Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.

Journal Article

Transgenic mice harboring the SV40 large T antigen gene in a C57B1/6J genetic background (SV11) first express this gene at 1-2 weeks of age, develop papillomas of the choroid plexus by 80-90 days, and die within 125 days after birth. Transgenic mice harboring the same transgene in a (SV11-C57Bl/6J x NZW/lacJ) F1 genetic background express considerably lower levels of the transgene mRNA at comparable times after birth. As a consequence, tumor development and death are delayed. The NZW mice appear to contribute a dominant negative regulator for the expression of the SV40 large T antigen transgene, which in turn has a dramatic effect upon the time of appearance of tumors and the death of these transgenic animals.

Full Text

Duke Authors

Cited Authors

  • Cho, HJ; Seiberg, M; Georgoff, I; Teresky, AK; Marks, JR; Levine, AJ

Published Date

  • September 1989

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 115 - 122

PubMed ID

  • 2478718

International Standard Serial Number (ISSN)

  • 0360-4012

Digital Object Identifier (DOI)

  • 10.1002/jnr.490240116

Language

  • eng

Conference Location

  • United States