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Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs.

Publication ,  Journal Article
Iwa, M; Strickland, C; Nakade, Y; Pappas, TN; Takahashi, T
Published in: Dig Dis Sci
July 2005

It has been shown that acupuncture relieves symptoms of abdominal pain and bloating in patients with irritable bowel syndrome (IBS). However, the mechanism of beneficial effects of acupuncture still remains unproven. The aim of the present study was to investigate the mechanisms of the antinociceptive effects of acupuncture in conscious dogs. We evaluated the increase in mean arterial blood pressure (MAP) caused by rectal distension as an index of visceral pain. Electroacupuncture (EA; 10 Hz) at ST-36 (lower leg), but not at BL-21 (back), significantly reduced the increase in MAP in response to rectal distension (30 and 40 cm3). The antinociceptive effect of EA at ST-36 was abolished by pretreatment with naloxone (a central and peripheral opioid receptor antagonist) but not by naloxone methiodide (a peripheral opioid receptor antagonist). These results suggest that EA at ST-36 may reduce visceral pain via central opioid pathway. Acupuncture may be useful to treat visceral hypersensitivity in IBS patients.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

July 2005

Volume

50

Issue

7

Start / End Page

1264 / 1270

Location

United States

Related Subject Headings

  • Viscera
  • Rectal Diseases
  • Quaternary Ammonium Compounds
  • Pain Measurement
  • Pain
  • Narcotic Antagonists
  • Naloxone
  • Male
  • Hindlimb
  • Gastroenterology & Hepatology
 

Citation

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Iwa, M., Strickland, C., Nakade, Y., Pappas, T. N., & Takahashi, T. (2005). Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs. Dig Dis Sci, 50(7), 1264–1270. https://doi.org/10.1007/s10620-005-2770-y
Iwa, Masahiro, Carmen Strickland, Yukiomi Nakade, Theodore N. Pappas, and Toku Takahashi. “Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs.Dig Dis Sci 50, no. 7 (July 2005): 1264–70. https://doi.org/10.1007/s10620-005-2770-y.
Iwa M, Strickland C, Nakade Y, Pappas TN, Takahashi T. Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs. Dig Dis Sci. 2005 Jul;50(7):1264–70.
Iwa, Masahiro, et al. “Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs.Dig Dis Sci, vol. 50, no. 7, July 2005, pp. 1264–70. Pubmed, doi:10.1007/s10620-005-2770-y.
Iwa M, Strickland C, Nakade Y, Pappas TN, Takahashi T. Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs. Dig Dis Sci. 2005 Jul;50(7):1264–1270.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

July 2005

Volume

50

Issue

7

Start / End Page

1264 / 1270

Location

United States

Related Subject Headings

  • Viscera
  • Rectal Diseases
  • Quaternary Ammonium Compounds
  • Pain Measurement
  • Pain
  • Narcotic Antagonists
  • Naloxone
  • Male
  • Hindlimb
  • Gastroenterology & Hepatology