Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.

Journal Article (Journal Article)

Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.

Full Text

Duke Authors

Cited Authors

  • Zhou, YT; Shimabukuro, M; Wang, MY; Lee, Y; Higa, M; Milburn, JL; Newgard, CB; Unger, RH

Published Date

  • July 21, 1998

Published In

Volume / Issue

  • 95 / 15

Start / End Page

  • 8898 - 8903

PubMed ID

  • 9671776

Pubmed Central ID

  • PMC21174

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.95.15.8898


  • eng

Conference Location

  • United States