Thomas Myron Coffman | Scholars@Duke

Thomas Myron Coffman
James R. Clapp Distinguished Professor of Medicine, in the School of Medicine

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Current Appointments & Affiliations

James R. Clapp Distinguished Professor of Medicine, in the School of Medicine, Medicine, Nephrology, Medicine 2002
Professor of Medicine, Medicine, Nephrology, Medicine 1999
Professor in Cell Biology, Cell Biology, Basic Science Departments 2005
Professor in Immunology, Immunology, Basic Science Departments 2006

Contact Information

Duke Box 103015, Durham, NC 27710
Room 2018/MSBR2, 106 Research Drive, Durham, NC 27710
coffm002@duke.edu (919) 684-9788

Background
Education, Training, & Certifications
- Fellowship in Nephrology, Duke University School of Medicine 1983 - 1985
- M.D., Ohio State University 1980
Duke Appointment History
- Chief, Division of Nephrology, Medicine, Nephrology, Medicine 1997 - 2014
- Senior Vice-chair for Academic Affairs in the Department of Medicine, Medicine, Clinical Science Departments 2007 - 2014
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1994 - 1998
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1987 - 1994
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1985 - 1986
Recognition
In the News
- MAR 27, 2020 Magnify Magazine
  
  Duke Researchers Pivot to Attack the New Coronavirus
- DEC 15, 2014
  
  Thomas Coffman Named Dean-Designate of Duke-NUS Medical School
Awards & Honors
- Excellence Award for Hypertension Research. American Heart Association. 2014
- Water and Electrolyte Homeostasis Section/Ernest H. Starling Distinguished Lecture. American Physiological Society. 2006
Expertise
Global Scholarship
- Research
  - Singapore (Country)
Research
Selected Grants
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Postdoctoral Training in Genomic Medicine Research awarded by National Institutes of Health 2017 - 2021
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
- Paracrine Control of Blood Pressure by Renal Intercalated Cells awarded by National Institutes of Health 2015 - 2020
- Actions of Angiotensin II Along the Nephron to Regulate Blood Pressure awarded by National Institutes of Health 2014 - 2019
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Student Supplement awarded by National Institutes of Health 2012 - 2017
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus awarded by National Institutes of Health 2011 - 2016
- Immune Mechanisms in Diabetic Nephropathy awarded by Georgia Regents University 2014 - 2015
- Prostaglandin E2 and Regulation of Kidney Function awarded by National Institutes of Health 2005 - 2015
- A New Locus for Hereditary FSGS on Chromosome 2p awarded by National Institutes of Health 2009 - 2014
- Renal Endothelin-1: Control of Sodium Excretion and Blood Pressure awarded by National Institutes of Health 2012 - 2013
- A Novel Mouse Model of Podocyte Injury awarded by National Institutes of Health 2009 - 2012
- Characterization of TRPC6 As A Cause for Focal and Segmental Glomerulosclerosis awarded by National Institutes of Health 2006 - 2012
- Angiotensin Receptor Genes and Blood Pressure Regulation awarded by National Institutes of Health 1997 - 2012
- Genetic Determinants of Susceptibility to Kidney Disease in African Americans awarded by National Institutes of Health 2009 - 2012
- Angiogenic Signals in Diabetic Complications awarded by National Institutes of Health 2006 - 2012
- B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function awarded by National Institutes of Health 2002 - 2012
- IPA - Natalia Makhanova awarded by Durham Veterans Affairs Medical Center 2010 - 2011
- Pathophysiology of Renal Allograft Dysfunction awarded by National Institutes of Health 1988 - 2011
- Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects awarded by National Institutes of Health 2007 - 2009
- Role of mPGES1 in Regulation of Kidney Function awarded by National Institutes of Health 2006 - 2008
- IPA - Galen Hoover awarded by Veterans Adminsitration Medical Center 2006 - 2008
- Actions of Angiotensin II in Vascular Smooth Muscle awarded by National Institutes of Health 2006 - 2008
- Rac, Superoxide and Antioxidants in Hypertension awarded by National Institutes of Health 1996 - 2007
- Duke-UNC-Stanford AMDC Unit awarded by National Institutes of Health 2001 - 2006
- Genes that Regulate Target Organ Damage in Hypertension awarded by National Institutes of Health 2001 - 2006
- Pathophysiology of Renal Allograft Dysfunction awarded by National Institutes of Health 1988 - 2004
- Pathophysiology of renal allograft dysfunction awarded by National Institutes of Health 1988 - 2004
- Same awarded by National Institutes of Health 1988 - 2004
- Duke/NIDDK Functional Genomics Center awarded by National Institutes of Health 2000 - 2003
- Duke Training Grant In Nephrology awarded by National Institutes of Health 1995 - 2000
- same awarded by National Institutes of Health 1995 - 2000
- Angiotensin Receptor Genes And Blood Pressure Regulation awarded by National Institutes of Health 1997 - 1999
- same awarded by National Institutes of Health 1997 - 1999
- Duke Training Grant In Nephrology awarded by National Institutes of Health 1995 - 1999
External Relationships
- Duke-NUS Medical school
- Janssen Pharmaceuticals (Johnson & Johnson)
- Kidney Research Institute-University of Washington
- King Faisal Specialist Hospital and Research Center
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lerman, Lilach O., Theodore W. Kurtz, Rhian M. Touyz, David H. Ellison, Alejandro R. Chade, Steven D. Crowley, David L. Mattson, et al. “Animal Models of Hypertension: A Scientific Statement From the American Heart Association.” Hypertension 73, no. 6 (June 2019): e87–120. https://doi.org/10.1161/HYP.0000000000000090.
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  - Sabanayagam, Charumathi, Miao Li Chee, Riswana Banu, Ching-Yu Cheng, Su Chi Lim, E Shyong Tai, Thomas Coffman, and Tien Y. Wong. “Association of Diabetic Retinopathy and Diabetic Kidney Disease With All-Cause and Cardiovascular Mortality in a Multiethnic Asian Population.” Jama Netw Open 2, no. 3 (March 1, 2019): e191540. https://doi.org/10.1001/jamanetworkopen.2019.1540.
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  - Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension.” J Am Heart Assoc 8, no. 4 (February 19, 2019): e010745. https://doi.org/10.1161/JAHA.118.010745.
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  - Gurley, Susan B., Sujoy Ghosh, Stacy A. Johnson, Kengo Azushima, Rashidah Binte Sakban, Simi E. George, Momoe Maeda, Timothy W. Meyer, and Thomas M. Coffman. “Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.” Diabetes 67, no. 10 (October 2018): 2096–2106. https://doi.org/10.2337/db17-1323.
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  - Azushima, Kengo, Susan B. Gurley, and Thomas M. Coffman. “Modelling diabetic nephropathy in mice.” Nat Rev Nephrol 14, no. 1 (January 2018): 48–56. https://doi.org/10.1038/nrneph.2017.142.
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  - Coffman, Thomas M. “Oliver Smithies: A Remembrance.” Hypertension 70, no. 1 (July 2017): 3–4. https://doi.org/10.1161/HYPERTENSIONAHA.117.09118.
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  - Stegbauer, Johannes, Daian Chen, Marcela Herrera, Matthew A. Sparks, Ting Yang, Eva Königshausen, Susan B. Gurley, and Thomas M. Coffman. “Resistance to hypertension mediated by intercalated cells of the collecting duct.” Jci Insight 2, no. 7 (April 6, 2017): e92720. https://doi.org/10.1172/jci.insight.92720.
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  - Tyson, Crystal C., and Thomas M. Coffman. “In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?” Nephron 135, no. 4 (2017): 287–90. https://doi.org/10.1159/000455130.
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  - Tinning, Anne R., Boye L. Jensen, Iben Johnsen, Daian Chen, Thomas M. Coffman, and Kirsten Madsen. “Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.” Am J Physiol Renal Physiol 311, no. 3 (September 1, 2016): F586–99. https://doi.org/10.1152/ajprenal.00221.2016.
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  - Chen, Daian, Johannes Stegbauer, Matthew A. Sparks, Donald Kohan, Robert Griffiths, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension.” Hypertension 67, no. 6 (June 2016): 1291–97. https://doi.org/10.1161/HYPERTENSIONAHA.115.06987.
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  - Sparks, Matthew A., Johannes Stegbauer, Daian Chen, Jose A. Gomez, Robert C. Griffiths, Hooman A. Azad, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.” J Am Soc Nephrol 26, no. 12 (December 2015): 2953–62. https://doi.org/10.1681/ASN.2014080816.
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  - Stegbauer, Johannes, and Thomas M. Coffman. “Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.” J Clin Invest 125, no. 11 (November 2, 2015): 4008–10. https://doi.org/10.1172/JCI84753.
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  - Dimke, Henrik, Matthew A. Sparks, Benjamin R. Thomson, Sebastian Frische, Thomas M. Coffman, and Susan E. Quaggin. “Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney.” J Am Soc Nephrol 26, no. 5 (May 2015): 1027–38. https://doi.org/10.1681/ASN.2014010060.
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  - Yang, Yanqiang, Jose A. Gomez, Marcela Herrera, Romelia Perez-Marco, Peter Repenning, Zhiping Zhang, Alan Payne, et al. “Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4.” Hypertension 65, no. 5 (May 2015): 1047–54. https://doi.org/10.1161/HYPERTENSIONAHA.114.04611.
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  - Chen, Daian, and Thomas M. Coffman. “AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.” Curr Opin Pharmacol 21 (April 2015): 122–26. https://doi.org/10.1016/j.coph.2015.01.006.
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  - Young, Colin N., Donald A. Morgan, Scott D. Butler, Kamal Rahmouni, Susan B. Gurley, Thomas M. Coffman, Allyn L. Mark, and Robin L. Davisson. “Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.” Mol Metab 4, no. 4 (April 2015): 337–43. https://doi.org/10.1016/j.molmet.2015.01.007.
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  - Dolber, Paul C., Huixia Jin, Rashid Nassar, Thomas M. Coffman, Susan B. Gurley, and Matthew O. Fraser. “The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice.” Neurourol Urodyn 34, no. 1 (January 2015): 72–78. https://doi.org/10.1002/nau.22511.
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  - Smithies, Oliver, and Tom Coffman. “A conversation with Oliver Smithies.” Annu Rev Physiol 77 (2015): 1–11. https://doi.org/10.1146/annurev-physiol-021014-071806.
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  - Young, C. N., D. A. Morgan, S. D. Butler, K. Rahmouni, S. B. Gurley, T. M. Coffman, A. L. Mark, and R. L. Davisson. “Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis.” Molecular Metabolism 4, no. 4 (January 1, 2015): 337–43. https://doi.org/10.1016/j.molmet.2015.01.007.
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  - Sparks, Matthew A., Steven D. Crowley, Susan B. Gurley, Maria Mirotsou, and Thomas M. Coffman. “Classical Renin-Angiotensin system in kidney physiology.” Compr Physiol 4, no. 3 (July 2014): 1201–28. https://doi.org/10.1002/cphy.c130040.
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  - Coffman, Thomas M. “The inextricable role of the kidney in hypertension.” J Clin Invest 124, no. 6 (June 2014): 2341–47. https://doi.org/10.1172/JCI72274.
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  - Wang, L., T. A. Fields, K. Pazmino, Q. Dai, J. L. Burchette, D. N. Howell, T. M. Coffman, and R. F. Spurney. “Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622)).” Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126. https://doi.org/10.1681/ASN.2013080868.
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  - Xie, Luke, Matthew A. Sparks, Wei Li, Yi Qi, Chunlei Liu, Thomas M. Coffman, and G Allan Johnson. “Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice.” Nmr Biomed 26, no. 12 (December 2013): 1853–63. https://doi.org/10.1002/nbm.3039.
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  - Dolber, P. C., H. Jin, R. Nassar, T. M. Coffman, S. B. Gurley, and M. O. Fraser. “The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice.” Neurourol Urodyn, October 28, 2013. https://doi.org/10.1002/nau.22511.
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  - Le, T. H., S. D. Crowley, S. B. Gurley, and T. M. Coffman. “The Renin-Angiotensin System” 1 (September 12, 2013): 427–50. https://doi.org/10.1016/B978-0-12-381462-3.00015-X.
