Thomas Myron Coffman | Scholars@Duke

Thomas Myron Coffman
James R. Clapp Distinguished Professor of Medicine, in the School of Medicine

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Current Appointments & Affiliations

James R. Clapp Distinguished Professor of Medicine, in the School of Medicine, Medicine, Nephrology, Medicine 2002
Professor of Medicine, Medicine, Nephrology, Medicine 1999
Professor in Cell Biology, Cell Biology, Basic Science Departments 2005
Professor in Immunology, Integrative Immunobiology, Basic Science Departments 2006

Contact Information

Duke Box 103015, Durham, NC 27710
Room 2018/MSBR2, 106 Research Drive, Durham, NC 27710
coffm002@duke.edu (919) 684-9788

Background
Education, Training, & Certifications
- Fellowship in Nephrology, Duke University School of Medicine 1983 - 1985
- M.D., Ohio State University 1980
Previous Appointments & Affiliations
- Chief, Division of Nephrology, Medicine, Nephrology, Medicine 1997 - 2014
- Senior Vice-chair for Academic Affairs in the Department of Medicine, Medicine, Clinical Science Departments 2007 - 2014
- Associate Professor of Medicine with Tenure, Medicine, Nephrology, Medicine 1994 - 1998
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1987 - 1994
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1985 - 1986
Recognition
In the News
- MAR 27, 2020 Magnify Magazine
  
  Duke Researchers Pivot to Attack the New Coronavirus
- DEC 15, 2014
  
  Thomas Coffman Named Dean-Designate of Duke-NUS Medical School
Awards & Honors
- Excellence Award for Hypertension Research. American Heart Association. 2014
- Water and Electrolyte Homeostasis Section/Ernest H. Starling Distinguished Lecture. American Physiological Society. 2006
Expertise
Global Scholarship
- Research
  - Singapore (Country)
Research
Selected Grants
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
- Paracrine Control of Blood Pressure by Renal Intercalated Cells awarded by National Institutes of Health 2015 - 2020
- Actions of Angiotensin II Along the Nephron to Regulate Blood Pressure awarded by National Institutes of Health 2014 - 2019
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Student Supplement awarded by National Institutes of Health 2012 - 2017
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus awarded by National Institutes of Health 2011 - 2016
- Immune Mechanisms in Diabetic Nephropathy awarded by Georgia Regents University 2014 - 2015
- Prostaglandin E2 and Regulation of Kidney Function awarded by National Institutes of Health 2005 - 2015
- A New Locus for Hereditary FSGS on Chromosome 2p awarded by National Institutes of Health 2009 - 2014
- Renal Endothelin-1: Control of Sodium Excretion and Blood Pressure awarded by National Institutes of Health 2012 - 2013
- A Novel Mouse Model of Podocyte Injury awarded by National Institutes of Health 2009 - 2012
- Characterization of TRPC6 As A Cause for Focal and Segmental Glomerulosclerosis awarded by National Institutes of Health 2006 - 2012
- Angiotensin Receptor Genes and Blood Pressure Regulation awarded by National Institutes of Health 1997 - 2012
- Genetic Determinants of Susceptibility to Kidney Disease in African Americans awarded by National Institutes of Health 2009 - 2012
- Angiogenic Signals in Diabetic Complications awarded by National Institutes of Health 2006 - 2012
- B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function awarded by National Institutes of Health 2002 - 2012
- IPA - Natalia Makhanova awarded by Durham Veterans Affairs Medical Center 2010 - 2011
- Pathophysiology of Renal Allograft Dysfunction awarded by National Institutes of Health 1988 - 2011
- Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects awarded by National Institutes of Health 2007 - 2009
- Role of mPGES1 in Regulation of Kidney Function awarded by National Institutes of Health 2006 - 2008
- IPA - Galen Hoover awarded by Veterans Adminsitration Medical Center 2006 - 2008
- Actions of Angiotensin II in Vascular Smooth Muscle awarded by National Institutes of Health 2006 - 2008
- Rac, Superoxide and Antioxidants in Hypertension awarded by National Institutes of Health 1996 - 2007
- Duke-UNC-Stanford AMDC Unit awarded by National Institutes of Health 2001 - 2006
- Genes that Regulate Target Organ Damage in Hypertension awarded by National Institutes of Health 2001 - 2006
- Pathophysiology of Renal Allograft Dysfunction awarded by National Institutes of Health 1988 - 2004
- Pathophysiology of renal allograft dysfunction awarded by National Institutes of Health 1988 - 2004
- Same awarded by National Institutes of Health 1988 - 2004
- Duke/NIDDK Functional Genomics Center awarded by National Institutes of Health 2000 - 2003
- Duke Training Grant In Nephrology awarded by National Institutes of Health 1995 - 2000
- same awarded by National Institutes of Health 1995 - 2000
- Angiotensin Receptor Genes And Blood Pressure Regulation awarded by National Institutes of Health 1997 - 1999
- same awarded by National Institutes of Health 1997 - 1999
- Duke Training Grant In Nephrology awarded by National Institutes of Health 1995 - 1999
External Relationships
- Duke-NUS Medical School-Singapore
- King Faisal Specialist Hospital and Research Center
- Singapore Health Services Pte Ltd (SingHealth), Singapore
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Okuno, Keisuke, Keiichi Torimoto, Stephanie M. Cicalese, Kyle Preston, Victor Rizzo, Tomoki Hashimoto, Thomas M. Coffman, Matthew A. Sparks, and Satoru Eguchi. “Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II.” Hypertension 80, no. 3 (March 2023): 668–77. https://doi.org/10.1161/HYPERTENSIONAHA.122.20601.
    Full Text Link to Item
  - Nelson, Jonathan W., David I. Ortiz-Melo, Natalie K. Mattocks, Jacqueline M. Emathinger, Jessica Prescott, Katherine Xu, Robert C. Griffiths, et al. “Soluble ACE2 Is Filtered into the Urine.” Kidney360 3, no. 12 (December 29, 2022): 2086–94. https://doi.org/10.34067/KID.0001622022.
    Full Text Link to Item
  - Widjaja, Anissa A., Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, et al. “Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.” Nat Commun 13, no. 1 (December 5, 2022): 7497. https://doi.org/10.1038/s41467-022-35306-1.
    Full Text Link to Item
  - Teo, Calesta Hui Yi, Molly Tzu-Yu Lin, Isabelle Xin Yu Lee, Siew-Kwan Koh, Lei Zhou, Dylan Shaoying Goh, Hyungwon Choi, et al. “Oral Peroxisome Proliferator-Activated Receptor-Alpha (PPAR)-α Agonist Enhances Corneal Nerve Regeneration in Patients with Type II Diabetes Mellitus.” Diabetes, November 29, 2022. https://doi.org/10.2337/db22-0611.
    Full Text Link to Item
  - Yang, Ting, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, and Thomas M. Coffman. “Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages.” J Am Heart Assoc 11, no. 19 (October 4, 2022): e026581. https://doi.org/10.1161/JAHA.122.026581.
    Full Text Link to Item
  - Widjaja, Anissa A., Shamini G. Shekeran, Eleonora Adami, Joyce G Wei Ting, Jessie Tan, Sivakumar Viswanathan, Sze Yun Lim, et al. “A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.” J Am Soc Nephrol 33, no. 4 (April 2022): 718–30. https://doi.org/10.1681/ASN.2021040577.
    Full Text Link to Item
  - Sheng, Xin, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, Steven Vitale, et al. “Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.” Nat Genet 53, no. 9 (September 2021): 1322–33. https://doi.org/10.1038/s41588-021-00909-9.
    Full Text Link to Item
  - Sparks, Matthew A., Emre Dilmen, Donna L. Ralph, Fitra Rianto, Thien A. Hoang, Alison Hollis, Edward J. Diaz, et al. “Vascular control of kidney epithelial transporters.” Am J Physiol Renal Physiol 320, no. 6 (June 1, 2021): F1080–92. https://doi.org/10.1152/ajprenal.00084.2021.
    Full Text Link to Item
  - Harrison, David G., Thomas M. Coffman, and Christopher S. Wilcox. “Pathophysiology of Hypertension: The Mosaic Theory and Beyond.” Circ Res 128, no. 7 (April 2, 2021): 847–63. https://doi.org/10.1161/CIRCRESAHA.121.318082.
    Full Text Link to Item
  - Sparks, Matthew A., Fitra Rianto, Edward Diaz, Ritika Revoori, Thien Hoang, Lucas Bouknight, Johannes Stegbauer, et al. “Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy.” Hypertension 77, no. 2 (February 2021): 393–404. https://doi.org/10.1161/HYPERTENSIONAHA.119.14079.
    Full Text Link to Item
  - Coffman, Thomas M., Choong Meng Chan, Lina Hui-Lin Choong, Ian Curran, Hak Koon Tan, and Chorh Chuan Tan. “Perspectives on COVID-19 from Singapore: Impact on ESKD Care and Medical Education.” J Am Soc Nephrol 31, no. 10 (October 2020): 2242–45. https://doi.org/10.1681/ASN.2020050721.
    Full Text Link to Item
  - Lerman, Lilach O., Theodore W. Kurtz, Rhian M. Touyz, David H. Ellison, Alejandro R. Chade, Steven D. Crowley, David L. Mattson, et al. “Animal Models of Hypertension: A Scientific Statement From the American Heart Association.” Hypertension 73, no. 6 (June 2019): e87–120. https://doi.org/10.1161/HYP.0000000000000090.
    Full Text Link to Item
  - Sabanayagam, Charumathi, Miao Li Chee, Riswana Banu, Ching-Yu Cheng, Su Chi Lim, E Shyong Tai, Thomas Coffman, and Tien Y. Wong. “Association of Diabetic Retinopathy and Diabetic Kidney Disease With All-Cause and Cardiovascular Mortality in a Multiethnic Asian Population.” Jama Netw Open 2, no. 3 (March 1, 2019): e191540. https://doi.org/10.1001/jamanetworkopen.2019.1540.
    Full Text Link to Item
  - Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension.” J Am Heart Assoc 8, no. 4 (February 19, 2019): e010745. https://doi.org/10.1161/JAHA.118.010745.
    Full Text Open Access Copy Link to Item
  - Gurley, Susan B., Sujoy Ghosh, Stacy A. Johnson, Kengo Azushima, Rashidah Binte Sakban, Simi E. George, Momoe Maeda, Timothy W. Meyer, and Thomas M. Coffman. “Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.” Diabetes 67, no. 10 (October 2018): 2096–2106. https://doi.org/10.2337/db17-1323.
    Full Text Link to Item
  - Forrester, Steven J., George W. Booz, Curt D. Sigmund, Thomas M. Coffman, Tatsuo Kawai, Victor Rizzo, Rosario Scalia, and Satoru Eguchi. “Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.” Physiol Rev 98, no. 3 (July 1, 2018): 1627–1738. https://doi.org/10.1152/physrev.00038.2017.
    Full Text Link to Item
  - Neubauer, Bjoern, Julia Schrankl, Dominik Steppan, Katharina Neubauer, Maria Luisa Sequeira-Lopez, Li Pan, R Ariel Gomez, et al. “Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo?” Hypertension 71, no. 6 (June 2018): 1075–82. https://doi.org/10.1161/HYPERTENSIONAHA.117.10357.
    Full Text Link to Item
  - Azushima, Kengo, Susan B. Gurley, and Thomas M. Coffman. “Modelling diabetic nephropathy in mice.” Nat Rev Nephrol 14, no. 1 (January 2018): 48–56. https://doi.org/10.1038/nrneph.2017.142.
    Full Text Link to Item
  - Coffman, Thomas M. “Oliver Smithies: A Remembrance.” Hypertension 70, no. 1 (July 2017): 3–4. https://doi.org/10.1161/HYPERTENSIONAHA.117.09118.
    Full Text Link to Item
  - Stegbauer, Johannes, Daian Chen, Marcela Herrera, Matthew A. Sparks, Ting Yang, Eva Königshausen, Susan B. Gurley, and Thomas M. Coffman. “Resistance to hypertension mediated by intercalated cells of the collecting duct.” Jci Insight 2, no. 7 (April 6, 2017): e92720. https://doi.org/10.1172/jci.insight.92720.
    Full Text Link to Item
  - Tyson, Crystal C., and Thomas M. Coffman. “In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?” Nephron 135, no. 4 (2017): 287–90. https://doi.org/10.1159/000455130.
    Full Text Link to Item
  - Tinning, Anne R., Boye L. Jensen, Iben Johnsen, Daian Chen, Thomas M. Coffman, and Kirsten Madsen. “Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.” Am J Physiol Renal Physiol 311, no. 3 (September 1, 2016): F586–99. https://doi.org/10.1152/ajprenal.00221.2016.
    Full Text Link to Item
  - Chen, Daian, Johannes Stegbauer, Matthew A. Sparks, Donald Kohan, Robert Griffiths, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension.” Hypertension 67, no. 6 (June 2016): 1291–97. https://doi.org/10.1161/HYPERTENSIONAHA.115.06987.
    Full Text Link to Item
  - Sparks, Matthew A., Johannes Stegbauer, Daian Chen, Jose A. Gomez, Robert C. Griffiths, Hooman A. Azad, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.” J Am Soc Nephrol 26, no. 12 (December 2015): 2953–62. https://doi.org/10.1681/ASN.2014080816.
    Full Text Link to Item
  - Stegbauer, Johannes, and Thomas M. Coffman. “Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.” J Clin Invest 125, no. 11 (November 2, 2015): 4008–10. https://doi.org/10.1172/JCI84753.
    Full Text Link to Item
  - Yang, Yanqiang, Jose A. Gomez, Marcela Herrera, Romelia Perez-Marco, Peter Repenning, Zhiping Zhang, Alan Payne, et al. “Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4.” Hypertension 65, no. 5 (May 2015): 1047–54. https://doi.org/10.1161/HYPERTENSIONAHA.114.04611.
