Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins.


Journal Article

PCR fingerprinting with single non-specific primers was used to type vaginal isolates of C. albicans from Portugal, Angola, Madagascar, and two regions of Germany (Berlin and Munich). In addition to analysing isolates that exhibited the normal biotype of C. albicans, the study included atypical strains that failed to assimilate glucosamine and N-acetylglucosamine, which were isolated from women in Angola and Madagascar. A total of 212 strains of C. albicans were studied, representing 87 different multi-locus genotypes. The genotypes of strains from each geographical population were highly similar but not identical. There was one exception: a strain from Portugal grouped with the typical strains from Angola. The typical and especially the atypical populations from Africa displayed less genotype variation than the populations from Europe. The Portuguese samples exhibited the greatest genotypic heterogeneity. Distance analysis (UPGMA) revealed a statistically weak correlation between genotype and geographical origin of the C. albicans isolates.

Full Text

Duke Authors

Cited Authors

  • Pinto de Andrade, M; Schönian, G; Forche, A; Rosado, L; Costa, I; Müller, M; Presber, W; Mitchell, TG; Tietz, HJ

Published Date

  • March 2000

Published In

Volume / Issue

  • 290 / 1

Start / End Page

  • 97 - 104

PubMed ID

  • 11043986

Pubmed Central ID

  • 11043986

International Standard Serial Number (ISSN)

  • 1438-4221

Digital Object Identifier (DOI)

  • 10.1016/s1438-4221(00)80112-5


  • eng

Conference Location

  • Germany