Overview
Jose Conejo-Garcia’s research program focuses on understanding and targeting the mechanisms governing the balance between immunosuppression and protective immunity in the tumor microenvironment, with an emphasis on the crosstalk between innate (gamma/delta) and adaptive (alpha/beta) T cells, and B lymphocytes, including in Tertiary Lymphoid Structures. Discoveries for the Conejo-Garcia lab are also being translated in active clinical trials using CAR T cells to treat ovarian cancer patients.
Current Appointments & Affiliations
Professor in Integrative Immunobiology
·
2024 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors.
Journal Article Cancer Epidemiol Biomarkers Prev · April 3, 2025 BACKGROUND: Parity and breastfeeding are associated with systemic changes in maternal inflammation and reduced risk of ovarian cancer, but little is known about their impact on the ovarian tumor immune microenvironment. METHODS: We evaluated the associatio ... Full text Link to item CiteSupplementary Table 2 from Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors
Other · April 3, 2025 <p>Odds ratios (OR) and 95% confidence intervals (CI) for positivity of tumor infiltration of T cells associated with number of children compared to nulliparous participants in DOVE, NECC, NHS, and NHSII</p> ... Full text CiteSupplementary Table 4 from Associations between Parity, History of Breastfeeding, and T-cell Profile of Ovarian Tumors
Other · April 3, 2025 <p>Odds ratios (OR) and 95% confidence intervals (CI) for positivity of tumor infiltration of T cells associated with having ever breastfed compared to never among parous participants DOVE, NECC, NHS, and NHSII by number of children</p> ... Full text CiteRecent Grants
Novel immunotherapies using optimized tumor cell-penetrating antibodies
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2029Crosstalk between butyrophilins and gamma delta T cells in human cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Deciphering the interdependent anti-tumor potential of T and B cells within tertiary lymphoid structures
ResearchPrincipal Investigator · Awarded by Department of Defense · 2025 - 2029View All Grants
Education, Training & Certifications
University of Alcalá (Spain) ·
1998
MD./PhD.