Scholars@Duke
Philip John Walther

Philip John Walther

Professor of Urology
Urology
philip.walther@duke.edu
Box 3314 Med Ctr, Durham, NC 27710
3907 Saint Marks Rd, Durham, NC 27707

Selected Publications

Nrf2/keap1‐pathway activation and reduced susceptibility to chemotherapy treatment by acidification in esophageal adenocarcinoma cells

Journal Article Cancers · June 1, 2021 Chronic acid reflux causes cellular damage and inflammation in the lower esophagus. Due to these irritating insults, the squamous epithelium is replaced by metaplastic epithelium, which is a risk factor for the development of esophageal adenocarcinoma (EAC ... Full text Cite

Management of recurrent prostate cancer after radiotherapy: long-term results from CALGB 9687 (Alliance), a prospective multi-institutional salvage prostatectomy series.

Journal Article Prostate Cancer Prostatic Dis · May 2019 BACKGROUND: To evaluate efficacy and morbidity prospectively in a contemporary multi-institutional salvage radical prostatectomy (SRP) series. METHODS: Forty-one men were enrolled between 1997 and 2006, who suffered biopsy-proven recurrent prostate cancer ... Full text Link to item Cite

Effect of positive end-expiratory pressure on blood loss during retropubic and robot-assisted laparoscopic radical prostatectomy.

Journal Article Int J Urol · August 2016 OBJECTIVES: To study the effect of end-expiratory pressure used during anesthesia on blood loss during radical prostatectomy. METHODS: We evaluated 247 patients who underwent either radical retropubic prostatectomy or robot-assisted laparoscopic prostatect ... Full text Link to item Cite

Vitamin E and the risk of prostate cancer: Updated results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Journal Article Journal of Clinical Oncology · February 10, 2012 7 Background: The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a non-statistically significant incre ... Full text Cite

Perineural versus lymphovascular invasion: Which is a better marker for unfavorable biochemical outcomes following prostatectomy? Results from the Duke Prostate Center Database.

Journal Article J Clin Oncol · February 10, 2012 34 Background: Despite a substantial effort to study the clinical significance of perineural invasion in prostate biopsies (PNIb) its prognostic significance remains controversial. The limited data on perineural invasion in radical prostatectomy (RP) speci ... Link to item Cite

Vitamin E and the risk of prostate cancer: Updated results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Journal Article J Clin Oncol · February 10, 2012 7 Background: The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a non-statistically significant increase in prostate cancer risk ... Link to item Cite

Perineural versus lymphovascular invasion: Which is a better marker for unfavorable biochemical outcomes following prostatectomy? Results from the Duke Prostate Center Database.

Journal Article J Clin Oncol · February 10, 2012 34 Background: Despite a substantial effort to study the clinical significance of perineural invasion in prostate biopsies (PNIb) its prognostic significance remains controversial. The limited data on perineural invasion in radical prostatectomy (RP) speci ... Full text Link to item Cite

Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Journal Article JAMA · October 12, 2011 CONTEXT: The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a statistically nonsignificant increase in prostate cancer risk with ... Full text Link to item Cite

Factors predicting early and late phase decline of sexual health-related quality of life following radical prostatectomy.

Journal Article J Sex Med · October 2011 INTRODUCTION: The association between early and late phase sexual health-related quality of life (HRQoL) following radical prostatectomy (RP) is unclear. Moreover, factors that predict either early or late sexual HRQoL decline have not been fully investiga ... Full text Link to item Cite

Salvage radiation in men after prostate-specific antigen failure and the risk of death.

Journal Article Cancer · September 1, 2011 BACKGROUND: A survival benefit has been observed with salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure after radical prostatectomy (RP) in men with rapid rises in PSA doubling time (DT, < 6 months). Whether such a benefit exits in ... Full text Link to item Cite

Adjuvant versus salvage radiation therapy for prostate cancer and the risk of death.

Journal Article BJU Int · December 2010 OBJECTIVE: To investigate whether salvage radiation therapy (RT) for prostate-specific antigen (PSA) failure can provide the same result as adjuvant RT, which decreases the risk of all-cause mortality (ACM) for men with positive margins (R1), or extra-caps ... Full text Link to item Cite

Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death.

Journal Article Cancer · April 15, 2010 BACKGROUND: This report evaluated whether biochemical recurrence (BCR) as a time-dependent covariate (t) after radical prostatectomy (RP) for prostate cancer was associated with the risk of death and whether salvage therapy with radiotherapy (RT) and/or ho ... Full text Link to item Cite

Men older than 70 years have higher risk prostate cancer and poorer survival in the early and late prostate specific antigen eras.

Journal Article J Urol · November 2009 PURPOSE: We clarified whether men older than 70 years have a higher risk of prostate cancer and poorer survival in the early and late prostate specific antigen eras. MATERIALS AND METHODS: A cohort of 4,561 men who underwent radical prostatectomy were stra ... Full text Link to item Cite

Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.

