In vivo stereological assessment of caudate volume in man: effect of normal aging.

Journal Article (Journal Article)

Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p less than 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.

Full Text

Duke Authors

Cited Authors

  • Krishnan, KR; Husain, MM; McDonald, WM; Doraiswamy, PM; Figiel, GS; Boyko, OB; Ellinwood, EH; Nemeroff, CB

Published Date

  • 1990

Published In

Volume / Issue

  • 47 / 15

Start / End Page

  • 1325 - 1329

PubMed ID

  • 2233134

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(90)90196-x


  • eng

Conference Location

  • Netherlands