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Altered inflammatory responses in leukotriene-deficient mice.

Publication ,  Journal Article
Goulet, JL; Snouwaert, JN; Latour, AM; Coffman, TM; Koller, BH
Published in: Proc Natl Acad Sci U S A
December 20, 1994
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Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention.

Duke Scholars

Thomas Myron Coffman
Author Thomas Myron Coffman Medicine, Nephrology
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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.91.26.12852

ISSN

0027-8424

Publication Date

December 20, 1994

Volume

91

Issue

26

Start / End Page

12852 / 12856

Location

United States

Related Subject Headings

  • Thromboxane B2
  • Platelet Activating Factor
  • Neutrophils
  • Mice, Knockout
  • Mice
  • Macrophages
  • Leukotrienes
  • Leukotriene C4
  • Inflammation
  • Edema
 

Citation

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Goulet, J. L., Snouwaert, J. N., Latour, A. M., Coffman, T. M., & Koller, B. H. (1994). Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A, 91(26), 12852–12856. https://doi.org/10.1073/pnas.91.26.12852
Goulet, J. L., J. N. Snouwaert, A. M. Latour, T. M. Coffman, and B. H. Koller. “Altered inflammatory responses in leukotriene-deficient mice.” Proc Natl Acad Sci U S A 91, no. 26 (December 20, 1994): 12852–56. https://doi.org/10.1073/pnas.91.26.12852.
Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH. Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12852–6.
Goulet, J. L., et al. “Altered inflammatory responses in leukotriene-deficient mice.” Proc Natl Acad Sci U S A, vol. 91, no. 26, Dec. 1994, pp. 12852–56. Pubmed, doi:10.1073/pnas.91.26.12852.
Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH. Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12852–12856.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.91.26.12852

ISSN

0027-8424

Publication Date

December 20, 1994

Volume

91

Issue

26

Start / End Page

12852 / 12856

Location

United States

Related Subject Headings

  • Thromboxane B2
  • Platelet Activating Factor
  • Neutrophils
  • Mice, Knockout
  • Mice
  • Macrophages
  • Leukotrienes
  • Leukotriene C4
  • Inflammation
  • Edema