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Jeffrey R. Marks

Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery
Surgery, Surgical Sciences
Box 3873 Med Ctr, Durham, NC 27710
B216, LSRC, Duke University, Durham, NC 27710

Overview


I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches.  I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.  

Current Duke Appointments & Affiliations


Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery · 2022 - Present Surgery, Surgical Sciences, Surgery
Professor in Surgery · 2019 - Present Surgery, Surgical Sciences, Surgery
Professor of Pathology · 2019 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 1988 - Present Duke Cancer Institute, Institutes and Centers

Recent News Items


Published November 13, 2025
Obesity Weakens Cancer Immunity: Can GLP-1 Drugs Turn It Back On?
Published May 18, 2022
University Awards 24 New Distinguished Professorships

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Recent Scholarly Works


Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression.

Journal article Cancer Cell · June 8, 2026 Immune escape during the ductal carcinoma in situ (DCIS)-to-invasive breast cancer (IBC) transition shapes tumor evolution. Through transcriptomic mapping of the immune landscapes of normal breast, DCIS, and IBC from large patient cohorts, we identified T ... Full text Link to item Cite

Spatial proteomics of breast ductal carcinoma in situ reveal distinct regional differences.

Journal article Sci Rep · March 13, 2026 Breast ductal carcinoma in situ is a common non-invasive clinical finding that can progress to invasive breast cancer (IBC). Spatial proteomics can provide an additional dimension to our understanding of this disease and its capacity to progress. A subset ... Full text Link to item Cite

Prognostic Implications of Codon-Specific KRAS Mutations in Localized and Advanced Stages of Pancreatic Cancer.

Journal article JCO Precis Oncol · February 2026 PURPOSE: Although KRAS mutations represent the primary oncogenic driver in pancreatic ductal adenocarcinoma (PDAC), the association between codon-specific alterations and patient outcomes remains poorly elucidated, largely because of a lack of data sets co ... Full text Link to item Cite
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Recent Grants


A Multiscale Approach to Defining High-Risk Lesions and Neighborhoods for Breast Precancers

ResearchCo Investigator · Awarded by National Institutes of Health · 2026 - 2031

2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Center for Advancing Translational Sciences · 2025 - 2030

Duke Research Training Program in Surgical Oncology

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 2024 - 2029

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Education


University of California, San Diego · 1985 Ph.D.