Journal Article J Natl Med Assoc · July 2009 BACKGROUND: Individual variation in circulating insulinlike growth factor-1 (IGF1) and its major binding protein, insulinlike growth factor binding protein-3 (IGFBP3), have been etiologically linked to several chronic diseases, including some cancers. Fact ... Full text Link to item Cite

Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Journal Article JAMA · January 7, 2009 CONTEXT: Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer. OBJECTIVE: To determine whether selenium, vitamin E, or both c ... Full text Link to item Cite

Bladder cancer.

Journal Article J Natl Compr Canc Netw · January 2009 Full text Link to item Cite

Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery.

Journal Article Cancer Epidemiol Biomarkers Prev · December 2008 BACKGROUND: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies ... Full text Link to item Cite

Grade-specific prostate cancer associations of IGF1 (CA)19 repeats and IGFBP3-202A/C in blacks and whites.

Journal Article J Natl Med Assoc · July 2007 Carrying the cytosine-adenosine (CA)19 repeat polymorphism in insulin-like growth factor-1 (IGF1) is associated with lower serum proteins and decreased prostate cancer risk. Carrying the -202A/C genotype in insulin-like growth factor binding protein-3 (IGF ... Link to item Cite

Comparative financial analysis of minimally invasive surgery to open surgery for small renal tumours < or =3.5 cm: a single institutional experience.

Journal Article Eur Urol · March 2007 OBJECTIVE: We analysed total hospital costs by comparing minimally invasive surgery (MIS) procedures, such as laparoscopic cryoablation (LCA), laparoscopic partial nephrectomy (LPN), and hand-assisted laparoscopic nephrectomy (HALN), with conventional surg ... Full text Link to item Cite

Financial comparative analysis of minimally invasive surgery to open surgery for localized prostate cancer: a single-institution experience.

Journal Article Urology · February 2007 OBJECTIVES: To evaluate the financial implications of how the costs of new minimally invasive surgery such as laparoscopic robotic prostatectomy (LRP) and cryosurgical ablation of the prostate (CAP) technologies compare with those of conventional surgery. ... Full text Link to item Cite

Bladder cancer. Clinical guidelines in oncology.

Journal Article J Natl Compr Canc Netw · November 2006 Full text Link to item Cite

Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate.

Journal Article Prostate Cancer Prostatic Dis · 2006 To determine the timing and patterns of late recurrence after radical prostatectomy (RP) alone or RP plus adjuvant radiotherapy (RT). Between 1970 and 1983, 159 patients underwent RP for newly diagnosed adenocarcinoma of the prostate and were found to have ... Full text Link to item Cite

Supplement use among men with prostate cancer.

Journal Article Urology · July 2005 OBJECTIVES: To characterize supplement use within a sample population of men diagnosed with prostate cancer. METHODS: A census of men diagnosed with prostate cancer at Duke University Medical Center from 1997 to 2002 (n = 1402) was mailed a survey that asc ... Full text Link to item Cite

IGF1 (CA)19 repeat and IGFBP3 -202 A/C genotypes and the risk of prostate cancer in Black and White men.

Journal Article Cancer Epidemiol Biomarkers Prev · February 2005 We investigated the relationship between the insulin-like growth factor-1 (IGF1) cytosine-adenine repeat (CA)(19) polymorphism located upstream of the gene's transcription start site, the insulin-like growth factor binding protein-3 (IGFBP3) -202 A/C promo ... Full text Link to item Cite

Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

Journal Article J Natl Cancer Inst · January 19, 2005 Prostate cancer continues to be a major health threat, especially among African American men. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), which opened on July 25, 2001, was planned to study possible agents for the prevention of prostate ca ... Full text Link to item Cite

Bladder cancer. Clinical practice guidelines in oncology.

Journal Article J Natl Compr Canc Netw · January 2005 Urothelial tumors represent a spectrum of diseases with a range of prognosis. After a diagnosis is established at any point within the urothelial tract, the patient remains at risk for developing a new lesion at a different or the same location and at a si ... Link to item Cite

Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen.

Journal Article Urology · May 2004 OBJECTIVES: Dietary factors may influence the prostate and have an impact on prostatic growth and disease. A small number of studies have suggested that flaxseed-supplemented, fat-restricted diets may thwart prostate cancer growth in both animals and human ... Full text Link to item Cite

459: Supplement -Use Among Prostate Cancer Survivors

Conference Journal of Urology · April 2004 Full text Cite

Glucocorticoids manifest androgenic activity in a cell line derived from a metastatic prostate cancer.

Journal Article Cancer Res · December 15, 2001 Featured Publication The pathophysiological mechanism(s) by which androgen independence develops in prostate cancer remains to be determined. The identification in many prostate cancer specimens of a mutant androgen receptor, T877A, with altered ligand specificity has provided ... Link to item Cite

Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features.

Journal Article Urology · July 2001 Featured Publication OBJECTIVES: Dietary fat and fiber affect hormonal levels and may influence cancer progression. Flaxseed is a rich source of lignan and omega-3 fatty acids and may thwart prostate cancer. The potential effects of flaxseed may be enhanced with concomitant fa ... Full text Link to item Cite

Contemporary chemotherapeutic approaches for the treatment of hormone-refractory prostate carcinoma.

