Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.
Publication
, Journal Article
Berend, KR; Jung, JU; Boyle, TJ; DiMaio, JM; Mungal, SA; Desrosiers, RC; Lyerly, HK
Published in: J Virol
October 1993
Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.
Duke Scholars
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
October 1993
Volume
67
Issue
10
Start / End Page
6317 / 6321
Location
United States
Related Subject Headings
- Virology
- T-Lymphocytes, Cytotoxic
- T-Lymphocyte Subsets
- Recombinant Proteins
- Polymerase Chain Reaction
- Phenotype
- Lymphocyte Activation
- Killer Cells, Natural
- Interleukin-2
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Berend, K. R., Jung, J. U., Boyle, T. J., DiMaio, J. M., Mungal, S. A., Desrosiers, R. C., & Lyerly, H. K. (1993). Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. J Virol, 67(10), 6317–6321. https://doi.org/10.1128/JVI.67.10.6317-6321.1993
Berend, K. R., J. U. Jung, T. J. Boyle, J. M. DiMaio, S. A. Mungal, R. C. Desrosiers, and H. K. Lyerly. “Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.” J Virol 67, no. 10 (October 1993): 6317–21. https://doi.org/10.1128/JVI.67.10.6317-6321.1993.
Berend KR, Jung JU, Boyle TJ, DiMaio JM, Mungal SA, Desrosiers RC, et al. Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. J Virol. 1993 Oct;67(10):6317–21.
Berend, K. R., et al. “Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.” J Virol, vol. 67, no. 10, Oct. 1993, pp. 6317–21. Pubmed, doi:10.1128/JVI.67.10.6317-6321.1993.
Berend KR, Jung JU, Boyle TJ, DiMaio JM, Mungal SA, Desrosiers RC, Lyerly HK. Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. J Virol. 1993 Oct;67(10):6317–6321.
Published In
J Virol
DOI
ISSN
0022-538X
Publication Date
October 1993
Volume
67
Issue
10
Start / End Page
6317 / 6321
Location
United States
Related Subject Headings
- Virology
- T-Lymphocytes, Cytotoxic
- T-Lymphocyte Subsets
- Recombinant Proteins
- Polymerase Chain Reaction
- Phenotype
- Lymphocyte Activation
- Killer Cells, Natural
- Interleukin-2
- Humans