Overview
I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches. I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.
Current Appointments & Affiliations
Recent Publications
Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics.
Journal Article Cancer Res · December 15, 2025 UNLABELLED: Preinvasive breast cancer, or ductal carcinoma in situ (DCIS), shares many morphologic and genomic features with invasive breast cancer, yet most DCIS tumors remain indolent over decades. In this study, we performed spatial analyses of somatic ... Full text Link to item CitePatient-reported Outcomes After Routine Treatment of In Situ/Atypical Lesions: The PORTAL Study.
Journal Article Ann Surg Oncol · December 2025 BACKGROUND: Guideline concordant care (GCC) for ductal carcinoma in situ (DCIS) includes some combination of surgery, radiation, and/or endocrine treatment. Active monitoring (AM) is a common approach for high-risk breast histologies (e.g., atypical ductal ... Full text Link to item CiteAmbient air pollution and survival among Black women with epithelial ovarian cancer across diverse geographical regions of the United States.
Journal Article Environ Epidemiol · December 2025 BACKGROUND: Ovarian cancer is a leading cause of gynecologic cancer mortality, with Black women experiencing 5-year survival rates of only 41%. Disproportionate air pollution exposure may impact survival. We evaluated associations of fine particulate matte ... Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Duke Research Training Program in Surgical Oncology
Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 2024 - 2029Methylomic Basis of Survival Disparities Among Black and White Women With High-Grade Serous Ovarian Cancer
ResearchPrincipal Investigator · Awarded by H. Lee Moffitt Cancer Center & Research Institute · 2023 - 2027View All Grants