    Full Text Link to Item
  - Dimke, Henrik, Matthew A. Sparks, Benjamin R. Thomson, Sebastian Frische, Thomas M. Coffman, and Susan E. Quaggin. “Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney.” J Am Soc Nephrol 26, no. 5 (May 2015): 1027–38. https://doi.org/10.1681/ASN.2014010060.
    Full Text Link to Item
  - Chen, Daian, and Thomas M. Coffman. “AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.” Curr Opin Pharmacol 21 (April 2015): 122–26. https://doi.org/10.1016/j.coph.2015.01.006.
    Full Text Link to Item
  - Young, Colin N., Donald A. Morgan, Scott D. Butler, Kamal Rahmouni, Susan B. Gurley, Thomas M. Coffman, Allyn L. Mark, and Robin L. Davisson. “Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.” Mol Metab 4, no. 4 (April 2015): 337–43. https://doi.org/10.1016/j.molmet.2015.01.007.
    Full Text Link to Item
  - Young, C. N., D. A. Morgan, S. D. Butler, K. Rahmouni, S. B. Gurley, T. M. Coffman, A. L. Mark, and R. L. Davisson. “Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.” Molecular Metabolism 4, no. 4 (April 1, 2015): 337–43. https://doi.org/10.1016/j.molmet.2015.01.007.
    Full Text
  - Dolber, Paul C., Huixia Jin, Rashid Nassar, Thomas M. Coffman, Susan B. Gurley, and Matthew O. Fraser. “The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice.” Neurourol Urodyn 34, no. 1 (January 2015): 72–78. https://doi.org/10.1002/nau.22511.
    Full Text Link to Item
  - Smithies, Oliver, and Tom Coffman. “A conversation with Oliver Smithies.” Annu Rev Physiol 77 (2015): 1–11. https://doi.org/10.1146/annurev-physiol-021014-071806.
    Full Text Link to Item
  - Sparks, Matthew A., Steven D. Crowley, Susan B. Gurley, Maria Mirotsou, and Thomas M. Coffman. “Classical Renin-Angiotensin system in kidney physiology.” Compr Physiol 4, no. 3 (July 2014): 1201–28. https://doi.org/10.1002/cphy.c130040.
    Full Text Link to Item
  - Coffman, Thomas M. “The inextricable role of the kidney in hypertension.” J Clin Invest 124, no. 6 (June 2014): 2341–47. https://doi.org/10.1172/JCI72274.
    Full Text Link to Item
  - Wang, L., T. A. Fields, K. Pazmino, Q. Dai, J. L. Burchette, D. N. Howell, T. M. Coffman, and R. F. Spurney. “Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622)).” Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126. https://doi.org/10.1681/ASN.2013080868.
    Full Text
  - Xie, Luke, Matthew A. Sparks, Wei Li, Yi Qi, Chunlei Liu, Thomas M. Coffman, and G Allan Johnson. “Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice.” Nmr Biomed 26, no. 12 (December 2013): 1853–63. https://doi.org/10.1002/nbm.3039.
    Full Text Link to Item
  - Dolber, P. C., H. Jin, R. Nassar, T. M. Coffman, S. B. Gurley, and M. O. Fraser. “The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice.” Neurourology and Urodynamics, October 28, 2013.
  - Le, T. H., S. D. Crowley, S. B. Gurley, and T. M. Coffman. “The Renin-Angiotensin System” 1 (September 12, 2013): 427–50. https://doi.org/10.1016/B978-0-12-381462-3.00015-X.
    Full Text
  - Breyer, Matthew D., Thomas M. Coffman, Michael F. Flessner, Linda F. Fried, Raymond C. Harris, Christian J. Ketchum, Matthias Kretzler, et al. “Diabetic nephropathy: a national dialogue.” Clin J Am Soc Nephrol 8, no. 9 (September 2013): 1603–5. https://doi.org/10.2215/CJN.03640413.
    Full Text Link to Item
  - Konvalinka, Ana, Joyce Zhou, Apostolos Dimitromanolakis, Andrei P. Drabovich, Fei Fang, Susan Gurley, Thomas Coffman, et al. “Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).” J Biol Chem 288, no. 34 (August 23, 2013): 24834–47. https://doi.org/10.1074/jbc.M113.485326.
    Full Text Link to Item
  - Pippin, Jeffrey W., Matthew A. Sparks, Sean T. Glenn, Sandra Buitrago, Thomas M. Coffman, Jeremy S. Duffield, Kenneth W. Gross, and Stuart J. Shankland. “Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.” Am J Pathol 183, no. 2 (August 2013): 542–57. https://doi.org/10.1016/j.ajpath.2013.04.024.
    Full Text Link to Item
  - Herrera, Marcela, and Thomas M. Coffman. “Control of electrolyte balance through ubiquitination.” Proc Natl Acad Sci U S A 110, no. 19 (May 7, 2013): 7535–36. https://doi.org/10.1073/pnas.1305242110.
    Full Text Link to Item
  - Herrera, Marcela, Matthew A. Sparks, Adolfo R. Alfonso-Pecchio, Lisa M. Harrison-Bernard, and Thomas M. Coffman. “Response to lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein.” Hypertension 61, no. 4 (April 2013): e32. https://doi.org/10.1161/hypertensionaha.111.00982.
    Full Text Link to Item
  - Ortiz-Melo, David, and Thomas M. Coffman. “A trip to inner space: insights into salt balance from cosmonauts.” Cell Metab 17, no. 1 (January 8, 2013): 1–2. https://doi.org/10.1016/j.cmet.2012.12.009.
    Full Text Link to Item
  - Sparks, Matthew A., Natalia A. Makhanova, Robert C. Griffiths, John N. Snouwaert, Beverly H. Koller, and Thomas M. Coffman. “Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death.” Hypertension 61, no. 1 (January 2013): 166–73. https://doi.org/10.1161/HYPERTENSIONAHA.112.193250.
    Full Text Link to Item
  - Herrera, Marcela, Matthew A. Sparks, Adolfo R. Alfonso-Pecchio, Lisa M. Harrison-Bernard, and Thomas M. Coffman. “Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein.” Hypertension 61, no. 1 (January 2013): 253–58. https://doi.org/10.1161/HYPERTENSIONAHA.112.203679.
    Full Text Link to Item
  - Zhang, Jian-dong, Mehul B. Patel, Young-Soo Song, Robert Griffiths, James Burchette, Phillip Ruiz, Matthew A. Sparks, et al. “A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.” Circ Res 110, no. 12 (June 8, 2012): 1604–17. https://doi.org/10.1161/CIRCRESAHA.111.261768.
    Full Text Link to Item
  - Crowley, Steven D., and Thomas M. Coffman. “Recent advances involving the renin-angiotensin system.” Exp Cell Res 318, no. 9 (May 15, 2012): 1049–56. https://doi.org/10.1016/j.yexcr.2012.02.023.
    Full Text Link to Item
  - Gembardt, Florian, Richard van Veghel, Thomas M. Coffman, Heinz-Peter Schultheiss, Alexander H Jan Danser, and Thomas Walther. “Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors.” Hypertens Res 35, no. 5 (May 2012): 547–51. https://doi.org/10.1038/hr.2012.5.
    Full Text Link to Item
  - Chen, Daian, and Thomas M. Coffman. “The kidney and hypertension: lessons from mouse models.” Can J Cardiol 28, no. 3 (May 2012): 305–10. https://doi.org/10.1016/j.cjca.2012.01.002.
    Full Text Link to Item
  - Herrera, Marcela, and Thomas M. Coffman. “The kidney and hypertension: novel insights from transgenic models.” Curr Opin Nephrol Hypertens 21, no. 2 (March 2012): 171–78. https://doi.org/10.1097/MNH.0b013e3283503068.
    Full Text Link to Item
  - Cyphert, Jaime M., Irving C. Allen, Rachel J. Church, Anne M. Latour, John N. Snouwaert, Thomas M. Coffman, and Beverly H. Koller. “Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse.” Am J Physiol Lung Cell Mol Physiol 302, no. 1 (January 1, 2012): L140–51. https://doi.org/10.1152/ajplung.00152.2011.
    Full Text Link to Item
  - Stegbauer, Johannes, Susan B. Gurley, Matthew A. Sparks, Magdalena Woznowski, Donald E. Kohan, Ming Yan, Ruediger W. Lehrich, and Thomas M. Coffman. “AT1 receptors in the collecting duct directly modulate the concentration of urine.” J Am Soc Nephrol 22, no. 12 (December 2011): 2237–46. https://doi.org/10.1681/ASN.2010101095.
    Full Text Link to Item
  - Verlander, Jill W., Seongun Hong, Vladimir Pech, James L. Bailey, Diana Agazatian, Sharon W. Matthews, Thomas M. Coffman, et al. “Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.” Am J Physiol Renal Physiol 301, no. 6 (December 2011): F1314–25. https://doi.org/10.1152/ajprenal.00114.2011.
    Full Text Link to Item
  - Coffman, Thomas M. “Under pressure: the search for the essential mechanisms of hypertension.” Nat Med 17, no. 11 (November 7, 2011): 1402–9. https://doi.org/10.1038/nm.2541.
    Full Text Link to Item
  - Crowley, Steven D., Jiandong Zhang, Maria Herrera, Robert Griffiths, Phillip Ruiz, and Thomas M. Coffman. “Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension.” Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1124–30. https://doi.org/10.1152/ajprenal.00305.2011.
    Full Text Link to Item
  - Facemire, Carie S., Mytrang Nguyen, Leigh Jania, William H. Beierwaltes, Hyung-Suk Kim, Beverly H. Koller, and Thomas M. Coffman. “A major role for the EP4 receptor in regulation of renin.” Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1035–41. https://doi.org/10.1152/ajprenal.00054.2011.
    Full Text Link to Item
  - Snoeijs, Maarten G. J., Pieter R. Hoogland, Bas Boonen, Thomas M. Coffman, Carine J. Peutz-Kootstra, Wim A. Buurman, and LW Ernest van Heurn. “Thromboxane receptor signalling in renal ischemia reperfusion injury.” Free Radic Res 45, no. 6 (June 2011): 699–706. https://doi.org/10.3109/10715762.2011.571686.
    Full Text Link to Item
  - Gurley, Susan B., Anne D. M. Riquier-Brison, Jurgen Schnermann, Matthew A. Sparks, Andrew M. Allen, Volker H. Haase, John N. Snouwaert, et al. “AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.” Cell Metab 13, no. 4 (April 6, 2011): 469–75. https://doi.org/10.1016/j.cmet.2011.03.001.
    Full Text Link to Item
  - Sparks, Matthew A., Kelly K. Parsons, Johannes Stegbauer, Susan B. Gurley, Anuradha Vivekanandan-Giri, Christopher N. Fortner, Jay Snouwaert, et al. “Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension.” Hypertension 57, no. 3 (March 2011): 577–85. https://doi.org/10.1161/HYPERTENSIONAHA.110.165274.
    Full Text Link to Item
  - DiLillo, David J., Robert Griffiths, Surya V. Seshan, Cynthia M. Magro, Phillip Ruiz, Thomas M. Coffman, and Thomas F. Tedder. “B lymphocytes differentially influence acute and chronic allograft rejection in mice.” J Immunol 186, no. 4 (February 15, 2011): 2643–54. https://doi.org/10.4049/jimmunol.1002983.
    Full Text Link to Item
  - Stegbauer, Johannes, and Thomas M. Coffman. “New insights into angiotensin receptor actions: from blood pressure to aging.” Curr Opin Nephrol Hypertens 20, no. 1 (January 2011): 84–88. https://doi.org/10.1097/MNH.0b013e3283414d40.
    Full Text Link to Item
  - Makhanova, Natalia A., Steven D. Crowley, Robert C. Griffiths, and Thomas M. Coffman. “Gene expression profiles linked to AT1 angiotensin receptors in the kidney.” Physiol Genomics 42A, no. 3 (November 15, 2010): 211–18. https://doi.org/10.1152/physiolgenomics.00063.2010.
    Full Text Link to Item
  - Gurley, Susan B., Robert C. Griffiths, Michael E. Mendelsohn, Richard H. Karas, and Thomas M. Coffman. “Renal actions of RGS2 control blood pressure.” J Am Soc Nephrol 21, no. 11 (November 2010): 1847–51. https://doi.org/10.1681/ASN.2009121306.
    Full Text Link to Item
  - Gurley, Susan B., and Thomas M. Coffman. “An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy.” Cell Metab 12, no. 4 (October 6, 2010): 311–12. https://doi.org/10.1016/j.cmet.2010.09.007.
    Full Text Link to Item
  - Sparks, Matthew A., and Thomas M. Coffman. “The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad?” J Am Soc Nephrol 21, no. 10 (October 2010): 1597–99. https://doi.org/10.1681/ASN.2010080870.
    Full Text Link to Item
  - Esch, Joep H. M. van, Florian Gembardt, Anja Sterner-Kock, Silvia Heringer-Walther, Thu H. Le, Dirk Lassner, Theo Stijnen, et al. “Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.” Cardiovasc Res 86, no. 3 (June 1, 2010): 401–9. https://doi.org/10.1093/cvr/cvq004.
    Full Text Link to Item
  - Gurley, Susan B., Carrie L. Mach, Johannes Stegbauer, Jihong Yang, Kamie P. Snow, Ann Hu, Timothy W. Meyer, and Thomas M. Coffman. “Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.” Am J Physiol Renal Physiol 298, no. 3 (March 2010): F788–95. https://doi.org/10.1152/ajprenal.90515.2008.
    Full Text Link to Item
  - Madsen, Kirsten, Niels Marcussen, Michael Pedersen, Gitte Kjaersgaard, Carie Facemire, Thomas M. Coffman, and Boye L. Jensen. “Angiotensin II promotes development of the renal microcirculation through AT1 receptors.” J Am Soc Nephrol 21, no. 3 (March 2010): 448–59. https://doi.org/10.1681/ASN.2009010045.
