Diagnostic testing for coagulopathies in patients with ischemic stroke.

Journal Article (Journal Article;Review;Systematic Review)

BACKGROUND: Hypercoagulable states are a recognized, albeit uncommon, etiology of ischemic stroke. It is unclear how often the results of specialized coagulation tests affect management. Using data compiled from a systematic review of available studies, we employed quantitative methodology to assess the diagnostic yield of coagulation tests for identification of coagulopathies in ischemic stroke patients. SUMMARY OF REVIEW: We performed a MEDLINE search to identify controlled studies published during 1966-1999 that reported the prevalence of deficiencies of protein C, protein S, antithrombin III, plasminogen, activated protein C resistance (APCR)/factor V Leiden mutation (FVL), anticardiolipin antibodies (ACL), or lupus anticoagulant (LA) in patients with ischemic stroke. The cumulative prevalence rates (pretest probabilities) and positive likelihood ratios for all studies and for those including only patients aged

Full Text

Duke Authors

Cited Authors

  • Bushnell, CD; Goldstein, LB

Published Date

  • December 2000

Published In

Volume / Issue

  • 31 / 12

Start / End Page

  • 3067 - 3078

PubMed ID

  • 11108774

Electronic International Standard Serial Number (EISSN)

  • 1524-4628

Digital Object Identifier (DOI)

  • 10.1161/01.str.31.12.3067


  • eng

Conference Location

  • United States