Journal Article World J Urol · June 2000 Featured Publication The medical management of hormone-refractory prostate cancer remains difficult and largely palliative. The development of effective antineoplastic agents has been frustrated by difficulty in the establishment of satisfactory objective response criteria for ... Full text Link to item Cite

Time for a neoadjuvant chemotherapy strategy in prostate cancer?

Journal Article Curr Opin Urol · May 2000 Featured Publication Full text Link to item Cite

Early onset baldness and prostate cancer risk.

Journal Article Cancer Epidemiol Biomarkers Prev · March 2000 Featured Publication Prostatic carcinoma is the leading cancer among American men, yet few risk factors have been established. Although increased androgen levels have long been associated with both prostatic carcinoma and baldness, to date no studies have shown an association ... Link to item Cite

Interstitial brachytherapy for prostate cancer--just an expensive variant of 'watchful waiting'?

Journal Article Curr Opin Urol · May 1999 As a result of the recent resurgence of interest in interstitial brachytherapy, extended follow-up studies of early experience in this field are now being reported. However, such outcomes must be evaluated within the context of recent comprehensive assessm ... Full text Link to item Cite

Treatment options, selection, and satisfaction among African American and white men with prostate carcinoma in North Carolina.

Journal Article Cancer · July 15, 1998 BACKGROUND: In the U.S., prostate carcinoma mortality is greatest among African Americans. In North Carolina, the state with the fourth largest population of African Americans, the prostate carcinoma mortality rate is 2.5 times greater among African Americ ... Full text Link to item Cite

The treatment of metastatic renal cell carcinoma patients with recombinant human gamma interferon.

Journal Article Cancer J Sci Am · 1998 PURPOSE: Activity has been reported in phase II single-center, open-label studies after administration of low-dose recombinant interferon gamma-1b (rIFN-gamma) to patients with metastatic renal cell carcinoma, with an overall objective response proportion ... Link to item Cite

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer.

Journal Article Oncogene · December 18, 1997 Progression of prostate cancer from an androgen sensitive to androgen insensitive tumor has previously been shown to be accompanied by a change in alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in a rat model of prostate cancer. This ... Full text Link to item Cite

Enteric type adenocarcinoma of the upper tract urothelium associated with ectopic ureter and renal dysplasia: an oncological rationale for complete extirpation of this aberrant developmental anomaly.

Journal Article J Urol · October 1996 PURPOSE: Intestinal metaplasia of the urothelium occurs in chronically irritated retained urinary segments and can progress to enteric adenocarcinoma. We present a unique clinical experience with a closed segment ureter from a dysplastic kidney draining ec ... Link to item Cite

p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma.

Journal Article J Urol · May 1996 PURPOSE: Several reports have shown that cells with p53 mutations display increased resistance to ionizing radiation, a treatment often used clinically for localized prostate carcinoma. MATERIALS AND METHODS: Totals of 18 post-irradiated locally recurrent ... Link to item Cite

A prostate screening perspective.

Journal Article N C Med J · 1996 Link to item Cite

Phase III randomized trial of interleukin-2 with or without lymphokine-activated killer cells in the treatment of patients with advanced renal cell carcinoma.

Journal Article Cancer · September 1, 1995 BACKGROUND: Treatment with interleukin-2 (IL-2) and lymphokine-activated killer cells (LAK) resulted in responses in some patients with advanced renal cell carcinoma (RCC). However, the relative therapeutic benefit of the addition of LAK to IL-2 was unknow ... Full text Link to item Cite

Prostate cancer screening. Why the controversy?

Journal Article Surg Oncol Clin N Am · April 1995 The development of new technologies has stimulated a crusade of screening for earlier detection of prostate cancer. This effort has resulted in controversy regarding its clinical use in this format. Until randomized clinical screening trials define the val ... Link to item Cite

Genetic alterations in prostate adenocarcinoma.

Journal Article Surg Oncol Clin N Am · April 1995 The genetic alterations associated with prostate carcinogenesis, its progression, and the emergence of androgen independence gradually are being defined. This article focuses on a number of genetic defects that have been identified in prostate cancer, spec ... Link to item Cite

The association of oncogenic human papillomaviruses with urologic malignancy. The controversies and clinical implications.

Journal Article Surg Oncol Clin N Am · April 1995 Sexually transmitted human papillomaviruses (HPV) are linked to both benign and malignant lesions of the genitourinary tract. Evidence links oncogenic HPV types with carcinomas of the penis and urethra. An association with other common sites of urologic ma ... Link to item Cite

Oncogenic human papillomaviruses are rarely associated with squamous cell carcinoma of the bladder: evaluation by differential polymerase chain reaction.

Journal Article J Urol · February 1994 While a strong association between oncogenic human papillomaviruses and squamous cell cancers of the genital tract (penis, urethra and cervix) is known to exist, there is substantial controversy regarding the association of human papillomaviruses and cance ... Full text Link to item Cite

Combination versus single agent therapy in effecting complete therapeutic response in human bladder cancer: analysis of cisplatin and/or 5-fluorouracil in an in vivo survival model.

Journal Article Cancer Res · January 15, 1994 An in vivo study of cisplatin (CDDP) and 5-fluorouracil (5FU) cytotoxicity was performed using a multidose matrix with a human bladder transitional cell carcinoma xenograft tumor line (DU4284) tested by subrenal capsule assay in 154 nude mice (NM-SRCA). St ... Link to item Cite

A high association of oncogenic human papillomaviruses with carcinomas of the female urethra: polymerase chain reaction-based analysis of multiple histological types.

