Scholars@Duke
Larry Bruce Goldstein

Larry Bruce Goldstein

Adjunct Professor of Neurology
Neurology, Stroke and Vascular Neurology
golds004@mc.duke.edu
Duke Box 3651, Durham, NC 27710
740 S. Limestone Street, J401, University of Kentucky, Ky-Clinic, Lexington, KY 40536-0284

Selected Publications

Surviving a Stroke.

Journal Article Neurology · August 13, 2024 Full text Link to item Cite

Association of Antithrombotic Drug Use With Incident Intracerebral Hemorrhage Location.

Journal Article Neurology · June 25, 2024 BACKGROUND AND OBJECTIVES: Few population-based studies have assessed associations between the use of antithrombotic (platelet antiaggregant or anticoagulant) drugs and location-specific risks of spontaneous intracerebral hemorrhage (s-ICH). In this study, ... Full text Link to item Cite

Association of Statin Use With Risk of Stroke Recurrence After Intracerebral Hemorrhage.

Journal Article Neurology · October 31, 2023 BACKGROUND AND OBJECTIVES: Survivors of spontaneous intracerebral hemorrhage (ICH) may have indications for statin therapy. The effect of statins on the risk of subsequent hemorrhagic and ischemic stroke (IS) in this setting is uncertain. We sought to dete ... Full text Link to item Cite

Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association.

Journal Article Arterioscler Thromb Vasc Biol · October 2023 The objective of this scientific statement is to evaluate contemporary evidence that either supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol lowering or lipid lowering exerts toxic effects on the brain, leading to cogn ... Full text Link to item Cite

Skin capillary amylin deposition resembles brain amylin vasculopathy in rats.

Journal Article J Stroke Cerebrovasc Dis · September 2023 BACKGROUND AND PURPOSE: Human amylin is a 37 amino-acid pancreatic peptide that forms neuro-toxic aggregates that deposit in the endothelium of brain capillaries of patients with diabetes, potentially contributing to cerebral small vessel ischemic injury. ... Full text Link to item Cite

Rapid, scalable assay of amylin-β amyloid co-aggregation in brain tissue and blood.

Journal Article J Biol Chem · May 2023 Islet amyloid polypeptide (amylin) secreted from the pancreas crosses from the blood to the brain parenchyma and forms cerebral mixed amylin-β amyloid (Aβ) plaques in persons with Alzheimer's disease (AD). Cerebral amylin-Aβ plaques are found in both spora ... Full text Link to item Cite

Associations Between Long-Term Air Pollutant Exposure and 30-Day All-Cause Hospital Readmissions in US Patients With Stroke.

Journal Article Stroke · April 2023 BACKGROUND: Long-term exposure to air pollutants is associated with increased stroke incidence, morbidity, and mortality; however, research on the association of pollutant exposure with poststroke hospital readmissions is lacking. METHODS: We assessed asso ... Full text Link to item Cite

Association Between Statin Use and Intracerebral Hemorrhage Location: A Nested Case-Control Registry Study.

Journal Article Neurology · March 7, 2023 BACKGROUND AND OBJECTIVES: A causal relationship between statin use and intracerebral hemorrhage (ICH) is uncertain. We hypothesized that an association between long-term statin exposure and ICH risk might vary for different ICH locations. METHODS: We cond ... Full text Link to item Cite

Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas.

Journal Article Commun Biol · January 3, 2023 Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we show in human tissues and AD-model rats that bloodborne islet amyloid polypeptide (a ... Full text Link to item Cite

Association of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke.

Journal Article PLoS One · 2023 BACKGROUND: Whether stroke patients treated at hospitals with better short-term outcome metrics have better long-term outcomes is unknown. We investigated whether treatment at US hospitals with better 30-day hospital-level stroke outcome metrics was associ ... Full text Link to item Cite

Outcomes after ischemic stroke for dual-eligible Medicare-Medicaid beneficiaries in the United States.

Journal Article PLoS One · 2023 BACKGROUND: Medicaid serves as a safety net for low-income US Medicare beneficiaries with limited assets. Approximately 7.7 million Americans aged ≥65 years rely on a combination of Medicare and Medicaid to obtain critical medical services, yet little is k ... Full text Link to item Cite

Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing volumes or stable over time. Quantifying such changes may prove useful as a biomarker for ... Full text Link to item Cite

Amyloidogenic amylin deposits on red blood cells of stroke patients

Journal Article Alzheimer's and Dementia · December 1, 2022 Background: Amylin, a 37-residue amyloidogenic peptide, is co-secreted with insulin by pancreatic beta-cells (Verma et al. 2020). Vascular deposition of amylin has been noted in patients with diabetes and neurocognitive disorders (Ly et al., 2017) Emergent ... Full text Cite

Trends in 1-Year Recurrent Ischemic Stroke in the US Medicare Fee-for-Service Population.

Journal Article Stroke · November 2022 BackgroundThere have been important advances in secondary stroke prevention and a focus on healthcare delivery over the past decades. Yet, data on US trends in recurrent stroke are limited. We examined national and regional patterns in 1-year recu ... Full text Cite

Association of Long-term Statin Use With the Risk of Intracerebral Hemorrhage: A Danish Nationwide Case-Control Study.

Journal Article Neurology · August 15, 2022 BACKGROUND AND OBJECTIVES: A causal relationship between long-term statin use and the risk of intracerebral hemorrhage (ICH) remains uncertain. We investigated the association with statin use before hospital admission for ICH in a Danish population-based, ... Full text Link to item Cite

Rural Residence and Antihypertensive Medication Use in US Stroke Survivors.

Journal Article J Am Heart Assoc · August 2, 2022 Background Relatively greater increases in hypertension prevalence among US rural residents may contribute to geographic disparities in recurrent stroke. There is limited US information on poststroke antihypertensive medication use by rural/urban residence ... Full text Link to item Cite

Committee on High-quality Alzheimer's Disease Studies (CHADS) consensus report.

Journal Article Alzheimers Dement · June 2022 BACKGROUND: Consensus guidance for the development and identification of high-quality Alzheimer's disease clinical trials is needed for protocol development and conduct of clinical trials. METHODS: An ad hoc consensus committee was convened in conjunction ... Full text Link to item Cite

Cardiovascular Risk Factor Profiles, Emergency Department Visits, and Hospitalizations for Women and Men with a History of Stroke or Transient Ischemic Attack: A Cross-Sectional Study.

Journal Article J Womens Health (Larchmt) · June 2022 Background: The relationship between cardiovascular disease risk factors (CVD-RFs) and health care utilization may differ by sex. We determined whether having more CVD-RFs was associated with all-cause emergency department (ED) visits and all-cause hospita ... Full text Link to item Cite

Paradoxical Cerebral Air Embolism after Cardiac Ablation in Williams-Beuren Syndrome: A Clinico-Pathological Correlation.

Journal Article J Stroke Cerebrovasc Dis · April 2022 Non-traumatic neurological deterioration is a medical emergency that may arise from diverse causes, to include cerebral infarction or intracranial hemorrhage, meningoencephalitis, seizure, hypoxic-ischemic or toxic/metabolic encephalopathy, poisoning, or d ... Full text Link to item Cite

Stroke Prevention in Symptomatic Large Artery Intracranial Atherosclerosis Practice Advisory: Report of the AAN Guideline Subcommittee.

Journal Article Neurology · March 22, 2022 BACKGROUND AND OBJECTIVES: To review treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS). METHODS: The development of this practice advisory followed the process ... Full text Link to item Cite

Disparities in Internet Use Among US Stroke Survivors: Implications for Telerehabilitation During COVID-19 and Beyond.

Journal Article Stroke · March 2022 Despite evidence-based guidelines,1 stroke rehabilitation remains underutilized, particularly among women and minorities.2 Telerehabilitation is a promising alternative to traditional in-person rehabilitation and offers a novel strategy to overcome access ... Full text Link to item Cite

Mechanical Thrombectomy Access for All? Challenges in Increasing Endovascular Treatment for Acute Ischemic Stroke in the United States

Journal Article Journal of Stroke · January 1, 2022 Mechanical thrombectomy (MT) is the most effective treatment for selected patients with an acute ischemic stroke due to emergent large vessel occlusions (LVOs). There is an urgent need to identify and address challenges in access to MT to maximize the numb ... Full text Cite

The association of marital/partner status with patient-reported health outcomes following acute myocardial infarction or stroke: Protocol for a systematic review and meta-analysis.