    Full Text Link to Item
  - Facemire, Carie S., Robert Griffiths, Laurent P. Audoly, Beverly H. Koller, and Thomas M. Coffman. “The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.” Hypertension 55, no. 2 (February 2010): 531–38. https://doi.org/10.1161/HYPERTENSIONAHA.109.145631.
    Full Text Link to Item
  - Crowley, S. D., C. W. Frey, S. K. Gould, R. Griffiths, P. Ruiz, J. L. Burchette, D. N. Howell, et al. “Simulation of lymphoctye responses by angiotensin II promotes kidney injury in hypertension (American Journal Physiology-Renal Physiology (2008) 295, (F515-F524)).” American Journal of Physiology Renal Physiology 298, no. 5 (January 1, 2010). https://doi.org/10.1152/ajprenal.zh2-5901-corr.2010.
    Full Text
  - Brosius, Frank C., Charles E. Alpers, Erwin P. Bottinger, Matthew D. Breyer, Thomas M. Coffman, Susan B. Gurley, Raymond C. Harris, et al. “Mouse models of diabetic nephropathy.” J Am Soc Nephrol 20, no. 12 (December 2009): 2503–12. https://doi.org/10.1681/ASN.2009070721.
    Full Text Link to Item
  - Machura, Katharina, Dominik Steppan, Bjoern Neubauer, Natalia Alenina, Thomas M. Coffman, Carie S. Facemire, Karl F. Hilgers, Kai-Uwe Eckardt, Charlotte Wagner, and Armin Kurtz. “Developmental renin expression in mice with a defective renin-angiotensin system.” Am J Physiol Renal Physiol 297, no. 5 (November 2009): F1371–80. https://doi.org/10.1152/ajprenal.00378.2009.
    Full Text Link to Item
  - Lemarié, Catherine A., Stefania M. C. Simeone, Anna Nikonova, Talin Ebrahimian, Marie-Eve Deschênes, Thomas M. Coffman, Pierre Paradis, and Ernesto L. Schiffrin. “Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.” Circ Res 105, no. 9 (October 23, 2009): 852–59. https://doi.org/10.1161/CIRCRESAHA.109.196576.
    Full Text Link to Item
  - Facemire, Carie S., Andrew B. Nixon, Robert Griffiths, Herbert Hurwitz, and Thomas M. Coffman. “Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.” Hypertension 54, no. 3 (September 2009): 652–58. https://doi.org/10.1161/HYPERTENSIONAHA.109.129973.
    Full Text Link to Item
  - Crowley, Steven D., Matthew P. Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A Kathy Pazmino, Carie Facemire, et al. “Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.” J Clin Invest 119, no. 4 (April 2009): 943–53. https://doi.org/10.1172/JCI34862.
    Full Text Link to Item
  - Riquier, Anne D. M., Alicia A. McDonough, Dow-Ning Kou, Thomas M. Coffman, and Susan B. Gurley. “Role of the proximal tubule AT1A receptor in sodium transport regulation.” Faseb Journal 23 (April 1, 2009).
    Link to Item
  - Benigni, Ariela, Daniela Corna, Carla Zoja, Aurelio Sonzogni, Roberto Latini, Monica Salio, Sara Conti, et al. “Disruption of the Ang II type 1 receptor promotes longevity in mice.” J Clin Invest 119, no. 3 (March 2009): 524–30. https://doi.org/10.1172/JCI36703.
    Full Text Link to Item
  - Thu H., L., C. Steven D., G. Susan B., and C. Thomas M. “The Renin-Angiotensin System,” December 1, 2008, 343–57. https://doi.org/10.1016/B978-012088488-9.50016-4.
    Full Text
  - Athirakul, Krairerk, J Alyce Bradbury, Joan P. Graves, Laura M. DeGraff, Jixiang Ma, Yun Zhao, John F. Couse, et al. “Increased blood pressure in mice lacking cytochrome P450 2J5.” Faseb J 22, no. 12 (December 2008): 4096–4108. https://doi.org/10.1096/fj.08-114413.
    Full Text Link to Item
  - Spurney, Robert F., and Thomas M. Coffman. “Stressed-out podocytes in diabetes?” J Am Soc Nephrol 19, no. 11 (November 2008): 2035–37. https://doi.org/10.1681/ASN.2008090955.
    Full Text Link to Item
  - Crowley, Steven D., and Thomas M. Coffman. “In hypertension, the kidney breaks your heart.” Curr Cardiol Rep 10, no. 6 (November 2008): 470–76. https://doi.org/10.1007/s11886-008-0074-5.
    Full Text Link to Item
  - Francois, Helene, Natalia Makhanova, Philip Ruiz, Jonathan Ellison, Lan Mao, Howard A. Rockman, and Thomas M. Coffman. “A role for the thromboxane receptor in L-NAME hypertension.” Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096–1102. https://doi.org/10.1152/ajprenal.00369.2007.
    Full Text Link to Item
  - Gembardt, Florian, Silvia Heringer-Walther, Joep H. M. van Esch, Anja Sterner-Kock, Richard van Veghel, Thu H. Le, Ingrid M. Garrelds, et al. “Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.” Faseb J 22, no. 8 (August 2008): 3068–77. https://doi.org/10.1096/fj.08-108316.
    Full Text Link to Item
  - Crowley, Steven D., Campbell W. Frey, Samantha K. Gould, Robert Griffiths, Phillip Ruiz, James L. Burchette, David N. Howell, et al. “Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.” Am J Physiol Renal Physiol 295, no. 2 (August 2008): F515–24. https://doi.org/10.1152/ajprenal.00527.2007.
    Full Text Link to Item
  - Coggins, Kenneth G., Thomas M. Coffman, and Beverly H. Koller. “The Hippocratic finger points the blame at PGE2.” Nat Genet 40, no. 6 (June 2008): 691–92. https://doi.org/10.1038/ng0608-691.
    Full Text Link to Item
  - Gurley, Susan B., and Thomas M. Coffman. “Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages.” Exp Physiol 93, no. 5 (May 2008): 538–42. https://doi.org/10.1113/expphysiol.2007.040014.
    Full Text Link to Item
  - Wooldridge, Anne A., Christopher N. Fortner, Beata Lontay, Takayuki Akimoto, Ronald L. Neppl, Carie Facemire, Michael B. Datto, et al. “Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.” J Biol Chem 283, no. 17 (April 25, 2008): 11850–59. https://doi.org/10.1074/jbc.M708628200.
    Full Text Link to Item
  - Coffman, Thomas M., and Steven D. Crowley. “Kidney in hypertension: guyton redux.” Hypertension 51, no. 4 (April 2008): 811–16. https://doi.org/10.1161/HYPERTENSIONAHA.105.063636.
    Full Text Link to Item
  - Le, Thu H., and Thomas M. Coffman. “Targeting genes in the renin-angiotensin system.” Curr Opin Nephrol Hypertens 17, no. 1 (January 2008): 57–63. https://doi.org/10.1097/MNH.0b013e3282f2fd39.
    Full Text Link to Item
  - Francois, Helene, Carie Facemire, Anil Kumar, Laurent Audoly, Beverly Koller, and Thomas Coffman. “Role of microsomal prostaglandin E synthase 1 in the kidney.” J Am Soc Nephrol 18, no. 5 (May 2007): 1466–75. https://doi.org/10.1681/ASN.2006040343.
    Full Text Link to Item
  - Ashton, Anthony W., Shankar Mukherjee, F. N. U. Nagajyothi, Huan Huang, Vicki L. Braunstein, Mahalia S. Desruisseaux, Stephen M. Factor, et al. “Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection.” J Exp Med 204, no. 4 (April 16, 2007): 929–40. https://doi.org/10.1084/jem.20062432.
    Full Text Link to Item
  - Parsons, Kelly K., and Thomas M. Coffman. “The renin-angiotensin system: it's all in your head.” J Clin Invest 117, no. 4 (April 2007): 873–76. https://doi.org/10.1172/JCI31856.
    Full Text Link to Item
  - Crowley, Steven D., and Thomas M. Coffman. “In hypertension, the kidney rules.” Curr Hypertens Rep 9, no. 2 (April 2007): 148–53. https://doi.org/10.1007/s11906-007-0026-2.
    Full Text Link to Item
  - Gurley, Susan B., and Thomas M. Coffman. “The renin-angiotensin system and diabetic nephropathy.” Semin Nephrol 27, no. 2 (March 2007): 144–52. https://doi.org/10.1016/j.semnephrol.2007.01.009.
    Full Text Link to Item
  - Quaggin, Susan E., and Thomas M. Coffman. “Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?” J Am Soc Nephrol 18, no. 2 (February 2007): 364–66. https://doi.org/10.1681/ASN.2006121396.
    Full Text Link to Item
  - Crowley, Steven D., Susan B. Gurley, and Thomas M. Coffman. “AT(1) receptors and control of blood pressure: the kidney and more..” Trends Cardiovasc Med 17, no. 1 (January 2007): 30–34. https://doi.org/10.1016/j.tcm.2006.11.002.
    Full Text Link to Item
  - Crowley, Steven D., Susan B. Gurley, Maria J. Herrera, Phillip Ruiz, Robert Griffiths, Anil P. Kumar, Hyung-Suk Kim, Oliver Smithies, Thu H. Le, and Thomas M. Coffman. “Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.” Proc Natl Acad Sci U S A 103, no. 47 (November 21, 2006): 17985–90. https://doi.org/10.1073/pnas.0605545103.
    Full Text Link to Item
  - Rajagopal, Keshava, Erin J. Whalen, Jonathan D. Violin, Jonathan A. Stiber, Paul B. Rosenberg, Richard T. Premont, Thomas M. Coffman, Howard A. Rockman, and Robert J. Lefkowitz. “Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.” Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284–89. https://doi.org/10.1073/pnas.0607583103.
    Full Text Link to Item
  - Coffman, Thomas M. “A WNK in the kidney controls blood pressure.” Nat Genet 38, no. 10 (October 2006): 1105–6. https://doi.org/10.1038/ng1006-1105.
    Full Text Link to Item
  - Chansel, Dominique, Magali Ciroldi, Sophie Vandermeersch, Leslie F. Jackson, Ana-Maria Gomez, Daniel Henrion, David C. Lee, et al. “Heparin binding EGF is necessary for vasospastic response to endothelin.” Faseb J 20, no. 11 (September 2006): 1936–38. https://doi.org/10.1096/fj.05-5328fje.
    Full Text Link to Item
  - Gurley, Susan B., Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, et al. “Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.” J Clin Invest 116, no. 8 (August 2006): 2218–25. https://doi.org/10.1172/JCI16980.
    Full Text Link to Item
  - Wysocki, Jan, Minghao Ye, Maria José Soler, Susan B. Gurley, Hong D. Xiao, Kenneth E. Bernstein, Thomas M. Coffman, Sheldon Chen, and Daniel Batlle. “ACE and ACE2 activity in diabetic mice.” Diabetes 55, no. 7 (July 2006): 2132–39. https://doi.org/10.2337/db06-0033.
    Full Text Link to Item
  - Elased, Khalid M., Tatiana S. Cunha, Susan B. Gurley, Thomas M. Coffman, and Mariana Morris. “New mass spectrometric assay for angiotensin-converting enzyme 2 activity.” Hypertension 47, no. 5 (May 2006): 1010–17. https://doi.org/10.1161/01.HYP.0000215588.38536.30.
    Full Text Link to Item
  - Le, Thu H., and Thomas M. Coffman. “A new cardiac MASTer switch for the renin-angiotensin system.” J Clin Invest 116, no. 4 (April 2006): 866–69. https://doi.org/10.1172/JCI28312.
    Full Text Link to Item
  - Allen, Irving C., John M. Hartney, Thomas M. Coffman, Raymond B. Penn, Jürgen Wess, and Beverly H. Koller. “Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism.” Am J Physiol Lung Cell Mol Physiol 290, no. 3 (March 2006): L526–33. https://doi.org/10.1152/ajplung.00340.2005.
    Full Text Link to Item
  - Gurley, Susan B., Sharon E. Clare, Kamie P. Snow, Ann Hu, Timothy W. Meyer, and Thomas M. Coffman. “Impact of genetic background on nephropathy in diabetic mice.” Am J Physiol Renal Physiol 290, no. 1 (January 2006): F214–22. https://doi.org/10.1152/ajprenal.00204.2005.
    Full Text Link to Item
  - Woost, Philip G., Robert J. Kolb, Margaret Finesilver, Irene Mackraj, Hans Imboden, Thomas M. Coffman, and Ulrich Hopfer. “Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines.” In Vitro Cell Dev Biol Anim 42, no. 7 (2006): 189–200. https://doi.org/10.1290/0511076.1.
    Full Text Link to Item
  - Francois, H., K. Athirakul, D. Howell, R. Dash, L. Mao, H. S. Kim, H. A. Rockman, G. A. FitzGerald, B. H. Koller, and T. M. Coffman. “NSAIDs and cardiovascular risk - Reply [2].” Cell Metabolism 2, no. 6 (December 1, 2005): 339–40. https://doi.org/10.1016/j.cmet.2005.11.009.
    Full Text
  - Wang, Liming, Timothy A. Fields, Kathy Pazmino, Qunsheng Dai, James L. Burchette, David N. Howell, Thomas M. Coffman, and Robert F. Spurney. “Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury.” J Am Soc Nephrol 16, no. 12 (December 2005): 3611–22. https://doi.org/10.1681/ASN.2005020167.
    Full Text Link to Item
  - Ouyang, Xiaosen, Thu H. Le, Carlos Roncal, Christine Gersch, Jaime Herrera-Acosta, Bernardo Rodriguez-Iturbe, Thomas M. Coffman, Richard J. Johnson, and Wei Mu. “Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice.” Am J Physiol Renal Physiol 289, no. 4 (October 2005): F902–10. https://doi.org/10.1152/ajprenal.00141.2005.