Journal Article J Urol · January 1994 Using polymerase chain reaction with type-specific human papillomavirus type 16 and 18 primers, and general primers screening for 9 other genotypes, we analyzed archival surgical specimens of urethral carcinoma from 18 women (17 with invasive cancer and 1 ... Full text Link to item Cite

Adenocarcinoma of the prostate. Part II: Tissue prognosticators.

Journal Article Am J Clin Pathol · September 1993 In this second review article of a two-part series on adenocarcinoma of the prostate, both established and experimental tissue prognosticators for adenocarcinoma of the prostate will be discussed. Consideration should be given to tissue indicators of progn ... Full text Link to item Cite

Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma.

Journal Article Hum Pathol · September 1993 The expression of tenascin, an extracellular matrix glycoprotein, was studied in three human prostatic carcinoma cell lines by Northern and Western blot analyses and in human prostate tissues by immunohistochemistry and Western blot analysis. All three car ... Full text Link to item Cite

p53 gene alterations in human prostate carcinoma.

Journal Article J Urol · July 1993 Alterations of the p53 gene are among the most frequent genetic lesions in a variety of human malignancies. Their role in prostate cancer is, however, unclear. We have analyzed 10 primary and two metastatic human prostate carcinomas as well as 3 prostate c ... Full text Link to item Cite

Workshop summary: approaches to radical prostatectomy.

Journal Article Eur Urol · 1993 The retropubic approach has recently become the method of choice for radical prostatectomy. This has been particularly evident since the 1970s, when open staging lymphadenectomy became an important part of the diagnostic workup, as both procedures could be ... Full text Link to item Cite

Radical perineal vs. retropubic prostatectomy: a review of optimal application and technical considerations in the utilization of these exposures.

Journal Article Eur Urol · 1993 Radical prostatectomy can be performed either with a retropubic or perineal approach. While the former has enjoyed popularity in recent years, perineal prostatectomy has undergone a substantial resurgence because of interest in laparoscopic pelvic lymphade ... Full text Link to item Cite

Squamous cell carcinoma of the prostate: 2 cases of a rare malignancy and review of the literature.

Journal Article J Urol · January 1993 Primary squamous cell carcinoma of the prostate is an extremely uncommon malignancy, accounting for less than 1% of all prostatic cancers. We report on 2 patients with primary squamous cell carcinoma of the prostate: 1 with organ-confined disease and 1 wit ... Full text Link to item Cite

Combined treatment approaches in regionally advanced bladder cancer.

Journal Article Urol Clin North Am · November 1992 Multimodal therapy for locally advanced bladder carcinoma is being pursued in a wide diversity of protocols at this same time. While a number of innovative approaches are being explored, neoadjuvant and adjuvant chemotherapy in conjunction with cystectomy ... Link to item Cite

Oncogenic human papillomavirus type 16 is associated with squamous cell cancer of the male urethra.

Journal Article Cancer Res · September 15, 1992 Human papillomaviruses (HPV), especially genotypes 16 and 18, are probable effectors of human urogenital malignancies. Although the male urethra is a proposed reservoir of HPV transmission, the association between HPV and squamous cell carcinoma (SCC) of t ... Link to item Cite

Interleukin-2-induced dermatotoxicity resembling toxic epidermal necrolysis.

Journal Article South Med J · June 1992 Interleukin-2 is a promising new immunotherapeutic antineoplastic agent, but it can cause severe multiorgan toxicity. Although dermatologic toxicity is seen in most patients receiving IL-2 therapy, it is usually manifested as pruritus and an erythematous m ... Full text Link to item Cite

Pedunculated scrotal mass: leiomyoma of scrotum.

Journal Article Urology · April 1992 Scrotal leiomyomas of the tunica dartos are extremely rare and usually misdiagnosed. A case of a pedunculated mass observed expectantly over thirty years demonstrates the benign oncologic natural history of this lesion despite its capability for substantia ... Full text Link to item Cite

Endoscopic release of retained Penrose drains: a simple solution for an old problem.

Journal Article J Urol · April 1992 The Penrose drain internally tethered by a fascial suture is a surgical complication with medical and legal implications. Correction of this problem usually has required open reexploration. A technique of endoscopic release of such a drain through the drai ... Full text Link to item Cite

Renal cell carcinoma treated with continuous-infusion interleukin-2 with ex vivo-activated killer cells.

Journal Article J Immunother (1991) · April 1992 High-dose recombinant interleukin-2 (rIL-2) results in tumor responses in patients with metastatic renal cell carcinoma ranging from 9 to 31%. Continuous infusion regimens of rIL-2 may be less toxic and may result in greater in vivo lymphokine-activated ki ... Full text Link to item Cite

Prevalence of human papillomavirus types 16 and 18 in squamous-cell carcinoma of the penis: a retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction.

