Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.
Publication
, Journal Article
Zhou, YT; Shimabukuro, M; Wang, MY; Lee, Y; Higa, M; Milburn, JL; Newgard, CB; Unger, RH
Published in: Proc Natl Acad Sci U S A
July 21, 1998
Expression of peroxisome proliferator-activated receptor alpha (PPARalpha) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R). Leptin, PPARalpha/retinoid x receptor ligands, and FA all up-regulate PPARalpha and enzymes of FA oxidation and stimulate [3H]-palmitate oxidation in normal islets but not in islets from fa/fa rats. Overexpression of normal OB-R in islets of fa/fa rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPARalpha is a OB-R-dependent factor required for normal fat homeostasis in islet cells.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 21, 1998
Volume
95
Issue
15
Start / End Page
8898 / 8903
Location
United States
Related Subject Headings
- Tretinoin
- Transcription Factors
- Receptors, Cytoplasmic and Nuclear
- Rats, Mutant Strains
- Rats
- Proteins
- Pancreatic Diseases
- Male
- Leptin
- Islets of Langerhans
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhou, Y. T., Shimabukuro, M., Wang, M. Y., Lee, Y., Higa, M., Milburn, J. L., … Unger, R. H. (1998). Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci U S A, 95(15), 8898–8903. https://doi.org/10.1073/pnas.95.15.8898
Zhou, Y. T., M. Shimabukuro, M. Y. Wang, Y. Lee, M. Higa, J. L. Milburn, C. B. Newgard, and R. H. Unger. “Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.” Proc Natl Acad Sci U S A 95, no. 15 (July 21, 1998): 8898–8903. https://doi.org/10.1073/pnas.95.15.8898.
Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, et al. Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8898–903.
Zhou, Y. T., et al. “Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.” Proc Natl Acad Sci U S A, vol. 95, no. 15, July 1998, pp. 8898–903. Pubmed, doi:10.1073/pnas.95.15.8898.
Zhou YT, Shimabukuro M, Wang MY, Lee Y, Higa M, Milburn JL, Newgard CB, Unger RH. Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8898–8903.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 21, 1998
Volume
95
Issue
15
Start / End Page
8898 / 8903
Location
United States
Related Subject Headings
- Tretinoin
- Transcription Factors
- Receptors, Cytoplasmic and Nuclear
- Rats, Mutant Strains
- Rats
- Proteins
- Pancreatic Diseases
- Male
- Leptin
- Islets of Langerhans