Translating musculoskeletal bioengineering into tissue regeneration therapies.

Journal Article (Review;Journal Article)

Musculoskeletal injuries and disorders are the leading cause of physical disability worldwide and a considerable socioeconomic burden. The lack of effective therapies has driven the development of novel bioengineering approaches that have recently started to gain clinical approvals. In this review, we first discuss the self-repair capacity of the musculoskeletal tissues and describe causes of musculoskeletal dysfunction. We then review the development of novel biomaterial, immunomodulatory, cellular, and gene therapies to treat musculoskeletal disorders. Last, we consider the recent regulatory changes and future areas of technological progress that can accelerate translation of these therapies to clinical practice.

Full Text

Duke Authors

Cited Authors

  • Khodabukus, A; Guyer, T; Moore, AC; Stevens, MM; Guldberg, RE; Bursac, N

Published Date

  • October 2022

Published In

Volume / Issue

  • 14 / 666

Start / End Page

  • eabn9074 -

PubMed ID

  • 36223445

Pubmed Central ID

  • PMC7614064

Electronic International Standard Serial Number (EISSN)

  • 1946-6242

International Standard Serial Number (ISSN)

  • 1946-6234

Digital Object Identifier (DOI)

  • 10.1126/scitranslmed.abn9074


  • eng