Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.

Journal Article (Journal Article)

The use of anesthetics and sedatives has been suggested to be a contributor to Alzheimer's disease neuropathogenesis. We wanted to address the in vivo relevance of those substances in the Tg2576 Alzheimer's mouse model. Tg7526 mice were anesthesia-sedated for 90 min once a week for 4 weeks. Y maze, Congo Red, and amyloid beta (Aβ) immunochemistry were performed. We did not find any significant change in the navigation behavior of the exposed mice compared to the controls. Significantly less deposition of Aβ in the CA1 area of the hippocampus and frontal cortex of mice exposed to isoflurane, propofol, diazepam, ketamine, and pentobarbital was observed. In the dentate gyrus, Aβ deposition was significantly greater in the group treated with pentobarbital. Congo Red staining evidenced significantly fewer fibrils in the cortex of mice exposed to diazepam, ketamine, or pentobarbital. The adopted repetitive exposure did not cause a significant detriment in Tg7526 mouse.

Full Text

Duke Authors

Cited Authors

  • Quiroga, C; Chaparro, RE; Karlnoski, R; Erasso, D; Gordon, M; Morgan, D; Bosco, G; Rubini, A; Parmagnani, A; Paoli, A; Mangar, D; Camporesi, EM

Published Date

  • November 2014

Published In

Volume / Issue

  • 26 / 4

Start / End Page

  • 414 - 421

PubMed ID

  • 24927827

Electronic International Standard Serial Number (EISSN)

  • 1476-3524

International Standard Serial Number (ISSN)

  • 1029-8428

Digital Object Identifier (DOI)

  • 10.1007/s12640-014-9478-8


  • eng