Natural killing in immunodeficient patients.

Published

Journal Article

Natural killing (NK) capacity was evaluated in peripheral blood mononuclear cells from 14 patients with well defined primary immunodeficiency disorders and compared with the activity of those cells in antibody-dependent cell-mediated cytotoxicity (ADCC) assays against antibody-coated erythrocyte (killed primarily by monocytes) and lymphoid or tumor targets (killed exclusively by lymphoid cells). A selective inability to lyse antibody-coated lymphocyte targets was observed with cells from patients with x-linked agammaglobulinemia, suggesting the involvement of either a different lymphocyte subpopulation or membrane receptor for NK and ADCC, or that a different functional susceptibility exists for the two types of killing. The only immunodeficiency state in which lymphocyte NK activity was found to be lacking was severe combined immunodediciency disease.

Full Text

Duke Authors

Cited Authors

  • Koren, HS; Amos, DB; Buckley, RH

Published Date

  • March 1, 1978

Published In

Volume / Issue

  • 120 / 3

Start / End Page

  • 796 - 799

PubMed ID

  • 632589

Pubmed Central ID

  • 632589

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States