Skip to main content

Larry Bruce Goldstein

Adjunct Professor of Neurology
Neurology, Stroke and Vascular Neurology
Duke Box 3651, Durham, NC 27710
740 S. Limestone Street, J401, University of Kentucky, Ky-Clinic, Lexington, KY 40536-0284

Overview


General Research Focus: Cerebrovascular Disease/Stroke. Research efforts have involved several aspects of cerebrovascular disease. In the laboratory, work has centered on developing an understanding of the mechanisms underlying pharmacological modulation of motor recovery after injury to the cerebral cortex and has led to several clinical studies in patients with stroke and traumatic brain injury. Research in stroke has also focused on health policy issues related to the use of carotid endarterectomy and optimization of stroke prevention strategies. Research involving new therapies for acute stroke has been carried out through clinical trials. Current focus is on identifying genes associated with small-vessel type stroke.

Specific Approaches: Laboratory Research: Studies of recovery after sensorimotor cortex injury have focused on measurement of neurobehavioral recovery as influenced by systemically administered drugs modulating the activities of specific central neurotransmitters. This work has involved behavioral measures, stereotactic lesioning, basic neurochemistry, cerebral microdialysis, and immunocytochemistry. Health Policy Research: Work has focused on clinical health policy related to cerebrovascular disease carried out in conjunction with the Center for Clinical Health Policy Research. These studies have centered on the utilization of carotid endarterectomy and the optimization of secondary and tertiary stroke prevention with an emphasis on outcome measures.

Clinical Trials: Principal investigator at Duke for several stroke acute treatment trials including studies of GM1-ganglioside and several neuroprotective drugs including CGS-19755 (Selfotel), Eliprodil, and a glycine receptor antagonist. Principal or co-investigator at Duke for several stroke prevention trials including the NIH-supported study of carotid angioplasty and stenting as compared with carotid endarterectomy (CREST), RESPECT (PFO closure), PROfESS (antiplatelet drugs and angiotensin receptor blocker). In addition, principal investigator for NIH-supported studies related to poststroke recovery and steering committee for SPARCL (statin for secondary stroke prevention).

Special Expertise: Effects of drugs on recovery after stroke and brain injury
Neuroplasticity and behavioral recovery after brain injury
Stroke trial design and outcomes measures
Carotid endarterectomy/ angioplasty-stenting
Stroke prevention (primary and secondary)
Stroke-related health policy and outcomes


Key Words: Neurorehabilitation, stroke, cerebrovascular disease, neurobehavior, carotid endarterectomy, angioplasty, health services, prevention, outcomes

Current Appointments & Affiliations


Adjunct Professor of Neurology · 2015 - Present Neurology, Stroke and Vascular Neurology, Neurology

In the News


Published December 17, 2014
Larry Goldstein comments: For first time a treatment helps patients with worst kind of stroke, study says
Published October 3, 2014
Dr. Larry Goldstein comments: A mini-stroke called a TIA can spark post-traumatic stress
Published March 21, 2014
Dr. Larry Goldstein comments: Most U.S. women wouldn't know a stroke if they saw or felt one

View All News

Recent Publications


MRI Predictors of Cognitive Function After Lacunar Infarction.

Journal Article Stroke · May 14, 2025 BACKGROUND: Poststroke cognitive impairment is associated with disability and decreased quality of life. We assessed whether individual or collective magnetic resonance imaging (MRI) biomarkers can aid in predicting cognitive impairment after lacunar infar ... Full text Link to item Cite

Funds Flow in Academic Neurology Departments.

Journal Article Semin Neurol · March 17, 2025 The term "funds flow" refers to the financial relationships between the schools or colleges of medicine and its parent university, the hospital/health system, and clinical departments. Funds flow arrangements vary greatly among organizations based on the r ... Full text Link to item Cite
View All Publications

Recent Grants


Training for the Prevention and Treatment of Stroke in China

Inst. Training Prgm or CMECo Investigator · Awarded by National Institutes of Health · 2010 - 2017

Founders Affiliate Grant in Aid

ResearchPrincipal Investigator · Awarded by Yale University · 2013 - 2015

Locomotor Experience Applied Post-Stroke (LEAPS)

ResearchInvestigator · Awarded by National Institutes of Health · 2005 - 2012

View All Grants

Education, Training & Certifications


Icahn School of Medicine at Mount Sinai · 1981 M.D.