Altered inflammatory responses in leukotriene-deficient mice.

Journal Article (Journal Article)

Leukotrienes have been implicated in the regulation of immune responses, including inflammation and immediate hypersensitivity reactions. Here, we describe the phenotypic analysis of leukotriene-deficient mice generated by inactivation of the 5-lipoxygenase (5LO) gene. These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor. The intensity of an acute inflammatory response induced by arachidonic acid was similar in 5LO(-/-) mice and controls. However, the response in 5LO(-/-) mice, but not in controls, could be virtually eliminated by a cyclooxygenase inhibitor. These data suggest that inflammatory responses are modulated by arachidonic acid metabolites through a variety of interconnected mechanisms. This has important implications for understanding the early events of an inflammatory response and for designing drugs for use in therapeutic intervention.

Full Text

Duke Authors

Cited Authors

  • Goulet, JL; Snouwaert, JN; Latour, AM; Coffman, TM; Koller, BH

Published Date

  • December 20, 1994

Published In

Volume / Issue

  • 91 / 26

Start / End Page

  • 12852 - 12856

PubMed ID

  • 7809134

Pubmed Central ID

  • PMC45538

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.91.26.12852


  • eng

Conference Location

  • United States