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Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development.

Publication ,  Journal Article
Parker, W; Yu, PB; Holzknecht, ZE; Lundberg, K; Buckley, RH; Platt, JL
Published in: J Clin Immunol
July 1997

The origin of natural antibodies has long been a subject of controversy. Polyreactive natural antibodies recognize multiple ligands and are thought to arise from B1 B cells. Natural antibodies against carbohydrate antigens such as Gal alpha 1-3Gal or against blood groups A and B are thought to be "elicited" by gut bacteria, but their origin is uncertain. To explore the origin of naturally occurring anticarbohydrate antibodies, the specificity and function of the xenoreactive antibodies and isohemagglutinins were investigated in immunodeficient subjects. Subjects with defects in T cell-dependent antibody synthesis had normal levels of xenoreactive natural antibodies, most of which, like xenoreactive antibodies from normal individuals, were specific for Gal alpha 1-3Gal. On the other hand, some subjects with hyper-IgM syndrome who were able to synthesize abundant quantities of xenoreactive antibodies and polyreactive antibodies were devoid of anti-Gal alpha 1-3Gal antibodies. These results suggest that the lineages of B cells giving rise to anti-Gal alpha 1-3Gal antibodies and isohemagglutinins are distinct from B1 B cells or at least exist at a more "advanced" stage of development than those B1 B cells that give rise to polyreactive antibodies. The findings also suggest that B cells which synthesize anti-Gal alpha 1-3Gal antibodies and isohemagglutinins may be distinct from B2 B cells or exist at a more "primitive" stage of development than B2 B cells that synthesize elicited antibodies in normal individuals.

Duke Scholars

Published In

J Clin Immunol

DOI

ISSN

0271-9142

Publication Date

July 1997

Volume

17

Issue

4

Start / End Page

311 / 321

Location

Netherlands

Related Subject Headings

  • Wiskott-Aldrich Syndrome
  • Swine
  • Severe Combined Immunodeficiency
  • Male
  • Infant
  • Immunology
  • Immunologic Deficiency Syndromes
  • Humans
  • Hemagglutinins
  • Female
 

Citation

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Parker, W., Yu, P. B., Holzknecht, Z. E., Lundberg, K., Buckley, R. H., & Platt, J. L. (1997). Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development. J Clin Immunol, 17(4), 311–321. https://doi.org/10.1023/a:1027378716015
Parker, W., P. B. Yu, Z. E. Holzknecht, K. Lundberg, R. H. Buckley, and J. L. Platt. “Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development.J Clin Immunol 17, no. 4 (July 1997): 311–21. https://doi.org/10.1023/a:1027378716015.
Parker W, Yu PB, Holzknecht ZE, Lundberg K, Buckley RH, Platt JL. Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development. J Clin Immunol. 1997 Jul;17(4):311–21.
Parker, W., et al. “Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development.J Clin Immunol, vol. 17, no. 4, July 1997, pp. 311–21. Pubmed, doi:10.1023/a:1027378716015.
Parker W, Yu PB, Holzknecht ZE, Lundberg K, Buckley RH, Platt JL. Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development. J Clin Immunol. 1997 Jul;17(4):311–321.
Journal cover image

Published In

J Clin Immunol

DOI

ISSN

0271-9142

Publication Date

July 1997

Volume

17

Issue

4

Start / End Page

311 / 321

Location

Netherlands

Related Subject Headings

  • Wiskott-Aldrich Syndrome
  • Swine
  • Severe Combined Immunodeficiency
  • Male
  • Infant
  • Immunology
  • Immunologic Deficiency Syndromes
  • Humans
  • Hemagglutinins
  • Female