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Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.

Publication ,  Journal Article
Seo, SK; Regan, A; Cihlar, T; Lin, DC; Boulad, F; George, D; Prasad, VK; Kiehn, TE; Polsky, B
Published in: Clin Infect Dis
November 1, 2001

We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

Duke Scholars

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

November 1, 2001

Volume

33

Issue

9

Start / End Page

e105 / e108

Location

United States

Related Subject Headings

  • Organophosphorus Compounds
  • Organophosphonates
  • Microbiology
  • Immunocompromised Host
  • Humans
  • Ganciclovir
  • Foscarnet
  • Female
  • Encephalitis, Viral
  • Drug Resistance, Viral
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Seo, S. K., Regan, A., Cihlar, T., Lin, D. C., Boulad, F., George, D., … Polsky, B. (2001). Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance. Clin Infect Dis, 33(9), e105–e108. https://doi.org/10.1086/323022
Seo, S. K., A. Regan, T. Cihlar, D. C. Lin, F. Boulad, D. George, V. K. Prasad, T. E. Kiehn, and B. Polsky. “Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.Clin Infect Dis 33, no. 9 (November 1, 2001): e105–8. https://doi.org/10.1086/323022.
Seo, S. K., et al. “Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.Clin Infect Dis, vol. 33, no. 9, Nov. 2001, pp. e105–08. Pubmed, doi:10.1086/323022.
Seo SK, Regan A, Cihlar T, Lin DC, Boulad F, George D, Prasad VK, Kiehn TE, Polsky B. Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance. Clin Infect Dis. 2001 Nov 1;33(9):e105–e108.

Published In

Clin Infect Dis

DOI

ISSN

1058-4838

Publication Date

November 1, 2001

Volume

33

Issue

9

Start / End Page

e105 / e108

Location

United States

Related Subject Headings

  • Organophosphorus Compounds
  • Organophosphonates
  • Microbiology
  • Immunocompromised Host
  • Humans
  • Ganciclovir
  • Foscarnet
  • Female
  • Encephalitis, Viral
  • Drug Resistance, Viral