Skip to main content
Journal cover image

Allografts about the Knee in Young Patients with High-Grade Sarcoma.

Publication ,  Journal Article
Brigman, BE; Hornicek, FJ; Gebhardt, MC; Mankin, HJ
Published in: Clin Orthop Relat Res
April 2004

Reconstruction after resections for high-grade sarcomas about the knee in children and adolescents is a challenging problem because of the large soft tissue and skeletal defects, the effects of adjuvant therapy, and the potential for long-term use of the limb. One hundred sixteen patients, all 18 years or younger, with osteosarcoma or Ewing's sarcoma located between the middle femur and middle tibia, were treated with chemotherapy, resection, and allograft reconstruction. One hundred three patients with osteosarcoma and 13 patients with Ewing's sarcoma had 105 Stage II and 11 Stage III tumors. There were 72 osteoarticular grafts (39 femur, 33 tibia), 28 intercalary grafts (19 femur), seven allograft-prosthetic composites (all femur,) and nine allograft-arthrodeses (seven femur, two tibia). At latest followup, 49% of all of the allograft reconstructions were rated good or excellent, 14% were rated as fair, and 37% were failures. Sixteen percent had an infection develop. Twenty-seven percent of patients had a fracture, 34% had a nonunion, and 14 patients eventually required amputation. Reconstruction of large bone defects about the knee in young patients who are being treated with chemotherapy is difficult. Although complications significantly affect outcome, allografts are a viable option for reconstruction in children with high-grade sarcomas about the knee.

Duke Scholars

Published In

Clin Orthop Relat Res

DOI

ISSN

0009-921X

Publication Date

April 2004

Issue

421

Start / End Page

232 / 239

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Time Factors
  • Sarcoma, Ewing
  • Recovery of Function
  • Orthopedics
  • Male
  • Knee Joint
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brigman, B. E., Hornicek, F. J., Gebhardt, M. C., & Mankin, H. J. (2004). Allografts about the Knee in Young Patients with High-Grade Sarcoma. Clin Orthop Relat Res, (421), 232–239. https://doi.org/10.1097/01.blo.0000127132.12576.05
Brigman, Brian E., Francis J. Hornicek, Mark C. Gebhardt, and Henry J. Mankin. “Allografts about the Knee in Young Patients with High-Grade Sarcoma.Clin Orthop Relat Res, no. 421 (April 2004): 232–39. https://doi.org/10.1097/01.blo.0000127132.12576.05.
Brigman BE, Hornicek FJ, Gebhardt MC, Mankin HJ. Allografts about the Knee in Young Patients with High-Grade Sarcoma. Clin Orthop Relat Res. 2004 Apr;(421):232–9.
Brigman, Brian E., et al. “Allografts about the Knee in Young Patients with High-Grade Sarcoma.Clin Orthop Relat Res, no. 421, Apr. 2004, pp. 232–39. Pubmed, doi:10.1097/01.blo.0000127132.12576.05.
Brigman BE, Hornicek FJ, Gebhardt MC, Mankin HJ. Allografts about the Knee in Young Patients with High-Grade Sarcoma. Clin Orthop Relat Res. 2004 Apr;(421):232–239.
Journal cover image

Published In

Clin Orthop Relat Res

DOI

ISSN

0009-921X

Publication Date

April 2004

Issue

421

Start / End Page

232 / 239

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Time Factors
  • Sarcoma, Ewing
  • Recovery of Function
  • Orthopedics
  • Male
  • Knee Joint
  • Humans
  • Follow-Up Studies