Journal Article PLoS One · 2022 INTRODUCTION: Marital/Partner support is associated with lower mortality and morbidity following acute myocardial infarction (AMI) and stroke. Despite an increasing focus on the effect of patient-centered factors on health outcomes, little is known about t ... Full text Link to item Cite

Amylin-mediated regulation of LRP1 by miR-103/107 impairs β-amyloid efflux

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2021 BACKGROUND: To determine whether systemic pancreatic amylin dyshomeostasis impairs the efflux of amyloid-β (Aβ) across the blood-brain barrier (BBB), we studied cerebral microvessels in humans and a rat model of pancreatic amylin dyshomeostasis, and evalua ... Full text Cite

Amyloid-β removal from the brain is blocked by circulating amyloid-forming amylin secreted by the pancreas

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2021 BACKGROUND: Increasing amyloid-β (Aβ) transport from the brain provides a novel therapeutic approach for Alzheimer's disease (AD). Our team recently showed: 1, the brain microvasculature accumulates amylin, an amyloid-forming hormone secreted from the panc ... Full text Cite

Contemporary Neuroscience Core Curriculum for Medical Schools.

Journal Article Neurology · October 4, 2021 Medical students need to understand core neuroscience principles as a foundation for their required clinical experiences in neurology. In fact, they need a solid neuroscience foundation for their clinical experiences in all other medical disciplines also b ... Full text Link to item Cite

Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.

Journal Article J Neurosci Methods · August 1, 2021 BACKGROUND: White matter hyperintensities (WMH), associated with both dementia risk and progression, can individually progress, remain stable, or even regress influencing cognitive decline related to specific cerebrovascular-risks. This study details the d ... Full text Link to item Cite

Amylin Dyshomeostasis Hypothesis: Small Vessel-Type Ischemic Stroke in the Setting of Type-2 Diabetes.

Journal Article Stroke · June 2021 Recent histological analyses of human brains show that small vessel-type injuries in the setting of type-2 diabetes colocalize with deposits of amylin, an amyloid-forming hormone secreted by the pancreas. Amylin inclusions are also identified in circulatin ... Full text Link to item Cite

Treatments-Preventive.

Journal Article Stroke · March 2021 Full text Link to item Cite

Abstract P67: Role of Genetic Variants in Predicting Cognitive Outcomes Following Small Vessel Ischemic Stroke

Conference Stroke · March 2021 Background: About 20% of patients with small vessel ischemic stroke (SVS) have cognitive impairment; however, the role of genetic factors in predicting cognitive outcomes following SVS has not been fu ... Full text Cite

Neurologic complications of congenital heart disease in adults.

Journal Article Handb Clin Neurol · 2021 Congenital heart disease (CHD) is a heterogeneous group of structural abnormalities of the cardiovascular system that are present at birth. Advances in childhood medical and surgical treatment have led to increasing numbers of adults with CHD. Neurological ... Full text Link to item Cite

Stroke Care during the COVID-19 Pandemic: International Expert Panel Review.

Journal Article Cerebrovasc Dis · 2021 BACKGROUND: Coronavirus disease 2019 (COVID-19) has placed a tremendous strain on healthcare services. This study, prepared by a large international panel of stroke experts, assesses the rapidly growing research and personal experience with COVID-19 stroke ... Full text Link to item Cite

The association of circulating amylin with β-amyloid in familial Alzheimer's disease

Journal Article Alzheimer's and Dementia: Translational Research and Clinical Interventions · January 1, 2021 Introduction: This study assessed the hypothesis that circulating human amylin (amyloid-forming) cross-seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD). Methods: Evidence of amylin-AD pathology interaction was tested in brains of 31 familial ... Full text Cite

Preserving stroke care during the COVID-19 pandemic: Potential issues and solutions.

Journal Article Neurology · July 21, 2020 The coronavirus 2019 (COVID-19) pandemic requires drastic changes in allocation of resources, which can affect the delivery of stroke care, and many providers are seeking guidance. As caregivers, we are guided by 3 distinct principles that will occasionall ... Full text Link to item Cite

Stroke in young cannabis users (18-49 years): National trends in hospitalizations and outcomes.

Journal Article Int J Stroke · July 2020 BACKGROUND: Recent legalization of therapeutic and recreational cannabis use makes it imperative to have an insight into odds and trends in young-onset stroke-related hospitalizations among cannabis users (18-49 years). METHODS: The National Inpatient Samp ... Full text Link to item Cite

Atorvastatin Reduces First and Subsequent Vascular Events Across Vascular Territories: The SPARCL Trial.

Journal Article J Am Coll Cardiol · May 5, 2020 BACKGROUND: In the SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) trial, atorvastatin was compared with placebo in 4,731 participants with recent stroke or transient ischemic attack and no known coronary heart disease. Atorvastati ... Full text Link to item Cite

Funds flow in academic neurology: A potential path to financial success.

Journal Article Neurology · May 5, 2020 Funds flow arrangements define the financial relationships between departments, medical centers, and university entities within a coordinated academic health system. Although these funds flow frameworks differ, common themes emerge including those that are ... Full text Link to item Cite

Polypill Trials for Stroke Prevention-Main Results, Critical Appraisal, and Implications for US Population.

Journal Article Curr Neurol Neurosci Rep · April 15, 2020 PURPOSE OF REVIEW: The polypill, referring to a variety of combinations of low-cost cardiovascular and stroke preventive medications combined in a single tablet, has been evaluated as a population-based approach for cardiovascular disease prevention in sev ... Full text Link to item Cite

Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.

Journal Article J Stroke Cerebrovasc Dis · April 2020 BACKGROUND: African-Americans (AA) are 3 times more likely to have small-vessel-type ischemic strokes (SVS) than Whites. Small vessel strokes are associated with cognitive impairment, a relationship incompletely explained by white matter hyperintensity (WM ... Full text Link to item Cite

Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries.

Journal Article Kidney Int · January 2020 In the setting of type-2 diabetes, there are declines of structural stability and functionality of blood capillaries and red blood cells (RBCs), increasing the risk for microcirculatory disturbances. Correcting hyperglycemia is not entirely effective at re ... Full text Link to item Cite

Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers.

Journal Article Front Neurosci · 2020 Agglomerative hierarchical clustering analysis (HCA) is a commonly used unsupervised machine learning approach for identifying informative natural clusters of observations. HCA is performed by calculating a pairwise dissimilarity matrix and then clustering ... Full text Link to item Cite

Effect of Known Atrial Fibrillation and Anticoagulation Status on the Prehospital Identification of Large Vessel Occlusion.

Journal Article J Stroke Cerebrovasc Dis · December 2019 INTRODUCTION: The Cincinnati Prehospital Stroke Severity scale (C-STAT), Los Angeles Motor Scale (LAMS), Rapid Arterial Occlusion Evaluation (RACE) score, and Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scales were designed to aid em ... Full text Link to item Cite

Absence of Motor-Evoked Potentials Does Not Predict Poor Recovery in Patients With Severe-Moderate Stroke: An Exploratory Analysis

Journal Article Archives of Rehabilitation Research and Clinical Translation · December 1, 2019 Objective: To better understand the role of the presence or absence of motor-evoked potentials (MEPs) in predicting functional outcomes following a severe-moderate stroke. Design: Retrospective exploratory analysis. We compared the effects of the stimulati ... Full text Cite

Development of a Non-invasive Device for Swallow Screening in Patients at Risk of Oropharyngeal Dysphagia: Results from a Prospective Exploratory Study.

Journal Article Dysphagia · October 2019 Oropharyngeal dysphagia is prevalent in several at-risk populations, including post-stroke patients, patients in intensive care and the elderly. Dysphagia contributes to longer hospital stays and poor outcomes, including pneumonia. Early identification of ... Full text Link to item Cite

White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups.

Journal Article Brain Sci · July 19, 2019 Subcortical white matter hyperintensities (WMHs) in the aging population frequently represent vascular injury that may lead to cognitive impairment. WMH progression is well described, but the factors underlying WMH regression remain poorly understood. A sa ... Full text Link to item Cite

Water Pipe (Hookah) Smoking and Cardiovascular Disease Risk: A Scientific Statement From the American Heart Association.

Journal Article Circulation · May 7, 2019 Tobacco smoking with a water pipe or hookah is increasing globally. There are millions of water pipe tobacco smokers worldwide, and in the United States, water pipe use is more common among youth and young adults than among adults. The spread of water pipe ... Full text Link to item Cite

Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association.

