In vivo stereological assessment of caudate volume in man: effect of normal aging.
Journal Article (Journal Article)
Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p less than 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.
Full Text
Duke Authors
Cited Authors
- Krishnan, KR; Husain, MM; McDonald, WM; Doraiswamy, PM; Figiel, GS; Boyko, OB; Ellinwood, EH; Nemeroff, CB
Published Date
- 1990
Published In
Volume / Issue
- 47 / 15
Start / End Page
- 1325 - 1329
PubMed ID
- 2233134
International Standard Serial Number (ISSN)
- 0024-3205
Digital Object Identifier (DOI)
- 10.1016/0024-3205(90)90196-x
Language
- eng
Conference Location
- Netherlands