Role of vascular leukocytes in ovarian cancer neovascularization.

Book Section

Vascular leukocytes are a unique population of CD45+ VE-cadherin+ cells with diverse functions. VLCs are capable of antigen presentation, as well as formation of endothelial-like structures in vitro and in vivo. VLCs are largely present among CD45+ cells infiltrating human ovarian carcinomas and are highly represented in the beta-defensin-VEGF-ID8 syngenic mouse model. Vascular leukocytes are a new and promising novel therapeutic target for anti-angiogenic therapy. Their unique mechanism merits thorough and extensive exploration in the future.

Full Text

Duke Authors

Cited Authors

  • Balint, K; Conejo-Garcia, JR; Buckanovich, R; Coukos, G

Published Date

  • 2008

Volume / Issue

  • 622 /

Start / End Page

  • 273 - 280

PubMed ID

  • 18546635

Digital Object Identifier (DOI)

  • 10.1007/978-0-387-68969-2_22