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  - Breyer, Matthew D., Thomas M. Coffman, Michael F. Flessner, Linda F. Fried, Raymond C. Harris, Christian J. Ketchum, Matthias Kretzler, et al. “Diabetic nephropathy: a national dialogue.” Clin J Am Soc Nephrol 8, no. 9 (September 2013): 1603–5. https://doi.org/10.2215/CJN.03640413.
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  - Konvalinka, Ana, Joyce Zhou, Apostolos Dimitromanolakis, Andrei P. Drabovich, Fei Fang, Susan Gurley, Thomas Coffman, et al. “Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC).” J Biol Chem 288, no. 34 (August 23, 2013): 24834–47. https://doi.org/10.1074/jbc.M113.485326.
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  - Pippin, Jeffrey W., Matthew A. Sparks, Sean T. Glenn, Sandra Buitrago, Thomas M. Coffman, Jeremy S. Duffield, Kenneth W. Gross, and Stuart J. Shankland. “Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease.” Am J Pathol 183, no. 2 (August 2013): 542–57. https://doi.org/10.1016/j.ajpath.2013.04.024.
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  - Herrera, Marcela, and Thomas M. Coffman. “Control of electrolyte balance through ubiquitination.” Proc Natl Acad Sci U S A 110, no. 19 (May 7, 2013): 7535–36. https://doi.org/10.1073/pnas.1305242110.
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  - Herrera, Marcela, Matthew A. Sparks, Adolfo R. Alfonso-Pecchio, Lisa M. Harrison-Bernard, and Thomas M. Coffman. “Response to lack of specificity of commercial antibodies leads to misidentification of angiotensin type-1 receptor protein.” Hypertension 61, no. 4 (April 2013): e32. https://doi.org/10.1161/hypertensionaha.111.00982.
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  - Ortiz-Melo, David, and Thomas M. Coffman. “A trip to inner space: insights into salt balance from cosmonauts.” Cell Metab 17, no. 1 (January 8, 2013): 1–2. https://doi.org/10.1016/j.cmet.2012.12.009.
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  - Herrera, Marcela, Matthew A. Sparks, Adolfo R. Alfonso-Pecchio, Lisa M. Harrison-Bernard, and Thomas M. Coffman. “Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein.” Hypertension 61, no. 1 (January 2013): 253–58. https://doi.org/10.1161/HYPERTENSIONAHA.112.203679.
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  - Sparks, Matthew A., Natalia A. Makhanova, Robert C. Griffiths, John N. Snouwaert, Beverly H. Koller, and Thomas M. Coffman. “Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death.” Hypertension 61, no. 1 (January 2013): 166–73. https://doi.org/10.1161/HYPERTENSIONAHA.112.193250.
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  - Zhang, Jian-dong, Mehul B. Patel, Young-Soo Song, Robert Griffiths, James Burchette, Phillip Ruiz, Matthew A. Sparks, et al. “A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.” Circ Res 110, no. 12 (June 8, 2012): 1604–17. https://doi.org/10.1161/CIRCRESAHA.111.261768.
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  - Crowley, Steven D., and Thomas M. Coffman. “Recent advances involving the renin-angiotensin system.” Exp Cell Res 318, no. 9 (May 15, 2012): 1049–56. https://doi.org/10.1016/j.yexcr.2012.02.023.
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  - Chen, Daian, and Thomas M. Coffman. “The kidney and hypertension: lessons from mouse models.” Can J Cardiol 28, no. 3 (May 2012): 305–10. https://doi.org/10.1016/j.cjca.2012.01.002.
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  - Gembardt, Florian, Richard van Veghel, Thomas M. Coffman, Heinz-Peter Schultheiss, Alexander H Jan Danser, and Thomas Walther. “Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors.” Hypertens Res 35, no. 5 (May 2012): 547–51. https://doi.org/10.1038/hr.2012.5.
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  - Herrera, Marcela, and Thomas M. Coffman. “The kidney and hypertension: novel insights from transgenic models.” Curr Opin Nephrol Hypertens 21, no. 2 (March 2012): 171–78. https://doi.org/10.1097/MNH.0b013e3283503068.
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  - Cyphert, Jaime M., Irving C. Allen, Rachel J. Church, Anne M. Latour, John N. Snouwaert, Thomas M. Coffman, and Beverly H. Koller. “Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse.” Am J Physiol Lung Cell Mol Physiol 302, no. 1 (January 1, 2012): L140–51. https://doi.org/10.1152/ajplung.00152.2011.
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  - Stegbauer, Johannes, Susan B. Gurley, Matthew A. Sparks, Magdalena Woznowski, Donald E. Kohan, Ming Yan, Ruediger W. Lehrich, and Thomas M. Coffman. “AT1 receptors in the collecting duct directly modulate the concentration of urine.” J Am Soc Nephrol 22, no. 12 (December 2011): 2237–46. https://doi.org/10.1681/ASN.2010101095.
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  - Verlander, Jill W., Seongun Hong, Vladimir Pech, James L. Bailey, Diana Agazatian, Sharon W. Matthews, Thomas M. Coffman, et al. “Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.” Am J Physiol Renal Physiol 301, no. 6 (December 2011): F1314–25. https://doi.org/10.1152/ajprenal.00114.2011.
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  - Coffman, Thomas M. “Under pressure: the search for the essential mechanisms of hypertension.” Nat Med 17, no. 11 (November 7, 2011): 1402–9. https://doi.org/10.1038/nm.2541.
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  - Crowley, Steven D., Jiandong Zhang, Maria Herrera, Robert Griffiths, Phillip Ruiz, and Thomas M. Coffman. “Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension.” Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1124–30. https://doi.org/10.1152/ajprenal.00305.2011.
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  - Facemire, Carie S., Mytrang Nguyen, Leigh Jania, William H. Beierwaltes, Hyung-Suk Kim, Beverly H. Koller, and Thomas M. Coffman. “A major role for the EP4 receptor in regulation of renin.” Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1035–41. https://doi.org/10.1152/ajprenal.00054.2011.
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  - Snoeijs, Maarten G. J., Pieter R. Hoogland, Bas Boonen, Thomas M. Coffman, Carine J. Peutz-Kootstra, Wim A. Buurman, and LW Ernest van Heurn. “Thromboxane receptor signalling in renal ischemia reperfusion injury.” Free Radic Res 45, no. 6 (June 2011): 699–706. https://doi.org/10.3109/10715762.2011.571686.
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  - Gurley, Susan B., Anne D. M. Riquier-Brison, Jurgen Schnermann, Matthew A. Sparks, Andrew M. Allen, Volker H. Haase, John N. Snouwaert, et al. “AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.” Cell Metab 13, no. 4 (April 6, 2011): 469–75. https://doi.org/10.1016/j.cmet.2011.03.001.
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  - Sparks, Matthew A., Kelly K. Parsons, Johannes Stegbauer, Susan B. Gurley, Anuradha Vivekanandan-Giri, Christopher N. Fortner, Jay Snouwaert, et al. “Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension.” Hypertension 57, no. 3 (March 2011): 577–85. https://doi.org/10.1161/HYPERTENSIONAHA.110.165274.
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  - DiLillo, David J., Robert Griffiths, Surya V. Seshan, Cynthia M. Magro, Phillip Ruiz, Thomas M. Coffman, and Thomas F. Tedder. “B lymphocytes differentially influence acute and chronic allograft rejection in mice.” J Immunol 186, no. 4 (February 15, 2011): 2643–54. https://doi.org/10.4049/jimmunol.1002983.
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  - Stegbauer, Johannes, and Thomas M. Coffman. “New insights into angiotensin receptor actions: from blood pressure to aging.” Curr Opin Nephrol Hypertens 20, no. 1 (January 2011): 84–88. https://doi.org/10.1097/MNH.0b013e3283414d40.
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  - Makhanova, Natalia A., Steven D. Crowley, Robert C. Griffiths, and Thomas M. Coffman. “Gene expression profiles linked to AT1 angiotensin receptors in the kidney.” Physiol Genomics 42A, no. 3 (November 15, 2010): 211–18. https://doi.org/10.1152/physiolgenomics.00063.2010.
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  - Gurley, Susan B., Robert C. Griffiths, Michael E. Mendelsohn, Richard H. Karas, and Thomas M. Coffman. “Renal actions of RGS2 control blood pressure.” J Am Soc Nephrol 21, no. 11 (November 2010): 1847–51. https://doi.org/10.1681/ASN.2009121306.
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  - Gurley, Susan B., and Thomas M. Coffman. “An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy.” Cell Metab 12, no. 4 (October 6, 2010): 311–12. https://doi.org/10.1016/j.cmet.2010.09.007.
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  - Sparks, Matthew A., and Thomas M. Coffman. “The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad?” J Am Soc Nephrol 21, no. 10 (October 2010): 1597–99. https://doi.org/10.1681/ASN.2010080870.
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  - Esch, Joep H. M. van, Florian Gembardt, Anja Sterner-Kock, Silvia Heringer-Walther, Thu H. Le, Dirk Lassner, Theo Stijnen, et al. “Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts.” Cardiovasc Res 86, no. 3 (June 1, 2010): 401–9. https://doi.org/10.1093/cvr/cvq004.
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  - Crowley, S. D., C. W. Frey, S. K. Gould, R. Griffiths, P. Ruiz, J. L. Burchette, D. N. Howell, et al. “Simulation of lymphoctye responses by angiotensin II promotes kidney injury in hypertension (American Journal Physiology-Renal Physiology (2008) 295, (F515-F524)).” American Journal of Physiology Renal Physiology 298, no. 5 (May 1, 2010). https://doi.org/10.1152/ajprenal.zh2-5901-corr.2010.
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  - Gurley, Susan B., Carrie L. Mach, Johannes Stegbauer, Jihong Yang, Kamie P. Snow, Ann Hu, Timothy W. Meyer, and Thomas M. Coffman. “Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.” Am J Physiol Renal Physiol 298, no. 3 (March 2010): F788–95. https://doi.org/10.1152/ajprenal.90515.2008.
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  - Madsen, Kirsten, Niels Marcussen, Michael Pedersen, Gitte Kjaersgaard, Carie Facemire, Thomas M. Coffman, and Boye L. Jensen. “Angiotensin II promotes development of the renal microcirculation through AT1 receptors.” J Am Soc Nephrol 21, no. 3 (March 2010): 448–59. https://doi.org/10.1681/ASN.2009010045.
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  - Facemire, Carie S., Robert Griffiths, Laurent P. Audoly, Beverly H. Koller, and Thomas M. Coffman. “The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.” Hypertension 55, no. 2 (February 2010): 531–38. https://doi.org/10.1161/HYPERTENSIONAHA.109.145631.
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  - Brosius, Frank C., Charles E. Alpers, Erwin P. Bottinger, Matthew D. Breyer, Thomas M. Coffman, Susan B. Gurley, Raymond C. Harris, et al. “Mouse models of diabetic nephropathy.” J Am Soc Nephrol 20, no. 12 (December 2009): 2503–12. https://doi.org/10.1681/ASN.2009070721.
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  - Machura, Katharina, Dominik Steppan, Bjoern Neubauer, Natalia Alenina, Thomas M. Coffman, Carie S. Facemire, Karl F. Hilgers, Kai-Uwe Eckardt, Charlotte Wagner, and Armin Kurtz. “Developmental renin expression in mice with a defective renin-angiotensin system.” Am J Physiol Renal Physiol 297, no. 5 (November 2009): F1371–80. https://doi.org/10.1152/ajprenal.00378.2009.
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  - Lemarié, Catherine A., Stefania M. C. Simeone, Anna Nikonova, Talin Ebrahimian, Marie-Eve Deschênes, Thomas M. Coffman, Pierre Paradis, and Ernesto L. Schiffrin. “Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors.” Circ Res 105, no. 9 (October 23, 2009): 852–59. https://doi.org/10.1161/CIRCRESAHA.109.196576.
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  - Facemire, Carie S., Andrew B. Nixon, Robert Griffiths, Herbert Hurwitz, and Thomas M. Coffman. “Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.” Hypertension 54, no. 3 (September 2009): 652–58. https://doi.org/10.1161/HYPERTENSIONAHA.109.129973.
