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Manesh Raman Patel

Richard Sean Stack, M.D. Distinguished Professor
Medicine, Cardiology
DUMC 3330, Durham, NC 27710
2301 Erwin Road, HAFS Building, Room 8695, Durham, NC 27710

Overview


Manesh Patel is the Chief of the Division of Cardiology and the Division of Clinical Pharmacology.  His clinical interests include diagnostic and interventional coronary angiography, peripheral angiography and endovascular intervention.  His is involved in several clinical trials involving patients with cardiovascular disease and in cardiac imaging.  He is also the Chair of the American College of Cardiology Task Force for Appropriate Use Criteria for Cardiovascular Procedures and is Chair of the American Heart Association Diagnostic and Interventional Cath Committee.

Patel's interest in cardiac imaging, quality of care, cardiac devices is also evident in his research.  His integration of these efforts into his roles at Duke was recognized in 2010 when he received the prestigious Duke Cardiology Fellowship Mentor Award.   In 2011, Dr. Patel was named the endowed John Bush Simpson Assistant Professor of Cardiology.  In 2013, Dr. Patel received the Robert M. Califf Faculty clinical research Award.

Currently, Dr. Patel is leading an effort to redesign the delivery of care to patients undergoing invasive catheterization procedures in the health system with a specific aim of measure and providing individualized, patient centered, innovative, and efficient care.

Current Appointments & Affiliations


Richard Sean Stack, M.D. Distinguished Professor · 2020 - Present Medicine, Cardiology, Medicine
Professor of Medicine · 2017 - Present Medicine, Cardiology, Medicine
Chief, Division of Clinical Pharmacology · 2016 - Present Medicine, Cardiology, Medicine
Chief, Division of Cardiology · 2016 - Present Medicine, Cardiology, Medicine
Member in the Duke Clinical Research Institute · 2006 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published February 7, 2024
Gift to Support Heart Transplant Patients and Their Families
Published April 15, 2022
School of Medicine Celebrates 2022 Faculty Achievement Awards
Published August 9, 2021
Study Will Determine Rate of COVID Heart Inflammation Among Elite Athletes

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Recent Publications


Systemic Embolic Events in Atrial Fibrillation: An Individual Patient Data Meta-analysis of 71 683 Participants Randomized to NOAC Versus Warfarin.

Journal Article Circulation · February 24, 2026 BACKGROUND: Systemic embolic events (SEEs) are a serious but underrecognized complication of atrial fibrillation. Although non-vitamin K antagonist oral anticoagulants prevent ischemic stroke (IS), their efficacy in SEE and the clinical characteristics of ... Full text Link to item Cite

Major adverse cardiovascular and bleeding outcomes in paroxysmal vs. non-paroxysmal atrial fibrillation: an individual patient-level data analysis of a large cohort of patients from the COMBINE-AF.

Journal Article Eur J Intern Med · February 18, 2026 BACKGROUND: We performed an individual patient data analysis of COMBINE AF to assess differences in 14 clinically relevant outcomes between patients with paroxysmal (PAF) vs. non-PAF. METHODS: Cox-proportional-hazards models stratified by trial and adjuste ... Full text Link to item Cite

The association of risk factors on coronary computed tomography angiography derived atherosclerotic plaque volume - Lessons from the ADVANCE registry.

Journal Article Atherosclerosis · February 2026 BACKGROUND: Diabetes mellitus, smoking, hypertension, and hyperlipidemia are well-studied cardiovascular risk factors (CVRF) for coronary artery disease (CAD). However, their combined and individual influence on atherosclerotic total plaque volume (TPV) an ... Full text Link to item Cite
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Recent Grants


1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2030

1/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029

Splanchnic Nerve Modulation In Heart Failure (Splanchnic X)

ResearchCollaborator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2029

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Education


Emory University · 1997 M.D.