Journal Article Arterioscler Thromb Vasc Biol · February 2019 One in 4 Americans >40 years of age takes a statin to reduce the risk of myocardial infarction, ischemic stroke, and other complications of atherosclerotic disease. The most effective statins produce a mean reduction in low-density lipoprotein cholesterol ... Full text Link to item Cite

Hospital Quality Metrics: "America's Best Hospitals" and Outcomes After Ischemic Stroke.

Journal Article J Stroke Cerebrovasc Dis · February 2019 BACKGROUND: Developing quality metrics to assess hospital-level care and outcomes is increasingly popular in the United States. The U.S. News & World Report ranking of "America's Best Hospitals" is an existing, popular hospital-profiling system, but it is ... Full text Link to item Cite

Increasing Stroke Knowledge and Decreasing Stroke Risk in a Latino Immigrant Population.

Journal Article J Immigr Minor Health · December 2018 Stroke knowledge is poor and stroke risk is growing for the U.S. Latino immigrant population. We present results of an evaluation of a tailored, community-based intervention in Durham, North Carolina. The intervention included integration of stroke knowled ... Full text Link to item Cite

Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial.

Journal Article JAMA Neurol · December 1, 2018 IMPORTANCE: Data from animal models show that the administration of dextroamphetamine combined with task-relevant training facilitates recovery after focal brain injury. Results of clinical trials in patients with stroke have been inconsistent. OBJECTIVES: ... Full text Link to item Cite

Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission.

Journal Article Stroke · December 2018 Background and Purpose- Kidney dysfunction is common among patients hospitalized for ischemic stroke. Understanding the association of kidney disease with poststroke outcomes is important to properly adjust for case mix in outcome studies, payment models a ... Full text Link to item Cite

Status epilepticus alert reduces time to administration of second-line antiseizure medications.

Journal Article Neurol Clin Pract · December 2018 BACKGROUND: Status epilepticus (SE) is a neurologic emergency with high morbidity and mortality. Delays in SE treatment are common in clinical practice and can be associated with poorer outcomes. Our goal was to determine whether the implementation of an S ... Full text Link to item Cite

Outcomes after carotid endarterectomy among elderly dual Medicare-Medicaid-eligible patients.

Journal Article Neurology · October 23, 2018 OBJECTIVE: To determine whether patients who are dual eligible for Medicare and Medicaid benefits have outcomes after carotid endarterectomy (CEA) that are comparable to the outcomes of those eligible for Medicare alone. METHODS: The study cohort included ... Full text Link to item Cite

Twenty-First Century Cures Act.

Journal Article Stroke · October 2018 Full text Link to item Cite

Randomized Sham-Controlled Trial of Navigated Repetitive Transcranial Magnetic Stimulation for Motor Recovery in Stroke.

Journal Article Stroke · September 2018 Background and Purpose- We aimed to determine whether low-frequency electric field navigated repetitive transcranial magnetic stimulation to noninjured motor cortex versus sham repetitive transcranial magnetic stimulation avoiding motor cortex could improv ... Full text Link to item Cite

Impact of Stroke Call on the Stroke Neurology Workforce in the United States: Possible Challenges and Opportunities.

Journal Article J Stroke Cerebrovasc Dis · July 2018 BACKGROUND: The Stroke & Vascular Neurology Section of the American Academy of Neurology was charged to identify challenges to the recruitment and retention of stroke neurologists and to make recommendations to address any identified problems. The Section ... Full text Link to item Cite

Advances in Stroke 2017.

Journal Article Stroke · May 2018 Full text Link to item Cite

Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1-42 and Hypertension.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Alzheimer's disease (AD) pathology and hypertension (HTN) are risk factors for development of white matter (WM) alterations and might be independently associated with these alterations in older adults. OBJECTIVE: To evaluate the independent and ... Full text Link to item Cite

Revascularization for acute ischemic stroke: Contemporary perspectives on the role and yield of thrombolytic therapy and endovascular intervention

Chapter · January 1, 2018 Intravenous thrombolysis for selected patients with acute ischemic stroke leads to improved outcomes and has revolutionized stroke care. Several trials now demonstrate the benefit of endovascular thrombectomy in patients with large vessel occlusions. ... Full text Cite

Influence of Dietary Salt Knowledge, Perceptions, and Beliefs on Consumption Choices after Stroke in Uganda.

Journal Article J Stroke Cerebrovasc Dis · December 2017 BACKGROUND: Previous research on Uganda's poststroke population revealed that their level of dietary salt knowledge did not lead to healthier consumption choices. PURPOSE: Identify barriers and motivators for healthy dietary behaviors and evaluate the unde ... Full text Link to item Cite

Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks: Results of an Analysis of 13 Biomarkers From the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial.

Journal Article Stroke · December 2017 BACKGROUND AND PURPOSE: Established risk factors do not fully identify patients at risk for recurrent stroke. The SPARCL trial (Stroke Prevention by Aggressive Reduction in Cholesterol Levels) evaluated the effect of atorvastatin on stroke risk in patients ... Full text Link to item Cite

Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack.

Journal Article Stroke · December 2017 BACKGROUND AND PURPOSE: Although there is no overall association between statin use and intracerebral hemorrhage (ICH), whether there is an increased risk among those with a history of ischemic stroke (IS) or transient ischemic attack (TIA) remains controv ... Full text Link to item Cite

Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.

Journal Article Ann Neurol · August 2017 OBJECTIVE: The brain blood vessels of patients with type 2 diabetes and dementia have deposition of amylin, an amyloidogenic hormone cosecreted with insulin. It is not known whether vascular amylin deposition is a consequence or a trigger of vascular injur ... Full text Link to item Cite

Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.

Journal Article J Stroke Cerebrovasc Dis · July 2017 BACKGROUND: We investigated the independent association of depression status at 3 and 12 months after stroke and functional decline. METHODS: Data were obtained as part of the multicenter Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) regi ... Full text Link to item Cite

Adverse Effects of Statins.

Journal Article JAMA · March 14, 2017 Full text Link to item Cite

Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality: Findings From Get With The Guidelines-Stroke.

Journal Article Stroke · February 2017 BACKGROUND AND PURPOSE: Kidney disease is a frequent comorbidity in patients presenting with acute ischemic stroke. We evaluated whether the estimated glomerular filtration rate (eGFR) on admission is associated with poststroke in-hospital mortality or dis ... Full text Link to item Cite

BE-FAST (Balance, Eyes, Face, Arm, Speech, Time): Reducing the Proportion of Strokes Missed Using the FAST Mnemonic.

Journal Article Stroke · February 2017 BACKGROUND AND PURPOSE: The FAST algorithm (Face, Arm, Speech, Time) helps identify persons having an acute stroke. We determined the proportion of patients with acute ischemic stroke not captured by FAST and evaluated a revised mnemonic. METHODS: Records ... Full text Link to item Cite

Utility of Urgent Computed Tomography Angiography in the Setting of Intraparenchymal Brain Hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · February 2017 BACKGROUND AND PURPOSE: Patients presenting with an intracerebral hemorrhage (ICH) generally have an initial noncontrast computed tomography (NCCT) of the brain. Computed tomography angiography (CTA) can help identify secondary causes of ICH and detect a " ... Full text Link to item Cite

Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat.

Journal Article J Cereb Blood Flow Metab · December 2016 Scoring systems are used to measure behavioral deficits in stroke research. Video-assisted training is used to standardize stroke-related neurologic deficit scoring in humans. We hypothesized that a video-assisted training and certification program can imp ... Full text Open Access Link to item Cite

Influence of sodium consumption and associated knowledge on poststroke hypertension in Uganda.

Journal Article Neurology · September 20, 2016 OBJECTIVE: We assessed 24-hour urine sodium levels as an index of dietary salt consumption and its association with dietary salt knowledge and hypertension among poststroke patients with and without a history of hypertension in Uganda. METHODS: A case-cont ... Full text Link to item Cite

Average Temperature, Diurnal Temperature Variation, and Stroke Hospitalizations.

Journal Article J Stroke Cerebrovasc Dis · June 2016 BACKGROUND: Studies assessing the relationship between meteorological factors and stroke incidence are inconsistent. We assessed the associations of average temperature and diurnal temperature fluctuations with ischemic stroke hospitalizations in a nationa ... Full text Link to item Cite

Accuracy of ICD-9-CM Codes by Hospital Characteristics and Stroke Severity: Paul Coverdell National Acute Stroke Program.

