Altered inflammatory responses in leukotriene-deficient mice.
Journal Article (Journal Article)
Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention.
Full Text
Duke Authors
Cited Authors
- Goulet, JL; Snouwaert, JN; Latour, AM; Coffman, TM; Koller, BH
Published Date
- December 20, 1994
Published In
Volume / Issue
- 91 / 26
Start / End Page
- 12852 - 12856
PubMed ID
- 7809134
Pubmed Central ID
- PMC45538
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.91.26.12852
Language
- eng
Conference Location
- United States