Thomas Myron Coffman | Scholars@Duke

Thomas Myron Coffman
James R. Clapp Professor of Medicine, in the School of Medicine

My laboratory is interested mechanisms of kidney injury in disease states and the role of the kidney in regulation of blood pressure. Our research addresses issues that are relevant to disorders such as hypertension, diabetic nephropathy, transplant rejection, and autoimmune diseases. We have been particularly interested in two hormone systems that impact these processes: (1) the renin-angiotensin system and (2) lipid mediators derived from cyco-oxygenase metabolism of arachidonic acid. Our studies have taken advantage of available technologies for producing genetic alterations in mice to study the physiology of these systems. As one example, we generated and characterized lines of mice lacking the major physiological receptors for angiotensin II in the mouse. These studies have provided novel information regarding the role of these receptors in blood pressure homeostasis, in promoting kidney injury in disease states, and in the regulation of inflammation. A major objective of our work is to identify new approaches to treatment and disease prevention. To this end, we are using molecular genetic technology to develop and refine mouse models of human diseases such as diabetic nephropathy, kidney transplant rejection, and hypertension.

Current Appointments & Affiliations

James R. Clapp Professor of Medicine, in the School of Medicine, Medicine, Nephrology, Medicine 2002
Professor of Medicine, Medicine, Nephrology, Medicine 1999
Professor in Cell Biology, Cell Biology, Basic Science Departments 2005
Professor in Immunology, Immunology, Basic Science Departments 2006

Contact Information

Duke Box 103015, Durham, NC 27710
Room 2018/msbr2, 106 Research Drive, Durham, NC 27710
coffm002@duke.edu (919) 684-9788

Background
Education, Training, & Certifications
- Fellowship In Nephrology, Duke University School of Medicine 1983 - 1985
- M.D., Ohio State University 1980
Duke Appointment History
- Chief, Division of Nephrology, Medicine, Nephrology, Medicine 1997 - 2014
- Senior Vice-chair for Academic Affairs in the Department of Medicine, Medicine, Clinical Science Departments 2007 - 2014
- Associate Professor of Medicine, Medicine, Nephrology, Medicine 1994 - 1998
- Assistant Professor of Medicine, Medicine, Nephrology, Medicine 1987 - 1994
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1985 - 1986
Recognition
In the News
- DEC 15, 2014
  
  Thomas Coffman Named Dean-Designate of Duke-NUS Medical School
Awards & Honors
- Water and Electrolyte Homeostasis Section/Ernest H. Starling Distinguished Lecture. American Physiological Society. 2006
Expertise
Global Scholarship
- Research
  - Singapore (Country)
Research
Selected Grants
- Postdoctoral training in genomic medicine research awarded by National Institutes of Health 2017 - 2022
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2021
- Paracrine Control of Blood Pressure by Renal Intercalated Cells awarded by National Institutes of Health 2015 - 2020
- Actions of Angiotensin II Along the Nephron to Regulate Blood Pressure awarded by National Institutes of Health 2014 - 2019
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Student Supplement awarded by National Institutes of Health 2012 - 2017
- Role of Gq Signaling in Promoting Podocyte Injury in Diabetes Mellitus awarded by National Institutes of Health 2011 - 2016
- Immune Mechanisms in Diabetic Nephropathy awarded by Georgia Regents University 2014 - 2015
- Prostaglandin E2 and Regulation of Kidney Function awarded by National Institutes of Health 2005 - 2015
- A New Locus for Hereditary FSGS on Chromosome 2p awarded by National Institutes of Health 2009 - 2014
- Renal Endothelin-1: Control of Sodium Excretion and Blood Pressure awarded by National Institutes of Health 2012 - 2013
- A Novel Mouse Model of Podocyte Injury awarded by National Institutes of Health 2009 - 2012
- Characterization of TRPC6 As A Cause for Focal and Segmental Glomerulosclerosis awarded by National Institutes of Health 2006 - 2012
- Angiotensin Receptor Genes and Blood Pressure Regulation awarded by National Institutes of Health 1997 - 2012
- Genetic Determinants of Susceptibility to Kidney Disease in African Americans awarded by National Institutes of Health 2009 - 2012
- Angiogenic Signals in Diabetic Complications awarded by National Institutes of Health 2006 - 2012
- B-Arrestins and G Protein-Coupled Receptor Kinases in Cardiovascular Function awarded by National Institutes of Health 2002 - 2012
- IPA - Natalia Makhanova awarded by Durham Veterans Affairs Medical Center 2010 - 2011
- Pathophysiology of Renal Allograft Dysfunction awarded by National Institutes of Health 1988 - 2011
- Genes That Regulate Progression of Kidney Disease and Its Cardiovascular Effects awarded by National Institutes of Health 2007 - 2009
- Role of mPGES1 in Regulation of Kidney Function awarded by National Institutes of Health 2006 - 2008
- IPA - Galen Hoover awarded by Veterans Adminsitration Medical Center 2006 - 2008
- Actions of Angiotensin II in Vascular Smooth Muscle awarded by National Institutes of Health 2006 - 2008
- Rac, Superoxide and Antioxidants in Hypertension awarded by National Institutes of Health 1996 - 2007
- Duke-UNC-Stanford AMDC Unit awarded by National Institutes of Health 2001 - 2006
- Genes that Regulate Target Organ Damage in Hypertension awarded by National Institutes of Health 2001 - 2006
- Pathophysiology of Renal Allograft Dysfunction awarded by National Institutes of Health 1988 - 2004
- Pathophysiology of renal allograft dysfunction awarded by National Institutes of Health 1988 - 2004
- Pathophysiology of renal allograft dysfunction (Minority Suppl) awarded by National Institutes of Health 1988 - 2004
- Duke/NIDDK Functional Genomics Center awarded by National Institutes of Health 2000 - 2003
- Duke Training Grant In Nephrology awarded by National Institutes of Health 1995 - 2000
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2000
- Angiotensin receptor genes and blood pressure regulation awarded by National Institutes of Health 1997 - 1999
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Briet, M, Barhoumi, T, Sierra, C, Coffman, TM, Paradis, P, and Schiffrin, EL. "Aldosterone-Induced Small Artery Remodeling and Endothelial Dysfunction Requires Functional Angiotensin Type 1a Receptor." November 2011. Link to Item
  - Sabaa, N, Miroux, B, Coffman, TM, Collins, S, Ricquier, D, Dussaule, JC, and Tharaux, PL. "UCP-2 does not modulate angiotensin II-induced high blood pressure but limits the development of hypertensive renal sclerosis." August 2005. Full Text Link to Item
- Journal Articles
  - Tyson, CC, and Coffman, TM. "In the Wake of Systolic Blood Pressure Intervention Trial: New Targets for Improving Hypertension Management in Chronic Kidney Disease?." Nephron 135, no. 4 (January 2017): 287-290. Full Text
  - Chen, D, Stegbauer, J, Sparks, MA, Kohan, D, Griffiths, R, Herrera, M, Gurley, SB, and Coffman, TM. "Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension." Hypertension (Dallas, Tex. : 1979) 67, no. 6 (June 2016): 1291-1297. Full Text
  - Sparks, MA, Stegbauer, J, Chen, D, Gomez, JA, Griffiths, RC, Azad, HA, Herrera, M, Gurley, SB, and Coffman, TM. "Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion." Journal of the American Society of Nephrology : JASN 26, no. 12 (December 2015): 2953-2962. Full Text
  - Stegbauer, J, and Coffman, TM. "Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin." Journal of Clinical Investigation 125, no. 11 (November 2015): 4008-4010. Full Text
  - Dimke, H, Sparks, MA, Thomson, BR, Frische, S, Coffman, TM, and Quaggin, SE. "Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney." Journal of the American Society of Nephrology : JASN 26, no. 5 (May 2015): 1027-1038. Full Text
  - Yang, Y, Gomez, JA, Herrera, M, Perez-Marco, R, Repenning, P, Zhang, Z, Payne, A, Pratt, RE, Koller, B, Beierwaltes, WH, Coffman, T, Mirotsou, M, and Dzau, VJ. "Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4." Hypertension (Dallas, Tex. : 1979) 65, no. 5 (May 2015): 1047-1054. Full Text
  - Chen, D, and Coffman, TM. "AT1 Angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation." Current opinion in pharmacology 21 (April 2015): 122-126. (Review) Full Text
  - Young, CN, Morgan, DA, Butler, SD, Rahmouni, K, Gurley, SB, Coffman, TM, Mark, AL, and Davisson, RL. "Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis." Molecular metabolism 4, no. 4 (April 2015): 337-343. Full Text
  - Dolber, PC, Jin, H, Nassar, R, Coffman, TM, Gurley, SB, and Fraser, MO. "The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice." Neurourology and urodynamics 34, no. 1 (January 2015): 72-78. Full Text
  - Smithies, O, and Coffman, T. "A conversation with Oliver Smithies." Annual review of physiology 77 (January 2015): 1-11. (Interview) Full Text
  - Young, CN, Morgan, DA, Butler, SD, Rahmouni, K, Gurley, SB, Coffman, TM, Mark, AL, and Davisson, RL. "Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis." Molecular Metabolism 4, no. 4 (January 1, 2015): 337-343. Full Text