Journal Article Int J Cancer · March 12, 1992 Human papillomaviruses (HPV), particularly types 16 and 18, may be carcinogenic effectors in a variety of human lower-genital-tract malignancies. Using the highly sensitive technique of differential polymerase chain reaction (D-PCR) with amplimers from the ... Full text Link to item Cite

Alterations of the P53 gene are associated with the progression of a human prostate carcinoma.

Journal Article J Urol · March 1992 P53 is a tumor suppressor gene that has been implicated in the molecular genetics of many human malignancies. Nucleotide alterations, most commonly single point mutations, have been shown not only to abrogate the p53 suppressor function but also to contrib ... Full text Link to item Cite

The role of flow cytometry in the management of bladder cancer.

Journal Article Hematol Oncol Clin North Am · February 1992 A substantial amount of investigation has been performed seeking to exploit the considerable technologic sophistication of automated flow cytometry for the management of bladder cancer. Although there is likely only a modest value for ploidy analysis of so ... Link to item Cite

Human papillomavirus types 16 and 18 are not involved in human prostate carcinogenesis: analysis of archival human prostate cancer specimens by differential polymerase chain reaction.

Journal Article J Urol · January 1992 Human papilloma viruses (HPV) have been implicated in the pathogenesis of a variety of malignancies, especially in carcinomas of the female genital tract. Recently, based on observations using the polymerase chain reaction amplification assay, HPV types 16 ... Full text Link to item Cite

Histologic grade, DNA ploidy, and intraglandular tumor extent as indicators of tumor progression of clinical stage B prostatic carcinoma. A direct comparison.

Journal Article Am J Surg Pathol · December 1991 Histologic grade, DNA ploidy, and percentage tumor area were assessed in prostatectomy specimens from 73 patients with clinical stage B adenocarcinoma of the prostate and analyzed for their value as predictors of tumor progression. Further, the relationshi ... Full text Link to item Cite

The therapeutic impact of dipyridamole: chemopotentiation of the cytotoxic combination 5-fluorouracil/cisplatin in an animal model of human bladder cancer.

Journal Article J Urol · November 1991 Using an in vivo assay of tumor cytotoxicity (the subrenal capsule assay in nude mice), two therapeutic strategies for the treatment of advanced human transitional cell carcinoma have been evaluated: 1) the use of 5-fluorouracil in combination with cisplat ... Full text Link to item Cite

alpha-Interferon and 5-fluorouracil: possible mechanisms of antitumor action.

Journal Article Semin Oncol · October 1991 We have treated 17 patients with 5-fluorouracil (5-FU, 300 mg/m2/d by continuous ambulatory infusion for 8 weeks) and interferon alfa-2b (escalating doses to cohorts of three to five patients, given subcutaneously on a daily schedule at 2.0, 3.5, 5.0, and ... Link to item Cite

Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1).

Journal Article J Urol · September 1991 A new human prostate adenocarcinoma cell line (DuPro-1) has been established from the athymic nude mouse supported xenograft DU5683. This was accomplished by embedding dispersed xenograft cells in 0.1 by 5.0 cm. spaghetti-like strands of Basement Membrane ... Full text Link to item Cite

Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management.

Journal Article Cancer · September 1, 1991 Adenoid cystic carcinoma (ACC) of the breast is a rare histologic type of breast cancer associated with a good prognosis. A woman who earlier had a pulmonary metastasis surgically resected 6 years postmastectomy developed clinically symptomatic bleeding fr ... Full text Link to item Cite

The impact of the "cisplatin era" of treatment on survival in testicular cancer

Journal Article World Journal of Urology · March 1, 1991 The records of all testicular cancer patients evaluated and treated at our medical center during two consecutive 9-year periods were reviewed and analyzed for prognostic factors, particularly the impact of cisplatin-based combination chemotherapy. The data ... Full text Cite

Chemosensitivity testing of human bladder carcinoma

Journal Article Acta Urologica Italica · December 1, 1990 Cite

Radical prostatectomy for clinical stage T1-2N0M0 prostatic adenocarcinoma: long-term results.

Journal Article J Urol · November 1990 A total of 441 stage T1-2N0M0 and 11 stage T1-2N0M0 cancer patients with an elevated acid phosphatase level only, and 18 stage T1-2N+M0 cancer patients underwent radical prostatectomy. Analysis of the 441 stage T1-2N0M0 cancer patients demonstrated that fa ... Full text Link to item Cite

Dipyridamole-cisplatin potentiation: enhanced in vivo cytotoxicity in xenograft models of human testicular and bladder cancers.

Journal Article J Urol · October 1990 The antitumor efficacy and host toxicity of dipyridamole (DP), methotrexate (MTX) and cisplatin (CDDP) alone and combined were evaluated in a nude mouse supported human bladder cancer model. Single agent post treatment tumor volume growth ratio [TGR] value ... Full text Link to item Cite

Characterization of a new model of human prostatic cancer: the multicellular tumor spheroid.

Journal Article Int J Cancer · August 15, 1990 Multicellular tumor spheroids (MTS) provide a closer in vitro correlate to in vivo malignancy than do conventional monolayer cultures; while simulating many parameters of in vivo growth, MTS systems provide those perquisites (i.e., experimental control, ec ... Full text Link to item Cite

Postoperative radiotherapy of the prostate for patients undergoing radical prostatectomy with positive margins, seminal vesicle involvement and/or penetration through the capsule.