    Full Text Link to Item
  - Francois, Helene, Krairerk Athirakul, David Howell, Rajesh Dash, Lan Mao, Hyung-Suk Kim, Howard A. Rockman, Garret A. Fitzgerald, Beverly H. Koller, and Thomas M. Coffman. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.” Cell Metab 2, no. 3 (September 2005): 201–7. https://doi.org/10.1016/j.cmet.2005.08.005.
    Full Text Link to Item
  - Bridgman, Paul, Mark A. Aronovitz, Rahul Kakkar, Michael I. Oliverio, Thomas M. Coffman, William M. Rand, Marvin A. Konstam, Michael E. Mendelsohn, and Richard D. Patten. “Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.” Am J Physiol Heart Circ Physiol 289, no. 2 (August 2005): H586–92. https://doi.org/10.1152/ajpheart.00474.2004.
    Full Text Link to Item
  - Rocha, Paulo N., Troy J. Plumb, Lisa A. Robinson, Robert Spurney, David Pisetsky, Beverly H. Koller, and Thomas M. Coffman. “Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.” Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896–903. https://doi.org/10.1128/CDLI.12.8.896-903.2005.
    Full Text Link to Item
  - Yang, Liu, Ramón Bataller, Jennyfer Dulyx, Thomas M. Coffman, Pere Ginès, Richard A. Rippe, and David A. Brenner. “Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.” J Hepatol 43, no. 2 (August 2005): 317–23. https://doi.org/10.1016/j.jhep.2005.02.034.
    Full Text Link to Item
  - Rudic, R Daniel, Derek Brinster, Yan Cheng, Susanne Fries, Wen-Liang Song, Sandra Austin, Thomas M. Coffman, and Garret A. FitzGerald. “COX-2-derived prostacyclin modulates vascular remodeling.” Circ Res 96, no. 12 (June 24, 2005): 1240–47. https://doi.org/10.1161/01.RES.0000170888.11669.28.
    Full Text Link to Item
  - Breyer, Matthew D., Erwin Böttinger, Frank C. Brosius, Thomas M. Coffman, Agnes Fogo, Raymond C. Harris, Charles W. Heilig, and Kumar Sharma. “Diabetic nephropathy: of mice and men.” Adv Chronic Kidney Dis 12, no. 2 (April 2005): 128–45. https://doi.org/10.1053/j.ackd.2005.01.004.
    Full Text Link to Item
  - Crowley, Steven D., Susan B. Gurley, Michael I. Oliverio, A Kathy Pazmino, Robert Griffiths, Patrick J. Flannery, Robert F. Spurney, et al. “Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.” J Clin Invest 115, no. 4 (April 2005): 1092–99. https://doi.org/10.1172/JCI23378.
    Full Text Link to Item
  - Chansel, D., M. Ciroldi, S. Vandermeersch, A. M. Gomez, L. F. Jackson, D. C. Lee, D. Henrion, et al. “Egf receptor activated by hb-egf is required to calcium influx and vasoconstriction induced by endothelin-1.” Journal of Hypertension 23, no. 8 (January 1, 2005). https://doi.org/10.1097/01.hjh.0000177372.24455.20.
    Full Text
  - Breyer, Matthew D., Erwin Böttinger, Frank C. Brosius, Thomas M. Coffman, Raymond C. Harris, Charles W. Heilig, Kumar Sharma, and Kumar AMDCC. “Mouse models of diabetic nephropathy.” J Am Soc Nephrol 16, no. 1 (January 2005): 27–45. https://doi.org/10.1681/ASN.2004080648.
    Full Text Link to Item
  - Benigni, Ariela, Daniela Corna, Carla Zoja, Lorena Longaretti, Elena Gagliardini, Norberto Perico, Thomas M. Coffman, and Giuseppe Remuzzi. “Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria.” J Am Soc Nephrol 15, no. 10 (October 2004): 2666–74. https://doi.org/10.1097/01.ASN.0000141465.81556.D2.
    Full Text Link to Item
  - Boffa, Jean-Jacques, Armin Just, Thomas M. Coffman, and William J. Arendshorst. “Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice.” J Am Soc Nephrol 15, no. 9 (September 2004): 2358–65. https://doi.org/10.1097/01.ASN.0000136300.72480.86.
    Full Text Link to Item
  - Francois, Helene, and Thomas M. Coffman. “Prostanoids and blood pressure: which way is up?” J Clin Invest 114, no. 6 (September 2004): 757–59. https://doi.org/10.1172/JCI22929.
    Full Text Link to Item
  - Le, Thu H., Michael I. Oliverio, Hyung-Suk Kim, Harmony Salzler, Rajesh C. Dash, David N. Howell, Oliver Smithies, Sarah Bronson, and Thomas M. Coffman. “A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.” Physiol Genomics 18, no. 3 (August 11, 2004): 290–98. https://doi.org/10.1152/physiolgenomics.00120.2003.
    Full Text Link to Item
  - Crowley, S. D., P. -. L. Tharaux, L. P. Audoly, and T. M. Coffman. “Exploring type I angiotensin (AT1) receptor functions through gene targeting.” Acta Physiol Scand 181, no. 4 (August 2004): 561–70. https://doi.org/10.1111/j.1365-201X.2004.01331.x.
    Full Text Link to Item
  - Goulet, Jennifer L., Amy J. Pace, Mikelle L. Key, Robert S. Byrum, MyTrang Nguyen, Stephen L. Tilley, Scott G. Morham, et al. “E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.” J Immunol 173, no. 2 (July 15, 2004): 1321–26. https://doi.org/10.4049/jimmunol.173.2.1321.
    Full Text Link to Item
  - Quan, Hui, Krairerk Athirakul, William C. Wetsel, Gonzalo E. Torres, Robert Stevens, Y. T. Chen, Thomas M. Coffman, and Marc G. Caron. “Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.” Mol Cell Biol 24, no. 10 (May 2004): 4166–73. https://doi.org/10.1128/MCB.24.10.4166-4173.2004.
    Full Text Link to Item
  - Le, Thu H., Agnes B. Fogo, Harmony R. Salzler, Tania Vinogradova, Michael I. Oliverio, Douglas A. Marchuk, and Thomas M. Coffman. “Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency.” Hypertension 43, no. 2 (February 2004): 445–51. https://doi.org/10.1161/01.HYP.0000112423.28987.00.
    Full Text Link to Item
  - Francois, Helene, Krairerk Athirakul, Lan Mao, Howard Rockman, and Thomas M. Coffman. “Role for thromboxane receptors in angiotensin-II-induced hypertension.” Hypertension 43, no. 2 (February 2004): 364–69. https://doi.org/10.1161/01.HYP.0000112225.27560.24.
    Full Text Link to Item
  - Thomas, Dennis W., Paulo N. Rocha, Chandra Nataraj, Lisa A. Robinson, Robert F. Spurney, Beverly H. Koller, and Thomas M. Coffman. “Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.” J Immunol 171, no. 12 (December 15, 2003): 6389–95. https://doi.org/10.4049/jimmunol.171.12.6389.
    Full Text Link to Item
  - Rocha, Paulo N., Troy J. Plumb, Steven D. Crowley, and Thomas M. Coffman. “Effector mechanisms in transplant rejection.” Immunol Rev 196 (December 2003): 51–64. https://doi.org/10.1046/j.1600-065x.2003.00090.x.
    Full Text Link to Item
  - Wagner, Charlotte, Helga Vitzthum, Hayo Castrop, Karl Schumacher, Michael Bucher, Sybille Albertin, Thomas M. Coffman, William J. Arendshorst, and Armin Kurtz. “Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.” Pflugers Arch 447, no. 2 (November 2003): 214–22. https://doi.org/10.1007/s00424-003-1157-1.
    Full Text Link to Item
  - Le, Thu H., Hyung-Suk Kim, Andrew M. Allen, Robert F. Spurney, Oliver Smithies, and Thomas M. Coffman. “Physiological impact of increased expression of the AT1 angiotensin receptor.” Hypertension 42, no. 4 (October 2003): 507–14. https://doi.org/10.1161/01.HYP.0000092000.07559.57.
    Full Text Link to Item
  - Robinson, Lisa A., Chandra Nataraj, Dennis W. Thomas, Josette M. Cosby, Robert Griffiths, Victoria L. Bautch, Dhavalkumar D. Patel, and Thomas M. Coffman. “The chemokine CX3CL1 regulates NK cell activity in vivo.” Cell Immunol 225, no. 2 (October 2003): 122–30. https://doi.org/10.1016/j.cellimm.2003.09.010.
    Full Text Link to Item
  - Rocha, Paulo N., Troy J. Plumb, and Thomas M. Coffman. “Eicosanoids: lipid mediators of inflammation in transplantation.” Springer Semin Immunopathol 25, no. 2 (September 2003): 215–27. https://doi.org/10.1007/s00281-003-0132-4.
    Full Text Link to Item
  - Tharaux, Pierre-Louis, Richard C. Bukoski, Paulo N. Rocha, Steven D. Crowley, Phillip Ruiz, Chandra Nataraj, David N. Howell, Kozo Kaibuchi, Robert F. Spurney, and Thomas M. Coffman. “Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.” J Immunol 171, no. 1 (July 1, 2003): 96–105. https://doi.org/10.4049/jimmunol.171.1.96.
    Full Text Link to Item
  - Wurth, Gene R., Judy H. Sherr, and Thomas M. Coffman. “Orthopaedic research and education foundation and industry.” Clin Orthop Relat Res, no. 412 (July 2003): 54–56. https://doi.org/10.1097/01.blo.0000074404.99625.bc.
    Full Text Link to Item
  - Cho, Moon J., Junling Liu, Tamara I. Pestina, Shirley A. Steward, Dennis W. Thomas, Thomas M. Coffman, Demin Wang, Carl W. Jackson, and T Kent Gartner. “The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.” Blood 101, no. 7 (April 1, 2003): 2646–51. https://doi.org/10.1182/blood-2002-05-1363.
    Full Text Link to Item
  - Harrison-Bernard, L. M., A. K. Cook, M. I. Oliverio, and T. M. Coffman. “Renal segmental microvascular responses to ANG II in AT1A receptor null mice.” American Journal of Physiology Renal Physiology 284, no. 3 53-3 (March 1, 2003).
  - Harrison-Bernard, Lisa M., Anthony K. Cook, Michael I. Oliverio, and Thomas M. Coffman. “Renal segmental microvascular responses to ANG II in AT1A receptor null mice.” Am J Physiol Renal Physiol 284, no. 3 (March 2003): F538–45. https://doi.org/10.1152/ajprenal.00340.2002.
    Full Text Link to Item
  - Flamant, Martin, Pierre-Louis Tharaux, Sandrine Placier, Daniel Henrion, Tom Coffman, Christos Chatziantoniou, and Jean-Claude Dussaule. “Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.” Faseb J 17, no. 2 (February 2003): 327–29. https://doi.org/10.1096/fj.02-0115fje.
    Full Text Link to Item
  - Le, Thu H., and Thomas M. Coffman. “RGS2: a "turn-off" in hypertension.” J Clin Invest 111, no. 4 (February 2003): 441–43. https://doi.org/10.1172/JCI17836.
    Full Text Link to Item
  - June Brickey, W., Nathan J. Felix, Robert Griffiths, Jinghua Zhang, Bo Wang, Janet F. Piskurich, Yoshie Itoh-Lindstrom, Thomas M. Coffman, and Jenny P-Y Ting. “Prolonged survival of class II transactivator-deficient cardiac allografts.” Transplantation 74, no. 9 (November 15, 2002): 1341–48. https://doi.org/10.1097/00007890-200211150-00024.
    Full Text Link to Item
  - Cervenka, Ludek, Vladislav Horácek, Ivana Vanecková, Jaroslav A. Hubácek, Michael I. Oliverio, Thomas M. Coffman, and L Gabriel Navar. “Essential role of AT1A receptor in the development of 2K1C hypertension.” Hypertension 40, no. 5 (November 2002): 735–41. https://doi.org/10.1161/01.hyp.0000036452.28493.74.
    Full Text Link to Item
  - Nguyen, MyTrang, Michael Solle, Laurent P. Audoly, Stephen L. Tilley, Jeffrey L. Stock, John D. McNeish, Thomas M. Coffman, David Dombrowicz, and Beverly H. Koller. “Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production.” J Immunol 169, no. 8 (October 15, 2002): 4586–93. https://doi.org/10.4049/jimmunol.169.8.4586.
    Full Text Link to Item
  - Bostom, Andrew D., Robert S. Brown, Blanche M. Chavers, Thomas M. Coffman, Fernando G. Cosio, Kenneth Culver, John J. Curtis, et al. “Prevention of post-transplant cardiovascular disease--report and recommendations of an ad hoc group.” Am J Transplant 2, no. 6 (July 2002): 491–500. https://doi.org/10.1034/j.1600-6143.2002.20602.x.
    Full Text Link to Item
  - Mannon, Roslyn B., Robert Griffiths, Phillip Ruiz, Jeffrey L. Platt, and Thomas M. Coffman. “Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection.” Kidney Int 62, no. 1 (July 2002): 290–300. https://doi.org/10.1046/j.1523-1755.2002.00422.x.
    Full Text Link to Item
  - Hunkeler, John D., Tom M. Coffman, Jerry Paugh, Alan Lang, Pamela Smith, and Nicholas Tarantino. “Characterization of visual phenomena with the Array multifocal intraocular lens.” J Cataract Refract Surg 28, no. 7 (July 2002): 1195–1204. https://doi.org/10.1016/s0886-3350(02)01208-7.
    Full Text Link to Item
  - Cheng, Yan, Sandra C. Austin, Bianca Rocca, Beverly H. Koller, Thomas M. Coffman, Tilo Grosser, John A. Lawson, and Garret A. FitzGerald. “Role of prostacyclin in the cardiovascular response to thromboxane A2.” Science 296, no. 5567 (April 19, 2002): 539–41. https://doi.org/10.1126/science.1068711.
