Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998.

Journal Article (Journal Article)

Population-based surveillance for unexplained death and critical illness possibly due to infectious causes (UNEX) was conducted in four U.S. Emerging Infections Program sites (population 7.7 million) from May 1, 1995, to December 31, 1998, to define the incidence, epidemiologic features, and etiology of this syndrome. A case was defined as death or critical illness in a hospitalized, previously healthy person, 1 to 49 years of age, with infection hallmarks but no cause identified after routine testing. A total of 137 cases were identified (incidence rate 0.5 per 100,000 per year). Patients' median age was 20 years, 72 (53%) were female, 112 (82%) were white, and 41 (30%) died. The most common clinical presentations were neurologic (29%), respiratory (27%), and cardiac (21%). Infectious causes were identified for 34 cases (28% of the 122 cases with clinical specimens); 23 (68%) were diagnosed by reference serologic tests, and 11 (32%) by polymerase chain reaction-based methods. The UNEX network model would improve U.S. diagnostic capacities and preparedness for emerging infections.

Full Text

Duke Authors

Cited Authors

  • Hajjeh, RA; Relman, D; Cieslak, PR; Sofair, AN; Passaro, D; Flood, J; Johnson, J; Hacker, JK; Shieh, W-J; Hendry, RM; Nikkari, S; Ladd-Wilson, S; Hadler, J; Rainbow, J; Tappero, JW; Woods, CW; Conn, L; Reagan, S; Zaki, S; Perkins, BA

Published Date

  • February 2002

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 145 - 153

PubMed ID

  • 11897065

Pubmed Central ID

  • PMC2732455

International Standard Serial Number (ISSN)

  • 1080-6040

Digital Object Identifier (DOI)

  • 10.3201/eid0802.010165


  • eng

Conference Location

  • United States