Journal Article J Am Heart Assoc · May 31, 2016 BACKGROUND: Epidemiological and health services research often use International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes to identify patients with clinical conditions in administrative databases. We determined whe ... Full text Link to item Cite

Evidence-Based Policy Making: Assessment of the American Heart Association's Strategic Policy Portfolio: A Policy Statement From the American Heart Association.

Journal Article Circulation · May 3, 2016 BACKGROUND: American Heart Association (AHA) public policy advocacy strategies are based on its Strategic Impact Goals. The writing group appraised the evidence behind AHA's policies to determine how well they address the association's 2020 cardiovascular ... Full text Link to item Cite

Routine 24-Hour Computed Tomography Brain Scan is not useful in stable patients Post Intravenous Tissue Plasminogen Activator.

Journal Article J Stroke Cerebrovasc Dis · March 2016 BACKGROUND: Obtaining a routine computed tomography (CT) brain scan 24 hours after treatment with intravenous tissue plasminogen activator (IV-tPA) is included in the American Heart Association/American Stroke Association acute stroke guidelines. The usefu ... Full text Link to item Cite

Development and Assessment of a Computer Algorithm for Stroke Vascular Localization Using Components of the National Institutes of Health Stroke Scale.

Journal Article J Stroke Cerebrovasc Dis · February 2016 BACKGROUND: The National Institutes of Health Stroke Scale (NIHSS) was not intended to be used to determine the stroke's vascular distribution. The aim of this study was to develop, assess the reliability, and validate a computer algorithm based on the NIH ... Full text Link to item Cite

Ischemic Stroke with Troponin Elevation: Patient Characteristics, Resource Utilization, and In-Hospital Outcomes.

Journal Article Cerebrovasc Dis · 2016 BACKGROUND: Among patients hospitalized for acute ischemic stroke, abnormal serum troponins are associated with higher risk of short-term mortality. However, most findings have been reported from European hospitals. Whether troponin elevation after stroke ... Full text Link to item Cite

Preventing a First Stroke

Chapter · January 1, 2016 Full text Cite

Chronic Systemic Immune Dysfunction in African-Americans with Small Vessel-Type Ischemic Stroke.

Journal Article Transl Stroke Res · December 2015 The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflamma ... Full text Link to item Cite

Treating In-Hospital Stroke.

Journal Article JAMA Neurol · December 2015 Full text Link to item Cite

Neighborhood socioeconomic status and the prevalence of stroke and coronary heart disease in rural China: a population-based study.

Journal Article Int J Stroke · April 2015 BACKGROUND: Lower neighborhood-level socioeconomic status (SES) is associated with an increased risk of vascular disease in developed countries. AIMS: This study aims to identify village- and individual-level determinants of stroke and coronary heart disea ... Full text Link to item Cite

Development of a Multidisciplinary Stroke Program.

Journal Article Fed Pract · March 2015 Several gaps and no formal system existed for coordinating stroke-related care at the Durham VAMC until a team of dedicated health care providers developed a new program. ... Link to item Cite

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association.

Journal Article Stroke · December 2014 The aim of this updated statement is to provide comprehensive and timely evidence-based recommendations on the prevention of stroke among individuals who have not previously experienced a stroke or transient ischemic attack. Evidence-based recommendations ... Full text Link to item Cite

Out-of-hospital stroke screen accuracy in a state with an emergency medical services protocol for routing patients to acute stroke centers.

Journal Article Ann Emerg Med · November 2014 STUDY OBJECTIVE: Emergency medical services (EMS) protocols, which route patients with suspected stroke to stroke centers, rely on the use of accurate stroke screening criteria. Our goal is to conduct a statewide EMS agency evaluation of the accuracies of ... Full text Link to item Cite

Chronic kidney disease and stroke.

Journal Article Adv Chronic Kidney Dis · November 2014 Chronic kidney disease (CKD) is associated with an increased risk of both ischemic and hemorrhagic stroke. In addition to shared risk factors, this higher cerebrovascular risk is mediated by several CKD-associated mechanisms including platelet dysfunction, ... Full text Link to item Cite

Effect of high-dose atorvastatin on renal function in subjects with stroke or transient ischemic attack in the SPARCL trial.

Journal Article Stroke · October 2014 BACKGROUND AND PURPOSE: Higher low-density lipoprotein cholesterol is associated with more rapid chronic kidney disease progression; reduction in cholesterol with statins, in conjunction with statins' pleiotropic effects, such as decreasing inflammation, m ... Full text Link to item Cite

Atherogenic dyslipidemia and residual cardiovascular risk in statin-treated patients.

Journal Article Stroke · May 2014 BACKGROUND AND PURPOSE: Treatment with statins reduces the rate of cardiovascular events in high-risk patients, but residual risk persists. At least part of that risk may be attributable to atherogenic dyslipidemia characterized by low high-density lipopro ... Full text Link to item Cite

Compliance with acute stroke care quality measures in hospitals with and without primary stroke center certification: the North Carolina Stroke Care Collaborative.

Journal Article J Am Heart Assoc · April 10, 2014 BACKGROUND: Organized stroke care is associated with improved outcomes. Data are limited on differences in changes in the quality of acute stroke care at The Joint Commission-certified Primary Stroke Centers (PSCs) versus non-PSCs over time. METHODS AND RE ... Full text Link to item Cite

Prediction of major vascular events after stroke: the stroke prevention by aggressive reduction in cholesterol levels trial.

Journal Article J Stroke Cerebrovasc Dis · April 2014 BACKGROUND: Identifying patients with recent stroke or transient ischemic attack (TIA) at high risk of major vascular events (MVEs; stroke, myocardial infarction, or vascular death) may help optimize the intensity of secondary preventive interventions. We ... Full text Link to item Cite

Preface

Chapter · January 1, 2014 Full text Cite

An assessment by the Statin Cognitive Safety Task Force: 2014 update.

Journal Article J Clin Lipidol · 2014 The National Lipid Association's Safety Task Force convened a consensus conference of experts to develop a position statement on cognitive function to revise and update that published originally by the Association in the 2006 assessment of statin safety by ... Full text Link to item Cite

Modern medical management of acute ischemic stroke.

Journal Article Methodist Debakey Cardiovasc J · 2014 The modern management of patients with ischemic stroke begins by having a system in place that organizes the provision of preventive, acute treatment, and rehabilitative services. In the acute setting, initial evaluation is aimed at rapidly establishing a ... Full text Link to item Cite

A geographic information system analysis of the impact of a statewide acute stroke emergency medical services routing protocol on community hospital bypass.

Journal Article J Stroke Cerebrovasc Dis · 2014 BACKGROUND: Our goal was to determine if a statewide Emergency Medical Services (EMSs) Stroke Triage and Destination Plan (STDP), specifying bypass of hospitals unable to routinely treat stroke patients with thrombolytics (community hospitals), changed byp ... Full text Link to item Cite

Preventable readmissions within 30 days of ischemic stroke among Medicare beneficiaries.

Journal Article Stroke · December 2013 BACKGROUND AND PURPOSE: The Centers for Medicare and Medicaid Services proposes to use 30-day hospital readmissions after ischemic stroke as part of the Hospital Inpatient Quality Reporting Program for payment determination beginning in 2016. The proportio ... Full text Link to item Cite

Are acute stroke-ready hospitals ready?

Journal Article Stroke · December 2013 Full text Link to item Cite

Death and rehospitalization after transient ischemic attack or acute ischemic stroke: one-year outcomes from the adherence evaluation of acute ischemic stroke-longitudinal registry.

Journal Article J Stroke Cerebrovasc Dis · October 2013 BACKGROUND: Longitudinal data directly comparing the rates of death and rehospitalization of patients discharged after transient ischemic attack (TIA) versus acute ischemic stroke (AIS) are lacking. METHODS: Data were analyzed from 2802 patients (TIA n = 5 ... Full text Link to item Cite

Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.

Journal Article Stroke · October 2013 BACKGROUND AND PURPOSE: In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established car ... Full text Link to item Cite

Forecasting the future of stroke in the United States: a policy statement from the American Heart Association and American Stroke Association.

Journal Article Stroke · August 2013 BACKGROUND AND PURPOSE: Stroke is a leading cause of disability, cognitive impairment, and death in the United States and accounts for 1.7% of national health expenditures. Because the population is aging and the risk of stroke more than doubles for each s ... Full text Link to item Cite

JURaSSiC: accuracy of clinician vs risk score prediction of ischemic stroke outcomes.