Journal Article J Urol · June 1990 A group of 159 patients previously reported as having margins positive for disease after radical prostatectomy with or without adjunctive postoperative radiation was reanalyzed to determine whether the reported benefit did indeed exist. Upon re-examination ... Full text Link to item Cite

Flow cytometric assessment of deoxyribonucleic acid content in renal adenocarcinoma: does ploidy status enhance prognostic stratification over stage alone?

Journal Article J Urol · March 1990 Flow cytometry was used to analyze deparaffinized primary renal cell carcinoma specimens from 106 patients to evaluate deoxyribonucleic acid ploidy as a predictor of disease progression and survival. Of these specimens 62 (58%) demonstrated aneuploid stem ... Full text Link to item Cite

Delay in diagnosis and survival in testicular cancer: impact of effective therapy and changes during 18 years.

Journal Article J Urol · March 1990 In an effort to determine the impact of a delayed diagnosis in testicular cancer the records of 148 patients with a known interval of delay were reviewed. The over-all mean symptomatic interval of this population was 21.1 weeks and did not change significa ... Full text Link to item Cite

Refusal of cancer therapy in testicular cancer: Recognizing and preventing a significant problem

Journal Article World Journal of Urology · March 1, 1990 Of 244 patients with testicular cancer who were treated at our medical center between 1970 and 1987, 7 (2.9%) refused all or a portion of their cancer therapy. All refusers died of cancer, and 6 of the 7 deaths were directly attributable to the refusal. Re ... Full text Cite

The evolving role for surgery in the management of nonseminomatous testicular carcinoma

Journal Article World Journal of Urology · March 1, 1990 Once the only therapy available for locoregional disease extension, the approriate role for surgical management by retroperitoneal lymphadenectomy (RPND) of nonseminomatous germ cell testicular cancer is now being redefined in an algorithm of management co ... Full text Cite

Enhanced in vivo cytotoxicity of recombinant human tumor necrosis factor with etoposide in human renal cell carcinoma. Evaluation in a pre-clinical model.

Journal Article Urol Res · 1990 The combination of tumor necrosis factor (TNF) and etoposide (ETP) was evaluated for potential cytotoxic efficacy against a human renal cell carcinoma xenograft using an in vivo assay employing an athymic mouse host with tumor implanted a the subrenal caps ... Full text Link to item Cite

Complications of therapy for testicular cancer.

Journal Article J Urol · December 1989 Of 244 patients with testis cancer seen between January 1970 and December 1987 (mean followup 70 months) 88 (36.1%) experienced 1 or more early complications (within 1 year), while 16 (6.6%) had a late (greater than 1 year) complication. Chemotherapy-relat ... Full text Link to item Cite

Rationale for immunotoxin therapy of metastatic prostate carcinoma formatted as a multi-stage delivery system.

Journal Article J Urol · August 1989 A family of triple hybridomas secreting hybrid monoclonal antibodies has been developed in our laboratory. The hybrid monoclonal antibodies exhibit bimolecular specificity towards both antigenic determinants on the prostate carcinoma cell surface as well a ... Full text Link to item Cite

Schedule-dependent enhanced lethality with combined administration of actinomycin D and tumor necrosis factor in mice.

Journal Article J Biol Response Mod · June 1989 While additive in vitro antitumor cytotoxicity has been observed with tumor necrosis factor (TNF) in combination with cytotoxic agents, particularly actinomycin D (AMD), the critical issue of potentially enhanced host toxicity has not been assessed with su ... Link to item Cite

Is grade or stage of primary importance in determining the outcome after radical prostatectomy for disease clinically confined to the prostate?

Journal Article Br J Urol · March 1989 A series of 145 patients with T1-2NOMO prostatic carcinoma underwent radical prostatectomy. Specimens were analysed by Gleason sum and categorised according to whether the disease was organ-confined, specimen-confined or margin-positive. The failure of tre ... Full text Link to item Cite

The role of radical prostatectomy in the management of prostatic adenocarcinoma - Biologic factors influencing the likelihood of local and systemic control

Journal Article World Journal of Urology · March 1, 1989 Radical prostatectomy has been the mainstay of treatment for localized prostate cancer for over 50 years, but its value has been controversial. This report evaluates the impact of this therapeutic modality by assessing the value of various prognostic strat ... Full text Cite

Recombinant human tumor necrosis factor alone and with chemotherapeutic agents. Effect on nude mouse-supported human bladder cancer heterografts.

Journal Article Arch Surg · January 1989 Although studies done in tissue culture (in vitro) have shown synergism between recombinant human tumor necrosis factor (rhTNF) and chemotherapeutic agents, whether such synergism exists in a complex in vivo environment with acceptable toxic side effects h ... Full text Link to item Cite

Paraneoplastic limbic encephalopathy with testicular carcinoma. A reversible neurologic syndrome.

Journal Article Cancer · November 15, 1988 Limbic encephalitis (encephalopathy) is a rare paraneoplastic syndrome which rarely responds to antineoplastic therapy. The authors report the first case of limbic encephalopathy associated with testicular carcinoma and the first histologically confirmed e ... Full text Link to item Cite

Flow cytometric determination of ploidy in prostatic adenocarcinoma: a comparison with seminal vesicle involvement and histopathological grading as a predictor of clinical recurrence.

