cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.
Publication
, Journal Article
Tripathi, S; Najem, H; Mahajan, AS; Zhang, P; Low, JT; Stegh, AH; Curran, MA; Ashley, DM; James, CD; Heimberger, AB
Published in: F1000Res
2022
Median survival of patients with glioblastoma (GBM) treated with standard of care which consists of maximal safe resection of the contrast-enhancing portion of the tumor followed by radiation therapy with concomitant adjuvant temozolomide (TMZ) remains 15 months. The tumor microenvironment (TME) is known to contain immune suppressive myeloid cells with minimal effector T cell infiltration. Stimulator of interferon genes (STING) is an important activator of immune response and results in production of Type 1 interferon and antigen presentation by myeloid cells. This review will discuss important developments in STING agonists, potential biomarkers for STING response, and new combinatorial therapeutic approaches in gliomas.
Duke Scholars
Published In
F1000Res
DOI
EISSN
2046-1402
Publication Date
2022
Volume
11
Start / End Page
1010
Location
England
Related Subject Headings
- Tumor Microenvironment
- Nucleotidyltransferases
- Membrane Proteins
- Interferons
- Humans
- Glioma
- 1112 Oncology and Carcinogenesis
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Tripathi, S., Najem, H., Mahajan, A. S., Zhang, P., Low, J. T., Stegh, A. H., … Heimberger, A. B. (2022). cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma. F1000Res, 11, 1010. https://doi.org/10.12688/f1000research.125163.1
Tripathi, Shashwat, Hinda Najem, Akanksha Sanjay Mahajan, Peng Zhang, Justin T. Low, Alexander H. Stegh, Michael A. Curran, David M. Ashley, Charles David James, and Amy B. Heimberger. “cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.” F1000Res 11 (2022): 1010. https://doi.org/10.12688/f1000research.125163.1.
Tripathi S, Najem H, Mahajan AS, Zhang P, Low JT, Stegh AH, et al. cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma. F1000Res. 2022;11:1010.
Tripathi, Shashwat, et al. “cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma.” F1000Res, vol. 11, 2022, p. 1010. Pubmed, doi:10.12688/f1000research.125163.1.
Tripathi S, Najem H, Mahajan AS, Zhang P, Low JT, Stegh AH, Curran MA, Ashley DM, James CD, Heimberger AB. cGAS-STING pathway targeted therapies and their applications in the treatment of high-grade glioma. F1000Res. 2022;11:1010.
Published In
F1000Res
DOI
EISSN
2046-1402
Publication Date
2022
Volume
11
Start / End Page
1010
Location
England
Related Subject Headings
- Tumor Microenvironment
- Nucleotidyltransferases
- Membrane Proteins
- Interferons
- Humans
- Glioma
- 1112 Oncology and Carcinogenesis
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology