Overview
2. Impact of histocompatibility and other determinants of alloreactivity on clinical outcomes of unrelated cord blood transplants.
3. Studies to analyse the impact of Killer Immunoglobulin receptors on the outcomes of hematopoietic stem cell transplantation utilizing haploidentical, CD34 selected, familial grafts.
4. Propective longitudinal study of serial monitoring of adenovirus in allogenic transpants(SMAART)patients.
5. Use of mesenchymal stem cells for the treatment of GVHD
Current Appointments & Affiliations
Medical Professor in the Department of Pediatrics
·
2025 - Present
Pediatrics, Transplant and Cellular Therapy,
Pediatrics
Member of the Duke Cancer Institute
·
2003 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Newborn Screening for Hurler Syndrome Facilitates Early Transplant and Good Outcomes.
Journal Article Pediatr Neurol · February 2025 BACKGROUND: Hematopoietic cell transplantation (HCT) is the standard of care treatment for children with Hurler syndrome (HS). This study describes the impact of newborn screening (NBS) on HCT outcomes for these patients. METHODS: Retrospective study of HS ... Full text Link to item CiteSafety and feasibility of umbilical cord blood transplantation in children with neuronal ceroid lipofuscinosis: a retrospective study.
Journal Article Stem Cells Transl Med · January 17, 2025 Ceroid lipofuscinosis neuronal (CLN) encompasses rare inherited neurodegenerative disorders that present in childhood with clinical features including epilepsy, psychomotor delay, progressive vision loss, and premature death. Published experience utilizing ... Full text Link to item CiteHematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy.
Journal Article N Engl J Med · October 10, 2024 BACKGROUND: Gene therapy with elivaldogene autotemcel (eli-cel) consisting of autologous CD34+ cells transduced with lentiviral vector containing ABCD1 complementary DNA (Lenti-D) has shown efficacy in clinical studies for the treatment of cerebral adrenol ... Full text Link to item CiteRecent Grants
A Phase IIa, Open-label, Multiple Ascending Dose Confirmation Study of the Safety and Tolerability of Intravenous Brincidofovir in Subjects with Adenovirus Infection
Clinical TrialPrincipal Investigator · Awarded by SymBio Pharmaceuticals Limited · 2022 - 2025Multicentre Study of nomacopan in Paediatric Haematopoietic Stem-Cell Transplant Associated Thrombotic Microangiopathy
Clinical TrialPrincipal Investigator · Awarded by Akari Therapeutics · 2023 - 2025Identifying Predictors of Poor Health-Related Quality of Life among Pediatric Hematopoietic Stem Cell Donors
ResearchPrincipal Investigator · Awarded by National Marrow Donor Program · 2023 - 2024View All Grants
Education, Training & Certifications
Maulana Azad Medical College (India) ·
1981
M.B.B.S.