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Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer.

Publication ,  Journal Article
Hollins, AW; Hein, RE; Atia, AN; Zhang, GX; Sergesketter, AR; Darner, G; Morris, M; Mithani, SK
Published in: Plast Reconstr Surg
May 1, 2023

BACKGROUND: Aromatase inhibitors (AIs), such as letrozole and anastrozole, have been demonstrated to have significant musculoskeletal symptoms in patients. The purpose of this study was to evaluate the effect of specific AI medications on the incidence of trigger finger and independent factors affecting treatment outcomes within this population. METHODS: A retrospective chart review was performed at the authors' institution between the years 2014 and 2018 in patients with the diagnosis of breast cancer. This cohort was then sorted based on receiving medication regimens, trigger finger diagnosis, steroid injections, and need for surgical release of trigger finger. RESULTS: A total of 15,144 patients were included for initial review. The overall rate of trigger finger diagnosis was 2.75% in the entire breast cancer population and 4.5% for patients receiving AI therapy. Patients taking letrozole and anastrozole had an increased odds ratio of 2.0 and 1.7, respectively, for developing trigger finger. Patients who switched between letrozole and anastrozole during treatment had a higher rate of failed steroid injection treatment (45.2% versus 23.5%; P = 0.021). Among patients receiving AI treatment diagnosed with trigger finger, diabetes and hemoglobin A1c level greater than 6.5 were associated with significantly increased rates of failed steroid therapy. CONCLUSIONS: Patients receiving AI therapy have an increased incidence of trigger finger. The outcomes of treatment are equivalent between AI and non-AI trigger finger populations. However, steroid therapy is more likely to fail in patients who require switching of regimens because of significant musculoskeletal symptoms. Poorly controlled diabetes was also an independent factor for compromised steroid treatment of trigger finger. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.

Duke Scholars

Published In

Plast Reconstr Surg

DOI

EISSN

1529-4242

Publication Date

May 1, 2023

Volume

151

Issue

5

Start / End Page

1043 / 1050

Location

United States

Related Subject Headings

  • Trigger Finger Disorder
  • Surgery
  • Steroids
  • Retrospective Studies
  • Letrozole
  • Incidence
  • Humans
  • Female
  • Breast Neoplasms
  • Aromatase Inhibitors
 

Citation

APA
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ICMJE
MLA
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Hollins, A. W., Hein, R. E., Atia, A. N., Zhang, G. X., Sergesketter, A. R., Darner, G., … Mithani, S. K. (2023). Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer. Plast Reconstr Surg, 151(5), 1043–1050. https://doi.org/10.1097/PRS.0000000000010087
Hollins, Andrew W., Rachel E. Hein, Andrew N. Atia, Gloria X. Zhang, Amanda R. Sergesketter, Grant Darner, Miranda Morris, and Suhail K. Mithani. “Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer.Plast Reconstr Surg 151, no. 5 (May 1, 2023): 1043–50. https://doi.org/10.1097/PRS.0000000000010087.
Hollins AW, Hein RE, Atia AN, Zhang GX, Sergesketter AR, Darner G, et al. Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer. Plast Reconstr Surg. 2023 May 1;151(5):1043–50.
Hollins, Andrew W., et al. “Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer.Plast Reconstr Surg, vol. 151, no. 5, May 2023, pp. 1043–50. Pubmed, doi:10.1097/PRS.0000000000010087.
Hollins AW, Hein RE, Atia AN, Zhang GX, Sergesketter AR, Darner G, Morris M, Mithani SK. Variations in Incidence of Trigger Finger and Response to Corticosteroid Injection after Aromatase Inhibitor Therapy for Breast Cancer. Plast Reconstr Surg. 2023 May 1;151(5):1043–1050.

Published In

Plast Reconstr Surg

DOI

EISSN

1529-4242

Publication Date

May 1, 2023

Volume

151

Issue

5

Start / End Page

1043 / 1050

Location

United States

Related Subject Headings

  • Trigger Finger Disorder
  • Surgery
  • Steroids
  • Retrospective Studies
  • Letrozole
  • Incidence
  • Humans
  • Female
  • Breast Neoplasms
  • Aromatase Inhibitors