    Full Text Link to Item
  - Coffman, Thomas M. “Another cystic mystery solved.” Nat Genet 30, no. 3 (March 2002): 247–48. https://doi.org/10.1038/ng0302-247.
    Full Text Link to Item
  - Brooks, H. L., A. J. Allred, K. T. Beutler, T. M. Coffman, and M. A. Knepper. “Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice.” Hypertension 39, no. 2 Pt 2 (February 2002): 470–73.
  - Brooks, Heddwen L., Alicia J. Allred, Kathleen T. Beutler, Thomas M. Coffman, and Mark A. Knepper. “Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice.” Hypertension 39, no. 2 Pt 2 (February 2002): 470–73. https://doi.org/10.1161/hy02t2.102959.
    Full Text Link to Item
  - Coggins, Kenneth G., Ann Latour, Mytrang S. Nguyen, Laurent Audoly, Thomas M. Coffman, and Beverly H. Koller. “Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.” Nat Med 8, no. 2 (February 2002): 91–92. https://doi.org/10.1038/nm0202-91.
    Full Text Link to Item
  - Gurley, S. B., T. H. Le, and T. M. Coffman. “Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease.” Cold Spring Harb Symp Quant Biol 67 (2002): 451–57. https://doi.org/10.1101/sqb.2002.67.451.
    Full Text Link to Item
  - Athirakul, K., H. S. Kim, L. P. Audoly, O. Smithies, and T. M. Coffman. “Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition.” Kidney Int 60, no. 6 (December 2001): 2324–29. https://doi.org/10.1046/j.1523-1755.2001.00072.x.
    Full Text Link to Item
  - Goulet, J. L., R. C. Griffiths, P. Ruiz, R. B. Mannon, P. Flannery, J. L. Platt, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.” J Immunol 167, no. 11 (December 1, 2001): 6631–36. https://doi.org/10.4049/jimmunol.167.11.6631.
    Full Text Link to Item
  - Nataraj, C., D. W. Thomas, S. L. Tilley, M. T. Nguyen, R. Mannon, B. H. Koller, and T. M. Coffman. “Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.” J Clin Invest 108, no. 8 (October 2001): 1229–35. https://doi.org/10.1172/JCI13640.
    Full Text Link to Item
  - Tilley, S. L., T. M. Coffman, and B. H. Koller. “Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.” J Clin Invest 108, no. 1 (July 2001): 15–23. https://doi.org/10.1172/JCI13416.
    Full Text Link to Item
  - Kelly, Susan J., Marielle Delnomdedieu, Michael I. Oliverio, L David Williams, Mark G. P. Saifer, Merry R. Sherman, Thomas M. Coffman, G Allan Johnson, and Michael S. Hershfield. “Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.” J Am Soc Nephrol 12, no. 5 (May 2001): 1001–9. https://doi.org/10.1681/ASN.V1251001.
    Full Text Link to Item
  - Morris, M., S. Means, M. I. Oliverio, and T. M. Coffman. “Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors.” Am J Physiol Regul Integr Comp Physiol 280, no. 4 (April 2001): R1177–84. https://doi.org/10.1152/ajpregu.2001.280.4.R1177.
    Full Text Link to Item
  - Fabre, J. E., M. Nguyen, K. Athirakul, K. Coggins, J. D. McNeish, S. Austin, L. K. Parise, G. A. FitzGerald, T. M. Coffman, and B. H. Koller. “Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.” J Clin Invest 107, no. 5 (March 2001): 603–10. https://doi.org/10.1172/JCI10881.
    Full Text Link to Item
  - Coffman, Thomas M., Laurent P. Audoly, and Michael I. Oliverio. “Review: Gene targeting studies of angiotensin II type 1 (AT1) receptors.” J Renin Angiotensin Aldosterone Syst 2, no. 1_suppl (March 2001): S10–15. https://doi.org/10.1177/14703203010020010201.
    Full Text Link to Item
  - Stock, J. L., K. Shinjo, J. Burkhardt, M. Roach, K. Taniguchi, T. Ishikawa, H. S. Kim, et al. “The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.” J Clin Invest 107, no. 3 (February 2001): 325–31. https://doi.org/10.1172/JCI6749.
    Full Text Link to Item
  - Audoly, L. P., X. Ruan, V. A. Wagner, J. L. Goulet, S. L. Tilley, B. H. Koller, T. M. Coffman, and W. J. Arendshorst. “Role of EP₂ and EP₃ PGE₂ receptors in control of murine renal hemodynamics.” American Journal of Physiology Heart and Circulatory Physiology 280, no. 1 49-1 (2001): H327–33.
  - Tharaux, P. L., and T. M. Coffman. “Transgenic mice as a tool to study the renin-angiotensin system.” Contrib Nephrol, no. 135 (2001): 72–91. https://doi.org/10.1159/000060158.
    Full Text Link to Item
  - Audoly, L. P., X. Ruan, V. A. Wagner, J. L. Goulet, S. L. Tilley, B. H. Koller, T. M. Coffman, and W. J. Arendshorst. “Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics.” Am J Physiol Heart Circ Physiol 280, no. 1 (January 2001): H327–33. https://doi.org/10.1152/ajpheart.2001.280.1.H327.
    Full Text Link to Item
  - Mistlberger, R. E., M. C. Antle, M. I. Oliverio, T. M. Coffman, and M. Morris. “Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors.” Physiol Behav 74, no. 4–5 (2001): 457–64. https://doi.org/10.1016/s0031-9384(01)00591-1.
    Full Text Link to Item
  - Robinson, L. A., C. Nataraj, D. W. Thomas, D. N. Howell, R. Griffiths, V. Bautch, D. D. Patel, L. Feng, and T. M. Coffman. “A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.” J Immunol 165, no. 11 (December 1, 2000): 6067–72. https://doi.org/10.4049/jimmunol.165.11.6067.
    Full Text Link to Item
  - Audoly, L. P., M. I. Oliverio, and T. M. Coffman. “Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.” Trends Endocrinol Metab 11, no. 7 (September 2000): 263–69. https://doi.org/10.1016/s1043-2760(00)00279-4.
    Full Text Link to Item
  - Morrissey, J. J. “Angiotensin II: an immune costimulator?” Am J Kidney Dis 36, no. 2 (August 2000): 434–40. https://doi.org/10.1053/ajkd.2000.9000.
    Full Text Link to Item
  - Oliverio, Michael I., and Thomas M. Coffman. “Angiotensin II Receptor Physiology Using Gene Targeting.” News Physiol Sci 15 (August 2000): 171–75. https://doi.org/10.1152/physiologyonline.2000.15.4.171.
    Full Text Link to Item
  - Felix, N. J., W. J. Brickey, R. Griffiths, J. Zhang, L. Van Kaer, T. Coffman, and J. P. Ting. “H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.” J Exp Med 192, no. 1 (July 3, 2000): 31–40. https://doi.org/10.1084/jem.192.1.31.
    Full Text Link to Item
  - Davisson, R. L., M. I. Oliverio, T. M. Coffman, and C. D. Sigmund. “Divergent functions of angiotensin II receptor isoforms in the brain.” J Clin Invest 106, no. 1 (July 2000): 103–6. https://doi.org/10.1172/JCI10022.
    Full Text Link to Item
  - Audoly, L. P., B. Rocca, J. E. Fabre, B. H. Koller, D. Thomas, A. L. Loeb, T. M. Coffman, and G. A. FitzGerald. “Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.” Circulation 101, no. 24 (June 20, 2000): 2833–40. https://doi.org/10.1161/01.cir.101.24.2833.
    Full Text Link to Item
  - Butterly, D. W., R. F. Spurney, P. Ruiz, R. Griffiths, C. Albrightson, and T. M. Coffman. “A role for leukotrienes in cyclosporine nephrotoxicity.” Kidney Int 57, no. 6 (June 2000): 2586–93. https://doi.org/10.1046/j.1523-1755.2000.00118.x.
    Full Text Link to Item
  - Mannon, R. B., C. Doyle, R. Griffiths, M. Bustos, J. L. Platt, and T. M. Coffman. “Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts.” Transplantation 69, no. 10 (May 27, 2000): 2137–43. https://doi.org/10.1097/00007890-200005270-00031.
    Full Text Link to Item
  - Audoly, L. P., T. H. Le, and T. M. Coffman. “What can knockout mice contribute to an understanding of hypertension?” Curr Hypertens Rep 2, no. 2 (April 2000): 192–97. https://doi.org/10.1007/s11906-000-0081-4.
    Full Text Link to Item
  - Oliverio, M. I., C. F. Best, O. Smithies, and T. M. Coffman. “Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II.” Hypertension 35, no. 2 (February 2000): 550–54. https://doi.org/10.1161/01.hyp.35.2.550.
    Full Text Link to Item
  - Pace, A. J., E. Lee, K. Athirakul, T. M. Coffman, D. A. O’Brien, and B. H. Koller. “Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter.” J Clin Invest 105, no. 4 (February 2000): 441–50. https://doi.org/10.1172/JCI8553.
    Full Text Link to Item
  - Schnermann, J., T. Traynor, H. Pohl, D. W. Thomas, T. M. Coffman, and J. P. Briggs. “Vasoconstrictor responses in thromboxane receptor knockout mice: tubuloglomerular feedback and ureteral obstruction.” Acta Physiol Scand 168, no. 1 (January 2000): 201–7. https://doi.org/10.1046/j.1365-201x.2000.00641.x.
    Full Text Link to Item
  - Oliverio, M. I., M. Delnomdedieu, C. F. Best, P. Li, M. Morris, M. F. Callahan, G. A. Johnson, O. Smithies, and T. M. Coffman. “Abnormal water metabolism in mice lacking the type 1A receptor for ANG II.” Am J Physiol Renal Physiol 278, no. 1 (January 2000): F75–82. https://doi.org/10.1152/ajprenal.2000.278.1.F75.
    Full Text Link to Item
  - Cervenka, L., K. D. Mitchell, M. I. Oliverio, T. M. Coffman, and L. Gabriel Navar. “Renal function in the at1A receptor knockout mouse during normal and volume-expanded conditions.” Kidney International 56, no. 5 (December 1, 1999): 1846–54.
  - Nataraj, C., M. I. Oliverio, R. B. Mannon, P. J. Mannon, L. P. Audoly, C. S. Amuchastegui, P. Ruiz, O. Smithies, and T. M. Coffman. “Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway.” J Clin Invest 104, no. 12 (December 1999): 1693–1701. https://doi.org/10.1172/JCI7451.
    Full Text Link to Item
  - Ruan, X., M. I. Oliverio, T. M. Coffman, and W. J. Arendshorst. “Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.” J Am Soc Nephrol 10, no. 12 (December 1999): 2620–30. https://doi.org/10.1681/ASN.V10122620.
    Full Text Link to Item
  - Cervenka, L., K. D. Mitchell, M. I. Oliverio, T. M. Coffman, and L. G. Navar. “Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions.” Kidney Int 56, no. 5 (November 1999): 1855–62. https://doi.org/10.1046/j.1523-1755.1999.00757.x.
    Full Text Link to Item
  - Fabre, J. E., M. Nguyen, A. Latour, J. A. Keifer, L. P. Audoly, T. M. Coffman, and B. H. Koller. “Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.” Nat Med 5, no. 10 (October 1999): 1199–1202. https://doi.org/10.1038/13522.
    Full Text Link to Item
  - Neylan, J. F., M. H. Sayegh, T. M. Coffman, G. M. Danovitch, A. M. Krensky, T. B. Strom, L. A. Turka, and W. E. Harmon. “The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology.” Journal of the American Society of Nephrology : Jasn 10, no. 10 (October 1999): 2237–43.
  - Neylan, J. F., M. H. Sayegh, T. M. Coffman, G. M. Danovitch, A. M. Krensky, T. B. Strom, L. A. Turka, and W. E. Harmon. “The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology.” J Am Soc Nephrol 10, no. 10 (October 1999): 2237–43. https://doi.org/10.1681/ASN.V10102237.
    Full Text Link to Item
  - Mannon, R. B., K. Roberts, P. Ruiz, V. Laubach, and T. M. Coffman. “Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection.” J Heart Lung Transplant 18, no. 9 (September 1999): 819–27. https://doi.org/10.1016/s1053-2498(99)00052-2.
    Full Text Link to Item
  - Audoly, L. P., S. L. Tilley, J. Goulet, M. Key, M. Nguyen, J. L. Stock, J. D. McNeish, B. H. Koller, and T. M. Coffman. “Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.” Am J Physiol 277, no. 3 (September 1999): H924–30. https://doi.org/10.1152/ajpheart.1999.277.3.H924.
    Full Text Link to Item
  - Goulet, J. L., R. C. Griffiths, P. Ruiz, R. F. Spurney, D. S. Pisetsky, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.” J Immunol 163, no. 1 (July 1, 1999): 359–66.
    Link to Item
  - Le, T. H., and T. M. Coffman. “Genetic manipulation of the renin-angiotensin system.” Curr Opin Nephrol Hypertens 8, no. 4 (July 1999): 397–403. https://doi.org/10.1097/00041552-199907000-00001.
    Full Text Link to Item
  - Mannon, R. B., and T. M. Coffman. “Gene targeting: applications in transplantation research.” Kidney Int 56, no. 1 (July 1999): 18–27. https://doi.org/10.1046/j.1523-1755.1999.00513.x.
    Full Text Link to Item
  - Tilley, S. L., L. P. Audoly, E. H. Hicks, H. S. Kim, P. J. Flannery, T. M. Coffman, and B. H. Koller. “Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor.” J Clin Invest 103, no. 11 (June 1999): 1539–45. https://doi.org/10.1172/JCI6579.
