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NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.

Publication ,  Journal Article
Krystal, AD; Edinger, JD; Wohlgemuth, WK; Marsh, GR
Published in: Sleep
September 15, 2002

STUDY OBJECTIVES: To determine whether the frequency spectrum of the sleep EEG is a physiologic correlate of 1) the degree to which individuals with persistent primary insomnia (PPI) underestimate their sleep time compared with the traditionally scored polysomnogram (PSG) and 2) the sleep complaints in PPI subjects who have relatively long traditionally scored PSG sleep times and relatively greater underestimation of sleep time. DESIGN: We compared EEG frequency spectra from REM and NREM sleep in PPI subjects subtyped as subjective insomnia sufferers (those with relatively long total sleep time and relative underestimation of sleep time compared with PSG), and objective insomnia sufferers (those with relatively short PSG total sleep time) with EEG frequency spectra in normals. We also studied the correlation between these indices and the degree of underestimation of sleep. Further, we determined the degree to which sleep EEG indexes related to sleep complaints. SETTING: Duke University Medical Center Sleep Laboratory. PARTICIPANTS: Normal (N=20), subjective insomnia (N=12), and objective insomnia (N=18) subjects. INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Lower delta and greater alpha, sigma, and beta NREM EEG activity were found in the patients with subjective insomnia but not those with objective insomnia, compared with the normal subjects. These results were robust to changes in the subtyping criteria. No effects were found for REM spectral indexes. Less delta non- REM EEG activity predicted greater deviation between subjective and PSG estimates of sleep time across all subjects. For the subjective insomnia subjects, diminished low-frequency and elevated higher frequency non- REM EEG activity was associated with their sleep complaints. CONCLUSIONS: NREM EEG frequency spectral indexes appear to be physiologic correlates of sleep complaints in patients with subjective insomnia and may reflect heightened arousal during sleep.

Duke Scholars

Published In

Sleep

ISSN

0161-8105

Publication Date

September 15, 2002

Volume

25

Issue

6

Start / End Page

630 / 640

Location

United States

Related Subject Headings

  • Sleep, REM
  • Sleep Stages
  • Sleep Initiation and Maintenance Disorders
  • Polysomnography
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electroencephalography
 

Citation

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Krystal, A. D., Edinger, J. D., Wohlgemuth, W. K., & Marsh, G. R. (2002). NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep, 25(6), 630–640.
Krystal, Andrew D., Jack D. Edinger, William K. Wohlgemuth, and Gail R. Marsh. “NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.Sleep 25, no. 6 (September 15, 2002): 630–40.
Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep. 2002 Sep 15;25(6):630–40.
Krystal, Andrew D., et al. “NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes.Sleep, vol. 25, no. 6, Sept. 2002, pp. 630–40.
Krystal AD, Edinger JD, Wohlgemuth WK, Marsh GR. NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes. Sleep. 2002 Sep 15;25(6):630–640.
Journal cover image

Published In

Sleep

ISSN

0161-8105

Publication Date

September 15, 2002

Volume

25

Issue

6

Start / End Page

630 / 640

Location

United States

Related Subject Headings

  • Sleep, REM
  • Sleep Stages
  • Sleep Initiation and Maintenance Disorders
  • Polysomnography
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Electroencephalography