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Manesh Raman Patel

Richard Sean Stack, M.D. Distinguished Professor
Medicine, Cardiology
DUMC 3330, Durham, NC 27710
2301 Erwin Road, HAFS Building, Room 8695, Durham, NC 27710

Overview


Manesh Patel is the Chief of the Division of Cardiology and the Division of Clinical Pharmacology.  His clinical interests include diagnostic and interventional coronary angiography, peripheral angiography and endovascular intervention.  His is involved in several clinical trials involving patients with cardiovascular disease and in cardiac imaging.  He is also the Chair of the American College of Cardiology Task Force for Appropriate Use Criteria for Cardiovascular Procedures and is Chair of the American Heart Association Diagnostic and Interventional Cath Committee.

Patel's interest in cardiac imaging, quality of care, cardiac devices is also evident in his research.  His integration of these efforts into his roles at Duke was recognized in 2010 when he received the prestigious Duke Cardiology Fellowship Mentor Award.   In 2011, Dr. Patel was named the endowed John Bush Simpson Assistant Professor of Cardiology.  In 2013, Dr. Patel received the Robert M. Califf Faculty clinical research Award.

Currently, Dr. Patel is leading an effort to redesign the delivery of care to patients undergoing invasive catheterization procedures in the health system with a specific aim of measure and providing individualized, patient centered, innovative, and efficient care.

Current Appointments & Affiliations


Richard Sean Stack, M.D. Distinguished Professor · 2020 - Present Medicine, Cardiology, Medicine
Professor of Medicine · 2017 - Present Medicine, Cardiology, Medicine
Chief, Division of Clinical Pharmacology · 2016 - Present Medicine, Cardiology, Medicine
Chief, Division of Cardiology · 2016 - Present Medicine, Cardiology, Medicine
Member in the Duke Clinical Research Institute · 2006 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published February 7, 2024
Gift to Support Heart Transplant Patients and Their Families
Published April 15, 2022
School of Medicine Celebrates 2022 Faculty Achievement Awards
Published August 9, 2021
Study Will Determine Rate of COVID Heart Inflammation Among Elite Athletes

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Recent Publications


Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism.

Journal Article Nat Rev Cardiol · November 2025 Therapeutic anticoagulation is essential to prevent and treat venous and arterial thromboembolism. The available agents target coagulation factors involved in thrombus formation but are associated with an increased risk of bleeding. Factor XI plays a minor ... Full text Link to item Cite

Accuracy of instantaneous wave-free ratio and fractional flow reserve derived from single coronary angiographic projections.

Journal Article Am Heart J · October 2025 BACKGROUND: Angiography-derived fractional flow reserve (FFR) software has been developed using pressure wire based FFR as the reference, however most software requires 2 angiographic views ≥25 degrees apart limiting their clinical utility. This study aims ... Full text Link to item Cite

Survival After Initial Stress Testing vs Anatomic Testing in Suspected Coronary Artery Disease: Long-Term Follow-Up of the PROMISE Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 1, 2025 IMPORTANCE: Symptoms suggestive of coronary artery disease (CAD) often require noninvasive testing for diagnostic and prognostic evaluation. OBJECTIVE: To determine long-term outcomes in patients randomized to functional (stress) vs anatomic (coronary comp ... Full text Link to item Cite
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Recent Grants


1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2030

1/2 Low dose colchicine in pAtients with peripheral artery DiseasE to assess residual vascular risk (LEADER-PAD)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029

Splanchnic Nerve Modulation In Heart Failure (Splanchnic X)

ResearchCollaborator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2029

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Education, Training & Certifications


Emory University · 1997 M.D.