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Adherent biofilms in bacterial vaginosis.

Publication ,  Journal Article
Swidsinski, A; Mendling, W; Loening-Baucke, V; Ladhoff, A; Swidsinski, S; Hale, LP; Lochs, H
Published in: Obstet Gynecol
November 2005

OBJECTIVE: Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens. METHODS: We investigated the composition and spatial organization of bacteria associated with the vaginal epithelium in biopsy specimens from 20 patients with bacterial vaginosis and 40 normal premenopausal and postmenopausal controls using a broad range of fluorescent bacterial group-specific rRNA-targeted oligonucleotide probes. RESULTS: Bacterial vaginosis was associated with greater occurrence and higher concentrations of a variety of bacterial groups. However, only Gardnerella vaginalis developed a characteristic adherent biofilm that was specific for bacterial vaginosis. CONCLUSION: A biofilm comprised of confluent G vaginalis with other bacterial groups incorporated in the adherent layer is a prominent feature of bacterial vaginosis. LEVEL OF EVIDENCE: II-2.

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Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

November 2005

Volume

106

Issue

5 Pt 1

Start / End Page

1013 / 1023

Location

United States

Related Subject Headings

  • Vaginosis, Bacterial
  • Vagina
  • Obstetrics & Reproductive Medicine
  • In Situ Hybridization, Fluorescence
  • Humans
  • Gram-Positive Bacteria
  • Female
  • Epithelium
  • Colony Count, Microbial
  • Child
 

Citation

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Swidsinski, A., Mendling, W., Loening-Baucke, V., Ladhoff, A., Swidsinski, S., Hale, L. P., & Lochs, H. (2005). Adherent biofilms in bacterial vaginosis. Obstet Gynecol, 106(5 Pt 1), 1013–1023. https://doi.org/10.1097/01.AOG.0000183594.45524.d2
Swidsinski, Alexander, Werner Mendling, Vera Loening-Baucke, Axel Ladhoff, Sonja Swidsinski, Laura P. Hale, and Herbert Lochs. “Adherent biofilms in bacterial vaginosis.Obstet Gynecol 106, no. 5 Pt 1 (November 2005): 1013–23. https://doi.org/10.1097/01.AOG.0000183594.45524.d2.
Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, et al. Adherent biofilms in bacterial vaginosis. Obstet Gynecol. 2005 Nov;106(5 Pt 1):1013–23.
Swidsinski, Alexander, et al. “Adherent biofilms in bacterial vaginosis.Obstet Gynecol, vol. 106, no. 5 Pt 1, Nov. 2005, pp. 1013–23. Pubmed, doi:10.1097/01.AOG.0000183594.45524.d2.
Swidsinski A, Mendling W, Loening-Baucke V, Ladhoff A, Swidsinski S, Hale LP, Lochs H. Adherent biofilms in bacterial vaginosis. Obstet Gynecol. 2005 Nov;106(5 Pt 1):1013–1023.
Journal cover image

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

November 2005

Volume

106

Issue

5 Pt 1

Start / End Page

1013 / 1023

Location

United States

Related Subject Headings

  • Vaginosis, Bacterial
  • Vagina
  • Obstetrics & Reproductive Medicine
  • In Situ Hybridization, Fluorescence
  • Humans
  • Gram-Positive Bacteria
  • Female
  • Epithelium
  • Colony Count, Microbial
  • Child