Journal Article Neurology · July 30, 2013 OBJECTIVE: We compared the accuracy of clinicians and a risk score (iScore) to predict observed outcomes following an acute ischemic stroke. METHODS: The JURaSSiC (Clinician JUdgment vs Risk Score to predict Stroke outComes) study assigned 111 clinicians w ... Full text Link to item Cite

Summary of evidence-based guideline: periprocedural management of antithrombotic medications in patients with ischemic cerebrovascular disease: report of the Guideline Development Subcommittee of the American Academy of Neurology.

Journal Article Neurology · May 28, 2013 OBJECTIVE: To assess evidence regarding periprocedural management of antithrombotic drugs in patients with ischemic cerebrovascular disease. The complete guideline on which this summary is based is available as an online data supplement to this article. ME ... Full text Link to item Cite

"Code stroke": hospitalized versus emergency department patients.

Journal Article J Stroke Cerebrovasc Dis · May 2013 Stroke rapid-response ("code stroke") teams facilitate the evaluation and treatment of patients presenting to emergency departments (EDs). Little is known about the usefulness of code stroke systems for patients hospitalized primarily for other conditions. ... Full text Link to item Cite

Seasonal variation in 30-day mortality after stroke: teaching versus nonteaching hospitals.

Journal Article Stroke · February 2013 BACKGROUND AND PURPOSE: A systematic review found an association between the July start of internships and residencies and higher mortality rates for hospitalized patients, but data related to stroke are limited. We assessed seasonal variations in 30-day r ... Full text Link to item Cite

Poststroke hypertension in Africa.

Journal Article Stroke · December 2012 BACKGROUND AND PURPOSE: Little is known about the frequency of hypertension and related knowledge in Africans who have had a stroke. The objective of this study was to determine the frequency of hypertension, its control, and associated knowledge among pat ... Full text Link to item Cite

Comparing the use of diagnostic imaging and receipt of carotid endarterectomy in elderly black and white stroke patients.

Journal Article J Stroke Cerebrovasc Dis · October 2012 Featured Publication BACKGROUND: Previous studies show that black patients undergo carotid endarterectomy (CEA) less frequently than white patients. Diagnostic imaging is necessary to determine whether a patient is a candidate for the operation. We determined whether there wer ... Full text Link to item Cite

Echocardiography for the detection of cardiac sources of embolism in patients with stroke or transient ischemic attack.

Journal Article J Stroke Cerebrovasc Dis · October 2012 Featured Publication BACKGROUND: Transthoracic echocardiography (TTE) is commonly obtained during the evaluation of patients with ischemic stroke or transient ischemic attack (TIA) to detect potential sources of cardiogenic embolism. Specific indications for the tests remain u ... Full text Link to item Cite

30-Day risk-standardized mortality and readmission rates after ischemic stroke in critical access hospitals.

Journal Article Stroke · October 2012 BACKGROUND AND PURPOSE: The critical access hospital (CAH) designation was established to provide rural residents with local access to emergency and inpatient care. CAHs, however, have poorer short-term outcomes for pneumonia, heart failure, and myocardial ... Full text Link to item Cite

Regional variation in recommended treatments for ischemic stroke and TIA: Get with the Guidelines--Stroke 2003-2010.

Journal Article Stroke · July 2012 BACKGROUND AND PURPOSE: Secondary stroke prevention treatments vary in different regions of the US. We determined the degree to which guideline-recommended stroke treatments vary by region for patients treated at hospitals participating in a voluntary nati ... Full text Link to item Cite

Depression and antidepressant use after stroke and transient ischemic attack.

Journal Article Stroke · June 2012 BACKGROUND AND PURPOSE: Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS: This study was a secondary analysis of a p ... Full text Link to item Cite

30-day mortality and readmission after hemorrhagic stroke among Medicare beneficiaries in Joint Commission primary stroke center-certified and noncertified hospitals.

Journal Article Stroke · December 2011 Featured Publication BACKGROUND AND PURPOSE: Ischemic stroke patients treated at Joint Commission Primary Stroke Center (JC-PSC)-certified hospitals have better outcomes. Data reflecting the impact of JC-PSC status on outcomes after hemorrhagic stroke are limited. We determine ... Full text Link to item Cite

Primary Prevention of Stroke

Journal Article · December 1, 2011 Full text Cite

Health-related quality of life after carotid stenting versus carotid endarterectomy: results from CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial).

Journal Article J Am Coll Cardiol · October 4, 2011 Featured Publication OBJECTIVES: The purpose of this study was to compare health-related quality of life (HRQOL) outcomes in patients treated with carotid artery stenting (CAS) versus carotid endarterectomy (CEA). BACKGROUND: In CREST (Carotid Revascularization Endarterectomy ... Full text Link to item Cite

Risk of stroke and cardiovascular events after ischemic stroke or transient ischemic attack in patients with type 2 diabetes or metabolic syndrome: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

Journal Article Arch Neurol · October 2011 Featured Publication OBJECTIVE: To perform a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial, which tested the effect of treatment with atorvastatin in reducing stroke in subjects with a recent stroke or transient ischem ... Full text Link to item Cite

Secondary preventive medication persistence and adherence 1 year after stroke.

Journal Article Neurology · September 20, 2011 Featured Publication OBJECTIVE: Data on long-term use of secondary prevention medications following stroke are limited. The Adherence eValuation After Ischemic stroke-Longitudinal (AVAIL) Registry assessed patient, provider, and system-level factors influencing continuation of ... Full text Link to item Cite

Stroke Treatment Academic Industry Roundtable (STAIR) recommendations for maximizing the use of intravenous thrombolytics and expanding treatment options with intra-arterial and neuroprotective therapies.

Journal Article Stroke · September 2011 Featured Publication BACKGROUND AND PURPOSE: The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of acute and restorative stroke therapies. Summary of Review- At the STAIR VII recommendations for strategies to maximize t ... Full text Link to item Cite

Novel platelet antiaggregants and the changing landscape of stroke prevention.

Journal Article Lancet Neurol · August 2011 Featured Publication Full text Link to item Cite

Left atrial enlargement: a cause of stroke?

Journal Article CMAJ · July 12, 2011 Featured Publication Full text Link to item Cite

Outcomes after ischemic stroke for hospitals with and without Joint Commission-certified primary stroke centers.

Journal Article Neurology · June 7, 2011 Featured Publication BACKGROUND: The Joint Commission (JC) began certifying primary stroke centers (PSCs) in the United States in 2003. We assessed whether 30-day risk-standardized mortality (RSMR) and readmission (RSRR) rates differed between hospitals with and without JC-cer ... Full text Link to item Cite

Statins after intracerebral hemorrhage: to treat or not to treat.

Journal Article Arch Neurol · May 2011 Featured Publication Full text Link to item Cite

[Neurology and cardiology: points of contact].

Journal Article Rev Esp Cardiol · April 2011 Featured Publication Strokes resulting from cardiac diseases, and cardiac abnormalities associated with neuromuscular disorders are examples of the many points of contact between neurology and cardiology. Approximately 20-30% of strokes are related to cardiac diseases, includi ... Full text Link to item Cite

Stroke: Organizing the disorganized: improving TIA patient care.

Journal Article Nat Rev Neurol · April 2011 Featured Publication Full text Link to item Cite

Neurology and cardiology: points of contact.

Journal Article Rev Esp Cardiol (Engl Ed) · April 2011 Strokes resulting from cardiac diseases, and cardiac abnormalities associated with neuromuscular disorders are examples of the many points of contact between neurology and cardiology. Approximately 20%-30% of strokes are related to cardiac diseases, includ ... Full text Link to item Cite

Primary prevention of stroke

Chapter · March 31, 2011 Full text Cite

Safety of stenting and endarterectomy by symptomatic status in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST).

Journal Article Stroke · March 2011 Featured Publication BACKGROUND AND PURPOSE: The safety of carotid artery stenting (CAS) and carotid endarterectomy (CEA) has varied by symptomatic status in previous trials. The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) data were analyzed to deter ... Full text Link to item Cite

Poststroke chronic disease management: towards improved identification and interventions for poststroke spasticity-related complications.

Journal Article Int J Stroke · February 2011 Featured Publication This paper represents the opinion of a group of researchers and clinicians with an established interest in poststroke care and is based on the recognised need for long-term care following stroke, especially in view of the global increase of disability due ... Full text Link to item Cite

Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.