  - Sparks, MA, Crowley, SD, Gurley, SB, Mirotsou, M, and Coffman, TM. "Classical Renin-Angiotensin system in kidney physiology." Comprehensive Physiology 4, no. 3 (July 2014): 1201-1228. (Review) Full Text
  - Coffman, TM. "The inextricable role of the kidney in hypertension." The Journal of clinical investigation 124, no. 6 (June 2, 2014): 2341-2347. (Review) Full Text
  - Wang, L, Fields, TA, Pazmino, K, Dai, Q, Burchette, JL, Howell, DN, Coffman, TM, and Spurney, RF. "Erratum: Activation of Gaq-coupled signaling pathways in glomerular podocytes promotes renal injury (Journal of the American Society of Nephrology (2005) 16 (3611-3622))." Journal of the American Society of Nephrology 24, no. 12 (December 9, 2013): 2126-. Full Text
  - Xie, L, Sparks, MA, Li, W, Qi, Y, Liu, C, Coffman, TM, and Johnson, GA. "Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice." NMR in Biomedicine 26, no. 12 (December 1, 2013): 1853-1863. Full Text
  - Xie, L, Sparks, MA, Li, W, Qi, Y, Liu, C, Coffman, TM, and Johnson, GA. "Quantitative susceptibility mapping of kidney inflammation and fibrosis in type 1 angiotensin receptor-deficient mice." NMR Biomed 26, no. 12 (December 2013): 1853-1863. Full Text Link to Item
  - Herrera, M, and Coffman, TM. "Control of electrolyte balance through ubiquitination." Proc Natl Acad Sci U S A 110, no. 19 (May 7, 2013): 7535-7536. Full Text Link to Item
  - Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, and Coffman, TM. "Response to Lack of Specificity of Commercial Antibodies Leads to Misidentification of Angiotensin Type-1 Receptor Protein." HYPERTENSION 61, no. 4 (April 2013): E32-E32. Full Text Link to Item
  - Ortiz-Melo, D, and Coffman, TM. "A trip to inner space: insights into salt balance from cosmonauts." Cell Metab 17, no. 1 (January 8, 2013): 1-2. Full Text Link to Item
  - Breyer, MD, Coffman, TM, Flessner, MF, Fried, LF, Harris, RC, Ketchum, CJ, Kretzler, M, Nelson, RG, Sedor, JR, and Susztak, K. "Diabetic nephropathy: A national dialogue." Clinical Journal of the American Society of Nephrology 8, no. 9 (2013): 1603-1605. Full Text
  - Dolber, PC, Jin, H, Nassar, R, Coffman, TM, Gurley, SB, and Fraser, MO. "The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice (Accepted)." Neurourology and Urodynamics (2013). Full Text
  - Herrera, M, Sparks, MA, Alfonso-Pecchio, AR, Harrison-Bernard, LM, and Coffman, TM. "Lack of specificity of commercial antibodies leads to misidentification of angiotensin type 1 receptor protein." Hypertension (Dallas, Tex. : 1979) 61, no. 1 (January 2013): 253-258. Full Text
  - Konvalinka, A, Zhou, J, Dimitromanolakis, A, Drabovich, AP, Fang, F, Gurley, S, Coffman, T, John, R, Zhang, S-L, Diamandis, EP, and Scholey, JW. "Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC)." Journal of Biological Chemistry 288, no. 34 (2013): 24834-24847. Full Text
  - Le, TH, Crowley, SD, Gurley, SB, and Coffman, TM. "The Renin-Angiotensin System." Seldin and Geibisch's The Kidney 1 (2013): 427-450. Full Text
  - Pippin, JW, Sparks, MA, Glenn, ST, Buitrago, S, Coffman, TM, Duffield, JS, Gross, KW, and Shankland, SJ. "Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease." American Journal of Pathology 183, no. 2 (2013): 542-557. Full Text
  - Sparks, MA, Makhanova, NA, Griffiths, RC, Snouwaert, JN, Koller, BH, and Coffman, TM. "Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death." Hypertension 61, no. 1 (January 2013): 166-173. Full Text Link to Item
  - Zhang, J-D, Patel, MB, Song, Y-S, Griffiths, R, Burchette, J, Ruiz, P, Sparks, MA, Yan, M, Howell, DN, Gomez, JA, Spurney, RF, Coffman, TM, and Crowley, SD. "A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension." Circ Res 110, no. 12 (June 8, 2012): 1604-1617. Full Text Link to Item
  - Crowley, SD, and Coffman, TM. "Recent advances involving the renin-angiotensin system." Exp Cell Res 318, no. 9 (May 15, 2012): 1049-1056. (Review) Full Text Link to Item
  - Chen, D, and Coffman, TM. "The kidney and hypertension: lessons from mouse models." Can J Cardiol 28, no. 3 (May 2012): 305-310. (Review) Full Text Link to Item
  - Herrera, M, and Coffman, TM. "The kidney and hypertension: novel insights from transgenic models." Curr Opin Nephrol Hypertens 21, no. 2 (March 2012): 171-178. (Review) Full Text Link to Item
  - Cyphert, JM, Allen, IC, Church, RJ, Latour, AM, Snouwaert, JN, Coffman, TM, and Koller, BH. "Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse." American Journal of Physiology - Lung Cellular and Molecular Physiology 302, no. 1 (2012): L140-L151. Full Text
  - Gembardt, F, Veghel, RV, Coffman, TM, Schultheiss, H-P, Danser, AHJ, and Walther, T. "Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors." Hypertension Research 35, no. 5 (2012): 547-551. Full Text
  - Stegbauer, J, Gurley, SB, Sparks, MA, Woznowski, M, Kohan, DE, Yan, M, Lehrich, RW, and Coffman, TM. "AT1 receptors in the collecting duct directly modulate the concentration of urine." J Am Soc Nephrol 22, no. 12 (December 2011): 2237-2246. Full Text Link to Item
  - Coffman, TM. "Under pressure: the search for the essential mechanisms of hypertension. (Published online)" Nat Med 17, no. 11 (November 7, 2011): 1402-1409. (Review) Full Text Link to Item
  - Crowley, SD, Zhang, J, Herrera, M, Griffiths, R, Ruiz, P, and Coffman, TM. "Role of AT₁ receptor-mediated salt retention in angiotensin II-dependent hypertension." Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1124-F1130. Full Text Link to Item
  - Facemire, CS, Nguyen, M, Jania, L, Beierwaltes, WH, Kim, H-S, Koller, BH, and Coffman, TM. "A major role for the EP4 receptor in regulation of renin." Am J Physiol Renal Physiol 301, no. 5 (November 2011): F1035-F1041. Full Text Link to Item
  - Gurley, SB, Riquier-Brison, ADM, Schnermann, J, Sparks, MA, Allen, AM, Haase, VH, Snouwaert, JN, Le, TH, McDonough, AA, Koller, BH, and Coffman, TM. "AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure." Cell Metab 13, no. 4 (April 6, 2011): 469-475. Full Text Link to Item
  - Sparks, MA, Parsons, KK, Stegbauer, J, Gurley, SB, Vivekanandan-Giri, A, Fortner, CN, Snouwaert, J, Raasch, EW, Griffiths, RC, Haystead, TAJ, Le, TH, Pennathur, S, Koller, B, and Coffman, TM. "Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension." Hypertension 57, no. 3 (March 2011): 577-585. Full Text Link to Item
  - DiLillo, DJ, Griffiths, R, Seshan, SV, Magro, CM, Ruiz, P, Coffman, TM, and Tedder, TF. "B lymphocytes differentially influence acute and chronic allograft rejection in mice." J Immunol 186, no. 4 (February 15, 2011): 2643-2654. Full Text Link to Item
  - Snoeijs, MGJ, Hoogland, PR, Boonen, B, Coffman, TM, Peutz-Kootstra, CJ, Buurman, WA, and Heurn, LWEV. "Thromboxane receptor signalling in renal ischemia reperfusion injury." Free Radical Research 45, no. 6 (2011): 699-706. Full Text
  - Stegbauer, J, and Coffman, TM. "New insights into angiotensin receptor actions: from blood pressure to aging." Curr Opin Nephrol Hypertens 20, no. 1 (January 2011): 84-88. (Review) Full Text Link to Item
  - Verlander, JW, Hong, S, Pech, V, Bailey, JL, Agazatian, D, Matthews, SW, Coffman, TM, Le, T, Inagami, T, Whitehill, FM, David, IW, Farley, DB, Kim, YH, and Wall, SM. "Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin." American Journal of Physiology - Renal Physiology 301, no. 6 (2011): F1314-F1325. Full Text
  - Makhanova, NA, Crowley, SD, Griffiths, RC, and Coffman, TM. "Gene expression profiles linked to AT1 angiotensin receptors in the kidney." Physiol Genomics 42A, no. 3 (November 15, 2010): 211-218. Full Text Link to Item
  - Gurley, SB, Griffiths, RC, Mendelsohn, ME, Karas, RH, and Coffman, TM. "Renal actions of RGS2 control blood pressure." J Am Soc Nephrol 21, no. 11 (November 2010): 1847-1851. Full Text Link to Item
  - Gurley, SB, and Coffman, TM. "An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy." Cell Metab 12, no. 4 (October 6, 2010): 311-312. Full Text Link to Item
  - Gurley, SB, Mach, CL, Stegbauer, J, Yang, J, Snow, KP, Hu, A, Meyer, TW, and Coffman, TM. "Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice." Am J Physiol Renal Physiol 298, no. 3 (March 2010): F788-F795. Full Text Link to Item
  - Facemire, CS, Griffiths, R, Audoly, LP, Koller, BH, and Coffman, TM. "The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background." Hypertension 55, no. 2 (February 2010): 531-538. Full Text Link to Item
  - Crowley, SD, Frey, CW, Gould, SK, Griffiths, R, Ruiz, P, Burchette, JL, Howell, DN, Makhanova, N, Yan, M, Kim, H-S, Tharaux, P-L, and Coffman, TM. "Simulation of lymphoctye responses by angiotensin II promotes kidney injury in hypertension (American Journal Physiology-Renal Physiology (2008) 295, (F515-F524))." American Journal of Physiology - Renal Physiology 298, no. 5 (2010): F1286-. Full Text
  - Esch, JHMV, Gembardt, F, Sterner-Kock, A, Heringer-Walther, S, Le, TH, Laßner, D, Stijnen, T, Coffman, TM, Schultheiss, H-P, Danser, AHJ, and Walther, T. "Cardiac phenotype and angiotensin II levels in AT_1a, AT _1b, and AT₂ receptor single, double, and triple knockouts." Cardiovascular Research 86, no. 3 (2010): 401-409. Full Text
