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RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS.

Publication ,  Journal Article
Chusyd, DE; Brown, JL; Golzarri-Arroyo, L; Dickinson, SL; Kraus, VB; Siegal-Willott, J; Griffin, TM; Huebner, JL; Edwards, KL; Allison, DB; Austad, SN
Published in: J Zoo Wildl Med
January 2023

Osteoarthritis (OA) is common in zoo Asian (Elephas maximus) and African (Loxodonta africana) elephants. This study investigated the relationship between confirmed or suspected OA with ovarian cyclicity, gonadotropins, progestagens, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and collagen type I (CTX-I) in zoo elephants. In Asian elephants, odds of having confirmed or suspected OA decreased with cycling (OR = 0.22, P = 0.016; OR = 0.29, P = 0.020, respectively), however, not when adjusted for age (odds ratio [OR] = 0.31, P = 0.112; OR = 0.58, P = 0.369, respectively). In African elephants, none of the models between confirmed OA and cycling status were significant (P > 0.060), while the odds of having suspected OA decreased with cycling (OR = 0.12, P = 0.001), even after adjusting for age (OR = 0.15, P = 0.005). Progestagens (Asian elephants P > 0.096; African elephants P > 0.415), LH (Asian P > 0.129; African P > 0.359), and FSH (Asian P > 0.738; African P > 0.231) did not differ with confirmed or suspected OA status, unadjusted. CTX-I concentrations were not related to OA status (P > 0.655). This study concluded hormonal changes may not have a strong impact on OA, so additional investigation into other serologic biomarkers is warranted.

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Published In

J Zoo Wildl Med

DOI

ISSN

1042-7260

Publication Date

January 2023

Volume

53

Issue

4

Start / End Page

801 / 810

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Progestins
  • Osteoarthritis
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Elephants
  • Animals, Zoo
  • Animals
  • 3109 Zoology
  • 3009 Veterinary sciences
 

Citation

APA
Chicago
ICMJE
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Chusyd, D. E., Brown, J. L., Golzarri-Arroyo, L., Dickinson, S. L., Kraus, V. B., Siegal-Willott, J., … Austad, S. N. (2023). RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS. J Zoo Wildl Med, 53(4), 801–810. https://doi.org/10.1638/2021-0080
Chusyd, Daniella E., Janine L. Brown, Lilian Golzarri-Arroyo, Stephanie L. Dickinson, Virginia B. Kraus, Jessica Siegal-Willott, Timothy M. Griffin, et al. “RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS.J Zoo Wildl Med 53, no. 4 (January 2023): 801–10. https://doi.org/10.1638/2021-0080.
Chusyd DE, Brown JL, Golzarri-Arroyo L, Dickinson SL, Kraus VB, Siegal-Willott J, et al. RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS. J Zoo Wildl Med. 2023 Jan;53(4):801–10.
Chusyd, Daniella E., et al. “RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS.J Zoo Wildl Med, vol. 53, no. 4, Jan. 2023, pp. 801–10. Pubmed, doi:10.1638/2021-0080.
Chusyd DE, Brown JL, Golzarri-Arroyo L, Dickinson SL, Kraus VB, Siegal-Willott J, Griffin TM, Huebner JL, Edwards KL, Allison DB, Austad SN. RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS. J Zoo Wildl Med. 2023 Jan;53(4):801–810.

Published In

J Zoo Wildl Med

DOI

ISSN

1042-7260

Publication Date

January 2023

Volume

53

Issue

4

Start / End Page

801 / 810

Location

United States

Related Subject Headings

  • Veterinary Sciences
  • Progestins
  • Osteoarthritis
  • Luteinizing Hormone
  • Follicle Stimulating Hormone
  • Elephants
  • Animals, Zoo
  • Animals
  • 3109 Zoology
  • 3009 Veterinary sciences