    Full Text Link to Item
  - Mannon, R. B., J. B. Kopp, P. Ruiz, R. Griffiths, M. Bustos, J. L. Platt, P. E. Klotman, and T. M. Coffman. “Chronic rejection of mouse kidney allografts.” Kidney Int 55, no. 5 (May 1999): 1935–44. https://doi.org/10.1046/j.1523-1755.1999.00423.x.
    Full Text Link to Item
  - Wada, T., A. Schwarting, K. Kinoshita, T. Naito, R. C. Griffiths, T. M. Coffman, and V. R. Kelley. “Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice.” Kidney Int 55, no. 3 (March 1999): 841–51. https://doi.org/10.1046/j.1523-1755.1999.055003841.x.
    Full Text Link to Item
  - Morris, M., P. Li, M. F. Callahan, M. I. Oliverio, T. M. Coffman, S. M. Bosch, and D. I. Diz. “Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.” Hypertension 33, no. 1 Pt 2 (January 1999): 482–86.
  - Ruan, X., K. E. Purdy, M. I. Oliverio, T. M. Coffman, and W. J. Arendshorst. “Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice.” J Am Soc Nephrol 10 Suppl 11 (January 1999): S202–7.
    Link to Item
  - Oliverio, M. I., H. S. Kim, M. Ito, T. Le, L. Audoly, C. F. Best, S. Hiller, et al. “Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.” Proc Natl Acad Sci U S A 95, no. 26 (December 22, 1998): 15496–501. https://doi.org/10.1073/pnas.95.26.15496.
    Full Text Link to Item
  - Fleming, E. F., K. Athirakul, M. I. Oliverio, M. Key, J. Goulet, B. H. Koller, and T. M. Coffman. “Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2.” The American Journal of Physiology 275, no. 6 Pt 2 (December 1998): F955–61.
  - Thomas, D. W., R. B. Mannon, P. J. Mannon, A. Latour, J. A. Oliver, M. Hoffman, O. Smithies, B. H. Koller, and T. M. Coffman. “Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.” J Clin Invest 102, no. 11 (December 1, 1998): 1994–2001. https://doi.org/10.1172/JCI5116.
    Full Text Link to Item
  - Traynor, T., T. Yang, Y. G. Huang, L. Arend, M. I. Oliverio, T. Coffman, J. P. Briggs, and J. Schnermann. “Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice.” Am J Physiol 275, no. 6 (December 1998): F922–27. https://doi.org/10.1152/ajprenal.1998.275.6.F922.
    Full Text Link to Item
  - Fleming, Eric F., Krairek Athirakul, Michael I. Oliverio, Mikelle Key, Jennifer Goulet, Beverly H. Koller, and Thomas M. Coffman. “Urinary concentrating function in mice lacking EP3receptors for prostaglandin E2.” Am J Physiol Renal Physiol 275, no. 6 (December 1, 1998): F955–61. https://doi.org/10.1152/ajprenal.1998.275.6.F955.
    Full Text Link to Item
  - Neuringer, I. P., R. B. Mannon, T. M. Coffman, M. Parsons, K. Burns, J. R. Yankaskas, and R. M. Aris. “Immune cells in a mouse airway model of obliterative bronchiolitis.” Am J Respir Cell Mol Biol 19, no. 3 (September 1998): 379–86. https://doi.org/10.1165/ajrcmb.19.3.3023m.
    Full Text Link to Item
  - Thomas, D. W., and T. M. Coffman. “A genetic approach for studying the role of thromboxane A2 in the kidney.” Kidney Int Suppl 67 (September 1998): S84–87. https://doi.org/10.1046/j.1523-1755.1998.06717.x.
    Full Text Link to Item
  - Coffman, Thomas M., Robert F. Spurney, Roslyn B. Mannon, and Richard Levenson. “Thromboxane A2modulates the fibrinolytic system in glomerular mesangial cells.” Am J Physiol Renal Physiol 275, no. 2 (August 1, 1998): F262–69. https://doi.org/10.1152/ajprenal.1998.275.2.F262.
    Full Text Link to Item
  - Coffman, Thomas M. “Gene targeting in physiological investigations: studies of the renin-angiotensin system.” Am J Physiol Renal Physiol 274, no. 6 (June 1, 1998): F999–1005. https://doi.org/10.1152/ajprenal.1998.274.6.F999.
    Full Text Link to Item
  - Mannon, R. B., B. L. Kotzin, C. Nataraj, K. Ferri, E. Roper, R. J. Kurlander, and T. M. Coffman. “Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts.” J Clin Invest 101, no. 11 (June 1, 1998): 2517–27. https://doi.org/10.1172/JCI1229.
    Full Text Link to Item
  - Zhu, Z., S. H. Zhang, C. Wagner, A. Kurtz, N. Maeda, T. Coffman, and W. J. Arendshorst. “Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice.” Hypertension 31, no. 5 (May 1998): 1171–77. https://doi.org/10.1161/01.hyp.31.5.1171.
    Full Text Link to Item
  - Hamawaki, M., T. M. Coffman, A. Lashus, M. Koide, M. R. Zile, M. I. Oliverio, G. DeFreyte, G. Cooper, and B. A. Carabello. “Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.” The American Journal of Physiology 274, no. 3 Pt 2 (March 1998): H868–73.
  - Hamawaki, M., T. M. Coffman, A. Lashus, M. Koide, M. R. Zile, M. I. Oliverio, G. DeFreyte, G. Cooper, and B. A. Carabello. “Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.” Am J Physiol 274, no. 3 (March 1998): H868–73. https://doi.org/10.1152/ajpheart.1998.274.3.H868.
    Full Text Link to Item
  - Davisson, R. L., T. G. Beltz, M. I. Oliverio, A. K. Johnson, T. M. Coffman, and C. D. Sigmund. “Functional separation of brain AT1A and AT1B receptors in AT1A knockout mice.” Faseb Journal 12, no. 4 (1998): A52.
  - Morris, M., P. Li, M. F. Callahan, S. M. Bosch, T. M. Coffman, M. I. Oliverio, and D. I. Diz. “Effect of dehydration on angiotensin receptors in the AT-1a knockout mouse.” Faseb Journal 12, no. 4 (1998): A325.
  - Oliverio, M. I., K. Madsen, C. F. Best, M. Ito, N. Maeda, O. Smithies, and T. M. Coffman. “Renal growth and development in mice lacking AT1A receptors for angiotensin II.” Am J Physiol 274, no. 1 (January 1998): F43–50. https://doi.org/10.1152/ajprenal.1998.274.1.F43.
    Full Text Link to Item
  - Ruan, X., M. I. Oliverio, T. Coffman, and W. J. Arendshorst. “Angiotensin II causes renal vasoconstriction in mice with AT_1A receptor deleted by gene targeting.” Faseb Journal 12, no. 4 (1998): A109.
  - Traynor, T., T. Yang, Y. G. Huang, L. Arend, M. I. Oliverio, T. Coffman, J. P. Briggs, and J. B. Schnermann. “Inhibition of adenosine₁ receptor-mediated glomerular vasoconstriction in AT_1A-receptor deficient mice.” Faseb Journal 12, no. 4 (1998): A331.
  - Oliverio, M. I., K. Madsen, C. F. Best, M. Ito, N. Maeda, O. Smithies, and T. M. Coffman. “Renal growth and development in mice lacking AT(1A) receptors for angiotensin II.” American Journal of Physiology Renal Physiology 274, no. 1 43-1 (January 1, 1998).
  - Coffman, T. M. “A role for T cell co-stimulation in ischemic acute renal failure?” Kidney Int 52, no. 6 (December 1997): 1706–7. https://doi.org/10.1038/ki.1997.507.
    Full Text Link to Item
  - Li, P., M. F. Callahan, T. M. Coffman, M. I. Oliverio, and M. Morris. “Altered vasopressin axis in the AT-1a knockout mouse.” Faseb Journal 11, no. 3 (December 1, 1997).
  - Oliverio, M. I., C. F. Best, H. S. Kim, W. J. Arendshorst, O. Smithies, and T. M. Coffman. “Angiotensin II responses in at 1A receptor-deficient mice: A role for at 1B receptors in blood pressure regulation.” American Journal of Physiology 272, no. 4 PART 2 (December 1, 1997).
  - Nguyen, M., T. Camenisch, J. N. Snouwaert, E. Hicks, T. M. Coffman, P. A. Anderson, N. N. Malouf, and B. H. Koller. “The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.” Nature 390, no. 6655 (November 6, 1997): 78–81. https://doi.org/10.1038/36342.
    Full Text Link to Item
  - Spurney, R. F., and T. M. Coffman. “The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.” J Pharmacol Exp Ther 283, no. 1 (October 1997): 207–15.
    Link to Item
  - Wada, T., T. Naito, R. C. Griffiths, T. M. Coffman, and V. R. Kelley. “Systemic autoimmune nephritogenic components induce CSF-1 and TNF-alpha in MRL kidneys.” Kidney Int 52, no. 4 (October 1997): 934–41. https://doi.org/10.1038/ki.1997.415.
    Full Text Link to Item
  - Bustos, M., T. M. Coffman, S. Saadi, and J. L. Platt. “Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.” J Clin Invest 100, no. 5 (September 1, 1997): 1150–58. https://doi.org/10.1172/JCI119626.
    Full Text Link to Item
  - Coffman, T. M. “A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor.” Semin Nephrol 17, no. 5 (September 1997): 404–11.
    Link to Item
  - Schnermann, J. B., T. Traynor, T. Yang, Y. G. Huang, M. I. Oliverio, T. Coffman, and J. P. Briggs. “Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice.” Am J Physiol 273, no. 2 Pt 2 (August 1997): F315–20. https://doi.org/10.1152/ajprenal.1997.273.2.F315.
    Full Text Link to Item
  - Bruggeman, L. A., S. Dikman, C. Meng, S. E. Quaggin, T. M. Coffman, and P. E. Klotman. “Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression.” J Clin Invest 100, no. 1 (July 1, 1997): 84–92. https://doi.org/10.1172/JCI119525.
    Full Text Link to Item
  - Oliverio, M. I., C. F. Best, H. S. Kim, W. J. Arendshorst, O. Smithies, and T. M. Coffman. “Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.” Am J Physiol 272, no. 4 Pt 2 (April 1997): F515–20. https://doi.org/10.1152/ajprenal.1997.272.4.F515.
    Full Text Link to Item
  - Oliverio, M. I., and T. M. Coffman. “Angiotensin-II-receptors: new targets for antihypertensive therapy.” Clin Cardiol 20, no. 1 (January 1997): 3–6. https://doi.org/10.1002/clc.4960200103.
    Full Text Link to Item
  - Shellhaas, C. S., T. Coffman, P. J. Dargie, A. P. Killam, and H. H. Kay. “Intravillous eicosanoid compartmentalization and regulation of placental blood flow.” J Soc Gynecol Investig 4, no. 2 (1997): 58–63.
    Link to Item
  - Mannon, R. B., T. M. Coffman, and P. J. Mannon. “Distribution of binding sites for thromboxane A2 in the mouse kidney.” Am J Physiol 271, no. 6 Pt 2 (December 1996): F1131–38. https://doi.org/10.1152/ajprenal.1996.271.6.F1131.
    Full Text Link to Item
  - Mannon, R. B., B. L. Kotzin, E. Roper, C. Nataraj, R. J. Kurlander, and T. M. Coffman. “The intragraft CD8+ T cell response in renal allograft rejection in the mouse.” Transplantation 62, no. 1 (July 15, 1996): 96–104. https://doi.org/10.1097/00007890-199607150-00019.
    Full Text Link to Item
  - Naito, T., R. C. Griffiths, T. M. Coffman, and V. R. Kelley. “Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice.” Kidney Int 49, no. 1 (January 1996): 67–74. https://doi.org/10.1038/ki.1996.9.
    Full Text Link to Item
  - Burdmann, E. A., T. F. Andoh, C. C. Nast, A. Evan, B. A. Connors, T. M. Coffman, J. Lindsley, and W. M. Bennett. “Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.” The American Journal of Physiology 269, no. 4 Pt 2 (October 1995): F491–99.
  - Burdmann, E. A., T. F. Andoh, C. C. Nast, A. Evan, B. A. Connors, T. M. Coffman, J. Lindsley, and W. M. Bennett. “Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.” The American Journal of Physiology 269, no. 4 Pt 2 (October 1995): F491–99. https://doi.org/10.1152/ajprenal.1995.269.4.f491.
    Full Text
  - Cook, D. N., M. A. Beck, T. M. Coffman, S. L. Kirby, J. F. Sheridan, I. B. Pragnell, and O. Smithies. “Requirement of MIP-1 alpha for an inflammatory response to viral infection.” Science 269, no. 5230 (September 15, 1995): 1583–85. https://doi.org/10.1126/science.7667639.
    Full Text Link to Item
  - McCoy, M. C., Y. Wang, T. M. Coffman, A. P. Killam, and H. H. Kay. “Effects of low-dose aspirin therapy on plasma levels of polyunsaturated fatty acids: a preliminary investigation.” Am J Perinatol 12, no. 5 (September 1995): 371–74. https://doi.org/10.1055/s-2007-994499.
    Full Text Link to Item
  - Smith, S. R., S. A. Minda, G. P. Samsa, F. E. Harrell, J. C. Gunnells, T. M. Coffman, and D. W. Butterly. “Late withdrawal of cyclosporine in stable renal transplant recipients.” Am J Kidney Dis 26, no. 3 (September 1995): 487–94. https://doi.org/10.1016/0272-6386(95)90495-6.
    Full Text Link to Item
  - Butterly, D. W., R. F. Spurney, P. Ruiz, E. Pirotzky, P. Braquet, and T. M. Coffman. “Role of platelet activating factor in kidney transplant rejection in the rat.” Kidney Int 48, no. 2 (August 1995): 337–43. https://doi.org/10.1038/ki.1995.301.
