Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.


Journal Article

Eight cytotoxic compounds have been isolated from the CHCl3 extract of Amorpha fruticosa. One compound, 6'-O-D-beta-glucopyranosyldalpanol [10], is a new cytotoxic rotenoid. Another known rotenoid, 12 alpha beta-hydroxyamorphigenin [6], was first shown to exhibit extremely potent cytotoxicity (ED50 < 0.001 microgram/ml) in six neoplastic cell lines. In addition to these compounds, three isoflavones (afrormosin [1], 7,2',4', 5'-tetramethoxyisoflavone [2], 8-methylretusin [3]) and five rotenoids (amorphispironone [4], amorphigenin [5], dalpanol [7], 12a beta-hydroxydalpanol [8], and tephrosin [9]) were isolated. Compound 8 was isolated for the first time as a natural product from this plant. The structures of these compounds were established on the basis of spectral data; some were further confirmed by X-ray crystallographic analysis.

Full Text

Duke Authors

Cited Authors

  • Li, L; Wang, HK; Chang, JJ; McPhail, AT; McPhail, DR; Terada, H; Konoshima, T; Kokumai, M; Kozuka, M; Estes, JR

Published Date

  • May 1993

Published In

Volume / Issue

  • 56 / 5

Start / End Page

  • 690 - 698

PubMed ID

  • 8326318

Pubmed Central ID

  • 8326318

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

International Standard Serial Number (ISSN)

  • 0163-3864

Digital Object Identifier (DOI)

  • 10.1021/np50095a005


  • eng