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  - Crowley, Steven D., Matthew P. Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A Kathy Pazmino, Carie Facemire, et al. “Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis.” J Clin Invest 119, no. 4 (April 2009): 943–53. https://doi.org/10.1172/JCI34862.
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  - Benigni, Ariela, Daniela Corna, Carla Zoja, Aurelio Sonzogni, Roberto Latini, Monica Salio, Sara Conti, et al. “Disruption of the Ang II type 1 receptor promotes longevity in mice.” J Clin Invest 119, no. 3 (March 2009): 524–30. https://doi.org/10.1172/JCI36703.
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  - Athirakul, Krairerk, J Alyce Bradbury, Joan P. Graves, Laura M. DeGraff, Jixiang Ma, Yun Zhao, John F. Couse, et al. “Increased blood pressure in mice lacking cytochrome P450 2J5.” Faseb J 22, no. 12 (December 2008): 4096–4108. https://doi.org/10.1096/fj.08-114413.
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  - Thu H., L., C. Steven D., G. Susan B., and C. Thomas M. “The Renin-Angiotensin System,” December 1, 2008, 343–57. https://doi.org/10.1016/B978-012088488-9.50016-4.
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  - Crowley, Steven D., and Thomas M. Coffman. “In hypertension, the kidney breaks your heart.” Curr Cardiol Rep 10, no. 6 (November 2008): 470–76. https://doi.org/10.1007/s11886-008-0074-5.
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  - Spurney, Robert F., and Thomas M. Coffman. “Stressed-out podocytes in diabetes?” J Am Soc Nephrol 19, no. 11 (November 2008): 2035–37. https://doi.org/10.1681/ASN.2008090955.
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  - Francois, Helene, Natalia Makhanova, Philip Ruiz, Jonathan Ellison, Lan Mao, Howard A. Rockman, and Thomas M. Coffman. “A role for the thromboxane receptor in L-NAME hypertension.” Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096–1102. https://doi.org/10.1152/ajprenal.00369.2007.
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  - Crowley, Steven D., Campbell W. Frey, Samantha K. Gould, Robert Griffiths, Phillip Ruiz, James L. Burchette, David N. Howell, et al. “Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension.” Am J Physiol Renal Physiol 295, no. 2 (August 2008): F515–24. https://doi.org/10.1152/ajprenal.00527.2007.
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  - Gembardt, Florian, Silvia Heringer-Walther, Joep H. M. van Esch, Anja Sterner-Kock, Richard van Veghel, Thu H. Le, Ingrid M. Garrelds, et al. “Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors.” Faseb J 22, no. 8 (August 2008): 3068–77. https://doi.org/10.1096/fj.08-108316.
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  - Coggins, Kenneth G., Thomas M. Coffman, and Beverly H. Koller. “The Hippocratic finger points the blame at PGE2.” Nat Genet 40, no. 6 (June 2008): 691–92. https://doi.org/10.1038/ng0608-691.
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  - Gurley, Susan B., and Thomas M. Coffman. “Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages.” Exp Physiol 93, no. 5 (May 2008): 538–42. https://doi.org/10.1113/expphysiol.2007.040014.
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  - Wooldridge, Anne A., Christopher N. Fortner, Beata Lontay, Takayuki Akimoto, Ronald L. Neppl, Carie Facemire, Michael B. Datto, et al. “Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.” J Biol Chem 283, no. 17 (April 25, 2008): 11850–59. https://doi.org/10.1074/jbc.M708628200.
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  - Coffman, Thomas M., and Steven D. Crowley. “Kidney in hypertension: guyton redux.” Hypertension 51, no. 4 (April 2008): 811–16. https://doi.org/10.1161/HYPERTENSIONAHA.105.063636.
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  - Le, Thu H., and Thomas M. Coffman. “Targeting genes in the renin-angiotensin system.” Curr Opin Nephrol Hypertens 17, no. 1 (January 2008): 57–63. https://doi.org/10.1097/MNH.0b013e3282f2fd39.
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  - Francois, Helene, Carie Facemire, Anil Kumar, Laurent Audoly, Beverly Koller, and Thomas Coffman. “Role of microsomal prostaglandin E synthase 1 in the kidney.” J Am Soc Nephrol 18, no. 5 (May 2007): 1466–75. https://doi.org/10.1681/ASN.2006040343.
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  - Ashton, Anthony W., Shankar Mukherjee, F. N. U. Nagajyothi, Huan Huang, Vicki L. Braunstein, Mahalia S. Desruisseaux, Stephen M. Factor, et al. “Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection.” J Exp Med 204, no. 4 (April 16, 2007): 929–40. https://doi.org/10.1084/jem.20062432.
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  - Crowley, Steven D., and Thomas M. Coffman. “In hypertension, the kidney rules.” Curr Hypertens Rep 9, no. 2 (April 2007): 148–53. https://doi.org/10.1007/s11906-007-0026-2.
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  - Parsons, Kelly K., and Thomas M. Coffman. “The renin-angiotensin system: it's all in your head.” J Clin Invest 117, no. 4 (April 2007): 873–76. https://doi.org/10.1172/JCI31856.
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  - Gurley, Susan B., and Thomas M. Coffman. “The renin-angiotensin system and diabetic nephropathy.” Semin Nephrol 27, no. 2 (March 2007): 144–52. https://doi.org/10.1016/j.semnephrol.2007.01.009.
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  - Quaggin, Susan E., and Thomas M. Coffman. “Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?” J Am Soc Nephrol 18, no. 2 (February 2007): 364–66. https://doi.org/10.1681/ASN.2006121396.
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  - Crowley, Steven D., Susan B. Gurley, and Thomas M. Coffman. “AT(1) receptors and control of blood pressure: the kidney and more...” Trends Cardiovasc Med 17, no. 1 (January 2007): 30–34. https://doi.org/10.1016/j.tcm.2006.11.002.
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  - Crowley, Steven D., Susan B. Gurley, Maria J. Herrera, Phillip Ruiz, Robert Griffiths, Anil P. Kumar, Hyung-Suk Kim, Oliver Smithies, Thu H. Le, and Thomas M. Coffman. “Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.” Proc Natl Acad Sci U S A 103, no. 47 (November 21, 2006): 17985–90. https://doi.org/10.1073/pnas.0605545103.
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  - Rajagopal, Keshava, Erin J. Whalen, Jonathan D. Violin, Jonathan A. Stiber, Paul B. Rosenberg, Richard T. Premont, Thomas M. Coffman, Howard A. Rockman, and Robert J. Lefkowitz. “Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.” Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284–89. https://doi.org/10.1073/pnas.0607583103.
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  - Coffman, Thomas M. “A WNK in the kidney controls blood pressure.” Nat Genet 38, no. 10 (October 2006): 1105–6. https://doi.org/10.1038/ng1006-1105.
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  - Chansel, Dominique, Magali Ciroldi, Sophie Vandermeersch, Leslie F. Jackson, Ana-Maria Gomez, Daniel Henrion, David C. Lee, et al. “Heparin binding EGF is necessary for vasospastic response to endothelin.” Faseb J 20, no. 11 (September 2006): 1936–38. https://doi.org/10.1096/fj.05-5328fje.
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  - Gurley, Susan B., Alicia Allred, Thu H. Le, Robert Griffiths, Lan Mao, Nisha Philip, Timothy A. Haystead, et al. “Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.” J Clin Invest 116, no. 8 (August 2006): 2218–25. https://doi.org/10.1172/JCI16980.
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  - Woost, Philip G., Robert J. Kolb, Margaret Finesilver, Irene Mackraj, Hans Imboden, Thomas M. Coffman, and Ulrich Hopfer. “Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines.” In Vitro Cell Dev Biol Anim 42, no. 7 (July 2006): 189–200. https://doi.org/10.1290/0511076.1.
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  - Wysocki, Jan, Minghao Ye, Maria José Soler, Susan B. Gurley, Hong D. Xiao, Kenneth E. Bernstein, Thomas M. Coffman, Sheldon Chen, and Daniel Batlle. “ACE and ACE2 activity in diabetic mice.” Diabetes 55, no. 7 (July 2006): 2132–39. https://doi.org/10.2337/db06-0033.
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  - Elased, Khalid M., Tatiana S. Cunha, Susan B. Gurley, Thomas M. Coffman, and Mariana Morris. “New mass spectrometric assay for angiotensin-converting enzyme 2 activity.” Hypertension 47, no. 5 (May 2006): 1010–17. https://doi.org/10.1161/01.HYP.0000215588.38536.30.
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  - Le, Thu H., and Thomas M. Coffman. “A new cardiac MASTer switch for the renin-angiotensin system.” J Clin Invest 116, no. 4 (April 2006): 866–69. https://doi.org/10.1172/JCI28312.
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  - Allen, Irving C., John M. Hartney, Thomas M. Coffman, Raymond B. Penn, Jürgen Wess, and Beverly H. Koller. “Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism.” Am J Physiol Lung Cell Mol Physiol 290, no. 3 (March 2006): L526–33. https://doi.org/10.1152/ajplung.00340.2005.
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  - Gurley, Susan B., Sharon E. Clare, Kamie P. Snow, Ann Hu, Timothy W. Meyer, and Thomas M. Coffman. “Impact of genetic background on nephropathy in diabetic mice.” Am J Physiol Renal Physiol 290, no. 1 (January 2006): F214–22. https://doi.org/10.1152/ajprenal.00204.2005.
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  - Francois, H., K. Athirakul, D. Howell, R. Dash, L. Mao, H. S. Kim, H. A. Rockman, G. A. FitzGerald, B. H. Koller, and T. M. Coffman. “NSAIDs and cardiovascular risk - Reply [2].” Cell Metabolism 2, no. 6 (December 1, 2005): 339–40. https://doi.org/10.1016/j.cmet.2005.11.009.
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  - Wang, Liming, Timothy A. Fields, Kathy Pazmino, Qunsheng Dai, James L. Burchette, David N. Howell, Thomas M. Coffman, and Robert F. Spurney. “Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury.” J Am Soc Nephrol 16, no. 12 (December 2005): 3611–22. https://doi.org/10.1681/ASN.2005020167.
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  - Ouyang, Xiaosen, Thu H. Le, Carlos Roncal, Christine Gersch, Jaime Herrera-Acosta, Bernardo Rodriguez-Iturbe, Thomas M. Coffman, Richard J. Johnson, and Wei Mu. “Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice.” Am J Physiol Renal Physiol 289, no. 4 (October 2005): F902–10. https://doi.org/10.1152/ajprenal.00141.2005.
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  - Francois, Helene, Krairerk Athirakul, David Howell, Rajesh Dash, Lan Mao, Hyung-Suk Kim, Howard A. Rockman, Garret A. Fitzgerald, Beverly H. Koller, and Thomas M. Coffman. “Prostacyclin protects against elevated blood pressure and cardiac fibrosis.” Cell Metab 2, no. 3 (September 2005): 201–7. https://doi.org/10.1016/j.cmet.2005.08.005.
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  - Bridgman, Paul, Mark A. Aronovitz, Rahul Kakkar, Michael I. Oliverio, Thomas M. Coffman, William M. Rand, Marvin A. Konstam, Michael E. Mendelsohn, and Richard D. Patten. “Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.” Am J Physiol Heart Circ Physiol 289, no. 2 (August 2005): H586–92. https://doi.org/10.1152/ajpheart.00474.2004.
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  - Rocha, Paulo N., Troy J. Plumb, Lisa A. Robinson, Robert Spurney, David Pisetsky, Beverly H. Koller, and Thomas M. Coffman. “Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.” Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896–903. https://doi.org/10.1128/CDLI.12.8.896-903.2005.
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  - Yang, Liu, Ramón Bataller, Jennyfer Dulyx, Thomas M. Coffman, Pere Ginès, Richard A. Rippe, and David A. Brenner. “Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice.” J Hepatol 43, no. 2 (August 2005): 317–23. https://doi.org/10.1016/j.jhep.2005.02.034.
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  - Rudic, R Daniel, Derek Brinster, Yan Cheng, Susanne Fries, Wen-Liang Song, Sandra Austin, Thomas M. Coffman, and Garret A. FitzGerald. “COX-2-derived prostacyclin modulates vascular remodeling.” Circ Res 96, no. 12 (June 24, 2005): 1240–47. https://doi.org/10.1161/01.RES.0000170888.11669.28.