Journal Article Stroke · February 2011 Featured Publication BACKGROUND AND PURPOSE: This guideline provides an overview of the evidence on established and emerging risk factors for stroke to provide evidence-based recommendations for the reduction of risk of a first stroke. METHODS: Writing group members were nomin ... Full text Link to item Cite

Use of antithrombotic medications among elderly ischemic stroke patients.

Journal Article Circ Cardiovasc Qual Outcomes · January 1, 2011 Featured Publication BACKGROUND: The use of antithrombotic medications after ischemic stroke is recommended for deep vein thrombosis prophylaxis and secondary stroke prevention. We assessed the rate of receipt of these therapies among eligible ischemic stroke patients age ≥65 ... Full text Link to item Cite

Concerns for the reliability and validity of the National Stroke Project Stroke Severity Scale.

Journal Article Cerebrovasc Dis · 2011 Featured Publication BACKGROUND: The National Stroke Project (NSP) was a retrospective cohort study of US Medicare beneficiaries hospitalized with stroke or transient ischemic attack (TIA). The NSP included a simple assessment of stroke severity (NSP-Stroke Scale, NSP-SS). Use ... Full text Link to item Cite

Similar secondary stroke prevention and medication persistence rates among rural and urban patients.

Journal Article J Rural Health · 2011 Featured Publication PURPOSE: Rural residents are less likely to obtain optimal care for many serious conditions and have poorer health outcomes than those residing in more urban areas. We determined whether rural vs urban residence affected postdischarge medication persistenc ... Full text Link to item Cite

Exploration of a hypothesized independent association of a common 9p21.3 gene variant and ischemic stroke in patients with and without angiographic coronary artery disease.

Journal Article Cerebrovasc Dis · 2011 Featured Publication BACKGROUND: Single-nucleotide polymorphisms (SNPs) at the chromosome 9p21.3 locus are associated with coronary artery disease (CAD). An association of this genomic region with ischemic stroke independent of its effect on CAD could suggest an additional, st ... Full text Link to item Cite

Update on stroke risk factor management: Hyperlipidemia

Journal Article Cerebrovascular Diseases · January 1, 2011 Cite

Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain.

Journal Article Stroke · December 2010 Featured Publication BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) are areas of high signal detected by T2 and fluid-attenuated inversion recovery sequences on brain MRI. Although associated with aging, cerebrovascular risk factors, and cognitive impairment, the ... Full text Link to item Cite

Predictors of hospital readmission after stroke: a systematic review.

Journal Article Stroke · November 2010 Featured Publication BACKGROUND AND PURPOSE: Risk-standardized hospital readmission rates are used as publicly reported measures reflecting quality of care. Valid risk-standardized models adjust for differences in patient-level factors across hospitals. We conducted a systemat ... Full text Link to item Cite

What is the future of stroke prevention?: debate: polypill versus personalized risk factor modification.

Journal Article Stroke · October 2010 Featured Publication BACKGROUND AND PURPOSE: The control of stroke risk factors remains challenging. The "polypill" concept represents a novel approach for reducing stroke and cardiovascular risk factors in the entire population. The polypill would include several components a ... Full text Link to item Cite

Differential patterns of cognitive decline in anterior and posterior white matter hyperintensity progression.

Journal Article Stroke · September 2010 Featured Publication BACKGROUND AND PURPOSE: White matter hyperintensities (WMHs) found on brain MRI in elderly individuals are largely thought to be due to microvascular disease, and its progression has been associated with cognitive decline. The present study sought to deter ... Full text Link to item Cite

Physical activity and the risk of stroke.

Journal Article Expert Rev Neurother · August 2010 Featured Publication Several meta-analyses support the importance of participation in regular, leisure-time physical activity for the primary prevention of stroke and cardiovascular disease, as well as other associated health benefits. Whether both men and women benefit is not ... Full text Link to item Cite

Stroke: working toward a prioritized world agenda.

Journal Article Int J Stroke · August 2010 BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. METHODS: Preliminary work was performed by seven working groups of stroke leaders fo ... Full text Link to item Cite

Stroke: working toward a prioritized world agenda.

Journal Article Stroke · June 2010 BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. METHODS: Preliminary work was performed by 7 working groups of stroke leaders follow ... Full text Link to item Cite

Statewide hospital-based stroke services in North Carolina: changes over 10 years.

Journal Article Stroke · April 2010 Featured Publication BACKGROUND AND PURPOSE: Statewide assessments of stroke prevention and treatment services were performed in North Carolina in 1998 and 2003. The 2003 survey found certain technologies, but not stroke-related programs, were more widely available. The survey ... Full text Link to item Cite

Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician.

Journal Article J Thromb Thrombolysis · April 2010 Featured Publication Acute ischemic stroke is the result of abrupt interruption of focal cerebral blood flow. The majority of ischemic strokes are caused by embolic or thrombotic arterial occlusions. Acute stroke management is complex, in part because of the varying etiologies ... Full text Link to item Cite

Coronary heart disease risk in patients with stroke or transient ischemic attack and no known coronary heart disease: findings from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

Journal Article Stroke · March 2010 Featured Publication BACKGROUND AND PURPOSE: Noncoronary forms of atherosclerosis (including transient ischemic attacks or stroke of carotid origin or >50% stenosis of the carotid artery) are associated with a 10-year vascular risk of >20% and are considered as a coronary hear ... Full text Link to item Cite

Response to letter by Martínez-Sánchez et al

Journal Article Stroke · March 1, 2010 Full text Cite

Advances in prevention and health services delivery 2009.

Journal Article Stroke · February 2010 Featured Publication Full text Link to item Cite

Geographic variation in one-year recurrent ischemic stroke rates for elderly Medicare beneficiaries in the USA.

Journal Article Neuroepidemiology · 2010 Featured Publication BACKGROUND: While geographic disparities in stroke mortality are well documented, there are no data describing geographic variation in recurrent stroke. Accordingly, we evaluated geographic variations in 1-year recurrent ischemic stroke rates in the USA wi ... Full text Link to item Cite

Postendarterectomy mortality in octogenarians and nonagenarians in the USA from 1993 to 1999.

Journal Article Cerebrovasc Dis · January 2010 Featured Publication BACKGROUND: Relatively little is known about trends in the utilization or outcomes of carotid endarterectomy (CEA) in the very elderly. We determined trends in the rates of CEA and perioperative (in-hospital and 30-day) and long-term (1-, 2-, 3-, 4- and 5- ... Full text Link to item Cite

Trends in one-year recurrent ischemic stroke among the elderly in the USA: 1994-2002.

Journal Article Cerebrovasc Dis · 2010 Featured Publication BACKGROUND AND PURPOSE: Of the 795,000 strokes occurring in the USA each year, over 20% are recurrent events. Little is known about how the rates of recurrent stroke in the country have changed over time. Our objective was to determine national trends in 1 ... Full text Link to item Cite

Stroke: working toward a prioritized world agenda.

Journal Article Cerebrovasc Dis · 2010 Featured Publication BACKGROUND AND PURPOSE: The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. METHODS: Preliminary work was performed by 7 working groups of stroke leaders follow ... Full text Link to item Cite

The 2009 Feinberg lecture: the continuum of stroke research and policy.

Journal Article Stroke · December 2009 Featured Publication BACKGROUND AND PURPOSE: This annual Feinberg Award lecture is intended to present examples of the broad scope of stroke-related research and to show how different investigative approaches can advance the field to improve stroke patient's outcomes. In keepi ... Full text Link to item Cite

Hospital arrival time and intravenous t-PA use in US Academic Medical Centers, 2001-2004.

Journal Article Stroke · December 2009 Featured Publication BACKGROUND AND PURPOSE: Prompt care-seeking behavior is a focus of US national public stroke educational campaigns. We determined whether the time between symptom onset and hospital arrival and the receipt of intravenous tissue-type plasminogen activator ( ... Full text Link to item Cite

Stroke patient outcomes in US hospitals before the start of the Joint Commission Primary Stroke Center certification program.

Journal Article Stroke · November 2009 Featured Publication BACKGROUND AND PURPOSE: The Joint Commission (JC) began certifying Primary Stroke Centers in November 2003. Cross-sectional studies assessing the impact of certification could be biased if these centers had better outcomes before the start of the program. ... Full text Link to item Cite

Statin treatment and stroke outcome in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

Journal Article Stroke · November 2009 Featured Publication BACKGROUND AND PURPOSE: Laboratory experiments suggest statins reduce stroke severity and improve outcomes. The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial was a placebo-controlled, randomized trial designed to determine ... Full text Link to item Cite

Clopidogrel plus aspirin in atrial fibrillation.

