Current Appointments & Affiliations
George Barth Geller Distinguished Professor of Immunology
·
2004 - Present
Surgery, Surgical Sciences,
Surgery
Professor of Surgery
·
2011 - Present
Surgery, Surgical Sciences,
Surgery
Professor in Immunology
·
2017 - Present
Integrative Immunobiology,
Basic Science Departments
Professor of Pathology
·
2018 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
1983 - Present
Duke Cancer Institute,
Institutes and Centers
Affiliate, Duke Global Health Institute
·
2014 - Present
Duke Global Health Institute,
University Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Core Faculty Member, Duke-Margolis Institute for Health Policy
·
2024 - Present
Duke-Margolis Institute for Health Policy,
University Initiatives & Academic Support Units
In the News
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Recent Publications
Clinical impact of concurrent autologous adoptive T cells immunotherapy in active COVID-19 infected cancer patients for chemotherapy.
Journal Article Infect Agent Cancer · April 9, 2025 BACKGROUND: The concurrent presence of COVID-19 infection in advanced cancer patients has increased the mortality since the compromised immunity was inevitably worsen. The role and clinical impact of autologous adoptive T cell immunotherapy (ACT) designed ... Full text Link to item CiteEffective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd).
Journal Article Nat Commun · April 2, 2025 Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying ... Full text Link to item CiteNonlinear progression during the occult transition establishes cancer lethality.
Journal Article Dis Model Mech · March 1, 2025 Cancer screening relies upon a linear model of neoplastic growth and progression. Yet, historical observations suggest that malignant progression is uncoupled from growth, which may explain the paradoxical increase in early-stage breast cancer detection wi ... Full text Open Access Link to item CiteRecent Grants
Duke University Program in Environmental Health
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2029Single Cell and Spatial Analysis of Lethal Breast Cancers
ResearchPrincipal Investigator · Awarded by Department of Defense · 2024 - 2028The paradox of obesity, tumor progression, and checkpoint inhibition in TNBC
ResearchMentor · Awarded by Susan G Komen for the Cure · 2023 - 2026View All Grants
Education, Training & Certifications
University of California, Los Angeles ·
1983
M.D.