Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.
Journal Article (Journal Article)
Transgenic mice harboring the SV40 large T antigen gene in a C57B1/6J genetic background (SV11) first express this gene at 1-2 weeks of age, develop papillomas of the choroid plexus by 80-90 days, and die within 125 days after birth. Transgenic mice harboring the same transgene in a (SV11-C57Bl/6J x NZW/lacJ) F1 genetic background express considerably lower levels of the transgene mRNA at comparable times after birth. As a consequence, tumor development and death are delayed. The NZW mice appear to contribute a dominant negative regulator for the expression of the SV40 large T antigen transgene, which in turn has a dramatic effect upon the time of appearance of tumors and the death of these transgenic animals.
Full Text
Duke Authors
Cited Authors
- Cho, HJ; Seiberg, M; Georgoff, I; Teresky, AK; Marks, JR; Levine, AJ
Published Date
- September 1989
Published In
Volume / Issue
- 24 / 1
Start / End Page
- 115 - 122
PubMed ID
- 2478718
International Standard Serial Number (ISSN)
- 0360-4012
Digital Object Identifier (DOI)
- 10.1002/jnr.490240116
Language
- eng
Conference Location
- United States