Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
Eight cytotoxic compounds have been isolated from the CHCl3 extract of Amorpha fruticosa. One compound, 6'-O-D-beta-glucopyranosyldalpanol , is a new cytotoxic rotenoid. Another known rotenoid, 12 alpha beta-hydroxyamorphigenin , was first shown to exhibit extremely potent cytotoxicity (ED50 < 0.001 microgram/ml) in six neoplastic cell lines. In addition to these compounds, three isoflavones (afrormosin , 7,2',4', 5'-tetramethoxyisoflavone , 8-methylretusin ) and five rotenoids (amorphispironone , amorphigenin , dalpanol , 12a beta-hydroxydalpanol , and tephrosin ) were isolated. Compound 8 was isolated for the first time as a natural product from this plant. The structures of these compounds were established on the basis of spectral data; some were further confirmed by X-ray crystallographic analysis.
Li, L; Wang, HK; Chang, JJ; McPhail, AT; McPhail, DR; Terada, H; Konoshima, T; Kokumai, M; Kozuka, M; Estes, JR
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