  - Madsen, K, Marcussen, N, Pedersen, M, Kjærsgaard, G, Facemire, C, Coffman, TM, and Jensen, BL. "Angiotensin II promotes development of the renal microcirculation through AT₁ receptors." Journal of the American Society of Nephrology 21, no. 3 (2010): 448-459. Full Text
  - Sparks, MA, and Coffman, TM. "The EP4 receptor for prostaglandin E₂in glomerular disease: A good receptor turned bad?." Journal of the American Society of Nephrology 21, no. 10 (2010): 1597-1599. Full Text
  - Brosius, FC, Alpers, CE, Bottinger, EP, Breyer, MD, Coffman, TM, Gurley, SB, Harris, RC, Kakoki, M, Kretzler, M, Leiter, EH, Levi, M, McIndoe, RA, Sharma, K, Smithies, O, Susztak, K, Takahashi, N, Takahashi, T, and Animal Models of Diabetic Complications Consortium, . "Mouse models of diabetic nephropathy." J Am Soc Nephrol 20, no. 12 (December 2009): 2503-2512. (Review) Full Text Link to Item
  - Facemire, CS, Nixon, AB, Griffiths, R, Hurwitz, H, and Coffman, TM. "Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression." Hypertension 54, no. 3 (September 2009): 652-658. Full Text Link to Item
  - Crowley, SD, Vasievich, MP, Ruiz, P, Gould, SK, Parsons, KK, Pazmino, AK, Facemire, C, Chen, BJ, Kim, H-S, Tran, TT, Pisetsky, DS, Barisoni, L, Prieto-Carrasquero, MC, Jeansson, M, Foster, MH, and Coffman, TM. "Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis." J Clin Invest 119, no. 4 (April 2009): 943-953. Full Text Link to Item
  - Benigni, A, Corna, D, Zoja, C, Sonzogni, A, Latini, R, Salio, M, Conti, S, Rottoli, D, Longaretti, L, Cassis, P, Morigi, M, Coffman, TM, and Remuzzi, G. "Disruption of the Ang II type 1 receptor promotes longevity in mice." J Clin Invest 119, no. 3 (March 2009): 524-530. Full Text Link to Item
  - Lemarié, CA, Simeone, SMC, Nikonova, A, Ebrahimian, T, Deschênes, M-E, Coffman, TM, Paradis, P, and Schiffrin, EL. "Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors." Circulation Research 105, no. 9 (2009): 852-859. Full Text
  - Machura, K, Steppan, D, Neubauer, B, Alenina, N, Coffman, TM, Facemire, CS, Hilgers, KF, Eckardt, K-U, Wagner, C, and Kurtz, A. "Developmental renin expression in mice with a defective renin-angiotensin system." American Journal of Physiology - Renal Physiology 297, no. 5 (2009): F1371-F1380. Full Text
  - Athirakul, K, Bradbury, JA, Graves, JP, DeGraff, LM, Ma, J, Zhao, Y, Couse, JF, Quigley, R, Harder, DR, Zhao, X, Imig, JD, Pedersen, TL, Newman, JW, Hammock, BD, Conley, AJ, Korach, KS, Coffman, TM, and Zeldin, DC. "Increased blood pressure in mice lacking cytochrome P450 2J5." FASEB J 22, no. 12 (December 2008): 4096-4108. Full Text Link to Item
  - Thu H, L, Steven D, C, Susan B, G, and Thomas M, C. "The Renin-Angiotensin System." (December 1, 2008): 343-357. (Chapter) Full Text
  - Crowley, SD, and Coffman, TM. "In hypertension, the kidney breaks your heart." Curr Cardiol Rep 10, no. 6 (November 2008): 470-476. (Review) Link to Item
  - Spurney, RF, and Coffman, TM. "Stressed-out podocytes in diabetes?." J Am Soc Nephrol 19, no. 11 (November 2008): 2035-2037. Full Text Link to Item
  - Francois, H, Makhanova, N, Ruiz, P, Ellison, J, Mao, L, Rockman, HA, and Coffman, TM. "A role for the thromboxane receptor in L-NAME hypertension." Am J Physiol Renal Physiol 295, no. 4 (October 2008): F1096-F1102. Full Text Link to Item
  - Crowley, SD, Frey, CW, Gould, SK, Griffiths, R, Ruiz, P, Burchette, JL, Howell, DN, Makhanova, N, Yan, M, Kim, H-S, Tharaux, P-L, and Coffman, TM. "Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension." Am J Physiol Renal Physiol 295, no. 2 (August 2008): F515-F524. Full Text Link to Item
  - Coggins, KG, Coffman, TM, and Koller, BH. "The Hippocratic finger points the blame at PGE2." Nat Genet 40, no. 6 (June 2008): 691-692. Full Text Link to Item
  - Gurley, SB, and Coffman, TM. "Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages." Exp Physiol 93, no. 5 (May 2008): 538-542. (Review) Full Text Link to Item
  - Wooldridge, AA, Fortner, CN, Lontay, B, Akimoto, T, Neppl, RL, Facemire, C, Datto, MB, Kwon, A, McCook, E, Li, P, Wang, S, Thresher, RJ, Miller, SE, Perriard, J-C, Gavin, TP, Hickner, RC, Coffman, TM, Somlyo, AV, Yan, Z, and Haystead, TAJ. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle." J Biol Chem 283, no. 17 (April 25, 2008): 11850-11859. Full Text Link to Item
  - Coffman, TM, and Crowley, SD. "Kidney in hypertension: guyton redux." Hypertension 51, no. 4 (April 2008): 811-816. (Review) Full Text Link to Item
  - Gembardt, F, Heringer-Walther, S, Esch, JHMV, Sterner-Kock, A, Veghel, RV, Le, TH, Garrelds, IM, Coffman, TM, Danser, AHJ, Schultheiss, H-P, and Walther, T. "Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors." FASEB Journal 22, no. 8 (2008): 3068-3077. Full Text
  - Le, TH, and Coffman, TM. "Targeting genes in the renin-angiotensin system." Curr Opin Nephrol Hypertens 17, no. 1 (January 2008): 57-63. (Review) Full Text Link to Item
  - Ashton, AW, Mukherjee, S, Nagajyothi, FNU, Huang, H, Braunstein, VL, Desruisseaux, MS, Factor, SM, Lopez, L, Berman, JW, Wittner, M, Scherer, PE, Capra, V, Coffman, TM, Serhan, CN, Gotlinger, K, Wu, KK, Weiss, LM, and Tanowitz, HB. "Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection." J Exp Med 204, no. 4 (April 16, 2007): 929-940. Full Text Link to Item
  - Crowley, SD, and Coffman, TM. "In hypertension, the kidney rules." Curr Hypertens Rep 9, no. 2 (April 2007): 148-153. (Review) Link to Item
  - Parsons, KK, and Coffman, TM. "The renin-angiotensin system: it's all in your head." J Clin Invest 117, no. 4 (April 2007): 873-876. Full Text Link to Item
  - Gurley, SB, and Coffman, TM. "The renin-angiotensin system and diabetic nephropathy." Semin Nephrol 27, no. 2 (March 2007): 144-152. (Review) Full Text Link to Item
  - Quaggin, SE, and Coffman, TM. "Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link?." J Am Soc Nephrol 18, no. 2 (February 2007): 364-366. Full Text Link to Item
  - Crowley, SD, Gurley, SB, and Coffman, TM. "AT(1) receptors and control of blood pressure: the kidney and more.." Trends Cardiovasc Med 17, no. 1 (January 2007): 30-34. (Review) Full Text Link to Item
  - Francois, H, Facemire, C, Kumar, A, Audoly, L, Koller, B, and Coffman, T. "Role of microsomal prostaglandin E synthase 1 in the kidney." Journal of the American Society of Nephrology 18, no. 5 (2007): 1466-1475. Full Text
  - Crowley, SD, Gurley, SB, Herrera, MJ, Ruiz, P, Griffiths, R, Kumar, AP, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney." Proc Natl Acad Sci U S A 103, no. 47 (November 21, 2006): 17985-17990. Full Text Link to Item
  - Rajagopal, K, Whalen, EJ, Violin, JD, Stiber, JA, Rosenberg, PB, Premont, RT, Coffman, TM, Rockman, HA, and Lefkowitz, RJ. "Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes." Proc Natl Acad Sci U S A 103, no. 44 (October 31, 2006): 16284-16289. Full Text Link to Item
  - Coffman, TM. "A WNK in the kidney controls blood pressure." Nat Genet 38, no. 10 (October 2006): 1105-1106. Full Text Link to Item
  - Gurley, SB, Allred, A, Le, TH, Griffiths, R, Mao, L, Philip, N, Haystead, TA, Donoghue, M, Breitbart, RE, Acton, SL, Rockman, HA, and Coffman, TM. "Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice." J Clin Invest 116, no. 8 (August 2006): 2218-2225. Full Text Link to Item
  - Wysocki, J, Ye, M, Soler, MJ, Gurley, SB, Xiao, HD, Bernstein, KE, Coffman, TM, Chen, S, and Batlle, D. "ACE and ACE2 activity in diabetic mice." Diabetes 55, no. 7 (July 2006): 2132-2139. Full Text Link to Item
  - Elased, KM, Cunha, TS, Gurley, SB, Coffman, TM, and Morris, M. "New mass spectrometric assay for angiotensin-converting enzyme 2 activity." Hypertension 47, no. 5 (May 2006): 1010-1017. Full Text Link to Item
  - Le, TH, and Coffman, TM. "A new cardiac MASTer switch for the renin-angiotensin system." J Clin Invest 116, no. 4 (April 2006): 866-869. Full Text Link to Item
  - Allen, IC, Hartney, JM, Coffman, TM, Penn, RB, Wess, J, and Koller, BH. "Thromboxane A₂ induces airway constriction through an M ₃ muscarinic acetylcholine receptor-dependent mechanism." American Journal of Physiology - Lung Cellular and Molecular Physiology 290, no. 3 (2006): L526-L533. Full Text
  - Chansel, D, Ciroldi, M, Vandermeersch, S, Jackson, LF, Gomez, A-M, Henrion, D, Lee, DC, Coffman, TM, Richard, S, Dussaule, J-C, and Tharaux, P-L. "Heparin binding EGF is necessary for vasospastic response to endothelin." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20, no. 11 (2006): 1936-1938. Full Text
  - Chansel, D, Ciroldi, M, Vandermeersch, S, Jackson, LF, Gomez, A-M, Henrion, D, Lee, DC, Coffman, TM, Richard, S, Dussaule, J-C, and Tharaux, P-L. "Heparin binding EGF is necessary for vasospastic response to endothelin." FASEB Journal 20, no. 11 (2006): E1368-E1381. Full Text
  - Gurley, SB, Clare, SE, Snow, KP, Hu, A, Meyer, TW, and Coffman, TM. "Impact of genetic background on nephropathy in diabetic mice." Am J Physiol Renal Physiol 290, no. 1 (January 2006): F214-F222. Full Text Link to Item
  - Woost, PG, Kolb, RJ, Finesilver, M, Mackraj, I, Imboden, H, Coffman, TM, and Hopfer, U. "Strategy for the development of a matched set of transport-competent, angiotensin receptor-deficient proximal tubule cell lines." In Vitro Cellular and Developmental Biology - Animal 42, no. 7 (2006): 189-200.
