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DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.

Publication ,  Journal Article
Jones, CM; Lyons, KM; Lapan, PM; Wright, CV; Hogan, BL
Published in: Development
June 1992

Establishment of mesodermal tissues in the amphibian body involves a series of inductive interactions probably elicited by a variety of peptide growth factors. Results reported here suggest that mesodermal patterning involves an array of signalling molecules including DVR-4, a TGF-beta-like molecule. We show that ectopic expression of DVR-4 causes embryos to develop with an overall posterior and/or ventral character, and that DVR-4 induces ventral types of mesoderm in animal cap explants. Moreover, DVR-4 overrides the dorsalizing effects of activin. DVR-4 is therefore the first molecule reported both to induce posteroventral mesoderm and to counteract dorsalizing signals such as activin. Possible interactions between these molecules resulting in establishment of the embryonic body plan are discussed.

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Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 1992

Volume

115

Issue

2

Start / End Page

639 / 647

Location

England

Related Subject Headings

  • Xenopus laevis
  • Proteins
  • Morphogenesis
  • Molecular Sequence Data
  • Microinjections
  • Mesoderm
  • Inhibins
  • Growth Substances
  • Gene Expression
  • Embryonic Induction
 

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Jones, C. M., Lyons, K. M., Lapan, P. M., Wright, C. V., & Hogan, B. L. (1992). DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development, 115(2), 639–647. https://doi.org/10.1242/dev.115.2.639
Jones, C. M., K. M. Lyons, P. M. Lapan, C. V. Wright, and B. L. Hogan. “DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.Development 115, no. 2 (June 1992): 639–47. https://doi.org/10.1242/dev.115.2.639.
Jones CM, Lyons KM, Lapan PM, Wright CV, Hogan BL. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development. 1992 Jun;115(2):639–47.
Jones, C. M., et al. “DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.Development, vol. 115, no. 2, June 1992, pp. 639–47. Pubmed, doi:10.1242/dev.115.2.639.
Jones CM, Lyons KM, Lapan PM, Wright CV, Hogan BL. DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction. Development. 1992 Jun;115(2):639–647.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 1992

Volume

115

Issue

2

Start / End Page

639 / 647

Location

England

Related Subject Headings

  • Xenopus laevis
  • Proteins
  • Morphogenesis
  • Molecular Sequence Data
  • Microinjections
  • Mesoderm
  • Inhibins
  • Growth Substances
  • Gene Expression
  • Embryonic Induction