Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.

Journal Article (Journal Article)

We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.

Full Text

Duke Authors

Cited Authors

  • Seo, SK; Regan, A; Cihlar, T; Lin, DC; Boulad, F; George, D; Prasad, VK; Kiehn, TE; Polsky, B

Published Date

  • November 1, 2001

Published In

Volume / Issue

  • 33 / 9

Start / End Page

  • e105 - e108

PubMed ID

  • 11577375

International Standard Serial Number (ISSN)

  • 1058-4838

Digital Object Identifier (DOI)

  • 10.1086/323022


  • eng

Conference Location

  • United States