    Full Text Link to Item
  - Kooyman, D. L., G. W. Byrne, S. McClellan, D. Nielsen, M. Tone, H. Waldmann, T. M. Coffman, K. R. McCurry, J. L. Platt, and J. S. Logan. “In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.” Science 269, no. 5220 (July 7, 1995): 89–92. https://doi.org/10.1126/science.7541557.
    Full Text Link to Item
  - Rappaport, J., B. Hanss, J. B. Kopp, T. D. Copeland, L. A. Bruggeman, T. M. Coffman, and P. E. Klotman. “Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy.” Kidney Int 47, no. 5 (May 1995): 1462–69. https://doi.org/10.1038/ki.1995.205.
    Full Text Link to Item
  - Ito, M., M. I. Oliverio, P. J. Mannon, C. F. Best, N. Maeda, O. Smithies, and T. M. Coffman. “Regulation of blood pressure by the type 1A angiotensin II receptor gene.” Proc Natl Acad Sci U S A 92, no. 8 (April 11, 1995): 3521–25. https://doi.org/10.1073/pnas.92.8.3521.
    Full Text Link to Item
  - Kim, H. S., J. H. Krege, K. D. Kluckman, J. R. Hagaman, J. B. Hodgin, C. F. Best, J. C. Jennette, T. M. Coffman, N. Maeda, and O. Smithies. “Genetic control of blood pressure and the angiotensinogen locus.” Proc Natl Acad Sci U S A 92, no. 7 (March 28, 1995): 2735–39. https://doi.org/10.1073/pnas.92.7.2735.
    Full Text Link to Item
  - Mannon, R. B., C. Nataraj, B. L. Kotzin, R. Griffiths, S. Geier, S. Ibrahim, F. P. Sanfilippo, J. L. Platt, R. Kurlander, and T. M. Coffman. “Rejection of kidney allografts by MHC class I-deficient mice.” Transplantation 59, no. 5 (March 15, 1995): 746–55. https://doi.org/10.1097/00007890-199503150-00019.
    Full Text Link to Item
  - Goulet, J. L., J. N. Snouwaert, A. M. Latour, T. M. Coffman, and B. H. Koller. “Altered inflammatory responses in leukotriene-deficient mice.” Proc Natl Acad Sci U S A 91, no. 26 (December 20, 1994): 12852–56. https://doi.org/10.1073/pnas.91.26.12852.
    Full Text Link to Item
  - Spurney, R. F., P. Ruiz, C. R. Albrightson, D. S. Pisetsky, and T. M. Coffman. “Fish oil feeding modulates leukotriene production in murine lupus nephritis.” Prostaglandins 48, no. 5 (November 1994): 331–48. https://doi.org/10.1016/0090-6980(94)90032-9.
    Full Text Link to Item
  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am J Physiol 267, no. 3 Pt 2 (September 1994): F467–78. https://doi.org/10.1152/ajprenal.1994.267.3.F467.
    Full Text Link to Item
  - Kooyman, D., G. Byrne, S. McClellan, D. Nielsen, D. Kagan, T. Coffman, T. Masahide, H. Waldmann, J. Platt, and J. Logan. “Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells.” Transplant Proc 26, no. 3 (June 1994): 1241.
    Link to Item
  - Spurney, R. F., S. Ibrahim, D. Butterly, P. E. Klotman, F. Sanfilippo, and T. M. Coffman. “Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.” J Immunol 152, no. 2 (January 15, 1994): 867–76.
    Link to Item
  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am.J.Physiol. 267, no. 3 part 2 (January 1, 1994).
  - Smith, S. R., V. B. Kubacki, A. Rakhit, L. L. Martin, A. V. Schaffer, M. K. Jasani, D. J. Hefty, T. Johnston, C. Cannon, and W. M. Bennett. “Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity.” Transplantation 56, no. 6 (December 1993): 1422–26. https://doi.org/10.1097/00007890-199312000-00029.
    Full Text Link to Item
  - Smith, S. R., T. M. Coffman, and L. P. Svetkey. “Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril.” J Am Soc Nephrol 4, no. 5 (November 1993): 1133–39. https://doi.org/10.1681/ASN.V451133.
    Full Text Link to Item
  - Mannon, R. B., S. K. Sundar, F. P. Sanfilippo, and T. M. Coffman. “Alterations in renal interleukin-1 production during kidney transplant rejection in the rat. The effects of high-dose methylprednisolone.” Transplantation 56, no. 5 (November 1993): 1157–62. https://doi.org/10.1097/00007890-199311000-00021.
    Full Text Link to Item
  - Coffman, T., S. Geier, S. Ibrahim, R. Griffiths, R. Spurney, O. Smithies, B. Koller, and F. Sanfilippo. “Improved renal function in mouse kidney allografts lacking MHC class I antigens.” J Immunol 151, no. 1 (July 1, 1993): 425–35.
    Link to Item
  - Jevnikar, A. M., G. G. Singer, T. Coffman, L. H. Glimcher, and V. E. Kelley. “Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury.” J Am Soc Nephrol 3, no. 12 (June 1993): 1972–77. https://doi.org/10.1681/ASN.V3121972.
    Full Text Link to Item
  - Munger, K. A., T. M. Coffman, R. C. Griffiths, A. Fogo, and K. F. Badr. “The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney.” Transplantation 55, no. 6 (June 1993): 1219–24. https://doi.org/10.1097/00007890-199306000-00003.
    Full Text Link to Item
  - Fan, P. Y., C. R. Albrightson, D. N. Howell, C. Best, A. M. Badger, and T. M. Coffman. “The azaspirane SKF 105685 ameliorates renal allograft rejection in rats.” J Am Soc Nephrol 3, no. 10 (April 1993): 1680–85. https://doi.org/10.1681/ASN.V3101680.
    Full Text Link to Item
  - Jevnikar, A. M., G. G. Singer, T. Coffman, L. H. Glimcher, and V. E. Kelley. “Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model.” Transplant Proc 25, no. 1 Pt 1 (February 1993): 142–43.
    Link to Item
  - Spurney, R. F., J. J. Onorato, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Characterization of glomerular thromboxane receptors in murine lupus nephritis.” J Pharmacol Exp Ther 264, no. 2 (February 1993): 584–90.
    Link to Item
  - Spurney, R. F., J. J. Onorato, F. J. Albers, and T. M. Coffman. “Thromboxane binding and signal transduction in rat glomerular mesangial cells.” Am J Physiol 264, no. 2 Pt 2 (February 1993): F292–99. https://doi.org/10.1152/ajprenal.1993.264.2.F292.
    Full Text Link to Item
  - Mannon, R. B., and T. M. Coffman. “Immunologic mechanisms of transplant rejection.” Curr Opin Nephrol Hypertens 1, no. 2 (December 1992): 230–35. https://doi.org/10.1097/00041552-199212000-00007.
    Full Text Link to Item
  - Chouinard, M. L., L. L. Martin, T. Coffman, B. H. Hamilton, L. F. Linberg, A. Pamidi, J. P. Simke, and A. Rakhit. “Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients.” Clin Pharmacol Ther 52, no. 6 (December 1992): 597–604. https://doi.org/10.1038/clpt.1992.197.
    Full Text Link to Item
  - Ruiz, P., L. Rey, R. Spurney, T. Coffman, and A. Viciana. “Thromboxane augmentation of alloreactive T cell function.” Transplantation 54, no. 3 (September 1992): 498–505. https://doi.org/10.1097/00007890-199209000-00021.
    Full Text Link to Item
  - Gilkeson, G. S., R. Spurney, T. M. Coffman, R. Kurlander, P. Ruiz, and D. S. Pisetsky. “Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.” Clin Immunol Immunopathol 64, no. 2 (August 1992): 166–72. https://doi.org/10.1016/0090-1229(92)90195-t.
    Full Text Link to Item
  - Nesbitt, T., T. M. Coffman, R. Griffiths, and M. K. Drezner. “Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect.” J Clin Invest 89, no. 5 (May 1992): 1453–59. https://doi.org/10.1172/JCI115735.
    Full Text Link to Item
  - Spurney, R. F., P. Y. Fan, P. Ruiz, F. Sanfilippo, D. S. Pisetsky, and T. M. Coffman. “Thromboxane receptor blockade reduces renal injury in murine lupus nephritis.” Kidney Int 41, no. 4 (April 1992): 973–82. https://doi.org/10.1038/ki.1992.149.
    Full Text Link to Item
  - Smith, S. R., E. A. Creech, A. V. Schaffer, L. L. Martin, A. Rakhit, F. L. Douglas, P. E. Klotman, and T. M. Coffman. “Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity.” Kidney Int 41, no. 1 (January 1992): 199–205. https://doi.org/10.1038/ki.1992.27.
    Full Text Link to Item
  - Spurney, R. F., R. J. Bernstein, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Physiologic role for enhanced renal thromboxane production in murine lupus nephritis.” Prostaglandins 42, no. 1 (July 1991): 15–28. https://doi.org/10.1016/0090-6980(91)90090-3.
    Full Text Link to Item
  - Spurney, R. F., P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.” Kidney Int 39, no. 1 (January 1991): 95–102. https://doi.org/10.1038/ki.1991.12.
    Full Text Link to Item
  - Spurney, R. F., S. D. Mayros, D. Collins, P. Ruiz, P. E. Klotman, and T. Coffman. “Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats.” Prostaglandins 39, no. 2 (February 1990): 135–46. https://doi.org/10.1016/0090-6980(90)90070-c.
    Full Text Link to Item
  - Himmelstein, S. I., T. M. Coffman, W. E. Yarger, and P. E. Klotman. “Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction.” Am J Physiol 258, no. 2 Pt 2 (February 1990): F281–86. https://doi.org/10.1152/ajprenal.1990.258.2.F281.
    Full Text Link to Item
  - Collins, D. M., T. M. Coffman, P. Ruiz, and P. E. Klotman. “High-protein feeding stimulates renal thromboxane production in rats with streptozocin-induced diabetes.” J Lab Clin Med 114, no. 5 (November 1989): 545–53.
    Link to Item
  - Ruiz, P., T. M. Coffman, P. E. Klotman, and F. Sanfilippo. “Association of chronic thromboxane inhibition with reduced in situ cytotoxic T cell activity in rejecting rat renal allografts.” Transplantation 48, no. 4 (October 1989): 660–66.
    Link to Item
  - Coffman, T. M., S. Himmelstein, C. Best, and P. E. Klotman. “Post-transplant hypertension in the rat: effects of captopril and native nephrectomy.” Kidney Int 36, no. 1 (July 1989): 35–40. https://doi.org/10.1038/ki.1989.157.
    Full Text Link to Item
  - Coffman, T. M., P. Ruiz, F. Sanfilippo, and P. E. Klotman. “Chronic thromboxane inhibition preserves function of rejecting rat renal allografts.” Kidney Int 35, no. 1 (January 1989): 24–30. https://doi.org/10.1038/ki.1989.4.
    Full Text Link to Item
  - Humes, H. D., T. Coffman, H. Halderman, M. Mihatsch, M. Henry, and G. A. Porter. “Cyclosporine nephrotoxicity: a workshop to discuss mechanisms, diagnosis, and treatment.” Transplant Proc 20, no. 3 Suppl 3 (June 1988): 833–40.
    Link to Item
  - Coffman, T. M., D. Yohay, D. R. Carr, P. C. Brazy, W. E. Yarger, and P. E. Klotman. “Effect of dietary fish oil supplementation on eicosanoid production by rat renal allografts.” Transplantation 45, no. 2 (February 1988): 470–74. https://doi.org/10.1097/00007890-198802000-00045.
    Full Text Link to Item
  - Ruiz, P., T. M. Coffman, D. N. Howell, J. Straznickas, M. W. Scroggs, W. M. Baldwin, P. E. Klotman, and F. Sanfilippo. “Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection.” Transplantation 45, no. 1 (January 1988): 1–7. https://doi.org/10.1097/00007890-198801000-00002.
    Full Text Link to Item
  - Svetkey, L. P., N. R. Dunnick, T. M. Coffman, S. I. Himmelstein, R. R. Bollinger, R. L. McCann, R. H. Wilkinson, S. D. Braun, G. F. Newman, and R. H. Cohan. “Comparison of intravenous digital subtraction angiography and conventional arteriography in defining renal anatomy.” Transplantation 45, no. 1 (January 1988): 56–58. https://doi.org/10.1097/00007890-198801000-00013.
    Full Text Link to Item
  - Kolbeck, P. C., M. W. Scroggs, T. M. Coffman, P. E. Klotman, and F. Sanfilippo. “Associations between rat renal allograft function, inflammation, and host immunity.” Transplantation Proceedings 19, no. 1 I (April 27, 1987): 379–81.
  - Coffman, T. M., D. R. Carr, W. E. Yarger, and P. E. Klotman. “Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity.” Transplantation 43, no. 2 (February 1987): 282–85. https://doi.org/10.1097/00007890-198702000-00023.
    Full Text Link to Item
  - Kolbeck, P. C., M. W. Scroggs, T. M. Coffman, P. E. Klotman, and F. Sanfilippo. “Associations between rat renal allograft function, inflammation, and host immunity.” Transplant Proc 19, no. 1 Pt 1 (February 1987): 379–81.
    Link to Item
  - Coffman, T. M., P. C. Kolbeck, F. P. Sanfilippo, and P. E. Klotman. “Renal allograft function, arachidonic acid metabolism, and systemic cellular immunity after kidney transplantation in the rat.” Transplantation Proceedings 19, no. 3 (January 1, 1987): 3116–18.
  - Coffman, T. M., F. P. Sanfilippo, P. C. Brazy, W. E. Yarger, and P. E. Klotman. “Bilateral native nephrectomy improves renal isograft function in rats.” Kidney Int 30, no. 1 (July 1986): 20–26. https://doi.org/10.1038/ki.1986.145.