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  - Breyer, Matthew D., Erwin Böttinger, Frank C. Brosius, Thomas M. Coffman, Agnes Fogo, Raymond C. Harris, Charles W. Heilig, and Kumar Sharma. “Diabetic nephropathy: of mice and men.” Adv Chronic Kidney Dis 12, no. 2 (April 2005): 128–45. https://doi.org/10.1053/j.ackd.2005.01.004.
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  - Crowley, Steven D., Susan B. Gurley, Michael I. Oliverio, A Kathy Pazmino, Robert Griffiths, Patrick J. Flannery, Robert F. Spurney, et al. “Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system.” J Clin Invest 115, no. 4 (April 2005): 1092–99. https://doi.org/10.1172/JCI23378.
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  - Breyer, Matthew D., Erwin Böttinger, Frank C. Brosius, Thomas M. Coffman, Raymond C. Harris, Charles W. Heilig, Kumar Sharma, and Kumar AMDCC. “Mouse models of diabetic nephropathy.” J Am Soc Nephrol 16, no. 1 (January 2005): 27–45. https://doi.org/10.1681/ASN.2004080648.
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  - Chansel, D., M. Ciroldi, S. Vandermeersch, A. M. Gomez, L. F. Jackson, D. C. Lee, D. Henrion, et al. “Egf receptor activated by hb-egf is required to calcium influx and vasoconstriction induced by endothelin-1.” Journal of Hypertension 23, no. 8 (January 1, 2005). https://doi.org/10.1097/01.hjh.0000177372.24455.20.
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  - Benigni, Ariela, Daniela Corna, Carla Zoja, Lorena Longaretti, Elena Gagliardini, Norberto Perico, Thomas M. Coffman, and Giuseppe Remuzzi. “Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria.” J Am Soc Nephrol 15, no. 10 (October 2004): 2666–74. https://doi.org/10.1097/01.ASN.0000141465.81556.D2.
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  - Boffa, Jean-Jacques, Armin Just, Thomas M. Coffman, and William J. Arendshorst. “Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice.” J Am Soc Nephrol 15, no. 9 (September 2004): 2358–65. https://doi.org/10.1097/01.ASN.0000136300.72480.86.
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  - Francois, Helene, and Thomas M. Coffman. “Prostanoids and blood pressure: which way is up?” J Clin Invest 114, no. 6 (September 2004): 757–59. https://doi.org/10.1172/JCI22929.
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  - Le, Thu H., Michael I. Oliverio, Hyung-Suk Kim, Harmony Salzler, Rajesh C. Dash, David N. Howell, Oliver Smithies, Sarah Bronson, and Thomas M. Coffman. “A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice.” Physiol Genomics 18, no. 3 (August 11, 2004): 290–98. https://doi.org/10.1152/physiolgenomics.00120.2003.
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  - Crowley, S. D., P. -. L. Tharaux, L. P. Audoly, and T. M. Coffman. “Exploring type I angiotensin (AT1) receptor functions through gene targeting.” Acta Physiol Scand 181, no. 4 (August 2004): 561–70. https://doi.org/10.1111/j.1365-201X.2004.01331.x.
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  - Goulet, Jennifer L., Amy J. Pace, Mikelle L. Key, Robert S. Byrum, MyTrang Nguyen, Stephen L. Tilley, Scott G. Morham, et al. “E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.” J Immunol 173, no. 2 (July 15, 2004): 1321–26. https://doi.org/10.4049/jimmunol.173.2.1321.
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  - Quan, Hui, Krairerk Athirakul, William C. Wetsel, Gonzalo E. Torres, Robert Stevens, Y. T. Chen, Thomas M. Coffman, and Marc G. Caron. “Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.” Mol Cell Biol 24, no. 10 (May 2004): 4166–73. https://doi.org/10.1128/mcb.24.10.4166-4173.2004.
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  - Francois, Helene, Krairerk Athirakul, Lan Mao, Howard Rockman, and Thomas M. Coffman. “Role for thromboxane receptors in angiotensin-II-induced hypertension.” Hypertension 43, no. 2 (February 2004): 364–69. https://doi.org/10.1161/01.HYP.0000112225.27560.24.
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  - Le, Thu H., Agnes B. Fogo, Harmony R. Salzler, Tania Vinogradova, Michael I. Oliverio, Douglas A. Marchuk, and Thomas M. Coffman. “Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency.” Hypertension 43, no. 2 (February 2004): 445–51. https://doi.org/10.1161/01.HYP.0000112423.28987.00.
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  - Thomas, Dennis W., Paulo N. Rocha, Chandra Nataraj, Lisa A. Robinson, Robert F. Spurney, Beverly H. Koller, and Thomas M. Coffman. “Proinflammatory actions of thromboxane receptors to enhance cellular immune responses.” J Immunol 171, no. 12 (December 15, 2003): 6389–95. https://doi.org/10.4049/jimmunol.171.12.6389.
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  - Rocha, Paulo N., Troy J. Plumb, Steven D. Crowley, and Thomas M. Coffman. “Effector mechanisms in transplant rejection.” Immunol Rev 196 (December 2003): 51–64. https://doi.org/10.1046/j.1600-065x.2003.00090.x.
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  - Wagner, Charlotte, Helga Vitzthum, Hayo Castrop, Karl Schumacher, Michael Bucher, Sybille Albertin, Thomas M. Coffman, William J. Arendshorst, and Armin Kurtz. “Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.” Pflugers Arch 447, no. 2 (November 2003): 214–22. https://doi.org/10.1007/s00424-003-1157-1.
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  - Le, Thu H., Hyung-Suk Kim, Andrew M. Allen, Robert F. Spurney, Oliver Smithies, and Thomas M. Coffman. “Physiological impact of increased expression of the AT1 angiotensin receptor.” Hypertension 42, no. 4 (October 2003): 507–14. https://doi.org/10.1161/01.HYP.0000092000.07559.57.
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  - Robinson, Lisa A., Chandra Nataraj, Dennis W. Thomas, Josette M. Cosby, Robert Griffiths, Victoria L. Bautch, Dhavalkumar D. Patel, and Thomas M. Coffman. “The chemokine CX3CL1 regulates NK cell activity in vivo.” Cell Immunol 225, no. 2 (October 2003): 122–30. https://doi.org/10.1016/j.cellimm.2003.09.010.
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  - Rocha, Paulo N., Troy J. Plumb, and Thomas M. Coffman. “Eicosanoids: lipid mediators of inflammation in transplantation.” Springer Semin Immunopathol 25, no. 2 (September 2003): 215–27. https://doi.org/10.1007/s00281-003-0132-4.
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  - Tharaux, Pierre-Louis, Richard C. Bukoski, Paulo N. Rocha, Steven D. Crowley, Phillip Ruiz, Chandra Nataraj, David N. Howell, Kozo Kaibuchi, Robert F. Spurney, and Thomas M. Coffman. “Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells.” J Immunol 171, no. 1 (July 1, 2003): 96–105. https://doi.org/10.4049/jimmunol.171.1.96.
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  - Wurth, Gene R., Judy H. Sherr, and Thomas M. Coffman. “Orthopaedic research and education foundation and industry.” Clin Orthop Relat Res, no. 412 (July 2003): 54–56. https://doi.org/10.1097/01.blo.0000074404.99625.bc.
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  - Cho, Moon J., Junling Liu, Tamara I. Pestina, Shirley A. Steward, Dennis W. Thomas, Thomas M. Coffman, Demin Wang, Carl W. Jackson, and T Kent Gartner. “The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.” Blood 101, no. 7 (April 1, 2003): 2646–51. https://doi.org/10.1182/blood-2002-05-1363.
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  - Harrison-Bernard, L. M., A. K. Cook, M. I. Oliverio, and T. M. Coffman. “Renal segmental microvascular responses to ANG II in AT1A receptor null mice.” American Journal of Physiology Renal Physiology 284, no. 3 53-3 (March 1, 2003).
  - Harrison-Bernard, Lisa M., Anthony K. Cook, Michael I. Oliverio, and Thomas M. Coffman. “Renal segmental microvascular responses to ANG II in AT1A receptor null mice.” Am J Physiol Renal Physiol 284, no. 3 (March 2003): F538–45. https://doi.org/10.1152/ajprenal.00340.2002.
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  - Flamant, Martin, Pierre-Louis Tharaux, Sandrine Placier, Daniel Henrion, Tom Coffman, Christos Chatziantoniou, and Jean-Claude Dussaule. “Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.” Faseb J 17, no. 2 (February 2003): 327–29. https://doi.org/10.1096/fj.02-0115fje.
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  - Le, Thu H., and Thomas M. Coffman. “RGS2: a "turn-off" in hypertension.” J Clin Invest 111, no. 4 (February 2003): 441–43. https://doi.org/10.1172/JCI17836.
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  - June Brickey, W., Nathan J. Felix, Robert Griffiths, Jinghua Zhang, Bo Wang, Janet F. Piskurich, Yoshie Itoh-Lindstrom, Thomas M. Coffman, and Jenny P-Y Ting. “Prolonged survival of class II transactivator-deficient cardiac allografts.” Transplantation 74, no. 9 (November 15, 2002): 1341–48. https://doi.org/10.1097/00007890-200211150-00024.
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  - Cervenka, Ludek, Vladislav Horácek, Ivana Vanecková, Jaroslav A. Hubácek, Michael I. Oliverio, Thomas M. Coffman, and L Gabriel Navar. “Essential role of AT1A receptor in the development of 2K1C hypertension.” Hypertension 40, no. 5 (November 2002): 735–41. https://doi.org/10.1161/01.hyp.0000036452.28493.74.
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  - Nguyen, MyTrang, Michael Solle, Laurent P. Audoly, Stephen L. Tilley, Jeffrey L. Stock, John D. McNeish, Thomas M. Coffman, David Dombrowicz, and Beverly H. Koller. “Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production.” J Immunol 169, no. 8 (October 15, 2002): 4586–93. https://doi.org/10.4049/jimmunol.169.8.4586.
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  - Bostom, Andrew D., Robert S. Brown, Blanche M. Chavers, Thomas M. Coffman, Fernando G. Cosio, Kenneth Culver, John J. Curtis, et al. “Prevention of post-transplant cardiovascular disease--report and recommendations of an ad hoc group.” Am J Transplant 2, no. 6 (July 2002): 491–500. https://doi.org/10.1034/j.1600-6143.2002.20602.x.
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  - Hunkeler, John D., Tom M. Coffman, Jerry Paugh, Alan Lang, Pamela Smith, and Nicholas Tarantino. “Characterization of visual phenomena with the Array multifocal intraocular lens.” J Cataract Refract Surg 28, no. 7 (July 2002): 1195–1204. https://doi.org/10.1016/s0886-3350(02)01208-7.
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  - Mannon, Roslyn B., Robert Griffiths, Phillip Ruiz, Jeffrey L. Platt, and Thomas M. Coffman. “Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection.” Kidney Int 62, no. 1 (July 2002): 290–300. https://doi.org/10.1046/j.1523-1755.2002.00422.x.
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  - Cheng, Yan, Sandra C. Austin, Bianca Rocca, Beverly H. Koller, Thomas M. Coffman, Tilo Grosser, John A. Lawson, and Garret A. FitzGerald. “Role of prostacyclin in the cardiovascular response to thromboxane A2.” Science 296, no. 5567 (April 19, 2002): 539–41. https://doi.org/10.1126/science.1068711.
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  - Coffman, Thomas M. “Another cystic mystery solved.” Nature Genetics 30, no. 3 (March 2002): 247–48. https://doi.org/10.1038/ng0302-247.
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  - Brooks, H. L., A. J. Allred, K. T. Beutler, T. M. Coffman, and M. A. Knepper. “Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice.” Hypertension 39, no. 2 Pt 2 (February 2002): 470–73.
  - Brooks, Heddwen L., Alicia J. Allred, Kathleen T. Beutler, Thomas M. Coffman, and Mark A. Knepper. “Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice.” Hypertension 39, no. 2 Pt 2 (February 2002): 470–73. https://doi.org/10.1161/hy02t2.102959.