Journal Article N Engl J Med · September 24, 2009 Featured Publication Link to item Cite

Eating yourself to a stroke?

Journal Article Ann Neurol · August 2009 Featured Publication Full text Link to item Cite

Response

Journal Article Chest · August 1, 2009 Full text Cite

Cardiac assessment in acute stroke

Journal Article Emergency Medicine · July 17, 2009 Cite

Adult intimate partner violence perpetrators are significantly more likely to have witnessed intimate partner violence as a child than nonperpetrators.

Journal Article Am J Emerg Med · July 2009 BACKGROUND: In a previous study, no association was found between intimate partner violence (IPV) victims and being an adult who witnessed IPV as a child (ACW). OBJECTIVE: The objective of the present study was to determine whether perpetrators of IPV (Per ... Full text Link to item Cite

Relative and cumulative effects of lipid and blood pressure control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels trial.

Journal Article Stroke · July 2009 Featured Publication BACKGROUND AND PURPOSE: The relative contributions of on-treatment low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), triglycerides, and blood pressure (BP) control on the risk of recurrent stroke or major cardiovascular events in patients with ... Full text Link to item Cite

Statins and ischemic stroke severity: cytoprotection.

Journal Article Curr Atheroscler Rep · July 2009 Featured Publication Cytoprotective or neuroprotective interventions would be of value if they could block the processes leading to delayed neuronal death or if they could delay the period between the onset of ischemia and irreversible necrotic injury, thereby lengthening the ... Full text Link to item Cite

Elderly women have lower rates of stroke, cardiovascular events, and mortality after hospitalization for transient ischemic attack.

Journal Article Stroke · June 2009 Featured Publication BACKGROUND AND PURPOSE: Patients with transient ischemic attack (TIA) are at increased risk for stroke, cardiovascular events, and death, yet little is known about whether these risks differ for men and women. We determined whether there are sex-based diff ... Full text Link to item Cite

The cart and the horse: the advancing technology of carotid artery stenting.

Journal Article Circ Cardiovasc Interv · June 2009 Featured Publication Full text Link to item Cite

New data about stenting versus endarterectomy for symptomatic carotid artery stenosis.

Journal Article Curr Treat Options Cardiovasc Med · June 2009 Featured Publication Patients with symptomatic carotid artery stenosis should be counseled on diet, exercise, moderation of alcohol consumption, smoking cessation, and avoidance of environmental tobacco smoke. Medical therapy generally includes a platelet antiaggregant, blood ... Full text Link to item Cite

Baseline blood pressure, low- and high-density lipoproteins, and triglycerides and the risk of vascular events in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

Journal Article Atherosclerosis · June 2009 Featured Publication OBJECTIVE: To explore the relative contributions of baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) and lipoproteins on the risk of recurrent stroke or first major cardiovascular event (MCVE) and their potential impact on the bene ... Full text Link to item Cite

Advances in primary prevention and health services delivery.

Journal Article Stroke · May 2009 Featured Publication Full text Link to item Cite

Response to letter by bray and bladin

Journal Article Stroke · May 1, 2009 Full text Cite

The complex relationship between cholesterol and brain hemorrhage.

Journal Article Circulation · April 28, 2009 Featured Publication Full text Link to item Cite

Results of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial by stroke subtypes.

Journal Article Stroke · April 2009 Featured Publication BACKGROUND AND PURPOSE: The SPARCL trial showed that atorvastatin 80 mg/d reduces the risk of stroke and other cardiovascular events in patients with recent stroke or transient ischemic attack (TIA). We tested the hypothesis that the benefit of treatment v ... Full text Link to item Cite

Predicting aspiration in patients with ischemic stroke: comparison of clinical signs and aerodynamic measures of voluntary cough.

Journal Article Chest · March 2009 Featured Publication BACKGROUND: Clinical signs often fail to identify stroke patients who are at increased risk of aspiration. We hypothesized that objective measure of voluntary cough would improve the accuracy of the clinical evaluation of swallow to predict those patients ... Full text Link to item Cite

The Adherence eValuation After Ischemic Stroke Longitudinal (AVAIL) registry: design, rationale, and baseline patient characteristics.

Journal Article Am Heart J · March 2009 Featured Publication BACKGROUND: Approximately one third of the 780,000 people in the United States who have a stroke each year have recurrent events. Although efficacious secondary prevention measures are available, levels of adherence to these strategies in patients who have ... Full text Link to item Cite

Lack of impact of paramedic training and use of the cincinnati prehospital stroke scale on stroke patient identification and on-scene time.

Journal Article Stroke · March 2009 Featured Publication BACKGROUND AND PURPOSE: The Cincinnati Prehospital Stroke Scale (CPSS) is recommended for emergency medical services use in identifying patients with stroke. Data evaluating its performance in the field are limited. We assessed the impact of training and u ... Full text Link to item Cite

Amphetamine trials and tribulations.

Journal Article Stroke · March 2009 Featured Publication BACKGROUND: Laboratory experiments conducted since the 1940s show that amphetamine combined with task-relevant experience improves postbrain injury behavioral outcomes. Several small clinical trials evaluated the approach as a means of improving poststroke ... Full text Link to item Cite

Effect of atorvastatin in elderly patients with a recent stroke or transient ischemic attack.

Journal Article Neurology · February 24, 2009 Featured Publication BACKGROUND: It is unclear whether patients age 65 years and over with a recent stroke or TIA benefit from statin treatment to a similar degree as younger patients. METHODS: The 4,731 patient cohort in the SPARCL study was divided into an elderly group (65 ... Full text Link to item Cite

JUPITER and the world of stroke medicine.

Journal Article Lancet Neurol · February 2009 Featured Publication Full text Link to item Cite

Dysnomia, ataxia, choreoathetosis, sensory impairment, and gait imbalance after lentiform nucleus stroke.

Journal Article J Stroke Cerebrovasc Dis · 2009 Featured Publication We describe a patient in whom dysnomia, ataxia, choreoathetosis, sensory impairment, and severe gait imbalance resulted from an isolated left lentiform nucleus-posterior limb of internal capsule lacunar stroke. Each of these deficits has been described as ... Full text Link to item Cite

Stroke-related knowledge among uninsured Latino immigrants in Durham County, North Carolina.

Journal Article J Stroke Cerebrovasc Dis · 2009 Featured Publication BACKGROUND: Knowledge of stroke risk factors and symptoms is a necessary prerequisite for improving prevention and reducing treatment delays. Little is known about stroke-related knowledge among the US immigrant Latino population. METHODS: A previously pub ... Full text Link to item Cite

Utilization of intravenous tissue plasminogen activator for ischemic stroke: are there sex differences?

Journal Article Cerebrovasc Dis · 2009 Featured Publication BACKGROUND: We evaluated whether there were sex-related differences in the administration of intravenous tissue plasminogen activator (IV-tPA) to patients with acute ischemic stroke admitted to US academic medical centers. METHODS: Medical records were abs ... Full text Link to item Cite

Diagnostic evaluation for patients with ischemic stroke: are there sex differences?

Journal Article Cerebrovasc Dis · 2009 Featured Publication BACKGROUND AND PURPOSE: Differences in the management of women and men with acute coronary symptoms are well documented, but relatively little is known about practices for patients with ischemic stroke. We sought to determine whether there are sex-associat ... Full text Link to item Cite

Poststroke treatment: lost in translation.

Journal Article Stroke · January 2009 Featured Publication Full text Link to item Cite

Stroke recovery and rehabilitation.

Journal Article Handb Clin Neurol · 2009 Featured Publication Full text Link to item Cite

Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

Journal Article Stroke · December 2008 Featured Publication BACKGROUND AND PURPOSE: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial found that treatment with atorvastatin 80 mg per day reduced the risk of stroke and cardiovascular events in patients with a recent transient ischemi ... Full text Link to item Cite

The American Heart Association's 2008 Statement of Principles for Healthcare Reform.

Journal Article Circulation · November 18, 2008 Featured Publication Full text Link to item Cite

How much can be gained by more systematic prevention of stroke?

