Analysis of the mouse transcriptome for genes involved in the function of the nervous system.

Journal Article

We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including Family 3 G-protein coupled receptors, voltage-gated channels, and connexins. We also identified previously unknown candidates for secreted neuroactive molecules. The existence of a large number of unique brain ESTs suggests an additional molecular complexity that remains to be explored.A list of genes containing CAG stretches in the coding region represents a first step in the potential identification of candidates for hereditary neurological disorders.

Full Text

Duke Authors

Cited Authors

  • Gustincich, S; Batalov, S; Beisel, KW; Bono, H; Carninci, P; Fletcher, CF; Grimmond, S; Hirokawa, N; Jarvis, ED; Jegla, T; Kawasawa, Y; LeMieux, J; Miki, H; Raviola, E; Teasdale, RD; Tominaga, N; Yagi, K; Zimmer, A; Hayashizaki, Y; Okazaki, Y; RIKEN GER Group, ; GSL Members,

Published Date

  • June 2003

Published In

Volume / Issue

  • 13 / 6B

Start / End Page

  • 1395 - 1401

PubMed ID

  • 12819138

International Standard Serial Number (ISSN)

  • 1088-9051

Digital Object Identifier (DOI)

  • 10.1101/gr.1135303

Language

  • eng

Conference Location

  • United States