    Full Text Link to Item
  - Klotman, P. E., S. R. Smith, B. D. Volpp, T. M. Coffman, and W. E. Yarger. “Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys.” Am J Physiol 250, no. 2 Pt 2 (February 1986): F282–87. https://doi.org/10.1152/ajprenal.1986.250.2.F282.
    Full Text Link to Item
  - Coffman, T. M., U. Schwertschlag, and W. E. Yarger. “Lipid mediators in acute renal allograft rejection.” Transplantation Proceedings 18, no. 5 SUPPL. 4 (January 1, 1986): 94–97.
  - Coffman, T. M., W. E. Yarger, and P. E. Klotman. “Functional role of thromboxane production by acutely rejecting renal allografts in rats.” J Clin Invest 75, no. 4 (April 1985): 1242–48. https://doi.org/10.1172/JCI111822.
    Full Text Link to Item
  - Mitnick, P., A. Greenberg, T. Coffman, E. Kelepouris, C. J. Wolf, and S. Goldfarb. “Effects of two models of hypercalcemia on renal acid base metabolism.” Kidney Int 21, no. 4 (April 1982): 613–20. https://doi.org/10.1038/ki.1982.68.
    Full Text Link to Item
  - Mitnick, P. D., A. Greenberg, P. B. DeOreo, B. M. Weiner, T. M. Coffman, B. R. Walker, Z. S. Agus, and S. Goldfarb. “Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.” Clin Pharmacol Ther 28, no. 5 (November 1980): 680–89. https://doi.org/10.1038/clpt.1980.221.
    Full Text Link to Item
- Book Sections
  - Le, T. H., S. D. Crowley, S. B. Gurley, and T. M. Coffman. “The Renin-Angiotensin System.” In Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, 427–50, 2012. https://doi.org/10.1016/B978-0-12-381462-3.00015-X.
    Full Text
- Conference Papers
  - Yang, Ting, Marcela Herrera, Matthew A. Sparks, Michael Manning, Beverly H. Koller, and Thomas M. Coffman. “Unexpected Actions of the Endothelial-EP4 Receptor for PGE(2) to Promote Hypertension.” In Hypertension, Vol. 68. LIPPINCOTT WILLIAMS & WILKINS, 2016.
    Link to Item
  - Paradis, Pierre, Marie Briet, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Suellen C. Coelho, Yohann Rautureau, Thomas M. Coffman, and Ernesto L. Schiffrin. “PS 07-16 CROSSTALK BETWEEN ALDOSTERONE-STIMULATED MINERALOCORTICOID RECEPTOR AND ANGIOTENSIN RECEPTOR PATHWAYS PLAYS A ROLE IN ALDOSTERONE-INDUCED VASCULAR INJURY.” In Journal of Hypertension, 34:e287–88. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1097/01.hjh.0000500680.24040.e2.
    Full Text
  - Briet, Marie, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Suellen C. Coelho, Sofiane Ouerd, Yohann Rautureau, Thomas M. Coffman, Pierre Paradis, and Ernesto L. Schiffrin. “Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors.” In Hypertension, 67:897–905, 2016. https://doi.org/10.1161/HYPERTENSIONAHA.115.07074.
    Full Text Link to Item
  - Dimke, Henrik, Matthew A. Sparks, Sebastian Frische, Thomas M. Coffman, and Susan E. Quaggin. “Tubular Vegfa is Required for Renal Microvasculature and Oxygen Sensing.” In Hypertension, Vol. 62. LIPPINCOTT WILLIAMS & WILKINS, 2013.
    Link to Item
  - Sparks, Matthew A., Johannes Stegbauer, Daian Chen, Jose A. Gomez, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Compensatory Activation of the Sympathetic Nervous System after Deletion of Angiotensin Type 1 Receptors from Vascular Smooth Muscle Cells.” In Hypertension, Vol. 62. LIPPINCOTT WILLIAMS & WILKINS, 2013.
    Link to Item
  - Herrera, Marcela, Matthew A. Sparks, Beverky H. Koller, and Thomas M. Coffman. “Diverse Actions of the EP4 Prostaglandin E2 Receptor in Blood Pressure Control.” In Hypertension, Vol. 62. LIPPINCOTT WILLIAMS & WILKINS, 2013.
    Link to Item
  - Herrera, Marcela, Beverly Koller, and Thomas M. Coffman. “Sex-specific actions of the Prostaglandin E type 4 (EP4) receptor to attenuate salt sensitivity and hypertension.” In Faseb Journal, Vol. 27. FEDERATION AMER SOC EXP BIOL, 2013.
    Link to Item
  - Herrera, Marcela, Matthew A. Sparks, and Thomas M. Coffman. “Lack of specificity for AT1 angiotensin receptor antibodies in Western blot analysis.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.
    Link to Item
  - Gembardt, Florian, Joep H. van Esch, Thomas M. Coffman, Heinz-Peter Schultheiss, AH Jan Danser, and Thomas Walther. “Hemodynamic Effects of Angiotensin-(1-7) Do Not Depend On AT1 Or AT2.” In Hypertension, 58:E83–E83. LIPPINCOTT WILLIAMS & WILKINS, 2011.
    Link to Item
  - Herrera, Marcela, Johannes Stegbauer, Susan B. Gurley, and Thomas M. Coffman. “AT1 Receptor Activation Stimulates COX2 Expression in Mouse Collecting Duct Epithelium.” In Hypertension, 58:E46–E46. LIPPINCOTT WILLIAMS & WILKINS, 2011.
    Link to Item
  - Sparks, Matthew A., Johannas Stegbauer, Susan B. Gurley, and Thomas M. Coffman. “Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Contribute to Blood Pressure Control, Salt Sensitivity and Hypertension.” In Hypertension, 58:E51–E51. LIPPINCOTT WILLIAMS & WILKINS, 2011.
    Link to Item
  - Young, Colin N., Scott D. Butler, Anfei Li, Kelly K. Parsons, Thomas M. Coffman, Allyn L. Mark, and Robin L. Davisson. “Angiotensin Type 1a Receptors (AT(1a)) in the Subfornical Organ Contribute to the Weight-Reducing Effects of Leptin.” In Hypertension, 58:E42–E42. LIPPINCOTT WILLIAMS & WILKINS, 2011.
    Link to Item
  - Liu, Jun, Hong Ji, Wei Zheng, Bilkish Bajaj, Xie Wu, Susan B. Gurley, Thomas M. Coffman, and Kathryn Sandberg. “Angiotensin Converting Enzyme 2 (ACE2) Contributes to Female Protection from Angiotensin II-Dependent Hypertension.” In Hypertension, 56:E55–E55. LIPPINCOTT WILLIAMS & WILKINS, 2010.
    Link to Item
  - Sparks, Matthew A., Kelly Parsons, Eric W. Raasch, Johannes Stegbauer, Susan Gurley, Anuradha Vivekanandan-Giri, Subramaniam Pennathur, Thu H. Le, and Thomas M. Coffman. “Absence of AT1A Angiotensin Receptors from Vascular Smooth Muscle Cells (VSMCs) Does not Attenuate Vascular Remodeling in Hypertension.” In Hypertension, 56:E74–E74. LIPPINCOTT WILLIAMS & WILKINS, 2010.
    Link to Item
  - Stegbauer, Johannes, Susan B. Gurley, Matthew Sparks, Thu H. Le, and Thomas M. Coffman. “Cell-Specific Deletion of the Type 1a (at(1a)) Angiotensin Receptor from Collecting Duct Exaggerates Angiotensin II-Dependent Hypertension.” In Hypertension, 56:E64–E64. LIPPINCOTT WILLIAMS & WILKINS, 2010.
    Link to Item
  - Coffman, Thomas M. “AT1 angiotensin receptors in the kidney: Normal physiology gone bad.” In Endocrine Journal, 57:S276–S276. JAPAN ENDOCRINE SOC, 2010.
    Link to Item
  - Coffman, Thomas M. “Actions of glomerular AT1 angiotensin receptors to promote kidney injury and inflammation.” In Endocrine Journal, 57:S315–S315. JAPAN ENDOCRINE SOC, 2010.
    Link to Item
  - Wysocki, Jan, Karla Evora, Susan Gurley, Minghao Ye, Francisco R. Gonzalez-Pacheco, Thomas M. Coffman, and Daniel Batlle. “ACE2 Deficiency Increases Hydrogen Peroxide In Kidneys From Male Mice.” In Hypertension, 54:E112–E112. LIPPINCOTT WILLIAMS & WILKINS, 2009.
    Link to Item
  - Facemire, Carie S., Robert Griffiths, Laurent P. Audoly, Beverly H. Koller, and Thomas M. Coffman. “The Impact of Microsomal Prostaglandin E Synthase 1 on Blood Pressure is Determined by Genetic Background.” In Hypertension, 54:E45–E45. LIPPINCOTT WILLIAMS & WILKINS, 2009.
    Link to Item
  - Makhanova, Natalia A., Steven D. Crowley, Robert Griffiths, and Thomas M. Coffman. “Identification of Angiotensin II-Responsive Genes in the Kidney Using Genomewide Transcriptional Analysis.” In Hypertension, 54:E74–75. LIPPINCOTT WILLIAMS & WILKINS, 2009.
    Link to Item
  - Wang, Zheng, Shiyou Chen, Laureano D. Asico, Crisanto Escano, Van Anthony M. Villar, Quansheng Lu, Thomas M. Coffman, et al. “AT1R dysregulation is crucial in the hypertension of human GRK4 gamma A142V transgenic mice.” In Faseb Journal, Vol. 23. FEDERATION AMER SOC EXP BIOL, 2009.
    Link to Item
  - Coffman, Thomas M. “AT1 ANGIOTENSIN RECEPTORS IN THE KIDNEY: A KEY TO BLOOD PRESSURE CONTROL.” In Journal of Physiological Sciences, 59:85–85. SPRINGER TOKYO, 2009.
    Link to Item
  - Crowley, Steven D., Gregory Sprung, Robert Griffiths, Eugene Lin, and Thomas M. Coffman. “AT(1) receptors on bone marrow cells modulate kidney injury in hypertension.” In Hypertension, 52:E40–E40. LIPPINCOTT WILLIAMS & WILKINS, 2008.
    Link to Item
  - Gurley, Susan B., Andrew M. Allen, Volker H. Haase, John N. Snouwaert, Beverly H. Koller, Thu H. Le, and Thomas M. Coffman. “AT1 angiotensin receptors in the proximal tubule of the kidney are essential for blood pressure regulation.” In Hypertension, 52:E47–E47. LIPPINCOTT WILLIAMS & WILKINS, 2008.
    Link to Item
  - Gurley, Susan B., Kelly K. Parsons, Volker H. Haase, John N. Snouwaert, Beverly H. Koller, Thu H. Le, and Thomas M. Coffman. “Attenuated salt sensitivity in mice with tissue-specific deletion of AT1A angiotensin receptors from renal proximal tubule.” In Hypertension, 50:E99–E99. LIPPINCOTT WILLIAMS & WILKINS, 2007.
    Link to Item
  - Henriques, Tracy A., Steven D. Crowley, Campbell W. Frey, and Thomas M. Coffman. “COX-1 from bone marrow-derived cells promotes angiotensin II-dependent hypertension.” In Hypertension, 50:E89–E89. LIPPINCOTT WILLIAMS & WILKINS, 2007.
    Link to Item
  - Parsons, Kelly K., Susan B. Gurley, John N. Snouwaert, Chapel Hill, Thu H. Le, and Thomas M. Coffman. “Elimination of AT(1A) angiotensin receptors from smooth muscle does not alter blood pressure.” In Hypertension, 50:E77–E77. LIPPINCOTT WILLIAMS & WILKINS, 2007.
    Link to Item
  - Crowley, Steven D., Samantha K. Gould, Phillip Ruiz, Robert Griffiths, and Thomas M. Coffman. “Immune mechanisms promote kidney injury in angiotensin II-Dependent hypertension.” In Hypertension, 48:E73–E73. LIPPINCOTT WILLIAMS & WILKINS, 2006.
    Link to Item
  - Gurley, Susan B., Thu H. Le, Robert Griffiths, Nisha Phillip, Timothy A. Haystead, and Thomas M. Coffman. “Enhanced susceptibility to Ang II-induced hypertension and impaired Ang II metabolism in ACE2-deficient mice.” In Hypertension, 48:E26–E26. LIPPINCOTT WILLIAMS & WILKINS, 2006.
    Link to Item
  - Parsons, Kelly K., Mitchel D. Harris, Thomas M. Coffman, and Thu H. Le. “Glutathione-s-transferase mu-1 is a candidate modifier gene for renal vascular pathology.” In Hypertension, 48:E43–E43. LIPPINCOTT WILLIAMS & WILKINS, 2006.
    Link to Item
  - Sabaa, Nathalie, Bruno Miroux, Thomas M. Coffman, Stephane Germain, Sheila Collins, Daniel Ricquier, Jean-Claude Dussaule, and Pierre-Louis Tharaux. “UCP-2 limits the development of angiotensin II-induced renal sclerosis.” In Nephrology Dialysis Transplantation, 21:290–290. OXFORD UNIV PRESS, 2006.
    Link to Item
  - Sabaa, N., B. Miroux, T. M. Coffman, S. Collins, D. Ricquier, J. C. Dussaule, and P. L. Tharaux. “Ucp-2 does not modulate angiotensin ii-induced high blood pressure but limits the development of hypertensive renal sclerosis.” In Journal of Hypertension, Vol. 23, 2005. https://doi.org/10.1097/01.hjh.0000177375.70196.08.
    Full Text
  - Morris, M., P. Li, M. F. Callahan, M. I. Oliverio, T. M. Coffman, S. M. Bosch, and D. I. Diz. “Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.” In Hypertension, 33:482–86, 1999. https://doi.org/10.1161/01.hyp.33.1.482.
    Full Text Link to Item
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Awards & Honors

Global Scholarship

Research

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses