Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery.

Journal Article (Journal Article;Review)

Molecular imaging is a vital tool to non-invasively measure nanoparticle delivery to solid tumors. Despite the myriad of nanoparticles studied for cancer, successful applications of nanoparticles in humans is limited by inconsistent and ineffective delivery. Successful nanoparticle delivery in preclinical models is often attributed to enhanced permeability and retention (EPR)-a set of conditions that is heterogeneous and transient in patients. Thus, researchers are evaluating therapeutic strategies to modify nanoparticle delivery, particularly treatments which have demonstrated effects on EPR conditions. Imaging nanoparticle distribution provides a means to measure the effects of therapeutic intervention on nanoparticle delivery to solid tumors. This review focuses on the utility of imaging to measure treatment-induced changes in nanoparticle delivery to tumors and provides preclinical examples studying a broad range of therapeutic interventions.

Full Text

Duke Authors

Cited Authors

  • Blocker, SJ; Shields, AF

Published Date

  • June 2018

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 340 - 351

PubMed ID

  • 29188418

Pubmed Central ID

  • PMC6836466

Electronic International Standard Serial Number (EISSN)

  • 1860-2002

Digital Object Identifier (DOI)

  • 10.1007/s11307-017-1142-2


  • eng

Conference Location

  • United States