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Blood coagulation and idiopathic thromboembolism among fertile women.

Publication ,  Journal Article
Dreyer, NA; Pizzo, SV
Published in: Contraception
August 1980

A case-control study of fibrinolytic activity and antithrombin-III (AT-III) was conducted comparing 16 women within the childbearing ages who had a recent history of idiopathic thromboembolism to 29 age- and race-matched female controls without a history of thromboembolism. All subjects had stopped using oral contraceptives at least 12 months prior to study. No difference in AT-III was evident between cases and controls. The mean fibrinolytic response to venous occlusion in cases was significantly lower; however, baseline fibrinolysis was essentially identical. These data demonstrated a bimodal distribution of fibrinolytic response among controls. By dichotomizing fibrinolytic response between the two modes in the controls, we estimated that the rate of low fibrinolytic response was 6 times as frequent in cases as controls. Thus, low fibrinolytic response may signal a natural predisposition to thromboembolism which could be triggered by use of synthetic estrogens.

Duke Scholars

Published In

Contraception

DOI

ISSN

0010-7824

Publication Date

August 1980

Volume

22

Issue

2

Start / End Page

123 / 135

Location

United States

Related Subject Headings

  • Thromboembolism
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Humans
  • Fibrinolysis
  • Female
  • Blood Coagulation
  • Antithrombin III
  • Adult
  • 4203 Health services and systems
 

Citation

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Dreyer, N. A., & Pizzo, S. V. (1980). Blood coagulation and idiopathic thromboembolism among fertile women. Contraception, 22(2), 123–135. https://doi.org/10.1016/0010-7824(80)90057-8
Dreyer, N. A., and S. V. Pizzo. “Blood coagulation and idiopathic thromboembolism among fertile women.Contraception 22, no. 2 (August 1980): 123–35. https://doi.org/10.1016/0010-7824(80)90057-8.
Dreyer NA, Pizzo SV. Blood coagulation and idiopathic thromboembolism among fertile women. Contraception. 1980 Aug;22(2):123–35.
Dreyer, N. A., and S. V. Pizzo. “Blood coagulation and idiopathic thromboembolism among fertile women.Contraception, vol. 22, no. 2, Aug. 1980, pp. 123–35. Pubmed, doi:10.1016/0010-7824(80)90057-8.
Dreyer NA, Pizzo SV. Blood coagulation and idiopathic thromboembolism among fertile women. Contraception. 1980 Aug;22(2):123–135.
Journal cover image

Published In

Contraception

DOI

ISSN

0010-7824

Publication Date

August 1980

Volume

22

Issue

2

Start / End Page

123 / 135

Location

United States

Related Subject Headings

  • Thromboembolism
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Humans
  • Fibrinolysis
  • Female
  • Blood Coagulation
  • Antithrombin III
  • Adult
  • 4203 Health services and systems