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Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.

Publication ,  Journal Article
Nesbeth, Y; Conejo-Garcia, JR
Published in: Clin Dev Immunol
2010

Adoptive T cell transfer therapy, the ex vivo activation, expansion, and subsequent administration of tumor-reactive T cells, is already the most effective therapy against certain types of cancer. However, recent evidence in animal models and clinical trials suggests that host conditioning interventions tailored for some of the most aggressive and frequent epithelial cancers will be needed to maximize the benefit of this approach. Similarly, the subsets, stage of differentiation, and ex vivo expansion procedure of tumor-reactive T cells to be adoptively transferred influence their in vivo effectiveness and may need to be adapted for different types of cancer and host conditioning interventions. The effects of adoptively transferred tumor-reactive T cells on the mechanisms of endogenous (host-derived) antitumor immunity, and how to maximize their combined effects, are further discussed.

Duke Scholars

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Published In

Clin Dev Immunol

DOI

EISSN

1740-2530

Publication Date

2010

Volume

2010

Start / End Page

139304

Location

Egypt

Related Subject Headings

  • Tumor Escape
  • T-Lymphocytes
  • Neoplasms
  • Lymphocyte Activation
  • Immunotherapy, Adoptive
  • Immunology
  • Immunologic Surveillance
  • Humans
  • Disease Progression
  • Cell Proliferation
 

Citation

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MLA
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Nesbeth, Y., & Conejo-Garcia, J. R. (2010). Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity. Clin Dev Immunol, 2010, 139304. https://doi.org/10.1155/2010/139304
Nesbeth, Yolanda, and Jose R. Conejo-Garcia. “Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.Clin Dev Immunol 2010 (2010): 139304. https://doi.org/10.1155/2010/139304.
Nesbeth, Yolanda, and Jose R. Conejo-Garcia. “Harnessing the effect of adoptively transferred tumor-reactive T cells on endogenous (host-derived) antitumor immunity.Clin Dev Immunol, vol. 2010, 2010, p. 139304. Pubmed, doi:10.1155/2010/139304.

Published In

Clin Dev Immunol

DOI

EISSN

1740-2530

Publication Date

2010

Volume

2010

Start / End Page

139304

Location

Egypt

Related Subject Headings

  • Tumor Escape
  • T-Lymphocytes
  • Neoplasms
  • Lymphocyte Activation
  • Immunotherapy, Adoptive
  • Immunology
  • Immunologic Surveillance
  • Humans
  • Disease Progression
  • Cell Proliferation