Neuroleptic-induced oral movements in rats: methodological issues.

Journal Article (Journal Article)

In three separate experiments groups of rats were chronically administered neuroleptics in a variety of ways (chronic injections, subcutaneous implants, and decanoate injections) and examined for oral movements (OMs) in two different tests: in an open cage using a human observer, or in a plexiglas tube enclosure, where OMs were monitored both by a human observer and computerized video analysis system. These two testing methods showed different effects of neuroleptic administration. In the open cage, OMs tended to be enhanced during chronic neuroleptic exposure and to rapidly subside upon drug withdrawal. The enhanced OMs were especially present just after drug injections, when activity levels were low. In the observation tube environment, however, OMs tended to be low soon after drug treatments, and elevated upon withdrawal. Thus, the type of behavioral test used determines how neuroleptic-induced increases in oral activity should be interpreted.

Full Text

Duke Authors

Cited Authors

  • Levy, AD; See, RE; Levin, ED; Ellison, GD

Published Date

  • September 21, 1987

Published In

Volume / Issue

  • 41 / 12

Start / End Page

  • 1499 - 1506

PubMed ID

  • 2887997

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(87)90715-6


  • eng

Conference Location

  • Netherlands