Is grade or stage of primary importance in determining the outcome after radical prostatectomy for disease clinically confined to the prostate?


Journal Article

A series of 145 patients with T1-2NOMO prostatic carcinoma underwent radical prostatectomy. Specimens were analysed by Gleason sum and categorised according to whether the disease was organ-confined, specimen-confined or margin-positive. The failure of treatment was indicated by elevation of acid phosphatase, by the appearance of biopsy proven local disease or distant nodal disease, or by parenchymal or nodal disease by any imaging modality. Analysis of the data demonstrated that the outcome of surgical intervention was related to the anatomical extent of disease. The Gleason sum was related to the extent of disease and predicted the probability of disease outside the organ of origin.

Full Text

Duke Authors

Cited Authors

  • Paulson, DF; Walther, PJ

Published Date

  • March 1989

Published In

Volume / Issue

  • 63 / 3

Start / End Page

  • 301 - 305

PubMed ID

  • 2702428

Pubmed Central ID

  • 2702428

International Standard Serial Number (ISSN)

  • 0007-1331

Digital Object Identifier (DOI)

  • 10.1111/j.1464-410x.1989.tb05193.x


  • eng

Conference Location

  • England