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D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.

Publication ,  Journal Article
Levin, ED; Ellison, GD; See, RE; South, D; Young, E
Published in: Pharmacol Biochem Behav
July 1989

To investigate the relationship between dopamine (DA) and acetylcholine (ACh) systems in the control of oral movement, we studied the effects of specific D1 and D2 drugs on vacuous chewing movements induced by the muscarinic ACh agonist, pilocarpine. In previous experiments we found that when given alone, the D1 agonist SKF 38393 increased vacuous chewing and the D1 antagonist SCH 23390 decreased it, while both the D2 agonist LY 171555 (quinpirole) and the D2 antagonist sulpiride decreased vacuous chewing. In the present experiment, the effects of the D1 drugs had similar effects in rats concurrently given pilocarpine. In contrast, the effects of both of the D2 drugs were altered by pilocarpine. Surprisingly, the actions of D2 agonist and antagonist were affected in opposite ways. The effect of sulpiride in reducing oral movement activity was eliminated by pilocarpine, while the effect of LY 171555 in reducing oral movement was enhanced by pilocarpine.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

July 1989

Volume

33

Issue

3

Start / End Page

501 / 505

Location

United States

Related Subject Headings

  • Receptors, Dopamine D2
  • Receptors, Dopamine D1
  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Quinpirole
  • Pilocarpine
  • Neurology & Neurosurgery
  • Movement
  • Mouth
 

Citation

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ICMJE
MLA
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Levin, E. D., Ellison, G. D., See, R. E., South, D., & Young, E. (1989). D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. Pharmacol Biochem Behav, 33(3), 501–505. https://doi.org/10.1016/0091-3057(89)90376-6
Levin, E. D., G. D. Ellison, R. E. See, D. South, and E. Young. “D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.Pharmacol Biochem Behav 33, no. 3 (July 1989): 501–5. https://doi.org/10.1016/0091-3057(89)90376-6.
Levin ED, Ellison GD, See RE, South D, Young E. D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. Pharmacol Biochem Behav. 1989 Jul;33(3):501–5.
Levin, E. D., et al. “D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.Pharmacol Biochem Behav, vol. 33, no. 3, July 1989, pp. 501–05. Pubmed, doi:10.1016/0091-3057(89)90376-6.
Levin ED, Ellison GD, See RE, South D, Young E. D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. Pharmacol Biochem Behav. 1989 Jul;33(3):501–505.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

July 1989

Volume

33

Issue

3

Start / End Page

501 / 505

Location

United States

Related Subject Headings

  • Receptors, Dopamine D2
  • Receptors, Dopamine D1
  • Receptors, Dopamine
  • Rats, Inbred Strains
  • Rats
  • Quinpirole
  • Pilocarpine
  • Neurology & Neurosurgery
  • Movement
  • Mouth