Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.
Published
Journal Article
We describe a case of CMV ventriculoencephalitis in a severely immunocompromised bone marrow transplant recipient who was receiving combination therapy with ganciclovir and foscarnet for treatment of viremia and retinitis. Analysis of sequential viral isolates recovered from the patient's cerebrospinal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.
Full Text
Duke Authors
Cited Authors
- Seo, SK; Regan, A; Cihlar, T; Lin, DC; Boulad, F; George, D; Prasad, VK; Kiehn, TE; Polsky, B
Published Date
- November 2001
Published In
- Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Volume / Issue
- 33 / 9
Start / End Page
- e105 - e108
PubMed ID
- 11577375
Pubmed Central ID
- 11577375
Electronic International Standard Serial Number (EISSN)
- 1537-6591
International Standard Serial Number (ISSN)
- 1058-4838
Digital Object Identifier (DOI)
- 10.1086/323022
Language
- eng