D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.

Journal Article (Journal Article)

To investigate the relationship between dopamine (DA) and acetylcholine (ACh) systems in the control of oral movement, we studied the effects of specific D1 and D2 drugs on vacuous chewing movements induced by the muscarinic ACh agonist, pilocarpine. In previous experiments we found that when given alone, the D1 agonist SKF 38393 increased vacuous chewing and the D1 antagonist SCH 23390 decreased it, while both the D2 agonist LY 171555 (quinpirole) and the D2 antagonist sulpiride decreased vacuous chewing. In the present experiment, the effects of the D1 drugs had similar effects in rats concurrently given pilocarpine. In contrast, the effects of both of the D2 drugs were altered by pilocarpine. Surprisingly, the actions of D2 agonist and antagonist were affected in opposite ways. The effect of sulpiride in reducing oral movement activity was eliminated by pilocarpine, while the effect of LY 171555 in reducing oral movement was enhanced by pilocarpine.

Full Text

Duke Authors

Cited Authors

  • Levin, ED; Ellison, GD; See, RE; South, D; Young, E

Published Date

  • July 1, 1989

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 501 - 505

PubMed ID

  • 2573903

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(89)90376-6


  • eng

Conference Location

  • United States