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Herbert Kim Lyerly

George Barth Geller Distinguished Professor of Immunology
Surgery, Surgical Sciences
Box 2606 Med Ctr, Durham, NC 27710
203 Research Drive, Rm 433B, Box 2606, Durham, NC 27710

Selected Grants


Single Cell and Spatial Analysis of Lethal Breast Cancers

ResearchPrincipal Investigator · Awarded by Department of Defense · 2024 - 2028

The paradox of obesity, tumor progression, and checkpoint inhibition in TNBC

ResearchMentor · Awarded by Susan G Komen for the Cure · 2023 - 2026

A Window-of-Opportunity Trial Using Neoadjuvant Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer

ResearchCollaborator · Awarded by Marc Lustgarten Pancreatic Cancer Foundation · 2023 - 2026

Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer

ResearchCo-Mentor · Awarded by National Cancer Institute · 2021 - 2026

Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory

ResearchPrincipal Investigator · Awarded by Department of Defense · 2021 - 2025

Single Cell and Spatial Analysis of Lethal Breast Cancers

ResearchPrincipal Investigator · Awarded by Department of Defense · 2024 - 2028

The paradox of obesity, tumor progression, and checkpoint inhibition in TNBC

ResearchMentor · Awarded by Susan G Komen for the Cure · 2023 - 2026

A Window-of-Opportunity Trial Using Neoadjuvant Hepatic Artery Chemotherapy for Patients With Localized Pancreas Cancer

ResearchCollaborator · Awarded by Marc Lustgarten Pancreatic Cancer Foundation · 2023 - 2026

Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer

ResearchCo-Mentor · Awarded by National Cancer Institute · 2021 - 2026

Therapeutic targeting of breast cancer and host immune responses at inflection points in the disease trajectory

ResearchPrincipal Investigator · Awarded by Department of Defense · 2021 - 2025

Mouse Paint: A massively combinatorial approach for illuminating tumor heterogeneity in True Color

ResearchCo Investigator · Awarded by National Cancer Institute · 2022 - 2025

Duke University Program in Environmental Health

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2019 - 2024

Viral Oncology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1980 - 2024

Determinants of geographic disparities in mortality and multimorbidity in the U.S.

ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2024

Hebei Bio-High Technology Visiting Researcher Training

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Hebei Bio-High Technology Development CO. LTD · 2020 - 2022

Defining the Rules of Breast Cancer Cell Traffic Through Bone

ResearchCollaborator · Awarded by National Institutes of Health · 2017 - 2022

Detection and Elimination of Oncogenic Signaling Networks in Pre-malignant and Malignant Cells with Magnetic Resonance Imaging

ResearchPrincipal Investigator · Awarded by Department of Defense · 2012 - 2022

Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy

ResearchPrincipal Investigator · Awarded by Department of Defense · 2012 - 2022

Translational Research in Surgical Oncology

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2022

A Molecular Framework for Understanding DCIS

ResearchPrincipal Investigator · Awarded by Department of Defense · 2014 - 2022

Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior

ResearchCollaborator · Awarded by National Institutes of Health · 2017 - 2021

Mechanisms of Action and Resistance to PD-1 Immunotherapies in Breast Cancer

ResearchCollaborator · Awarded by Merck · 2017 - 2020

Immunotherapeutic Targeting of a Therapy Resistant Oncogenic HER2 Isoform

ResearchCo-Mentor · Awarded by Susan G. Komen Breast Cancer Foundation · 2017 - 2020

Investigating Adaptive Immune Recognition of Dormant Disseminated Tumor Cells

ResearchPrincipal Investigator · Awarded by Fred Hutchinson Cancer Research Center · 2017 - 2019

Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy

ResearchCo Investigator · Awarded by National Institutes of Health · 2013 - 2019

Duke University Program in Environmental Health

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2013 - 2019

3D Biology Signatures defined by Nanostring Max System

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2018 - 2019

Duke-Komen Fundamentals Training for Patient Advocates - AAADV

ConferencePrincipal Investigator · Awarded by Susan G. Komen Breast Cancer Foundation · 2018 - 2018

A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2018

AAADV Fundamentals

ConferencePrincipal Investigator · Awarded by Susan G. Komen Breast Cancer Foundation · 2017 - 2017

A Simple System for Early Detection of Breast Cancer

ResearchCo Investigator · Awarded by Arizona State University · 2014 - 2017

AAADV Scholars

ConferencePrincipal Investigator · Awarded by Millennium Pharmaceuticals, Inc. · 2016 - 2017