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  - Coggins, Kenneth G., Ann Latour, Mytrang S. Nguyen, Laurent Audoly, Thomas M. Coffman, and Beverly H. Koller. “Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.” Nat Med 8, no. 2 (February 2002): 91–92. https://doi.org/10.1038/nm0202-91.
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  - Gurley, S. B., T. H. Le, and T. M. Coffman. “Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease.” Cold Spring Harb Symp Quant Biol 67 (2002): 451–57. https://doi.org/10.1101/sqb.2002.67.451.
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  - Athirakul, K., H. S. Kim, L. P. Audoly, O. Smithies, and T. M. Coffman. “Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition.” Kidney Int 60, no. 6 (December 2001): 2324–29. https://doi.org/10.1046/j.1523-1755.2001.00072.x.
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  - Goulet, J. L., R. C. Griffiths, P. Ruiz, R. B. Mannon, P. Flannery, J. L. Platt, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.” J Immunol 167, no. 11 (December 1, 2001): 6631–36. https://doi.org/10.4049/jimmunol.167.11.6631.
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  - Mistlberger, R. E., M. C. Antle, M. I. Oliverio, T. M. Coffman, and M. Morris. “Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors.” Physiol Behav 74, no. 4–5 (November 2001): 457–64. https://doi.org/10.1016/s0031-9384(01)00591-1.
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  - Nataraj, C., D. W. Thomas, S. L. Tilley, M. T. Nguyen, R. Mannon, B. H. Koller, and T. M. Coffman. “Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse.” J Clin Invest 108, no. 8 (October 2001): 1229–35. https://doi.org/10.1172/JCI13640.
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  - Tilley, S. L., T. M. Coffman, and B. H. Koller. “Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.” J Clin Invest 108, no. 1 (July 2001): 15–23. https://doi.org/10.1172/JCI13416.
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  - Kelly, S. J., M. Delnomdedieu, M. I. Oliverio, L. D. Williams, M. G. Saifer, M. R. Sherman, T. M. Coffman, G. A. Johnson, and M. S. Hershfield. “Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.” J Am Soc Nephrol 12, no. 5 (May 2001): 1001–9.
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  - Morris, M., S. Means, M. I. Oliverio, and T. M. Coffman. “Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors.” Am J Physiol Regul Integr Comp Physiol 280, no. 4 (April 2001): R1177–84. https://doi.org/10.1152/ajpregu.2001.280.4.R1177.
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  - Coffman, Thomas M., Laurent P. Audoly, and Michael I. Oliverio. “Review: Gene targeting studies of angiotensin II type 1 (AT1) receptors.” J Renin Angiotensin Aldosterone Syst 2, no. 1_suppl (March 2001): S10–15. https://doi.org/10.1177/14703203010020010201.
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  - Fabre, J. E., M. Nguyen, K. Athirakul, K. Coggins, J. D. McNeish, S. Austin, L. K. Parise, G. A. FitzGerald, T. M. Coffman, and B. H. Koller. “Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation.” J Clin Invest 107, no. 5 (March 2001): 603–10. https://doi.org/10.1172/JCI10881.
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  - Stock, J. L., K. Shinjo, J. Burkhardt, M. Roach, K. Taniguchi, T. Ishikawa, H. S. Kim, et al. “The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.” J Clin Invest 107, no. 3 (February 2001): 325–31. https://doi.org/10.1172/JCI6749.
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  - Audoly, L. P., X. Ruan, V. A. Wagner, J. L. Goulet, S. L. Tilley, B. H. Koller, T. M. Coffman, and W. J. Arendshorst. “Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics.” Am J Physiol Heart Circ Physiol 280, no. 1 (January 2001): H327–33. https://doi.org/10.1152/ajpheart.2001.280.1.H327.
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  - Audoly, L. P., X. Ruan, V. A. Wagner, J. L. Goulet, S. L. Tilley, B. H. Koller, T. M. Coffman, and W. J. Arendshorst. “Role of EP₂ and EP₃ PGE₂ receptors in control of murine renal hemodynamics.” American Journal of Physiology Heart and Circulatory Physiology 280, no. 1 49-1 (2001): H327–33.
  - Audoly, L. P., X. Ruan, V. A. Wagner, J. L. Goulet, S. L. Tilley, B. H. Koller, T. M. Coffman, and W. J. Arendshorst. “Role of EP2 and EP3 PGE2 receptors in control of murine renal hemodynamics.” American Journal of Physiology Heart and Circulatory Physiology 280, no. 1 49-1 (January 1, 2001). https://doi.org/10.1152/ajpheart.2001.280.1.h327.
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  - Morris, M., S. Means, M. I. Oliverio, and T. M. Coffman. “Enhanced central response to dehydration in mice lacking angiotensin AT1a receptors.” American Journal of Physiology Regulatory Integrative and Comparative Physiology 280, no. 4 49-4 (January 1, 2001). https://doi.org/10.1152/ajpregu.2001.280.4.r1177.
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  - Tharaux, P. L., and T. M. Coffman. “Transgenic mice as a tool to study the renin-angiotensin system.” Contrib Nephrol, no. 135 (2001): 72–91. https://doi.org/10.1159/000060158.
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  - Robinson, L. A., C. Nataraj, D. W. Thomas, D. N. Howell, R. Griffiths, V. Bautch, D. D. Patel, L. Feng, and T. M. Coffman. “A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection.” J Immunol 165, no. 11 (December 1, 2000): 6067–72. https://doi.org/10.4049/jimmunol.165.11.6067.
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  - Audoly, L. P., M. I. Oliverio, and T. M. Coffman. “Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.” Trends Endocrinol Metab 11, no. 7 (September 2000): 263–69. https://doi.org/10.1016/s1043-2760(00)00279-4.
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  - Morrissey, J. J. “Angiotensin II: an immune costimulator?” Am J Kidney Dis 36, no. 2 (August 2000): 434–40. https://doi.org/10.1053/ajkd.2000.9000.
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  - Oliverio, Michael I., and Thomas M. Coffman. “Angiotensin II Receptor Physiology Using Gene Targeting.” News Physiol Sci 15 (August 2000): 171–75. https://doi.org/10.1152/physiologyonline.2000.15.4.171.
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  - Felix, N. J., W. J. Brickey, R. Griffiths, J. Zhang, L. Van Kaer, T. Coffman, and J. P. Ting. “H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.” J Exp Med 192, no. 1 (July 3, 2000): 31–40. https://doi.org/10.1084/jem.192.1.31.
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  - Davisson, R. L., M. I. Oliverio, T. M. Coffman, and C. D. Sigmund. “Divergent functions of angiotensin II receptor isoforms in the brain.” J Clin Invest 106, no. 1 (July 2000): 103–6. https://doi.org/10.1172/JCI10022.
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  - Audoly, L. P., B. Rocca, J. E. Fabre, B. H. Koller, D. Thomas, A. L. Loeb, T. M. Coffman, and G. A. FitzGerald. “Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.” Circulation 101, no. 24 (June 20, 2000): 2833–40. https://doi.org/10.1161/01.cir.101.24.2833.
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  - Butterly, D. W., R. F. Spurney, P. Ruiz, R. Griffiths, C. Albrightson, and T. M. Coffman. “A role for leukotrienes in cyclosporine nephrotoxicity.” Kidney Int 57, no. 6 (June 2000): 2586–93. https://doi.org/10.1046/j.1523-1755.2000.00118.x.
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  - Mannon, R. B., C. Doyle, R. Griffiths, M. Bustos, J. L. Platt, and T. M. Coffman. “Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts.” Transplantation 69, no. 10 (May 27, 2000): 2137–43. https://doi.org/10.1097/00007890-200005270-00031.
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  - Audoly, L. P., T. H. Le, and T. M. Coffman. “What can knockout mice contribute to an understanding of hypertension?” Curr Hypertens Rep 2, no. 2 (April 2000): 192–97. https://doi.org/10.1007/s11906-000-0081-4.
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  - Oliverio, M. I., C. F. Best, O. Smithies, and T. M. Coffman. “Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II.” Hypertension 35, no. 2 (February 2000): 550–54. https://doi.org/10.1161/01.hyp.35.2.550.
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  - Pace, A. J., E. Lee, K. Athirakul, T. M. Coffman, D. A. O’Brien, and B. H. Koller. “Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter.” J Clin Invest 105, no. 4 (February 2000): 441–50. https://doi.org/10.1172/JCI8553.
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  - Oliverio, M. I., M. Delnomdedieu, C. F. Best, P. Li, M. Morris, M. F. Callahan, G. A. Johnson, O. Smithies, and T. M. Coffman. “Abnormal water metabolism in mice lacking the type 1A receptor for ANG II.” Am J Physiol Renal Physiol 278, no. 1 (January 2000): F75–82. https://doi.org/10.1152/ajprenal.2000.278.1.F75.
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  - Oliverio, M. I., M. Delnomdedieu, C. F. Best, P. Li, M. Morris, M. F. Callahan, G. A. Johnson, O. Smithies, and T. M. Coffman. “Abnormal water metabolism in mice lacking the type 1A receptor for ANG II.” American Journal of Physiology Renal Physiology 278, no. 1 47-1 (January 1, 2000).
  - Schnermann, J., T. Traynor, H. Pohl, D. W. Thomas, T. M. Coffman, and J. P. Briggs. “Vasoconstrictor responses in thromboxane receptor knockout mice: tubuloglomerular feedback and ureteral obstruction.” Acta Physiol Scand 168, no. 1 (January 2000): 201–7. https://doi.org/10.1046/j.1365-201x.2000.00641.x.
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  - Cervenka, L., K. D. Mitchell, M. I. Oliverio, T. M. Coffman, and L. Gabriel Navar. “Renal function in the at1A receptor knockout mouse during normal and volume-expanded conditions.” Kidney International 56, no. 5 (December 1, 1999): 1846–54.
  - Nataraj, C., M. I. Oliverio, R. B. Mannon, P. J. Mannon, L. P. Audoly, C. S. Amuchastegui, P. Ruiz, O. Smithies, and T. M. Coffman. “Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway.” J Clin Invest 104, no. 12 (December 1999): 1693–1701. https://doi.org/10.1172/JCI7451.
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  - Ruan, X., M. I. Oliverio, T. M. Coffman, and W. J. Arendshorst. “Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT1A receptor null mice.” J Am Soc Nephrol 10, no. 12 (December 1999): 2620–30.
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  - Cervenka, L., K. D. Mitchell, M. I. Oliverio, T. M. Coffman, and L. G. Navar. “Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions.” Kidney Int 56, no. 5 (November 1999): 1855–62. https://doi.org/10.1046/j.1523-1755.1999.00757.x.
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  - Fabre, J. E., M. Nguyen, A. Latour, J. A. Keifer, L. P. Audoly, T. M. Coffman, and B. H. Koller. “Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.” Nat Med 5, no. 10 (October 1999): 1199–1202. https://doi.org/10.1038/13522.
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  - Neylan, J. F., M. H. Sayegh, T. M. Coffman, G. M. Danovitch, A. M. Krensky, T. B. Strom, L. A. Turka, and W. E. Harmon. “The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology.” Journal of the American Society of Nephrology : Jasn 10, no. 10 (October 1999): 2237–43.
  - Neylan, J. F., M. H. Sayegh, T. M. Coffman, G. M. Danovitch, A. M. Krensky, T. B. Strom, L. A. Turka, and W. E. Harmon. “The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology.” J Am Soc Nephrol 10, no. 10 (October 1999): 2237–43.
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  - Audoly, L. P., S. L. Tilley, J. Goulet, M. Key, M. Nguyen, J. L. Stock, J. D. McNeish, B. H. Koller, and T. M. Coffman. “Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.” Am J Physiol 277, no. 3 (September 1999): H924–30. https://doi.org/10.1152/ajpheart.1999.277.3.H924.
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  - Audoly, L. P., S. L. Tilley, J. Goulet, M. Key, M. Nguyen, J. L. Stock, J. D. McNeish, B. H. Koller, and T. M. Coffman. “Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.” American Journal of Physiology Heart and Circulatory Physiology 277, no. 3 46-3 (September 1, 1999).