  - Wang, L, Fields, TA, Pazmino, K, Dai, Q, Burchette, JL, Howell, DN, Coffman, TM, and Spurney, RF. "Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury." J Am Soc Nephrol 16, no. 12 (December 2005): 3611-3622. Full Text Link to Item
  - Francois, H, Athirakul, K, Howell, D, Dash, R, Mao, L, Kim, H-S, Rockman, HA, Fitzgerald, GA, Koller, BH, and Coffman, TM. "Prostacyclin protects against elevated blood pressure and cardiac fibrosis." Cell Metab 2, no. 3 (September 2005): 201-207. Full Text Link to Item
  - Chansel, D, Ciroldi, M, Vandermeersch, S, Gomez, AM, Jackson, LF, Lee, DC, Henrion, D, Richard, S, Coffman, TM, Dussaule, JC, and Tharaux, PL. "EGF receptor activated by HB-EGF is required to calcium influx and vasoconstriction induced by endothelin-1." Journal of Hypertension 23, no. 8 (August 2005): A9-A9. Full Text
  - Rocha, PN, Plumb, TJ, Robinson, LA, Spurney, R, Pisetsky, D, Koller, BH, and Coffman, TM. "Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide." Clin Diagn Lab Immunol 12, no. 8 (August 2005): 896-903. Full Text Link to Item
  - Rudic, RD, Brinster, D, Cheng, Y, Fries, S, Song, W-L, Austin, S, Coffman, TM, and FitzGerald, GA. "COX-2-derived prostacyclin modulates vascular remodeling." Circ Res 96, no. 12 (June 24, 2005): 1240-1247. Full Text Link to Item
  - Crowley, SD, Gurley, SB, Oliverio, MI, Pazmino, AK, Griffiths, R, Flannery, PJ, Spurney, RF, Kim, H-S, Smithies, O, Le, TH, and Coffman, TM. "Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system." J Clin Invest 115, no. 4 (April 2005): 1092-1099. Full Text Link to Item
  - Breyer, MD, Böttinger, E, III, FCB, Coffman, TM, Fogo, A, Harris, RC, Heilig, CW, and Sharma, K. "Diabetic nephropathy: Of mice and men." Advances in Chronic Kidney Disease 12, no. 2 (2005): 128-145. Full Text
  - Breyer, MD, Böttinger, E, III, FCB, Coffman, TM, Harris, RC, Heilig, CW, and Sharma, K. "Mouse models of diabetic nephropathy." Journal of the American Society of Nephrology 16, no. 1 (2005): 27-45. Full Text
  - Bridgman, P, Aronovitz, MA, Kakkar, R, Oliverio, MI, Coffman, TM, Rand, WM, Konstam, MA, Mendelsohn, ME, and Patten, RD. "Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor." American Journal of Physiology - Heart and Circulatory Physiology 289, no. 2 58-2 (2005): H586-H592. Full Text
  - Francois, H, Athirakul, K, Howell, D, Dash, R, Mao, L, Kim, H-S, Rockman, HA, FitzGerald, GA, Koller, BH, and Coffman, TM. "NSAIDs and cardiovascular risk - Reply [2]." Cell Metabolism 2, no. 6 (2005): 339-340. Full Text
  - Ouyang, X, Le, TH, Roncal, C, Gersch, C, Herrera-Acosta, J, Rodriguez-Iturbe, B, Coffman, TM, Johnson, RJ, and Mu, W. "Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT_1A and AT_1B double-knockout mice." American Journal of Physiology - Renal Physiology 289, no. 4 58-4 (2005): F902-F910. Full Text
  - Yang, L, Bataller, R, Dulyx, J, Coffman, TM, Ginès, P, Rippe, RA, and Brenner, DA. "Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice." Journal of Hepatology 43, no. 2 (2005): 317-323. Full Text
  - Le, TH, Oliverio, MI, Kim, HS, Salzler, H, Dash, RC, Howell, DN, Smithies, O, Bronson, S, and Coffman, TM. "A γGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice." Physiological Genomics 18 (October 1, 2004): 290-298. Full Text
  - Le, TH, Oliverio, MI, Kim, H-S, Salzler, H, Dash, RC, Howell, DN, Smithies, O, Bronson, S, and Coffman, TM. "A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. (Published online)" Physiol Genomics 18, no. 3 (August 11, 2004): 290-298. Full Text Link to Item
  - Crowley, SD, Tharaux, P-L, Audoly, LP, and Coffman, TM. "Exploring type I angiotensin (AT1) receptor functions through gene targeting." Acta Physiol Scand 181, no. 4 (August 2004): 561-570. (Review) Full Text Link to Item
  - Goulet, JL, Pace, AJ, Key, ML, Byrum, RS, Nguyen, M, Tilley, SL, Morham, SG, Langenbach, R, Stock, JL, McNeish, JD, Smithies, O, Coffman, TM, and Koller, BH. "E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation." J Immunol 173, no. 2 (July 15, 2004): 1321-1326. Link to Item
  - Quan, H, Athirakul, K, Wetsel, WC, Torres, GE, Stevens, R, Chen, YT, Coffman, TM, and Caron, MG. "Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2." Mol Cell Biol 24, no. 10 (May 2004): 4166-4173. Link to Item
  - Francois, H, Athirakul, K, Mao, L, Rockman, H, and Coffman, TM. "Role for thromboxane receptors in angiotensin-II-induced hypertension." Hypertension 43, no. 2 (February 2004): 364-369. Full Text Link to Item
  - Le, TH, Fogo, AB, Salzler, HR, Vinogradova, T, Oliverio, MI, Marchuk, DA, and Coffman, TM. "Modifier locus on mouse chromosome 3 for renal vascular pathology in AT1A receptor-deficiency." Hypertension 43, no. 2 (February 2004): 445-451. Full Text Link to Item
  - Benigni, A, Corna, D, Zoja, C, Longaretti, L, Gagliardini, E, Perico, N, Coffman, TM, and Remuzzi, G. "Targeted deletion of angiotensin II type 1A receptor does not protect mice from progressive nephropathy of overload proteinuria." Journal of the American Society of Nephrology 15, no. 10 (2004): 2666-2674. Full Text
  - Boffa, J-J, Just, A, Coffman, TM, and Arendshorst, WJ. "Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice." Journal of the American Society of Nephrology 15, no. 9 (2004): 2358-2365. Full Text
  - Francois, H, and Coffman, TM. "Prostanoids and blood pressure: Which way is up?." Journal of Clinical Investigation 114, no. 6 (2004): 757-759. Full Text
  - Thomas, DW, Rocha, PN, Nataraj, C, Robinson, LA, Spurney, RF, Koller, BH, and Coffman, TM. "Proinflammatory actions of thromboxane receptors to enhance cellular immune responses." J Immunol 171, no. 12 (December 15, 2003): 6389-6395. Link to Item
  - Rocha, PN, Plumb, TJ, Crowley, SD, and Coffman, TM. "Effector mechanisms in transplant rejection." Immunol Rev 196 (December 2003): 51-64. (Review) Link to Item
  - Le, TH, Kim, H-S, Allen, AM, Spurney, RF, Smithies, O, and Coffman, TM. "Physiological impact of increased expression of the AT1 angiotensin receptor." Hypertension 42, no. 4 (October 2003): 507-514. Full Text Link to Item
  - Rocha, PN, Plumb, TJ, and Coffman, TM. "Eicosanoids: lipid mediators of inflammation in transplantation." Springer Semin Immunopathol 25, no. 2 (September 2003): 215-227. (Review) Full Text Link to Item
  - Tharaux, P-L, Bukoski, RC, Rocha, PN, Crowley, SD, Ruiz, P, Nataraj, C, Howell, DN, Kaibuchi, K, Spurney, RF, and Coffman, TM. "Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells." J Immunol 171, no. 1 (July 1, 2003): 96-105. Link to Item
  - Harrison-Bernard, LM, Cook, AK, Oliverio, MI, and Coffman, TM. "Renal segmental microvascular responses to ANG II in AT(1A) receptor null mice." AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 284, no. 3 (March 2003): F538-F545. Full Text Link to Item
  - Cho, MJ, Liu, J, Pestina, TI, Steward, SA, Thomas, DW, Coffman, TM, Wang, D, Jackson, CW, and Gartner, TK. "The roles of α_IIbβ₃-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation." Blood 101, no. 7 (2003): 2646-2651. Full Text
  - Flamant, M, Tharaux, P-L, Placier, S, Henrion, D, Coffman, T, Chatziantoniou, C, and Dussaule, J-C. "Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice." The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, no. 2 (2003): 327-329.
  - Harrison-Bernard, LM, Cook, AK, Oliverio, MI, and Coffman, TM. "Renal segmental microvascular responses to ANG II in AT_1A receptor null mice." American Journal of Physiology - Renal Physiology 284, no. 3 53-3 (2003): F538-F545.
  - Le, TH, and Coffman, TM. "RGS2: A "turn-off" in hypertension." Journal of Clinical Investigation 111, no. 4 (2003): 441-443. Full Text
  - Robinson, LA, Nataraj, C, Thomas, DW, Cosby, JM, Griffiths, R, Bautch, VL, Patel, DD, and Coffman, TM. "The chemokine CX₃CL1 regulates NK cell activity in vivo." Cellular Immunology 225, no. 2 (2003): 122-130. Full Text
  - Wagner, C, Vitzthum, H, Castrop, H, Schumacher, K, Bucher, M, Albertin, S, Coffman, TM, Arendshorst, WJ, and Kurtz, A. "Differential regulation of renin and Cox-2 expression in the renal cortex of C57B1/6 mice." Pflugers Archiv European Journal of Physiology 447, no. 2 (2003): 214-222. Full Text
  - Wurth, GR, Sherr, JH, and Coffman, TM. "Orthopaedic research and education foundation and industry." Clinical Orthopaedics and Related Research , no. 412 (2003): 54-56.
  - Mannon, RB, Griffiths, R, Ruiz, P, Platt, JL, and Coffman, TM. "Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection." Kidney Int 62, no. 1 (July 2002): 290-300. Full Text Link to Item
  - Brooks, HL, Allred, AJ, Beutler, KT, Coffman, TM, and Knepper, MA. "Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice." Hypertension 39, no. 2 Pt 2 (February 2002): 470-473. (Academic Article)
  - Bostom, AD, Jr, RSB, Chavers, BM, Coffman, TM, Cosio, FG, Culver, K, Curtis, JJ, Danovitch, GM, Everson, GT, First, MR, Garvey, C, Grimm, R, Hertz, MI, Hricik, DE, Hunsicker, LG, Ibrahim, H, Kasiske, BL, Kennedy, M, Klag, M, Knatterud, ME, Kobashigawa, J, Lake, JR, Light, JA, Matas, AJ, McDiarmid, SV, Miller, LW, Payne, WD, Rosenson, R, Sutherland, DER, Tejani, A, Textor, S, Valantine, HA, and Wiesner, RH. "Prevention of post-transplant cardiovascular disease - Report and recommendations of an ad hoc group." American Journal of Transplantation 2, no. 6 (2002): 491-500. Full Text
  - Brickey, WJ, Felix, NJ, Griffiths, R, Zhang, J, Wang, B, Piskurich, JF, Itoh-Lindstrom, Y, Coffman, TM, and Ting, JP-Y. "Prolonged survival of class II transactivator-deficient cardiac allografts." Transplantation 74, no. 9 (2002): 1341-1348.
