Synthesis and cytotoxicity of acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones.

Journal Article (Journal Article)

Several new acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9-diones were synthesized and evaluated for in vitro cytotoxicity by NCI against seven cancer cell types. 2,7-Diacetyl naphtho[2,3-b]thiophene-4,9-dione (9) showed significant cytotoxicity against leukemia cells with log GI50 values of -7.61 against SR cells and -7.18 against MOLT-4 cells. 3-Acetyl-naphtho[2,3-b]thiophene-4,9-dione (6) also demonstrated potent cytotoxicity in the latter cell line with log GI50 < -8.

Full Text

Duke Authors

Cited Authors

  • Huang, LJ; Kuo, SC; Perng, CY; Chao, YH; Wu, TS; McPhail, AT; Mauger, A; Cheng, HH; Lee, KH

Published Date

  • October 1998

Published In

Volume / Issue

  • 8 / 19

Start / End Page

  • 2763 - 2768

PubMed ID

  • 9873618

Pubmed Central ID

  • 9873618

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(98)00496-x


  • eng