  - Mannon, R. B., K. Roberts, P. Ruiz, V. Laubach, and T. M. Coffman. “Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection.” J Heart Lung Transplant 18, no. 9 (September 1999): 819–27. https://doi.org/10.1016/s1053-2498(99)00052-2.
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  - Goulet, J. L., R. C. Griffiths, P. Ruiz, R. F. Spurney, D. S. Pisetsky, B. H. Koller, and T. M. Coffman. “Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.” J Immunol 163, no. 1 (July 1, 1999): 359–66.
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  - Le, T. H., and T. M. Coffman. “Genetic manipulation of the renin-angiotensin system.” Curr Opin Nephrol Hypertens 8, no. 4 (July 1999): 397–403. https://doi.org/10.1097/00041552-199907000-00001.
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  - Mannon, R. B., and T. M. Coffman. “Gene targeting: applications in transplantation research.” Kidney Int 56, no. 1 (July 1999): 18–27. https://doi.org/10.1046/j.1523-1755.1999.00513.x.
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  - Tilley, S. L., L. P. Audoly, E. H. Hicks, H. S. Kim, P. J. Flannery, T. M. Coffman, and B. H. Koller. “Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor.” J Clin Invest 103, no. 11 (June 1999): 1539–45. https://doi.org/10.1172/JCI6579.
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  - Mannon, R. B., J. B. Kopp, P. Ruiz, R. Griffiths, M. Bustos, J. L. Platt, P. E. Klotman, and T. M. Coffman. “Chronic rejection of mouse kidney allografts.” Kidney Int 55, no. 5 (May 1999): 1935–44. https://doi.org/10.1046/j.1523-1755.1999.00423.x.
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  - Wada, T., A. Schwarting, K. Kinoshita, T. Naito, R. C. Griffiths, T. M. Coffman, and V. R. Kelley. “Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice.” Kidney Int 55, no. 3 (March 1999): 841–51. https://doi.org/10.1046/j.1523-1755.1999.055003841.x.
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  - Morris, M., P. Li, M. F. Callahan, M. I. Oliverio, T. M. Coffman, S. M. Bosch, and D. I. Diz. “Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.” Hypertension 33, no. 1 Pt 2 (January 1999): 482–86.
  - Morris, M., P. Li, M. F. Callahan, M. I. Oliverio, T. M. Coffman, S. M. Bosch, and D. I. Diz. “Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.” Hypertension 33, no. 1 II (January 1, 1999): 482–86. https://doi.org/10.1161/01.hyp.33.1.482.
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  - Ruan, X., K. E. Purdy, M. I. Oliverio, T. M. Coffman, and W. J. Arendshorst. “Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice.” J Am Soc Nephrol 10 Suppl 11 (January 1999): S202–7.
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  - Oliverio, M. I., H. S. Kim, M. Ito, T. Le, L. Audoly, C. F. Best, S. Hiller, et al. “Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II.” Proc Natl Acad Sci U S A 95, no. 26 (December 22, 1998): 15496–501. https://doi.org/10.1073/pnas.95.26.15496.
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  - Fleming, E. F., K. Athirakul, M. I. Oliverio, M. Key, J. Goulet, B. H. Koller, and T. M. Coffman. “Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2.” The American Journal of Physiology 275, no. 6 Pt 2 (December 1998): F955–61.
  - Thomas, D. W., R. B. Mannon, P. J. Mannon, A. Latour, J. A. Oliver, M. Hoffman, O. Smithies, B. H. Koller, and T. M. Coffman. “Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.” J Clin Invest 102, no. 11 (December 1, 1998): 1994–2001. https://doi.org/10.1172/JCI5116.
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  - Traynor, T., T. Yang, Y. G. Huang, L. Arend, M. I. Oliverio, T. Coffman, J. P. Briggs, and J. Schnermann. “Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice.” Am J Physiol 275, no. 6 (December 1998): F922–27. https://doi.org/10.1152/ajprenal.1998.275.6.F922.
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  - Neuringer, I. P., R. B. Mannon, T. M. Coffman, M. Parsons, K. Burns, J. R. Yankaskas, and R. M. Aris. “Immune cells in a mouse airway model of obliterative bronchiolitis.” Am J Respir Cell Mol Biol 19, no. 3 (September 1998): 379–86. https://doi.org/10.1165/ajrcmb.19.3.3023m.
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  - Thomas, D. W., and T. M. Coffman. “A genetic approach for studying the role of thromboxane A2 in the kidney.” Kidney Int Suppl 67 (September 1998): S84–87. https://doi.org/10.1046/j.1523-1755.1998.06717.x.
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  - Coffman, T. M., R. F. Spurney, R. B. Mannon, and R. Levenson. “Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells.” American Journal of Physiology Renal Physiology 275, no. 2 44-2 (August 1, 1998).
  - Mannon, R. B., B. L. Kotzin, C. Nataraj, K. Ferri, E. Roper, R. J. Kurlander, and T. M. Coffman. “Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts.” J Clin Invest 101, no. 11 (June 1, 1998): 2517–27. https://doi.org/10.1172/JCI1229.
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  - Zhu, Z., S. H. Zhang, C. Wagner, A. Kurtz, N. Maeda, T. Coffman, and W. J. Arendshorst. “Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice.” Hypertension 31, no. 5 (May 1998): 1171–77. https://doi.org/10.1161/01.hyp.31.5.1171.
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  - Hamawaki, M., T. M. Coffman, A. Lashus, M. Koide, M. R. Zile, M. I. Oliverio, G. DeFreyte, G. Cooper, and B. A. Carabello. “Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.” The American Journal of Physiology 274, no. 3 Pt 2 (March 1998): H868–73.
  - Hamawaki, M., T. M. Coffman, A. Lashus, M. Koide, M. R. Zile, M. I. Oliverio, G. DeFreyte, G. Cooper, and B. A. Carabello. “Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors.” Am J Physiol 274, no. 3 (March 1998): H868–73. https://doi.org/10.1152/ajpheart.1998.274.3.H868.
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  - Coffman, T. M. “Gene targeting in physiological investigations: Studies of the renin- angiotensin system.” American Journal of Physiology Renal Physiology 274, no. 6 43-6 (January 1, 1998). https://doi.org/10.1152/ajprenal.1998.274.6.f999.
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  - Davisson, R. L., T. G. Beltz, M. I. Oliverio, A. K. Johnson, T. M. Coffman, and C. D. Sigmund. “Functional separation of brain AT1A and AT1B receptors in AT1A knockout mice.” Faseb Journal 12, no. 4 (1998): A52.
  - Morris, M., P. Li, M. F. Callahan, S. M. Bosch, T. M. Coffman, M. I. Oliverio, and D. I. Diz. “Effect of dehydration on angiotensin receptors in the AT-1a knockout mouse.” Faseb Journal 12, no. 4 (1998): A325.
  - Oliverio, M. I., K. Madsen, C. F. Best, M. Ito, N. Maeda, O. Smithies, and T. M. Coffman. “Renal growth and development in mice lacking AT1A receptors for angiotensin II.” Am J Physiol 274, no. 1 (January 1998): F43–50. https://doi.org/10.1152/ajprenal.1998.274.1.F43.
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  - Oliverio, M. I., K. Madsen, C. F. Best, M. Ito, N. Maeda, O. Smithies, and T. M. Coffman. “Renal growth and development in mice lacking AT(1A) receptors for angiotensin II.” American Journal of Physiology Renal Physiology 274, no. 1 43-1 (January 1, 1998).
  - Ruan, X., M. I. Oliverio, T. Coffman, and W. J. Arendshorst. “Angiotensin II causes renal vasoconstriction in mice with AT_1A receptor deleted by gene targeting.” Faseb Journal 12, no. 4 (1998).
  - Traynor, T., T. Yang, Y. G. Huang, L. Arend, M. I. Oliverio, T. Coffman, J. P. Briggs, and J. B. Schnermann. “Inhibition of adenosine₁ receptor-mediated glomerular vasoconstriction in AT_1A-receptor deficient mice.” Faseb Journal 12, no. 4 (1998): A331.
  - Coffman, T. M. “A role for T cell co-stimulation in ischemic acute renal failure?” Kidney Int 52, no. 6 (December 1997): 1706–7. https://doi.org/10.1038/ki.1997.507.
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  - Li, P., M. F. Callahan, T. M. Coffman, M. I. Oliverio, and M. Morris. “Altered vasopressin axis in the AT-1a knockout mouse.” Faseb Journal 11, no. 3 (December 1, 1997).
  - Oliverio, M. I., C. F. Best, H. S. Kim, W. J. Arendshorst, O. Smithies, and T. M. Coffman. “Angiotensin II responses in at 1A receptor-deficient mice: A role for at 1B receptors in blood pressure regulation.” American Journal of Physiology 272, no. 4 PART 2 (December 1, 1997).
  - Nguyen, M., T. Camenisch, J. N. Snouwaert, E. Hicks, T. M. Coffman, P. A. Anderson, N. N. Malouf, and B. H. Koller. “The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.” Nature 390, no. 6655 (November 6, 1997): 78–81. https://doi.org/10.1038/36342.
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  - Spurney, R. F., and T. M. Coffman. “The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line.” J Pharmacol Exp Ther 283, no. 1 (October 1997): 207–15.
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  - Wada, T., T. Naito, R. C. Griffiths, T. M. Coffman, and V. R. Kelley. “Systemic autoimmune nephritogenic components induce CSF-1 and TNF-alpha in MRL kidneys.” Kidney Int 52, no. 4 (October 1997): 934–41. https://doi.org/10.1038/ki.1997.415.
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  - Bustos, M., T. M. Coffman, S. Saadi, and J. L. Platt. “Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.” J Clin Invest 100, no. 5 (September 1, 1997): 1150–58. https://doi.org/10.1172/JCI119626.
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  - Coffman, T. M. “A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor.” Semin Nephrol 17, no. 5 (September 1997): 404–11.
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  - Schnermann, J. B., T. Traynor, T. Yang, Y. G. Huang, M. I. Oliverio, T. Coffman, and J. P. Briggs. “Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice.” Am J Physiol 273, no. 2 Pt 2 (August 1997): F315–20. https://doi.org/10.1152/ajprenal.1997.273.2.F315.
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  - Bruggeman, L. A., S. Dikman, C. Meng, S. E. Quaggin, T. M. Coffman, and P. E. Klotman. “Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression.” J Clin Invest 100, no. 1 (July 1, 1997): 84–92. https://doi.org/10.1172/JCI119525.
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  - Oliverio, M. I., C. F. Best, H. S. Kim, W. J. Arendshorst, O. Smithies, and T. M. Coffman. “Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation.” Am J Physiol 272, no. 4 Pt 2 (April 1997): F515–20. https://doi.org/10.1152/ajprenal.1997.272.4.F515.
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  - Shellhaas, C. S., T. Coffman, P. J. Dargie, A. P. Killam, and H. H. Kay. “Intravillous eicosanoid compartmentalization and regulation of placental blood flow.” J Soc Gynecol Investig 4, no. 2 (March 1997): 58–63.
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  - Oliverio, M. I., C. F. Best, H. S. Kim, W. J. Arendshorst, O. Smithies, and T. M. Coffman. “Angiotensin II responses in AT(1a) receptor-deficient mice: A role for AT(1B) receptors in blood pressure regulation.” American Journal of Physiology Renal Physiology 272, no. 4 41-4 (January 1, 1997). https://doi.org/10.1152/ajprenal.1997.272.4.f515.
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  - Oliverio, M. I., and T. M. Coffman. “Angiotensin-II-receptors: new targets for antihypertensive therapy.” Clin Cardiol 20, no. 1 (January 1997): 3–6. https://doi.org/10.1002/clc.4960200103.
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  - Mannon, R. B., T. M. Coffman, and P. J. Mannon. “Distribution of binding sites for thromboxane A2 in the mouse kidney.” Am J Physiol 271, no. 6 Pt 2 (December 1996): F1131–38. https://doi.org/10.1152/ajprenal.1996.271.6.F1131.
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  - Mannon, R. B., B. L. Kotzin, E. Roper, C. Nataraj, R. J. Kurlander, and T. M. Coffman. “The intragraft CD8+ T cell response in renal allograft rejection in the mouse.” Transplantation 62, no. 1 (July 15, 1996): 96–104. https://doi.org/10.1097/00007890-199607150-00019.