  - Brooks, HL, Allred, AJ, Beutler, KT, Coffman, TM, and Knepper, MA. "Targeted proteomic profiling of renal Na⁺ transporter and channel abundances in angiotensin II type 1a receptor knockout mice." Hypertension 39, no. 2 II (2002): 470-473. Full Text
  - Cheng, Y, Austin, SC, Rocca, B, Koller, BH, Coffman, TM, Grosser, T, Lawson, JA, and FitzGerald, GA. "Role of prostacyclin in the cardiovascular response to thromboxane A₂." Science 296, no. 5567 (2002): 539-541. Full Text
  - Coffman, TM. "Another cystic mystery solved." Nature Genetics 30, no. 3 (2002): 247-248. Full Text
  - Coggins, KG, Latour, A, Nguyen, MS, Audoly, L, Coffman, TM, and Koller, BH. "Metabolism of PGE₂ by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus." Nature Medicine 8, no. 2 (2002): 91-92. Full Text
  - Gurley, SB, Le, TH, and Coffman, TM. "Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease." Cold Spring Harb Symp Quant Biol 67 (2002): 451-457. (Review) Link to Item
  - Nguyen, M, Solle, M, Audoly, LP, Tilley, SL, Stock, JL, McNeish, JD, Coffman, TM, Dombrowicz, D, and Koller, BH. "Receptors and signaling mechanisms required for prostaglandin E₂-mediated regulation of mast cell degranulation and IL-6 production." Journal of Immunology 169, no. 8 (2002): 4586-4593.
  - Červenka, L, Horáček, V, Vaněčková, I, Hubáček, JA, Oliverio, MI, Coffman, TM, and Navar, LG. "Essential role of AT_1A receptor in the development of 2K1C hypertension." Hypertension 40, no. 5 (2002): 735-741. Full Text
  - Athirakul, K, Kim, HS, Audoly, LP, Smithies, O, and Coffman, TM. "Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition." Kidney Int 60, no. 6 (December 2001): 2324-2329. Full Text Link to Item
  - Goulet, JL, Griffiths, RC, Ruiz, P, Mannon, RB, Flannery, P, Platt, JL, Koller, BH, and Coffman, TM. "Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice." J Immunol 167, no. 11 (December 1, 2001): 6631-6636. Link to Item
  - Nataraj, C, Thomas, DW, Tilley, SL, Nguyen, MT, Mannon, R, Koller, BH, and Coffman, TM. "Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse." J Clin Invest 108, no. 8 (October 2001): 1229-1235. Full Text Link to Item
  - Audoly, LP, Ruan, X, Wagner, VA, Goulet, JL, Tilley, SL, Koller, BH, Coffman, TM, and Arendshorst, WJ. "Role of EP2 and EP3 PGE2 receptors in control of murine renal hemodynamics." American Journal of Physiology - Heart and Circulatory Physiology 280, no. 1 49-1 (June 11, 2001).
  - Kelly, SJ, Delnomdedieu, M, Oliverio, MI, Williams, LD, Saifer, MG, Sherman, MR, Coffman, TM, Johnson, GA, and Hershfield, MS. "Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase." J Am Soc Nephrol 12, no. 5 (May 2001): 1001-1009. Link to Item
  - Morris, M, Means, S, Oliverio, MI, and Coffman, TM. "Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors." AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 280, no. 4 (April 2001): R1177-R1184. Link to Item
  - Audoly, LP, Ruan, X, Wagner, VA, Goulet, JL, Tilley, SL, Koller, BH, Coffman, TM, and Arendshorst, WJ. "Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics." Am J Physiol Heart Circ Physiol 280, no. 1 (January 2001): H327-H333. Link to Item
  - Audoly, LP, Ruan, X, Wagner, VA, Goulet, JL, Tilley, SL, Koller, BH, Coffman, TM, and Arendshorst, WJ. "Role of EP₂ and EP₃ PGE₂ receptors in control of murine renal hemodynamics." American Journal of Physiology - Heart and Circulatory Physiology 280, no. 1 49-1 (2001): H327-H333.
  - Coffman, TM, Audoly, LP, and Oliverio, MI. "Gene targeting studies of angiotensin II type 1 (AT₁) receptors." JRAAS - Journal of the Renin-Angiotensin-Aldosterone System 2, no. SUPPL. 1 (2001): S10-S15.
  - Fabre, J-E, Nguyen, M, Athirakul, K, Coggins, K, McNeish, JD, Austin, S, Parise, LK, FitzGerald, GA, Coffman, TM, and Koller, BH. "Activation of the murine EP3 receptor for PGE₂ inhibits cAMP production and promotes platelet aggregation." Journal of Clinical Investigation 107, no. 5 (2001): 603-610. Full Text
  - Mistlberger, RE, Antle, MC, Oliverio, MI, Coffman, TM, and Morris, M. "Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors." Physiology and Behavior 74, no. 4-5 (2001): 457-464. Full Text
  - Morris, M, Means, S, Oliverio, MI, and Coffman, TM. "Enhanced central response to dehydration in mice lacking angiotensin AT_1a receptors." American Journal of Physiology - Regulatory Integrative and Comparative Physiology 280, no. 4 49-4 (2001): R1177-R1184.
  - Stock, JL, Shinjo, K, Burkhardt, J, Roach, M, Taniguchi, K, Ishikawa, T, Kim, H-S, Flannery, PJ, Coffman, TM, McNeish, JD, and Audoly, LP. "The prostaglandin E₂ EP1 receptor mediates pain perception and regulates blood pressure." Journal of Clinical Investigation 107, no. 3 (2001): 325-331. Full Text
  - Tharaux, PL, and Coffman, TM. "Transgenic mice as a tool to study the renin-angiotensin system." Contrib Nephrol , no. 135 (2001): 72-91. (Review) Link to Item
  - Tilley, SL, Coffman, TM, and Koller, BH. "Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes." Journal of Clinical Investigation 108, no. 1 (2001): 15-23. Full Text
  - Robinson, LA, Nataraj, C, Thomas, DW, Howell, DN, Griffiths, R, Bautch, V, Patel, DD, Feng, L, and Coffman, TM. "A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection." J Immunol 165, no. 11 (December 1, 2000): 6067-6072. Link to Item
  - Audoly, LP, Oliverio, MI, and Coffman, TM. "Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting." Trends Endocrinol Metab 11, no. 7 (September 2000): 263-269. (Review) Link to Item
  - Oliverio, MI, and Coffman, TM. "Angiotensin II Receptor Physiology Using Gene Targeting." News Physiol Sci 15 (August 2000): 171-175. Link to Item
  - Audoly, LP, Rocca, B, Fabre, JE, Koller, BH, Thomas, D, Loeb, AL, Coffman, TM, and FitzGerald, GA. "Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo." Circulation 101, no. 24 (June 20, 2000): 2833-2840. Link to Item
  - Butterly, DW, Spurney, RF, Ruiz, P, Griffiths, R, Albrightson, C, and Coffman, TM. "A role for leukotrienes in cyclosporine nephrotoxicity." Kidney Int 57, no. 6 (June 2000): 2586-2593. Full Text Link to Item
  - Mannon, RB, Doyle, C, Griffiths, R, Bustos, M, Platt, JL, and Coffman, TM. "Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts." Transplantation 69, no. 10 (May 27, 2000): 2137-2143. Link to Item
  - Audoly, LP, Le, TH, and Coffman, TM. "What can knockout mice contribute to an understanding of hypertension?." Curr Hypertens Rep 2, no. 2 (April 2000): 192-197. (Review) Link to Item
  - Oliverio, MI, Best, CF, Smithies, O, and Coffman, TM. "Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II." Hypertension 35, no. 2 (February 2000): 550-554. Link to Item
  - Pace, AJ, Lee, E, Athirakul, K, Coffman, TM, O'Brien, DA, and Koller, BH. "Failure of spermatogenesis in mouse lines deficient in the Na+-K+-2Cl(-) cotransporter." JOURNAL OF CLINICAL INVESTIGATION 105, no. 4 (February 2000): 441-450. Full Text Link to Item
  - Davisson, RL, Oliverio, MI, Coffman, TM, and Sigmund, CD. "Divergent functions of angiotensin II receptor isoforms in the brain." Journal of Clinical Investigation 106, no. 1 (2000): 103-106. Full Text
  - Felix, NJ, Brickey, WJ, Griffiths, R, Zhang, J, Kaer, LV, Coffman, T, and Ting, JP-Y. "H2-DMα^-(/)^- mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection." Journal of Experimental Medicine 192, no. 1 (2000): 31-40. Full Text
  - Morrissey, JJ, Nataraj, C, and Coffman, TM. "Angiotensin II: An immune costimulator?." American Journal of Kidney Diseases 36, no. 2 (2000): 434-440.
  - Oliverio, MI, Delnomdedieu, M, Best, CF, Li, P, Morris, M, Callahan, MF, Johnson, GA, Smithies, O, and Coffman, TM. "Abnormal water metabolism in mice lacking the type 1A receptor for ANG II." Am J Physiol Renal Physiol 278, no. 1 (January 2000): F75-F82. Link to Item
  - Oliverio, MI, Delnomdedieu, M, Best, CF, Li, P, Morris, M, Callahan, MF, Johnson, GA, Smithies, O, and Coffman, TM. "Abnormal water metabolism in mice lacking the type 1A receptor for ANG II." American Journal of Physiology - Renal Physiology 278, no. 1 47-1 (2000): F75-F82.
