Overview
1. DEVELOPMENTAL THERAPEUTICS OF SYSTEMIC UROLOGIC CANCER
A continuation of an ongoing effort in preclinical screening for effective new agents for the treatment of urologic malignancy-especially bladder and prostate - particular addressing issues of drug synergy.
2. p53 MUTATIONS IN PROSTATE CANCER
The presence of p53 mutations in malignancy has been considered an important genetic change in the multistep process of carcinogenesis-including radiation failure.
3. ASSOCIATION OF ONCOGENIC TYPES OF HUMAN PAPILLOMAVIRUS WITH UROLOGIC MALIGNANCY
Oncogenic types of HPV may be an important promoter-initiator of carcinogenesis in a variety of epithelia. Using polymerase chain reaction, we have analyzed clinical specimens of urologic malignancy.
4. TREATMENT OF RENAL CANCER WITH GAMMA-INTERFERON
Principal Investigator (Duke site) for multi-institutional Phase II-III trial to determine the efficacy of this biologic response modifier.
5. ANDROGEN RECEPTOR-MEDIATED TRANSCRIPTIONAL REGULATION IN ANDROGEN-DEPENDENT HUMAN PROSTATE CANCER XENOGRAFT
A continuation of an ongoing effort in preclinical screening for effective new agents for the treatment of urologic malignancy-especially bladder and prostate - particular addressing issues of drug synergy.
2. p53 MUTATIONS IN PROSTATE CANCER
The presence of p53 mutations in malignancy has been considered an important genetic change in the multistep process of carcinogenesis-including radiation failure.
3. ASSOCIATION OF ONCOGENIC TYPES OF HUMAN PAPILLOMAVIRUS WITH UROLOGIC MALIGNANCY
Oncogenic types of HPV may be an important promoter-initiator of carcinogenesis in a variety of epithelia. Using polymerase chain reaction, we have analyzed clinical specimens of urologic malignancy.
4. TREATMENT OF RENAL CANCER WITH GAMMA-INTERFERON
Principal Investigator (Duke site) for multi-institutional Phase II-III trial to determine the efficacy of this biologic response modifier.
5. ANDROGEN RECEPTOR-MEDIATED TRANSCRIPTIONAL REGULATION IN ANDROGEN-DEPENDENT HUMAN PROSTATE CANCER XENOGRAFT
Current Appointments & Affiliations
Professor of Urology
·
1992 - Present
Urology,
Clinical Science Departments
Associate Professor of Pathology
·
1998 - Present
Pathology,
Clinical Science Departments
Recent Publications
Nrf2/keap1‐pathway activation and reduced susceptibility to chemotherapy treatment by acidification in esophageal adenocarcinoma cells
Journal Article Cancers · June 1, 2021 Chronic acid reflux causes cellular damage and inflammation in the lower esophagus. Due to these irritating insults, the squamous epithelium is replaced by metaplastic epithelium, which is a risk factor for the development of esophageal adenocarcinoma (EAC ... Full text CiteManagement of recurrent prostate cancer after radiotherapy: long-term results from CALGB 9687 (Alliance), a prospective multi-institutional salvage prostatectomy series.
Journal Article Prostate Cancer Prostatic Dis · May 2019 BACKGROUND: To evaluate efficacy and morbidity prospectively in a contemporary multi-institutional salvage radical prostatectomy (SRP) series. METHODS: Forty-one men were enrolled between 1997 and 2006, who suffered biopsy-proven recurrent prostate cancer ... Full text Link to item CiteEffect of positive end-expiratory pressure on blood loss during retropubic and robot-assisted laparoscopic radical prostatectomy.
Journal Article Int J Urol · August 2016 OBJECTIVES: To study the effect of end-expiratory pressure used during anesthesia on blood loss during radical prostatectomy. METHODS: We evaluated 247 patients who underwent either radical retropubic prostatectomy or robot-assisted laparoscopic prostatect ... Full text Link to item CiteRecent Grants
Immunotherapy with Renal Tumor RNA Transfected Dendritic Cells
ResearchCollaborator · Awarded by National Institutes of Health · 2001 - 2005Prostate Cancer Ctr Study: Black Vs White, Va Vs Private.
ResearchPrincipal Investigator · Awarded by Department of Veterans Affairs · 1998 - 2001Planning a Program of Research in Prostate Cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2000View All Grants
Education, Training & Certifications
Duke University ·
1997
M.B.A.
Duke University ·
1975
M.D.
Duke University ·
1974
Ph.D.