AAADV Scholars

ConferencePrincipal Investigator · Awarded by Pfizer, Inc. · 2016 - 2016

AAADV Scholars

ConferencePrincipal Investigator · Awarded by Genentech, Inc. · 2016 - 2016

AAADV Workshop

ConferencePrincipal Investigator · Awarded by Susan G Komen for the Cure · 2015 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Integrating Population and Basic Science in Cancer Research

ResearchAdvisor · Awarded by National Institutes of Health · 2009 - 2015

Clinical Oncology Research Career Development Program

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2015

2015 Accelerating Anticancer Agent Development and Validation Workshop

ConferencePrincipal Investigator · Awarded by Susan G Komen for the Cure · 2015 - 2015

A Cancer Rainbow Mouse for the Simultaneous Assessment of Multiple Oncogenes

ResearchCo Investigator · Awarded by National Institutes of Health · 2012 - 2015

Administrative Supplement for Recruitment of New Faculty

ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2009 - 2011

Immunotherapy with High Frequency, CEA Specific

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2011

SPORE in Breast Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2010

Cancer Center Core Grant Supplement - Accelerating Anticancer Agent Development Workshop

ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2009

Cancer Center Core Grant Supplement - Accelerating Anticancer Agent Dev Workshop

ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2005 - 2009

Targeting hCG-beta for Breast Cancer Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2009

Developing Biomarker-Based Prognostics in Breast Cancer

ResearchSponsor · Awarded by National Institutes of Health · 2004 - 2009

Vaccination with Regulatory T Cell Depletion

ResearchConsultant · Awarded by National Institutes of Health · 2006 - 2008

Novel Biomarkers for Aromatase Inhibitor Therapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2008

Markers of short term breast cancer risk in FNA

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2008

Phase II trial of Cetuximab & Carboplatin in Basal-like Breast Cancer

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 2008

Biomarker Studies for Novel Anti-Cancer Agents

ResearchConsultant · Awarded by National Institutes of Health · 2003 - 2008

Dendritic Cell Based Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007

Immunotherapy using peptide MHC tetramer isolated Tcells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007

Dendritic Cell Mobilization and Active Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2007

Immunologic Correlates of Effective Immunizations for Cancer Vaccines

ResearchConsultant · Awarded by National Institutes of Health · 2001 - 2006

Planning a Duke Academic Public Private Partnership Program (AP4) Center

Institutional SupportPrincipal Investigator · Awarded by National Cancer Institute · 2004 - 2006

Phase II Trial of Estradiol Therapy for Advanced Breast Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2005

Mentored Oriented Research Career Development Award

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2000 - 2005

Cancer Center Core Grant - CURE Supplment

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2003 - 2004

Immunotherapy of Prostate Cancer with Tumor Vaccines

ResearchSponsor · Awarded by National Institutes of Health · 1999 - 2004

RNA Transfected Dendritic Cells for Cancer Immunotherapy

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1999 - 2004

Dexasome Based Immunotherapy of Lung Cancer

ResearchConsultant · Awarded by National Institutes of Health · 2001 - 2004

Immunotherapy with TRICOM Modified Dendritic Cells

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2001 - 2003

Cytomation MoFlo High Performance Flow Cytometer

EquipmentPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2003

Dendritic Cell Immunotherapy For Breast Cancer

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2000

Cancer Immunotherapy With Rna Pulsed Dendritic Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 1999

Immunotherapy with peptide pulsed dendritic cell

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Immunotherapy With Peptide Pulsed Dendritic Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Viral Control And Immune Reconstitution In Hiv Infection

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1996 - 1999

Viral Control & Immune Reconstitution In Hiv Infection

Clinical TrialCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Immunotherapy of Breast Cancer with Gene Modified Tumors

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Immunotherapy Of Breast Cance5 With Gene Modified Tumor

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Immunotherapy Of Breast Cancer With Gene Modified Tumor

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1995 - 1999

DUMC AIDS Malignancy Program

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Dumc Aids Malignancy Program

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1999

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Spore In Breast Cancer

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1995 - 1998

Surrogate Markers Of Tumor Specific Immunity

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1994 - 1998

Preclinical Development Of Rna Decoys

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 1994 - 1998

Adoptive Immunotherapy For Aids Lymphoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1993 - 1996

Cellular Immunity Against Post-Transplant Lymphoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 1994

External Relationships


  • AlphaVax
  • Biologic Response Laboratories
  • HuaDong Pharmaceutical Company
  • ImmunityBio
  • Oncosec
  • AlphaVax
  • Biologic Response Laboratories
  • HuaDong Pharmaceutical Company
  • ImmunityBio
  • Oncosec
  • Replicate
  • Sonokine Bioscience
  • State of North Carolina Environmental Management Commission
  • TRIO Biopharma

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.