  - Pace, AJ, Lee, E, Athirakul, K, Coffman, TM, O'Brien, DA, and Koller, BH. "Failure of spermatogenesis in mouse lines deficient in the Na⁺-K⁺- 2Cl^- cotransporter." Journal of Clinical Investigation 105, no. 4 (2000): 441-450. Full Text
  - Schnermann, J, Traynor, T, Pohl, H, Thomas, DW, Coffman, TM, and Briggs, JP. "Vasoconstrictor responses in thromboxane receptor knockout mice: Tubuloglomerular feedback and ureteral obstruction." Acta Physiologica Scandinavica 168, no. 1 (2000): 201-207. Full Text
  - Nataraj, C, Oliverio, MI, Mannon, RB, Mannon, PJ, Audoly, LP, Amuchastegui, CS, Ruiz, P, Smithies, O, and Coffman, TM. "Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway." J Clin Invest 104, no. 12 (December 1999): 1693-1701. Full Text Link to Item
  - Fabre, JE, Nguyen, M, Latour, A, Keifer, JA, Audoly, LP, Coffman, TM, and Koller, BH. "Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice." Nat Med 5, no. 10 (October 1999): 1199-1202. Full Text Link to Item
  - Neylan, JF, Sayegh, MH, Coffman, TM, Danovitch, GM, Krensky, AM, Strom, TB, Turka, LA, and Harmon, WE. "The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology." Journal of the American Society of Nephrology : JASN 10, no. 10 (October 1999): 2237-2243. (Academic Article)
  - Audoly, LP, Tilley, SL, Goulet, J, Key, M, Nguyen, M, Stock, JL, McNeish, JD, Koller, BH, and Coffman, TM. "Identification of specific EP receptors responsible for the hemodynamic effects of PGE2." Am J Physiol 277, no. 3 Pt 2 (September 1999): H924-H930. Link to Item
  - Mannon, RB, Roberts, K, Ruiz, P, Laubach, V, and Coffman, TM. "Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection." J Heart Lung Transplant 18, no. 9 (September 1999): 819-827. Link to Item
  - Goulet, JL, Griffiths, RC, Ruiz, P, Spurney, RF, Pisetsky, DS, Koller, BH, and Coffman, TM. "Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice." J Immunol 163, no. 1 (July 1, 1999): 359-366. Link to Item
  - Le, TH, and Coffman, TM. "Genetic manipulation of the renin-angiotensin system." Curr Opin Nephrol Hypertens 8, no. 4 (July 1999): 397-403. (Review) Link to Item
  - Mannon, RB, and Coffman, TM. "Gene targeting: applications in transplantation research." Kidney Int 56, no. 1 (July 1999): 18-27. (Review) Full Text Link to Item
  - Mannon, RB, Kopp, JB, Ruiz, P, Griffiths, R, Bustos, M, Platt, JL, Klotman, PE, and Coffman, TM. "Chronic rejection of mouse kidney allografts." Kidney Int 55, no. 5 (May 1999): 1935-1944. Full Text Link to Item
  - Wada, T, Schwarting, A, Kinoshita, K, Naito, T, Griffiths, RC, Coffman, TM, and Kelley, VR. "Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice." Kidney Int 55, no. 3 (March 1999): 841-851. Full Text Link to Item
  - Audoly, LP, Tilley, SL, Goulet, J, Key, M, Nguyen, M, Stock, JL, McNeish, JD, Koller, BH, and Coffman, TM. "Identification of specific EP receptors responsible for the hemodynamic effects of PGE₂." American Journal of Physiology - Heart and Circulatory Physiology 277, no. 3 46-3 (1999): H924-H930.
  - Cervenka, L, Mitchell, KD, Oliverio, MI, Coffman, TM, and Navar, LG. "Renal function in the AT(1A) receptor knockout mouse during normal and volume-expanded conditions." Kidney International 56, no. 5 (1999): 1855-1862. Full Text
  - Cervenka, L, Mitchell, KD, Oliverio, MI, Coffman, TM, and Navar, LG. "Renal function in the at1A receptor knockout mouse during normal and volume-expanded conditions." Kidney International 56, no. 5 (1999): 1846-1854.
  - Morris, M, Li, P, Callahan, MF, Oliverio, MI, Coffman, TM, Bosch, SM, and Diz, DI. "Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor." Hypertension 33, no. 1 Pt 2 (January 1999): 482-486. (Academic Article)
  - Morris, M, Li, P, Callahan, MF, Oliverio, MI, Coffman, TM, Bosch, SM, and Diz, DI. "Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor." Hypertension 33, no. 1 II (1999): 482-486.
  - Neylan, JF, Sayegh, MH, Coffman, TM, Danovitch, GM, Krensky, AM, Strom, TB, Turka, LA, and Harmon, WE. "The allocation of cadaver kidneys for transplantation in the United States: Consensus and controversy." Journal of the American Society of Nephrology 10, no. 10 (1999): 2237-2243.
  - Ruan, X, Oliverio, MI, Coffman, TM, and Arendshorst, WJ. "Renal vascular reactivity in mice: AngII-induced vasoconstriction in AT(1A) receptor null mice." Journal of the American Society of Nephrology 10, no. 12 (1999): 2620-2630.
  - Ruan, X, Purdy, KE, Oliverio, MI, Coffman, TM, and Arendshorst, WJ. "Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice." Journal of the American Society of Nephrology 10, no. 1 SUPPL. 11 (1999): S202-S207.
  - Tilley, SL, Audoly, LP, Hicks, EH, Kim, H-S, Flannery, PJ, Coffman, TM, and Koller, BH. "Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E₂ receptor." Journal of Clinical Investigation 103, no. 11 (1999): 1539-1545. Full Text
  - Oliverio, MI, Kim, HS, Ito, M, Le, T, Audoly, L, Best, CF, Hiller, S, Kluckman, K, Maeda, N, Smithies, O, and Coffman, TM. "Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II." Proc Natl Acad Sci U S A 95, no. 26 (December 22, 1998): 15496-15501. Link to Item
  - Fleming, EF, Athirakul, K, Oliverio, MI, Key, M, Goulet, J, Koller, BH, and Coffman, TM. "Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2." The American journal of physiology 275, no. 6 Pt 2 (December 1998): F955-F961. (Academic Article)
  - Thomas, DW, Mannon, RB, Mannon, PJ, Latour, A, Oliver, JA, Hoffman, M, Smithies, O, Koller, BH, and Coffman, TM. "Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2." J Clin Invest 102, no. 11 (December 1, 1998): 1994-2001. Full Text Link to Item
  - Neuringer, IP, Mannon, RB, Coffman, TM, Parsons, M, Burns, K, Yankaskas, JR, and Aris, RM. "Immune cells in a mouse airway model of obliterative bronchiolitis." Am J Respir Cell Mol Biol 19, no. 3 (September 1998): 379-386. Full Text Link to Item
  - Thomas, DW, and Coffman, TM. "A genetic approach for studying the role of thromboxane A2 in the kidney." Kidney Int Suppl 67 (September 1998): S84-S87. (Review) Link to Item
  - Coffman, TM, Spurney, RF, Mannon, RB, and Levenson, R. "Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells." Am J Physiol 275, no. 2 Pt 2 (August 1998): F262-F269. Link to Item
  - Coffman, TM. "Gene targeting in physiological investigations: studies of the renin-angiotensin system." Am J Physiol 274, no. 6 Pt 2 (June 1998): F999-1005. (Review) Link to Item
  - Mannon, RB, Kotzin, BL, Nataraj, C, Ferri, K, Roper, E, Kurlander, RJ, and Coffman, TM. "Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts." J Clin Invest 101, no. 11 (June 1, 1998): 2517-2527. Full Text Link to Item
  - Hamawaki, M, Coffman, TM, Lashus, A, Koide, M, Zile, MR, Oliverio, MI, DeFreyte, G, Cooper, G, and Carabello, BA. "Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors." The American journal of physiology 274, no. 3 Pt 2 (March 1998): H868-H873. (Academic Article)
  - Coffman, TM, Spurney, RF, Mannon, RB, and Levenson, R. "Thromboxane A₂ modulates the fibrinolytic system in glomerular mesangial cells." American Journal of Physiology - Renal Physiology 275, no. 2 44-2 (1998): F262-F269.
  - Coffman, TM. "Gene targeting in physiological investigations: Studies of the renin- angiotensin system." American Journal of Physiology - Renal Physiology 274, no. 6 43-6 (1998): F999-F1005.
  - Davisson, RL, Beltz, TG, Oliverio, MI, Johnson, AK, Coffman, TM, and Sigmund, CD. "Functional separation of brain AT1A and AT1B receptors in AT1A knockout mice." FASEB Journal 12, no. 4 (1998): A52-.
  - Fleming, EF, Athirakul, K, Oliverio, MI, Key, M, Goulet, J, Koller, BH, and Coffman, TM. "Urinary concentrating function in mice lacking EP₃ receptors for prostaglandin E₂." American Journal of Physiology - Renal Physiology 275, no. 6 44-6 (1998): F955-F961.
  - Hamawaki, M, Coffman, TM, Lashus, A, Koide, M, Zile, MR, Oliverio, MI, DeFreyte, G, IV, GC, and Carabello, BA. "Pressure-overload hypertrophy is unabated in mice devoid of AT(1A) receptors." American Journal of Physiology - Heart and Circulatory Physiology 274, no. 3 43-3 (1998): H868-H873.
  - Morris, M, Li, P, Callahan, MF, Bosch, SM, Coffman, TM, Oliverio, MI, and Diz, DI. "Effect of dehydration on angiotensin receptors in the AT-1a knockout mouse." FASEB Journal 12, no. 4 (1998): A325-.
  - Oliverio, MI, Madsen, K, Best, CF, Ito, M, Maeda, N, Smithies, O, and Coffman, TM. "Renal growth and development in mice lacking AT1A receptors for angiotensin II." Am J Physiol 274, no. 1 Pt 2 (January 1998): F43-F50. Link to Item
  - Oliverio, MI, Madsen, K, Best, CF, Ito, M, Maeda, N, Smithies, O, and Coffman, TM. "Renal growth and development in mice lacking AT(1A) receptors for angiotensin II." American Journal of Physiology - Renal Physiology 274, no. 1 43-1 (1998): F43-F50.
  - Ruan, X, Oliverio, MI, Coffman, T, and Arendshorst, WJ. "Angiotensin II causes renal vasoconstriction in mice with AT_1A receptor deleted by gene targeting." FASEB Journal 12, no. 4 (1998): A109-.
  - Traynor, T, Yang, T, Huang, YG, Arend, L, Oliverio, MI, Coffman, T, Briggs, JP, and Schnermann, J. "Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT(1A) receptor-deficient mice." American Journal of Physiology - Renal Physiology 275, no. 6 44-6 (1998): F922-F927.
