ultrasound (n = 64) studies. CONCLUSIONS: Clinical evaluations, including head and neck examination and imaging, are feasible in the context of a screening study for HPV-OPSCC.

Full Text

Duke Authors

Cited Authors

  • Scott-Wittenborn, N; D'Souza, G; Aygun, N; Tewari, SR; Azadi, J; Vosler, P; Gooi, Z; Mehta, V; Mydlarz, W; Nance, M; Mlot, S; Patel, MR; Tan, M; Miles, BA; Troy, T; Fakhry, C

Published Date

  • January 2023

Published In

Volume / Issue

  • 45 / 1

Start / End Page

  • 95 - 102

PubMed ID

  • 36200696

Electronic International Standard Serial Number (EISSN)

  • 1097-0347

Digital Object Identifier (DOI)

  • 10.1002/hed.27212


  • eng

Conference Location

  • United States