Journal Article J Urol · October 1988 Flow cytometry was used to evaluate 88 deparaffinized radical prostatectomy specimens to compare deoxyribonucleic acid ploidy in prostatic adenocarcinoma as a predictor of disease progression with other well documented predictors of clinical recurrence. An ... Full text Link to item Cite

Radical prostatectomy in stage A prostatic adenocarcinoma.

Journal Article J Urol · September 1988 A total of 76 patients (18 with stage A1 and 58 with stage A2 cancer) underwent radical perineal prostatectomy. No perioperative deaths occurred and no patient suffered rectal injury or was incontinent postoperatively. Five patients (3 with stage A1 and 2 ... Full text Link to item Cite

Adult segmental cystic disease of the kidney: a renal-sparing management approach.

Journal Article J Urol · August 1988 Segmental cystic disease of the kidney is a rare entity with the gross and microscopic features of autosomal dominant polycystic kidney disease localized to only a portion of a kidney. We report a renal-sparing management approach to a patient in whom a mu ... Full text Link to item Cite

Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma.

Journal Article J Urol · July 1988 Pathological data from 321 patients who underwent radical prostatectomy or cystoprostatectomy with a diagnosis of prostatic adenocarcinoma were reviewed. Of these specimens 4 (1.2 per cent) demonstrated histopathological findings consistent with prostatic ... Full text Link to item Cite

SCHEDULE-DEPENDENT ENHANCED LETHAL TOXICITY IN MICE WITH COMBINED ADMINISTRATION OF ACTINOMYCIN-D AND TUMOR NECROSIS FACTOR

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1988 Link to item Cite

The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination.

Journal Article Cancer · November 1, 1987 Cisplatin is a recognized neurotoxic agent that commonly causes ototoxicity and peripheral neuropathy. In conjunction with characteristic peripheral neuropathy, two patients treated with high-dose cisplatin developed Lhermitte's sign, a manifestation of po ... Full text Link to item Cite

Intraoperative management of penile erection with intracorporeal phenylephrine during endoscopic surgery.

Journal Article J Urol · April 1987 Intraoperative penile tumescence during endoscopic surgery is a troublesome complication that often is refractory to recommended methods of management. We report a new approach of pharmacological management with intracorporeal penile injections of phenylep ... Full text Link to item Cite

PRODUCTION AND PARTIAL CHARACTERIZATION OF A PROSTATE CARCINOMA-DIRECTED MAB

Journal Article PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH · March 1, 1987 Link to item Cite

Fournier's gangrene: a complication of penile prosthetic implantation in a renal transplant patient.

Journal Article J Urol · February 1987 The management of erectile impotence in renal transplant patients remains problematical. The enhanced risk of surgical infection in this immunosuppressed patient population must be addressed if prosthetic implantation is contemplated. A case of Fournier's ... Full text Link to item Cite

Radical prostatectomy: anatomical predictors of success or failure.

Journal Article J Urol · November 1986 A total of 143 patients underwent radical prostatectomy. Surgical specimens were evaluated with respect to local extent of disease, Gleason grade of the primary and relative nuclear roundness of the surgical specimen. The probability of disease control in ... Full text Link to item Cite

Phase II study of etoposide for carcinoma of the prostate.

Journal Article Cancer Treat Rep · June 1986 The treatment of prostate carcinoma with the epipodophyllotoxin derivative etoposide was studied in a multi-institutional phase II trial. An iv dose schedule of 130 mg/m2 daily for 3 days every 3 weeks was utilized. A total of 36 patients were evaluable; t ... Link to item Cite

Computed tomographic imaging of microscopic dystrophic calcification in urachal adenocarcinoma.

Journal Article Urology · February 1986 Supravesical calcification noted on conventional radiography when associated with a bladder lesion has been considered nearly pathognomonic of the uncommon lesion, urachal adenocarcinoma. As the case reported here demonstrates, stippled microscopic calcifi ... Full text Link to item Cite

In vitro synergism between hybrid immunotoxins and chemotherapeutic drugs: relevance to immunotherapy of prostate carcinoma.

Journal Article Cancer Immunol Immunother · 1986 Cultured prostate carcinoma cells incubated in the presence of a novel hybrid immunotoxin and ricin A chain exhibited synergy with the chemotherapeutic drugs vinblastine, methotrexate, and bleomycin. No cooperative effect was noted with adriamycin. Under c ... Full text Link to item Cite

The management of the Kock continent ileal reservoir urinary diversion with single pigtail self-retaining ileal conduit stents.

Journal Article J Urol · December 1985 The use of single pigtail soft silicone self-retaining ileal conduit stents appears to have particular value in the perioperative management of patients with a Kock pouch continent urinary diversion. Stenting provides greater assurance of sustained interna ... Full text Link to item Cite

Chylothorax: a rare complication of metastatic prostatic carcinoma.