  - Traynor, T, Yang, T, Huang, YG, Arend, L, Oliverio, MI, Coffman, T, Briggs, JP, and Schnermann, JB. "Inhibition of adenosine₁ receptor-mediated glomerular vasoconstriction in AT_1A-receptor deficient mice." FASEB Journal 12, no. 4 (1998): A331-.
  - Zhu, Z, Zhang, SH, Wagner, C, Kurtz, A, Maeda, N, Coffman, T, and Arendshorst, WJ. "Angiotensin AT(1B) receptor mediates calcium signaling in vascular smooth muscle cells of AT(1A) receptor-deficient mice." Hypertension 31, no. 5 (1998): 1171-1177.
  - Spurney, RF, and Coffman, TM. "The C-terminus of the thromboxane receptor contributes to coupling and desensitization in a mouse mesangial cell line." J Pharmacol Exp Ther 283, no. 1 (October 1997): 207-215. Link to Item
  - Bustos, M, Coffman, TM, Saadi, S, and Platt, JL. "Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2." J Clin Invest 100, no. 5 (September 1, 1997): 1150-1158. Full Text Link to Item
  - Coffman, TM. "A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor." Semin Nephrol 17, no. 5 (September 1997): 404-411. (Review) Link to Item
  - Oliverio, MI, Best, CF, Kim, HS, Arendshorst, WJ, Smithies, O, and Coffman, TM. "Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation." Am J Physiol 272, no. 4 Pt 2 (April 1997): F515-F520. Link to Item
  - Shellhaas, CS, Coffman, T, Dargie, PJ, Killam, AP, and Kay, HH. "Intravillous eicosanoid compartmentalization and regulation of placental blood flow." J Soc Gynecol Investig 4, no. 2 (March 1997): 58-63. Link to Item
  - Bruggeman, LA, Dikman, S, Meng, C, Quaggin, SE, Coffman, TM, and Klotman, PE. "Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression." Journal of Clinical Investigation 100, no. 1 (1997): 84-92. Full Text
  - Coffman, TM. "A role for T cell co-stimulation in ischemic acute renal failure?." Kidney international 52, no. 6 (1997): 1706-1707.
  - Li, P, Callahan, MF, Coffman, TM, Oliverio, MI, and Morris, M. "Altered vasopressin axis in the AT-1a knockout mouse." FASEB Journal 11, no. 3 (1997): A462-.
  - Nguyen, M, Camenisch, T, Snouwaert, JN, Hicks, E, Coffman, TM, Anderson, PAW, Malouf, NN, and Koller, BH. "The prostaglandin receptor EP₄ triggers remodelling of the cardiovascular system at birth." Nature 390, no. 6655 (1997): 78-81. Full Text
  - Oliverio, MI, Best, CF, Kim, H-S, Arendshorst, WJ, Smithies, O, and Coffman, TM. "Angiotensin II responses in AT(1a) receptor-deficient mice: A role for AT(1B) receptors in blood pressure regulation." American Journal of Physiology - Renal Physiology 272, no. 4 41-4 (1997): F515-F520.
  - Oliverio, MI, Best, CF, Kim, H-S, Arendshorst, WJ, Smithies, O, and Coffman, TM. "Angiotensin II responses in at _1A receptor-deficient mice: A role for at _1B receptors in blood pressure regulation." American Journal of Physiology 272, no. 4 PART 2 (1997): F521-F530.
  - Oliverio, MI, and Coffman, TM. "Angiotensin-II-receptors: new targets for antihypertensive therapy." Clin Cardiol 20, no. 1 (January 1997): 3-6. (Review) Link to Item
  - Schnermann, JB, Traynor, T, Yang, T, Huang, YG, Oliverio, MI, Coffman, T, and Briggs, JP. "Absence of tubuloglomerular feedback responses in AT(1A) receptor- deficient mice." American Journal of Physiology - Renal Physiology 273, no. 2 42-2 (1997): F315-F320.
  - Wada, T, Naito, T, Griffiths, RC, Coffman, TM, and Kelley, VR. "Systemic autoimmune nephritogenic components induce CSF-1 and TNF-α in MRL kidneys." Kidney International 52, no. 4 (1997): 934-941.
  - Mannon, RB, Coffman, TM, and Mannon, PJ. "Distribution of binding sites for thromboxane A2 in the mouse kidney." Am J Physiol 271, no. 6 Pt 2 (December 1996): F1131-F1138. Link to Item
  - Mannon, RB, Kotzin, BL, Roper, E, Nataraj, C, Kurlander, RJ, and Coffman, TM. "The intragraft CD8+ T cell response in renal allograft rejection in the mouse." Transplantation 62, no. 1 (July 15, 1996): 96-104. Link to Item
  - Mannon, RB, Coffman, TM, and Mannon, PJ. "Distribution of binding sites for thromboxane A₂ in the mouse kidney." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 271, no. 6 40-6 (1996): F1131-F1138.
  - Naito, T, Griffiths, RC, Coffman, TM, and Kelley, VR. "Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice." Kidney International 49, no. 1 (1996): 67-74.
  - Burdmann, EA, Andoh, TF, Nast, CC, Evan, A, Connors, BA, Coffman, TM, Lindsley, J, and Bennett, WM. "Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril." The American journal of physiology 269, no. 4 Pt 2 (October 1995): F491-F499. (Academic Article)
  - McCoy, MC, Wang, Y, Coffman, TM, Killam, AP, and Kay, HH. "Effects of low-dose aspirin therapy on plasma levels of polyunsaturated fatty acids: a preliminary investigation." Am J Perinatol 12, no. 5 (September 1995): 371-374. Full Text Link to Item
  - Smith, SR, Minda, SA, Samsa, GP, Harrell, FE, Gunnells, JC, Coffman, TM, and Butterly, DW. "Late withdrawal of cyclosporine in stable renal transplant recipients." Am J Kidney Dis 26, no. 3 (September 1995): 487-494. Link to Item
  - Butterly, DW, Spurney, RF, Ruiz, P, Pirotzky, E, Braquet, P, and Coffman, TM. "Role of platelet activating factor in kidney transplant rejection in the rat." Kidney Int 48, no. 2 (August 1995): 337-343. Link to Item
  - Mannon, RB, Nataraj, C, Kotzin, BL, Griffiths, R, Geier, S, Ibrahim, S, Sanfilippo, FP, Platt, JL, Kurlander, R, and Coffman, TM. "Rejection of kidney allografts by MHC class I-deficient mice." Transplantation 59, no. 5 (March 15, 1995): 746-755. Link to Item
  - Burdmann, EA, Andoh, TF, Nast, CC, Evan, A, Connors, BA, Coffman, TM, Lindsley, J, and Bennett, WM. "Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 269, no. 4 38-4 (1995): F491-F499.
  - Cook, DN, Beck, MA, Coffman, TM, Kirby, SL, Sheridan, JF, Pragnell, IB, and Smithies, O. "Requirement of MIP-1α for an inflammatory response to viral infection." Science 269, no. 5230 (1995): 1583-1585.
  - Ito, M, Oliverio, MI, Mannon, PJ, Best, CF, Maeda, N, Smithies, O, and Coffman, TM. "Regulation of blood pressure by the type 1A angiotensin II receptor gene." Proceedings of the National Academy of Sciences of the United States of America 92, no. 8 (1995): 3521-3525.
  - Kim, H-S, Krege, JH, Kluckman, KD, Hagaman, JR, Hodgin, JB, Best, CF, Jennette, JC, Coffman, TM, Maeda, N, and Smithies, O. "Genetic control of blood pressure and the angiotensinogen locus." Proceedings of the National Academy of Sciences of the United States of America 92, no. 7 (1995): 2735-2739. Full Text
  - Kooyman, DL, Byrne, GW, McClellan, S, Nielsen, D, Tone, M, Waldmann, H, Coffman, TM, McCurry, KR, Platt, JL, and Logan, JS. "In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium." Science 269, no. 5220 (1995): 89-92.
  - Rappaport, J, Hanss, B, Kopp, JB, Copeland, TD, Bruggeman, LA, Coffman, TM, and Klotman, PE. "Transport of phosphorothioate oligonucleotides in kidney: Implications for molecular therapy." Kidney International 47, no. 5 (1995): 1462-1469.
  - Spurney, RF, Ruiz, P, Albrightson, CR, Pisetsky, DS, and Coffman, TM. "Fish oil feeding modulates leukotriene production in murine lupus nephritis." Prostaglandins 48, no. 5 (November 1994): 331-348. Link to Item
  - Spurney, RF, Middleton, JP, Raymond, JR, and Coffman, TM. "Modulation of thromboxane receptor activation in rat glomerular mesangial cells." Am J Physiol 267, no. 3 Pt 2 (September 1994): F467-F478. Link to Item
  - Spurney, RF, Ibrahim, S, Butterly, D, Klotman, PE, Sanfilippo, F, and Coffman, TM. "Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury." J Immunol 152, no. 2 (January 15, 1994): 867-876. Link to Item
  - Goulet, JL, Snouwaert, JN, Latour, AM, Coffman, TM, and Koller, BH. "Altered inflammatory responses in leukotriene-deficient mice." Proceedings of the National Academy of Sciences of the United States of America 91, no. 26 (1994): 12852-12856. Full Text
  - Kooyman, D, Byrne, G, McClellan, S, Nielsen, D, Kagan, D, Coffman, T, Masahide, T, Waldmann, H, Platt, J, and Logan, J. "Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells." Transplantation Proceedings 26, no. 3 (1994): 1241--.
  - Spurney, RF, Middleton, JP, Raymond, JR, and Coffman, TM. "Modulation of thromboxane receptor activation in rat glomerular mesangial cells." AM.J.PHYSIOL. 267, no. 3 part 2 (1994): F467-F478.
  - Spurney, RF, Middleton, JP, Raymond, JR, and Coffman, TM. "Modulation of thromboxane receptor activation in rat glomerular mesangial cells." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 267, no. 3 36-3 (1994): F467-F478.
