Blood coagulation and idiopathic thromboembolism among fertile women.


Journal Article

A case-control study of fibrinolytic activity and antithrombin-III (AT-III) was conducted comparing 16 women within the childbearing ages who had a recent history of idiopathic thromboembolism to 29 age- and race-matched female controls without a history of thromboembolism. All subjects had stopped using oral contraceptives at least 12 months prior to study. No difference in AT-III was evident between cases and controls. The mean fibrinolytic response to venous occlusion in cases was significantly lower; however, baseline fibrinolysis was essentially identical. These data demonstrated a bimodal distribution of fibrinolytic response among controls. By dichotomizing fibrinolytic response between the two modes in the controls, we estimated that the rate of low fibrinolytic response was 6 times as frequent in cases as controls. Thus, low fibrinolytic response may signal a natural predisposition to thromboembolism which could be triggered by use of synthetic estrogens.

Full Text

Duke Authors

Cited Authors

  • Dreyer, NA; Pizzo, SV

Published Date

  • August 1, 1980

Published In

Volume / Issue

  • 22 / 2

Start / End Page

  • 123 - 135

PubMed ID

  • 7449378

Pubmed Central ID

  • 7449378

International Standard Serial Number (ISSN)

  • 0010-7824

Digital Object Identifier (DOI)

  • 10.1016/0010-7824(80)90057-8


  • eng

Conference Location

  • United States