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  - Mannon, R. B., T. M. Coffman, and P. J. Mannon. “Distribution of binding sites for thromboxane a2 in the mouse kidney.” American Journal of Physiology 271, no. 6 PART 2 (January 1, 1996). https://doi.org/10.1152/ajprenal.1996.271.6.f1131.
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  - Naito, T., R. C. Griffiths, T. M. Coffman, and V. R. Kelley. “Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice.” Kidney Int 49, no. 1 (January 1996): 67–74. https://doi.org/10.1038/ki.1996.9.
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  - Burdmann, E. A., T. F. Andoh, C. C. Nast, A. Evan, B. A. Connors, T. M. Coffman, J. Lindsley, and W. M. Bennett. “Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.” The American Journal of Physiology 269, no. 4 Pt 2 (October 1995): F491–99.
  - Burdmann, E. A., T. F. Andoh, C. C. Nast, A. Evan, B. A. Connors, T. M. Coffman, J. Lindsley, and W. M. Bennett. “Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.” Am J Physiol 269, no. 4 Pt 2 (October 1995): F491–99. https://doi.org/10.1152/ajprenal.1995.269.4.F491.
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  - Cook, D. N., M. A. Beck, T. M. Coffman, S. L. Kirby, J. F. Sheridan, I. B. Pragnell, and O. Smithies. “Requirement of MIP-1 alpha for an inflammatory response to viral infection.” Science 269, no. 5230 (September 15, 1995): 1583–85. https://doi.org/10.1126/science.7667639.
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  - McCoy, M. C., Y. Wang, T. M. Coffman, A. P. Killam, and H. H. Kay. “Effects of low-dose aspirin therapy on plasma levels of polyunsaturated fatty acids: a preliminary investigation.” Am J Perinatol 12, no. 5 (September 1995): 371–74. https://doi.org/10.1055/s-2007-994499.
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  - Smith, S. R., S. A. Minda, G. P. Samsa, F. E. Harrell, J. C. Gunnells, T. M. Coffman, and D. W. Butterly. “Late withdrawal of cyclosporine in stable renal transplant recipients.” Am J Kidney Dis 26, no. 3 (September 1995): 487–94. https://doi.org/10.1016/0272-6386(95)90495-6.
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  - Butterly, D. W., R. F. Spurney, P. Ruiz, E. Pirotzky, P. Braquet, and T. M. Coffman. “Role of platelet activating factor in kidney transplant rejection in the rat.” Kidney Int 48, no. 2 (August 1995): 337–43. https://doi.org/10.1038/ki.1995.301.
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  - Kooyman, D. L., G. W. Byrne, S. McClellan, D. Nielsen, M. Tone, H. Waldmann, T. M. Coffman, K. R. McCurry, J. L. Platt, and J. S. Logan. “In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.” Science 269, no. 5220 (July 7, 1995): 89–92. https://doi.org/10.1126/science.7541557.
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  - Rappaport, J., B. Hanss, J. B. Kopp, T. D. Copeland, L. A. Bruggeman, T. M. Coffman, and P. E. Klotman. “Transport of phosphorothioate oligonucleotides in kidney: implications for molecular therapy.” Kidney Int 47, no. 5 (May 1995): 1462–69. https://doi.org/10.1038/ki.1995.205.
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  - Ito, M., M. I. Oliverio, P. J. Mannon, C. F. Best, N. Maeda, O. Smithies, and T. M. Coffman. “Regulation of blood pressure by the type 1A angiotensin II receptor gene.” Proc Natl Acad Sci U S A 92, no. 8 (April 11, 1995): 3521–25. https://doi.org/10.1073/pnas.92.8.3521.
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  - Kim, H. S., J. H. Krege, K. D. Kluckman, J. R. Hagaman, J. B. Hodgin, C. F. Best, J. C. Jennette, T. M. Coffman, N. Maeda, and O. Smithies. “Genetic control of blood pressure and the angiotensinogen locus.” Proc Natl Acad Sci U S A 92, no. 7 (March 28, 1995): 2735–39. https://doi.org/10.1073/pnas.92.7.2735.
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  - Mannon, R. B., C. Nataraj, B. L. Kotzin, R. Griffiths, S. Geier, S. Ibrahim, F. P. Sanfilippo, J. L. Platt, R. Kurlander, and T. M. Coffman. “Rejection of kidney allografts by MHC class I-deficient mice.” Transplantation 59, no. 5 (March 15, 1995): 746–55. https://doi.org/10.1097/00007890-199503150-00019.
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  - Goulet, J. L., J. N. Snouwaert, A. M. Latour, T. M. Coffman, and B. H. Koller. “Altered inflammatory responses in leukotriene-deficient mice.” Proc Natl Acad Sci U S A 91, no. 26 (December 20, 1994): 12852–56. https://doi.org/10.1073/pnas.91.26.12852.
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  - Spurney, R. F., P. Ruiz, C. R. Albrightson, D. S. Pisetsky, and T. M. Coffman. “Fish oil feeding modulates leukotriene production in murine lupus nephritis.” Prostaglandins 48, no. 5 (November 1994): 331–48. https://doi.org/10.1016/0090-6980(94)90032-9.
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  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am J Physiol 267, no. 3 Pt 2 (September 1994): F467–78. https://doi.org/10.1152/ajprenal.1994.267.3.F467.
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  - Kooyman, D., G. Byrne, S. McClellan, D. Nielsen, D. Kagan, T. Coffman, T. Masahide, H. Waldmann, J. Platt, and J. Logan. “Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells.” Transplant Proc 26, no. 3 (June 1994): 1241.
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  - Spurney, R. F., S. Ibrahim, D. Butterly, P. E. Klotman, F. Sanfilippo, and T. M. Coffman. “Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury.” J Immunol 152, no. 2 (January 15, 1994): 867–76.
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  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” Am.J.Physiol. 267, no. 3 part 2 (January 1, 1994).
  - Spurney, R. F., J. P. Middleton, J. R. Raymond, and T. M. Coffman. “Modulation of thromboxane receptor activation in rat glomerular mesangial cells.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 267, no. 3 36-3 (January 1, 1994). https://doi.org/10.1152/ajprenal.1994.267.3.f467.
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  - Smith, S. R., V. B. Kubacki, A. Rakhit, L. L. Martin, A. V. Schaffer, M. K. Jasani, D. J. Hefty, T. Johnston, C. Cannon, and W. M. Bennett. “Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity.” Transplantation 56, no. 6 (December 1993): 1422–26. https://doi.org/10.1097/00007890-199312000-00029.
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  - Mannon, R. B., S. K. Sundar, F. P. Sanfilippo, and T. M. Coffman. “Alterations in renal interleukin-1 production during kidney transplant rejection in the rat. The effects of high-dose methylprednisolone.” Transplantation 56, no. 5 (November 1993): 1157–62. https://doi.org/10.1097/00007890-199311000-00021.
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  - Smith, S. R., T. M. Coffman, and L. P. Svetkey. “Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril.” J Am Soc Nephrol 4, no. 5 (November 1993): 1133–39.
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  - Coffman, T., S. Geier, S. Ibrahim, R. Griffiths, R. Spurney, O. Smithies, B. Koller, and F. Sanfilippo. “Improved renal function in mouse kidney allografts lacking MHC class I antigens.” J Immunol 151, no. 1 (July 1, 1993): 425–35.
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  - Jevnikar, A. M., G. G. Singer, T. Coffman, L. H. Glimcher, and V. E. Kelley. “Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury.” J Am Soc Nephrol 3, no. 12 (June 1993): 1972–77.
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  - Munger, K. A., T. M. Coffman, R. C. Griffiths, A. Fogo, and K. F. Badr. “The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney.” Transplantation 55, no. 6 (June 1993): 1219–24. https://doi.org/10.1097/00007890-199306000-00003.
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  - Fan, P. Y., C. R. Albrightson, D. N. Howell, C. Best, A. M. Badger, and T. M. Coffman. “The azaspirane SKF 105685 ameliorates renal allograft rejection in rats.” J Am Soc Nephrol 3, no. 10 (April 1993): 1680–85.
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  - Jevnikar, A. M., G. G. Singer, T. Coffman, L. H. Glimcher, and V. E. Kelley. “Renal tubular cell expression of MHC class II (I-Eb) is insufficient to initiate immune injury in a transgenic kidney transplant model.” Transplant Proc 25, no. 1 Pt 1 (February 1993): 142–43.
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  - Spurney, R. F., J. J. Onorato, F. J. Albers, and T. M. Coffman. “Thromboxane binding and signal transduction in rat glomerular mesangial cells.” Am J Physiol 264, no. 2 Pt 2 (February 1993): F292–99. https://doi.org/10.1152/ajprenal.1993.264.2.F292.
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  - Spurney, R. F., J. J. Onorato, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Characterization of glomerular thromboxane receptors in murine lupus nephritis.” J Pharmacol Exp Ther 264, no. 2 (February 1993): 584–90.
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  - Spurney, R. F., J. J. Onorato, F. J. Albers, and T. M. Coffman. “Thromboxane binding and signal transduction in rat glomerular mesangial cells.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 264, no. 2 33-2 (January 1, 1993).
  - Chouinard, M. L., L. L. Martin, T. Coffman, B. H. Hamilton, L. F. Linberg, A. Pamidi, J. P. Simke, and A. Rakhit. “Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients.” Clin Pharmacol Ther 52, no. 6 (December 1992): 597–604. https://doi.org/10.1038/clpt.1992.197.
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  - Mannon, R. B., and T. M. Coffman. “Immunologic mechanisms of transplant rejection.” Curr Opin Nephrol Hypertens 1, no. 2 (December 1992): 230–35. https://doi.org/10.1097/00041552-199212000-00007.
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  - Ruiz, P., L. Rey, R. Spurney, T. Coffman, and A. Viciana. “Thromboxane augmentation of alloreactive T cell function.” Transplantation 54, no. 3 (September 1992): 498–505. https://doi.org/10.1097/00007890-199209000-00021.
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  - Gilkeson, G. S., R. Spurney, T. M. Coffman, R. Kurlander, P. Ruiz, and D. S. Pisetsky. “Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice.” Clin Immunol Immunopathol 64, no. 2 (August 1992): 166–72. https://doi.org/10.1016/0090-1229(92)90195-t.
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  - Nesbitt, T., T. M. Coffman, R. Griffiths, and M. K. Drezner. “Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect.” J Clin Invest 89, no. 5 (May 1992): 1453–59. https://doi.org/10.1172/JCI115735.
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  - Spurney, R. F., P. Y. Fan, P. Ruiz, F. Sanfilippo, D. S. Pisetsky, and T. M. Coffman. “Thromboxane receptor blockade reduces renal injury in murine lupus nephritis.” Kidney Int 41, no. 4 (April 1992): 973–82. https://doi.org/10.1038/ki.1992.149.
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  - Smith, S. R., E. A. Creech, A. V. Schaffer, L. L. Martin, A. Rakhit, F. L. Douglas, P. E. Klotman, and T. M. Coffman. “Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity.” Kidney Int 41, no. 1 (January 1992): 199–205. https://doi.org/10.1038/ki.1992.27.
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  - Spurney, R. F., R. J. Bernstein, P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Physiologic role for enhanced renal thromboxane production in murine lupus nephritis.” Prostaglandins 42, no. 1 (July 1991): 15–28. https://doi.org/10.1016/0090-6980(91)90090-3.
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  - Spurney, R. F., P. Ruiz, D. S. Pisetsky, and T. M. Coffman. “Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites.” Kidney Int 39, no. 1 (January 1991): 95–102. https://doi.org/10.1038/ki.1991.12.
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  - Himmelstein, S. I., T. M. Coffman, W. E. Yarger, and P. E. Klotman. “Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction.” Am J Physiol 258, no. 2 Pt 2 (February 1990): F281–86. https://doi.org/10.1152/ajprenal.1990.258.2.F281.
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  - Spurney, R. F., S. D. Mayros, D. Collins, P. Ruiz, P. E. Klotman, and T. Coffman. “Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats.” Prostaglandins 39, no. 2 (February 1990): 135–46. https://doi.org/10.1016/0090-6980(90)90070-c.