Journal Article J Urol · December 1985 Chylothorax is an uncommon condition rarely seen in urological oncology and it is an extremely rare complication of prostatic carcinoma. Such a case is described in which successful palliative management with a combination of chemotherapy and radiation the ... Full text Link to item Cite

Laboratory chemosensitivity testing of human bladder carcinoma

Journal Article World Journal of Urology · September 1, 1985 The variable sensitivity of similar tumors to cytotoxic drugs from patient to patient would suggest a potential role for a reliable laboratory method to identify effective as well as ineffective chemotherapeutic agents. While the known moderately responsiv ... Full text Cite

Evidence for a novel hybrid immunotoxin recognizing ricin A-chain by one antigen-combining site and a prostate-restricted antigen by the remaining antigen-combining site: potential for immunotherapy.

Journal Article Cancer Treat Rep · June 1985 We have used cell fusion technology to produce second-generation hybridomas which secrete a population of murine monoclonal antibodies (MABs), a portion of which are bifunctional antibodies. The bifunctional hybrid MABs produced are capable of recognizing ... Link to item Cite

Lethal complications of standard self-retaining ureteral stents in patients with ileal conduit urinary diversion.

Journal Article J Urol · May 1985 While standard commercially available pigtail ureteral stents are used commonly in the obstructed patient, particularly when metastatic disease has been identified, our recent experience suggests caution in the use of such stents for patients with ileal co ... Full text Link to item Cite

Effects of diethyldithiocarbamate and nine other nucleophiles on the intersubunit protein cross-linking and inactivation of purified human alpha 2-macroglobulin by cis-diamminedichloroplatinum(II).

Journal Article Cancer Res · December 1984 The cross-linking and inactivation of the plasma protein alpha 2-macroglobulin by cis-diamminedichloroplatinum(II) (cisplatin; Gonias, S. L., and Pizzo, S. V. J. Biol. Chem., 256: 12478-12484, 1981) was used to study platinum(II)-protein binding in the pre ... Link to item Cite

Effects of Diethyldithiocarbamate and Nine Other Nucleophiles on the Intersubunit Protein Cross-Linking and Inactivation of Purified Human α2-Macroglobulin by cis-Diamminedichloroplatinum(ll)

Journal Article Cancer Research · December 1, 1984 The cross-linking and inactivation of the plasma protein αz-macroglobulin by cis-diamminedichloroplatinum(ll) (cisplatin; Gonias, S. L., and Pizzo, S. V. J. Biol. Chem., 256: 12478-12484,1981) was used to study platinum(ll)-protein binding in the presence ... Cite

Increased releasable vascular plasminogen activator and a bleeding diathesis.

Journal Article Am J Med · September 1984 A 66-year-old man with metastatic prostatic carcinoma treated with high-dose (5 mg) diethylstilbestrol therapy underwent orchiectomy to allow discontinuation of estrogen. An extensive ecchymosis developed postoperatively in an area covered by elastic dress ... Full text Link to item Cite

Testicular seminoma revisited: Time for a multimodal therapeutic approach

Journal Article World Journal of Urology · March 1, 1984 The development of effective chemotherapy regimens for germ-cell carcinoma has mandated a reassessment of the management of testicular seminoma, since patients with advanced seminoma respond poorly to radiotherapy. Although traditional radiotherapy regimen ... Full text Cite

Characterization of prostate-tissue-directed monoclonal antibody, alpha-Pro 13.

Journal Article Cancer Immunol Immunother · 1984 The alpha-Pro 13-secreting hybridoma was produced by immunizing mice with an equal mixture of PC-3, DU145, and LNCaP established prostatic carcinoma cell lines. The specificity of alpha-Pro 13 monoclonal antibody was evaluated by the criteria of differenti ... Full text Link to item Cite

Mucinous adenocarcinoma of the prostate.

Journal Article J Comput Assist Tomogr · December 1982 Full text Link to item Cite

Aspiration biopsy of prostate.

Journal Article Urology · June 1982 Needle biopsy of the prostate has been widely practiced for more than twenty-five years, whereas transrectal aspiration biopsy, first described fifty years ago, has not. We describe our experience using the transrectal aspiration biopsy and correlate the r ... Full text Link to item Cite

Renal metastasis of adenocarcinoma of the lung: massive hematuria managed by therapeutic embolization.

Journal Article J Urol · September 1979 The rare complication of massive hematuria secondary to metastatic infiltrating adenocarcinoma of the lung to the kidney was managed with steel coil therapeutic embolization. The angiographic and pathologic picture as well as the advantages of this therape ... Full text Link to item Cite

Intracavitary mitomycin-C in the treatment of superficial urothelial tumors: a preliminary report.

Journal Article Trans Am Assoc Genitourin Surg · 1979 Nine patients with a variety of surface transitional cell neoplastic lesions received topical mitomycin-C. The results of treatment were encouraging, all patients responding completely or partially. Based on this experience the authors are participating in ... Link to item Cite

The importance of the preactivation peptide in the two-stage mechanism of human plasminogen activation.

Journal Article J Biol Chem · August 10, 1975 The two stages in the activation of human plasminogen by urokinase have been examined kinetically in order to evaluate the significance of each stage in the activation process. The cleavage of the preactivation peptide from the NH2 terminus of native plasm ... Link to item Cite