Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.


Journal Article

Herpesvirus saimiri (HVS) was used to infect and transform human CD8+ cytotoxic T lymphocytes (CTL), and the phenotypic and functional consequences of HVS infection of CD8+ T lymphocytes were investigated. HVS-transformed CTL no longer require antigen restimulation yet maintain their phenotype and HLA-restricted cytolytic function and specificity. The ability of HVS to transform CTL may have an important role in the functional analysis of human antigen-specific CTL.

Full Text

Duke Authors

Cited Authors

  • Berend, KR; Jung, JU; Boyle, TJ; DiMaio, JM; Mungal, SA; Desrosiers, RC; Lyerly, HK

Published Date

  • October 1993

Published In

Volume / Issue

  • 67 / 10

Start / End Page

  • 6317 - 6321

PubMed ID

  • 8396687

Pubmed Central ID

  • 8396687

International Standard Serial Number (ISSN)

  • 0022-538X


  • eng

Conference Location

  • United States