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  - Himmelstein, S. I., T. M. Coffman, W. E. Yarger, and P. E. Klotman. “Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 258, no. 2 27-2 (January 1, 1990). https://doi.org/10.1152/ajprenal.1990.258.2.f281.
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  - Collins, D. M., T. M. Coffman, P. Ruiz, and P. E. Klotman. “High-protein feeding stimulates renal thromboxane production in rats with streptozocin-induced diabetes.” J Lab Clin Med 114, no. 5 (November 1989): 545–53.
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  - Ruiz, P., T. M. Coffman, P. E. Klotman, and F. Sanfilippo. “Association of chronic thromboxane inhibition with reduced in situ cytotoxic T cell activity in rejecting rat renal allografts.” Transplantation 48, no. 4 (October 1989): 660–66.
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  - Coffman, T. M., S. Himmelstein, C. Best, and P. E. Klotman. “Post-transplant hypertension in the rat: effects of captopril and native nephrectomy.” Kidney Int 36, no. 1 (July 1989): 35–40. https://doi.org/10.1038/ki.1989.157.
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  - Coffman, T. M., P. Ruiz, F. Sanfilippo, and P. E. Klotman. “Chronic thromboxane inhibition preserves function of rejecting rat renal allografts.” Kidney Int 35, no. 1 (January 1989): 24–30. https://doi.org/10.1038/ki.1989.4.
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  - Humes, H. D., T. Coffman, H. Halderman, M. Mihatsch, M. Henry, and G. A. Porter. “Cyclosporine nephrotoxicity: a workshop to discuss mechanisms, diagnosis, and treatment.” Transplant Proc 20, no. 3 Suppl 3 (June 1988): 833–40.
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  - Coffman, T. M., D. Yohay, D. R. Carr, P. C. Brazy, W. E. Yarger, and P. E. Klotman. “Effect of dietary fish oil supplementation on eicosanoid production by rat renal allografts.” Transplantation 45, no. 2 (February 1988): 470–74. https://doi.org/10.1097/00007890-198802000-00045.
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  - Ruiz, P., T. M. Coffman, D. N. Howell, J. Straznickas, M. W. Scroggs, W. M. Baldwin, P. E. Klotman, and F. Sanfilippo. “Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection.” Transplantation 45, no. 1 (January 1988): 1–7. https://doi.org/10.1097/00007890-198801000-00002.
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  - Svetkey, L. P., N. R. Dunnick, T. M. Coffman, S. I. Himmelstein, R. R. Bollinger, R. L. McCann, R. H. Wilkinson, S. D. Braun, G. F. Newman, and R. H. Cohan. “Comparison of intravenous digital subtraction angiography and conventional arteriography in defining renal anatomy.” Transplantation 45, no. 1 (January 1988): 56–58. https://doi.org/10.1097/00007890-198801000-00013.
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  - Kolbeck, P. C., M. W. Scroggs, T. M. Coffman, P. E. Klotman, and F. Sanfilippo. “Associations between rat renal allograft function, inflammation, and host immunity.” Transplantation Proceedings 19, no. 1 I (April 27, 1987): 379–81.
  - Coffman, T. M., D. R. Carr, W. E. Yarger, and P. E. Klotman. “Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity.” Transplantation 43, no. 2 (February 1987): 282–85. https://doi.org/10.1097/00007890-198702000-00023.
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  - Kolbeck, P. C., M. W. Scroggs, T. M. Coffman, P. E. Klotman, and F. Sanfilippo. “Associations between rat renal allograft function, inflammation, and host immunity.” Transplant Proc 19, no. 1 Pt 1 (February 1987): 379–81.
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  - Coffman, T. M., P. C. Kolbeck, F. P. Sanfilippo, and P. E. Klotman. “Renal allograft function, arachidonic acid metabolism, and systemic cellular immunity after kidney transplantation in the rat.” Transplantation Proceedings 19, no. 3 (January 1, 1987): 3116–18.
  - Coffman, T. M., F. P. Sanfilippo, P. C. Brazy, W. E. Yarger, and P. E. Klotman. “Bilateral native nephrectomy improves renal isograft function in rats.” Kidney Int 30, no. 1 (July 1986): 20–26. https://doi.org/10.1038/ki.1986.145.
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  - Klotman, P. E., S. R. Smith, B. D. Volpp, T. M. Coffman, and W. E. Yarger. “Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys.” Am J Physiol 250, no. 2 Pt 2 (February 1986): F282–87. https://doi.org/10.1152/ajprenal.1986.250.2.F282.
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  - Coffman, T. M., U. Schwertschlag, and W. E. Yarger. “Lipid mediators in acute renal allograft rejection.” Transplantation Proceedings 18, no. 5 SUPPL. 4 (January 1, 1986): 94–97.
  - Klotman, P. E., S. R. Smith, B. D. Volpp, T. M. Coffman, and W. E. Yarger. “Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys.” American Journal of Physiology Renal Fluid and Electrolyte Physiology 250, no. 2 (19/2) (January 1, 1986). https://doi.org/10.1152/ajprenal.1986.250.2.f282.
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  - Coffman, T. M., W. E. Yarger, and P. E. Klotman. “Functional role of thromboxane production by acutely rejecting renal allografts in rats.” J Clin Invest 75, no. 4 (April 1985): 1242–48. https://doi.org/10.1172/JCI111822.
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  - Mitnick, P., A. Greenberg, T. Coffman, E. Kelepouris, C. J. Wolf, and S. Goldfarb. “Effects of two models of hypercalcemia on renal acid base metabolism.” Kidney Int 21, no. 4 (April 1982): 613–20. https://doi.org/10.1038/ki.1982.68.
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  - Mitnick, P. D., A. Greenberg, P. B. DeOreo, B. M. Weiner, T. M. Coffman, B. R. Walker, Z. S. Agus, and S. Goldfarb. “Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney.” Clin Pharmacol Ther 28, no. 5 (November 1980): 680–89. https://doi.org/10.1038/clpt.1980.221.
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- Conference Papers
  - Paradis, Pierre, Marie Briet, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Suellen C. Coelho, Yohann Rautureau, Thomas M. Coffman, and Ernesto L. Schiffrin. “PS 07-16 CROSSTALK BETWEEN ALDOSTERONE-STIMULATED MINERALOCORTICOID RECEPTOR AND ANGIOTENSIN RECEPTOR PATHWAYS PLAYS A ROLE IN ALDOSTERONE-INDUCED VASCULAR INJURY.” In Journal of Hypertension, 34:e287–88. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.1097/01.hjh.0000500680.24040.e2.
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  - Briet, Marie, Tlili Barhoumi, Muhammad Oneeb Rehman Mian, Suellen C. Coelho, Sofiane Ouerd, Yohann Rautureau, Thomas M. Coffman, Pierre Paradis, and Ernesto L. Schiffrin. “Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors.” In Hypertension, 67:897–905, 2016. https://doi.org/10.1161/HYPERTENSIONAHA.115.07074.
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  - Dimke, Henrik, Matthew A. Sparks, Sebastian Frische, Thomas M. Coffman, and Susan E. Quaggin. “Tubular Vegfa is Required for Renal Microvasculature and Oxygen Sensing.” In Hypertension, Vol. 62. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Sparks, Matthew A., Johannes Stegbauer, Daian Chen, Jose A. Gomez, Marcela Herrera, Susan B. Gurley, and Thomas M. Coffman. “Compensatory Activation of the Sympathetic Nervous System after Deletion of Angiotensin Type 1 Receptors from Vascular Smooth Muscle Cells.” In Hypertension, Vol. 62. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Herrera, Marcela, Matthew A. Sparks, and Thomas M. Coffman. “Lack of specificity for AT1 angiotensin receptor antibodies in Western blot analysis.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.
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  - Gembardt, Florian, Joep H. van Esch, Thomas M. Coffman, Heinz-Peter Schultheiss, AH Jan Danser, and Thomas Walther. “Hemodynamic Effects of Angiotensin-(1-7) Do Not Depend On AT1 Or AT2.” In Hypertension, 58:E83–E83. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Herrera, Marcela, Johannes Stegbauer, Susan B. Gurley, and Thomas M. Coffman. “AT1 Receptor Activation Stimulates COX2 Expression in Mouse Collecting Duct Epithelium.” In Hypertension, 58:E46–E46. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Sparks, Matthew A., Johannas Stegbauer, Susan B. Gurley, and Thomas M. Coffman. “Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Contribute to Blood Pressure Control, Salt Sensitivity and Hypertension.” In Hypertension, 58:E51–E51. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Young, Colin N., Scott D. Butler, Anfei Li, Kelly K. Parsons, Thomas M. Coffman, Allyn L. Mark, and Robin L. Davisson. “Angiotensin Type 1a Receptors (AT(1a)) in the Subfornical Organ Contribute to the Weight-Reducing Effects of Leptin.” In Hypertension, 58:E42–E42. LIPPINCOTT WILLIAMS & WILKINS, 2011.
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  - Wysocki, Jan, Karla Evora, Susan Gurley, Minghao Ye, Francisco R. Gonzalez-Pacheco, Thomas M. Coffman, and Daniel Batlle. “ACE2 Deficiency Increases Hydrogen Peroxide In Kidneys From Male Mice.” In Hypertension, 54:E112–E112. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Wang, Zheng, Shiyou Chen, Laureano D. Asico, Crisanto Escano, Van Anthony M. Villar, Quansheng Lu, Thomas M. Coffman, et al. “AT1R dysregulation is crucial in the hypertension of human GRK4 gamma A142V transgenic mice.” In Faseb Journal, Vol. 23. FEDERATION AMER SOC EXP BIOL, 2009.
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  - Crowley, Steven D., Gregory Sprung, Robert Griffiths, Eugene Lin, and Thomas M. Coffman. “AT(1) receptors on bone marrow cells modulate kidney injury in hypertension.” In Hypertension, 52:E40–E40. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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  - Gurley, Susan B., Andrew M. Allen, Volker H. Haase, John N. Snouwaert, Beverly H. Koller, Thu H. Le, and Thomas M. Coffman. “AT1 angiotensin receptors in the proximal tubule of the kidney are essential for blood pressure regulation.” In Hypertension, 52:E47–E47. LIPPINCOTT WILLIAMS & WILKINS, 2008.
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  - Gurley, Susan B., Kelly K. Parsons, Volker H. Haase, John N. Snouwaert, Beverly H. Koller, Thu H. Le, and Thomas M. Coffman. “Attenuated salt sensitivity in mice with tissue-specific deletion of AT1A angiotensin receptors from renal proximal tubule.” In Hypertension, 50:E99–E99. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Henriques, Tracy A., Steven D. Crowley, Campbell W. Frey, and Thomas M. Coffman. “COX-1 from bone marrow-derived cells promotes angiotensin II-dependent hypertension.” In Hypertension, 50:E89–E89. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Parsons, Kelly K., Susan B. Gurley, John N. Snouwaert, Chapel Hill, Thu H. Le, and Thomas M. Coffman. “Elimination of AT(1A) angiotensin receptors from smooth muscle does not alter blood pressure.” In Hypertension, 50:E77–E77. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Crowley, Steven D., Samantha K. Gould, Phillip Ruiz, Robert Griffiths, and Thomas M. Coffman. “Immune mechanisms promote kidney injury in angiotensin II-Dependent hypertension.” In Hypertension, 48:E73–E73. LIPPINCOTT WILLIAMS & WILKINS, 2006.
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  - Sabaa, N., B. Miroux, T. M. Coffman, S. Collins, D. Ricquier, J. C. Dussaule, and P. L. Tharaux. “Ucp-2 does not modulate angiotensin ii-induced high blood pressure but limits the development of hypertensive renal sclerosis.” In Journal of Hypertension, Vol. 23, 2005. https://doi.org/10.1097/01.hjh.0000177375.70196.08.
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  - Morris, M., P. Li, M. F. Callahan, M. I. Oliverio, T. M. Coffman, S. M. Bosch, and D. I. Diz. “Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor.” In Hypertension, 33:482–86, 1999. https://doi.org/10.1161/01.hyp.33.1.482.
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Teaching & Mentoring
Recent Courses
- CELLBIO 493: Research Independent Study 2020

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