  - Smith, SR, Kubacki, VB, Rakhit, A, Martin, LL, Schaffer, AV, Jasani, MK, Hefty, DJ, Johnston, T, Cannon, C, and Bennett, WM. "Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity." Transplantation 56, no. 6 (December 1993): 1422-1426. Link to Item
  - Mannon, RB, Sundar, SK, Sanfilippo, FP, and Coffman, TM. "Alterations in renal interleukin-1 production during kidney transplant rejection in the rat. The effects of high-dose methylprednisolone." Transplantation 56, no. 5 (November 1993): 1157-1162. Link to Item
  - Smith, SR, Coffman, TM, and Svetkey, LP. "Effect of low-dose aspirin on thromboxane production and the antihypertensive effect of captopril." J Am Soc Nephrol 4, no. 5 (November 1993): 1133-1139. Link to Item
  - Fan, PY, Albrightson, CR, Howell, DN, Best, C, Badger, AM, and Coffman, TM. "The azaspirane SKF 105685 ameliorates renal allograft rejection in rats." J Am Soc Nephrol 3, no. 10 (April 1993): 1680-1685. Link to Item
  - Spurney, RF, Onorato, JJ, Albers, FJ, and Coffman, TM. "Thromboxane binding and signal transduction in rat glomerular mesangial cells." Am J Physiol 264, no. 2 Pt 2 (February 1993): F292-F299. Link to Item
  - Spurney, RF, Onorato, JJ, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Characterization of glomerular thromboxane receptors in murine lupus nephritis." J Pharmacol Exp Ther 264, no. 2 (February 1993): 584-590. Link to Item
  - Coffman, T, Geier, S, Ibrahim, S, Griffiths, R, Spurney, R, Smithies, O, Koller, B, and Sanfilippo, F. "Improved renal function in mouse kidney allografts lacking MHC class I antigens." Journal of Immunology 151, no. 1 (1993): 425-435.
  - Jevnikar, AM, Singer, GG, Coffman, T, Glimcher, LH, and Kelley, VER. "Renal tubular cell expression of MHC class II (I-E^b) is insufficient to initiate immune injury in a transgenic kidney transplant model." Transplantation Proceedings 25, no. 1 (1993): 142-143.
  - Jevnikar, AM, Singer, GG, Coffman, T, Glimcher, LH, and Kelley, VER. "Transgenic tubular cell expression of class II is insufficient to initiate immune renal injury." Journal of the American Society of Nephrology 3, no. 12 (1993): 1972-1977.
  - Munger, KA, Coffman, TM, Griffiths, RC, Fogo, A, and Badr, KF. "The effects of surgery and acute rejection on glomerular hemodynamics in the transplanted rat kidney." Transplantation 55, no. 6 (1993): 1219-1224.
  - Spurney, RF, Onorato, JJ, Albers, FJ, and Coffman, TM. "Thromboxane binding and signal transduction in rat glomerular mesangial cells." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 264, no. 2 33-2 (1993): F292-F299.
  - Mannon, RB, and Coffman, TM. "Immunologic mechanisms of transplant rejection." Curr Opin Nephrol Hypertens 1, no. 2 (December 1992): 230-235. (Review) Link to Item
  - Gilkeson, GS, Spurney, R, Coffman, TM, Kurlander, R, Ruiz, P, and Pisetsky, DS. "Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice." Clin Immunol Immunopathol 64, no. 2 (August 1992): 166-172. Link to Item
  - Nesbitt, T, Coffman, TM, Griffiths, R, and Drezner, MK. "Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect." J Clin Invest 89, no. 5 (May 1992): 1453-1459. Full Text Link to Item
  - Spurney, RF, Fan, PY, Ruiz, P, Sanfilippo, F, Pisetsky, DS, and Coffman, TM. "Thromboxane receptor blockade reduces renal injury in murine lupus nephritis." Kidney Int 41, no. 4 (April 1992): 973-982. Link to Item
  - Chouinard, ML, Martin, LL, Coffman, T, Hamilton, BH, Linberg, LF, Pamidi, A, Simke, JP, and Rakhit, A. "Pharmacokinetics and biochemical efficacy of pirmagrel, a thromboxane synthase inhibitor, in renal allograft recipients." Clinical Pharmacology and Therapeutics 52, no. 6 (1992): 597-604.
  - Ruiz, P, Rey, L, Spurney, R, Coffman, T, and Viciana, A. "Thromboxane augmentation of alloreactive T cell function." Transplantation 54, no. 3 (1992): 498-505.
  - Smith, SR, Creech, EA, Schaffer, AV, Martin, LL, Rakhit, A, Douglas, FL, Klotman, PE, and Coffman, TM. "Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity." Kidney Int 41, no. 1 (January 1992): 199-205. Link to Item
  - Spurney, RF, Bernstein, RJ, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Physiologic role for enhanced renal thromboxane production in murine lupus nephritis." Prostaglandins 42, no. 1 (July 1991): 15-28. Link to Item
  - Spurney, RF, Ruiz, P, Pisetsky, DS, and Coffman, TM. "Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites." Kidney Int 39, no. 1 (January 1991): 95-102. Link to Item
  - Himmelstein, SI, Coffman, TM, Yarger, WE, and Klotman, PE. "Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction." Am J Physiol 258, no. 2 Pt 2 (February 1990): F281-F286. Link to Item
  - Spurney, RF, Mayros, SD, Collins, D, Ruiz, P, Klotman, PE, and Coffman, T. "Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats." Prostaglandins 39, no. 2 (February 1990): 135-146. Link to Item
  - Himmelstein, SI, Coffman, TM, Yarger, WE, and Klotman, PE. "Atrial natriuretic peptide-induced changes in renal prostacyclin production in ureteral obstruction." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 258, no. 2 27-2 (1990): F281-F286.
  - Collins, DM, Coffman, TM, Ruiz, P, and Klotman, PE. "High-protein feeding stimulates renal thromboxane production in rats with streptozocin-induced diabetes." J Lab Clin Med 114, no. 5 (November 1989): 545-553. Link to Item
  - Ruiz, P, Coffman, TM, Klotman, PE, and Sanfilippo, F. "Association of chronic thromboxane inhibition with reduced in situ cytotoxic T cell activity in rejecting rat renal allografts." Transplantation 48, no. 4 (October 1989): 660-666. Link to Item
  - Coffman, TM, Himmelstein, S, Best, C, and Klotman, PE. "Post-transplant hypertension in the rat: effects of captopril and native nephrectomy." Kidney Int 36, no. 1 (July 1989): 35-40. Link to Item
  - Coffman, TM, Ruiz, P, Sanfilippo, F, and Klotman, PE. "Chronic thromboxane inhibition preserves function of rejecting rat renal allografts." Kidney Int 35, no. 1 (January 1989): 24-30. Link to Item
  - Coffman, TM, Yohay, D, Carr, DR, Brazy, PC, Yarger, WE, and Klotman, PE. "Effect of dietary fish oil supplementation on eicosanoid production by rat renal allografts." Transplantation 45, no. 2 (February 1988): 470-474. Link to Item
  - Humes, HD, Coffman, T, Halderman, H, Mihatsch, M, Henry, M, and Porter, GA. "Cyclosporine nephrotoxicity: A workshop to discuss mechanisms, diagnosis, and treatment." Transplantation Proceedings 20, no. 3 SUPPL. 3 (1988): 833-840.
  - Ruiz, P, Coffman, TM, Howell, DN, Straznickas, J, Scroggs, MW, Baldwin, WM, Klotman, PE, and Sanfilippo, F. "Evidence that pretransplant donor blood transfusion prevents rat renal allograft dysfunction but not the in situ cellular alloimmune or morphologic manifestations of rejection." Transplantation 45, no. 1 (January 1988): 1-7. Link to Item
  - Svetkey, LP, Dunnick, NR, Coffman, TM, Himmelstein, SI, Bollinger, RR, McCann, RL, Wilkinson, RH, Braun, SD, Newman, GF, and Cohan, RH. "Comparison of intravenous digital subtraction angiography and conventional arteriography in defining renal anatomy." Transplantation 45, no. 1 (January 1988): 56-58. Link to Item
  - Coffman, TM, Carr, DR, Yarger, WE, and Klotman, PE. "Evidence that renal prostaglandin and thromboxane production is stimulated in chronic cyclosporine nephrotoxicity." Transplantation 43, no. 2 (February 1987): 282-285. Link to Item
  - Kolbeck, PC, Scroggs, MW, Coffman, TM, Klotman, PE, and Sanfilippo, F. "Associations between rat renal allograft function, inflammation, and host immunity." Transplant Proc 19, no. 1 Pt 1 (February 1987): 379-381. Link to Item
  - Coffman, TM, Kolbeck, PC, Sanfilippo, FP, and Klotman, PE. "Renal allograft function, arachidonic acid metabolism, and systemic cellular immunity after kidney transplantation in the rat." Transplantation Proceedings 19, no. 3 (1987): 3116-3118.
  - Kolbeck, PC, Scroggs, MW, Coffman, TM, Klotman, PE, and Sanfilippo, F. "Associations between rat renal allograft function, inflammation, and host immunity." Transplantation Proceedings 19, no. 1 I (1987): 379-381.
  - Coffman, TM, Sanfilippo, FP, Brazy, PC, Yarger, WE, and Klotman, PE. "Bilateral native nephrectomy improves renal isograft function in rats." Kidney Int 30, no. 1 (July 1986): 20-26. Link to Item
  - Klotman, PE, Smith, SR, Volpp, BD, Coffman, TM, and Yarger, WE. "Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys." Am J Physiol 250, no. 2 Pt 2 (February 1986): F282-F287. Link to Item
  - Coffman, TM, Schwertschlag, U, and Yarger, WE. "Lipid mediators in acute renal allograft rejection." Transplantation Proceedings 18, no. 5 SUPPL. 4 (1986): 94-97.
  - Klotman, PE, Smith, SR, Volpp, BD, Coffman, TM, and Yarger, WE. "Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys." American Journal of Physiology - Renal Fluid and Electrolyte Physiology 250, no. 2 (1986): 19/2-.
  - Coffman, TM, Yarger, WE, and Klotman, PE. "Functional role of thromboxane production by acutely rejecting renal allografts in rats." J Clin Invest 75, no. 4 (April 1985): 1242-1248. Full Text Link to Item
  - Mitnick, P, Greenberg, A, Coffman, T, Kelepouris, E, Wolf, CJ, and Goldfarb, S. "Effects of two models of hypercalcemia on renal acid base metabolism." Kidney Int 21, no. 4 (April 1982): 613-620. Link to Item
  - Mitnick, PD, Greenberg, A, DeOreo, PB, Weiner, BM, Coffman, TM, Walker, BR, Agus, ZS, and Goldfarb, S. "Effects of two nonsteroidal anti-inflammatory drugs, indomethacin and oxaprozin, on the kidney." Clin Pharmacol Ther 28, no. 5 (November 1980): 680-689. Link to Item
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