Journal Article Int J Stroke · November 2008 Featured Publication Clinical trials and observational studies provide evidence for a wide range of interventions of proven value for preventing a first or recurrent stroke. The available data indicate that strategies for primordial, primary and secondary stroke prevention are ... Full text Link to item Cite

Response to letter by Mascitelli et al

Journal Article Stroke · November 1, 2008 Full text Cite

Reducing death and disability from stroke: the role of governmental advocacy.

Journal Article Stroke · October 2008 Featured Publication Governmental actions affect our lives and the lives of our fellow citizens in a variety of ways. This is certainly true for both the conduct of biomedical research and the provision of medical care. Governmental policy-makers require accurate information u ... Full text Link to item Cite

Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study.

Journal Article Stroke · September 2008 Featured Publication BACKGROUND AND PURPOSE: In SPARCL, treatment with atorvastatin 80 mg daily reduced stroke risk in patients with recent stroke or TIA and no known coronary heart disease by 16% versus placebo over 4.9 years of follow-up. The purpose of this secondary analys ... Full text Link to item Cite

Primary central nervous system vasculitis: is biopsy appropriate?

Journal Article Ann Neurol · August 2008 Featured Publication Full text Link to item Cite

Minocycline treatment in acute stroke.

Journal Article Curr Atheroscler Rep · August 2008 Featured Publication Link to item Cite

10 questions about statins and stroke.

Journal Article Neurologist · July 2008 Featured Publication Full text Link to item Cite

Impact of comorbidities on ischemic stroke outcomes in women.

Journal Article Stroke · July 2008 Featured Publication BACKGROUND AND PURPOSE: We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke. METHODS: Prestroke comorbid conditions in 133 women admitted with acute ischemic stroke were scored with the Cha ... Full text Link to item Cite

Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study.

Journal Article Neurology · June 10, 2008 Featured Publication BACKGROUND: In the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study, atorvastatin 80 mg/day reduced the risk of stroke in patients with recent stroke or TIA. Post hoc analysis found this overall benefit included an increase in ... Full text Link to item Cite

Advances in prevention and health services delivery 2007.

Journal Article Stroke · February 2008 Featured Publication Full text Link to item Cite

Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure.

Journal Article J Toxicol Environ Health A · 2008 Featured Publication Imidacloprid, a neonicotinoid, is one of the fastest growing insecticides in use worldwide because of its selectivity for insects. The potential for neurotoxicity following in utero exposure to imidacloprid is not known. Timed pregnant Sprague-Dawley rats ... Full text Link to item Cite

Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study.

Journal Article Neurology · 2008 BACKGROUND: In the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study, atorvastatin 80 mg/day reduced the risk of stroke in patients with recent stroke or TIA. Post hoc analysis found this overall benefit included an increase in ... Cite

Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial.

Journal Article Stroke · December 2007 Featured Publication BACKGROUND AND PURPOSE: The intention-to-treat analysis of data from the placebo-controlled Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial found 80 mg atorvastatin per day reduced the risk of stroke and major coronary events ... Full text Link to item Cite

Surgery for Stroke Prevention

Chapter · November 12, 2007 Full text Cite

Statins for stroke prevention.

Journal Article Curr Atheroscler Rep · October 2007 Featured Publication Unlike coronary heart disease, epidemiologic studies find a weak and inconsistent relationship between cholesterol levels and overall stroke risk. There does, however, appear to be a positive relationship between total and low-density lipoprotein cholester ... Full text Link to item Cite

Reply from the editorialist [2]

Journal Article Neurology · October 1, 2007 Full text Cite

Acute ischemic stroke treatment in 2007.

Journal Article Circulation · September 25, 2007 Featured Publication Full text Link to item Cite

Reply from the editorialist [2]

Journal Article Neurology · September 1, 2007 Full text Cite

Independent predictors of stroke in patients with atrial fibrillation: a systematic review.

Journal Article Neurology · August 7, 2007 BACKGROUND: Absolute stroke rates vary widely among patients with nonvalvular atrial fibrillation. To balance the benefits and risks of chronic antithrombotic prophylaxis, it is important to estimate the absolute risk of stroke for individual patients. MET ... Full text Link to item Cite

Regulatory device approval for stroke: fair and balanced?

Journal Article Stroke · June 2007 Featured Publication Full text Link to item Cite

Low LDL cholesterol, statins, and brain hemorrhage: should we worry?

Journal Article Neurology · March 6, 2007 Featured Publication Full text Link to item Cite

Primary prevention and health services delivery.

Journal Article Stroke · February 2007 Featured Publication Full text Link to item Cite

Preface

Journal Article Revista Mexicana de Ciencias Geologicas · 2007 Cite

Stroke code chest radiographs are not useful.

Journal Article Cerebrovasc Dis · 2007 Featured Publication BACKGROUND: Routine chest radiographs at the time of hospital admission are not recommended for stroke patients in the absence of pulmonary symptoms. The usefulness of the test in patients being evaluated by a stroke team for hyperacute stroke symptoms was ... Full text Link to item Cite

Neuroimaging for acute ischemic stroke

Journal Article Emergency Medicine · January 1, 2007 Cite

Thrombolysis in stroke: a medicolegal quagmire.

Journal Article Stroke · November 2006 Featured Publication Full text Link to item Cite

Neurotransmitters and motor activity: effects on functional recovery after brain injury.

Journal Article NeuroRx · October 2006 Featured Publication There are complex relationships among behavioral experience, brain morphology, and functional recovery of an animal before and after brain injury. A large series of experimental studies have shown that exogenous manipulation of central neurotransmitter lev ... Full text Link to item Cite

In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats.

Journal Article Arch Toxicol · September 2006 Featured Publication This study was carried out to investigate the effect of in utero exposure to the cholinotoxicants, nicotine and chlorpyrifos, alone or in combination on neurobehavioral alterations and neuronal morphology latter in adult age. In the present study, 90 days ... Full text Link to item Cite

Advancing the study of stroke in women: summary and recommendations for future research from an NINDS-Sponsored Multidisciplinary Working Group.

Journal Article Stroke · September 2006 Featured Publication BACKGROUND AND PURPOSE: Women have poorer outcomes from stroke than men. Women also have risk factors that are unique, including pregnancy and hormone therapy. Hormone therapy for postmenopausal replacement increased the risk of ischemic stroke according t ... Full text Link to item Cite

High-dose atorvastatin after stroke or transient ischemic attack.

Journal Article N Engl J Med · August 10, 2006 Featured Publication BACKGROUND: Statins reduce the incidence of strokes among patients at increased risk for cardiovascular disease; whether they reduce the risk of stroke after a recent stroke or transient ischemic attack (TIA) remains to be established. METHODS: We randomly ... Full text Link to item Cite

Response to letter by Hart [5]

Journal Article Stroke · August 1, 2006 Full text Cite

Response to letter by Mysak et al [7]

Journal Article Stroke · August 1, 2006 Full text Cite

Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group.

Journal Article Circulation · June 20, 2006 Featured Publication BACKGROUND AND PURPOSE: This guideline provides an overview of the evidence on various established and potential stroke risk factors and provides recommendations for the reduction of stroke risk. METHODS: Writing group members were nominated by the committ ... Full text Link to item Cite

Statin use and sex-specific stroke outcomes in patients with vascular disease.

Journal Article Stroke · June 2006 Featured Publication BACKGROUND AND PURPOSE: Although statins reduce the risk of stroke in patients with coronary heart disease, possible differing effects of statins on stroke outcomes based on sex remain uncertain. We investigated the relationships between statin use and sex ... Full text Link to item Cite

Can the ROSIER scale diagnose patients with stroke accurately in the emergency department? Commentary

Journal Article Nature Clinical Practice Cardiovascular Medicine · May 1, 2006 Full text Cite

Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline.

Journal Article Circulation · March 14, 2006 Featured Publication The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of ischemic stroke or transient ischemic attack. Evidence-based recommendations are included for the co ... Link to item Cite

Improving the clinical diagnosis of stroke.

Journal Article Stroke · March 2006 Featured Publication Full text Link to item Cite

Advances in primary stroke prevention.

Journal Article Stroke · February 2006 Featured Publication Full text Link to item Cite

Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline.

Journal Article Stroke · February 2006 Featured Publication The aim of this new statement is to provide comprehensive and timely evidence-based recommendations on the prevention of ischemic stroke among survivors of ischemic stroke or transient ischemic attack. Evidence-based recommendations are included for the co ... Full text Link to item Cite

Primum non nocere: antithombotics after intracerebral hemorrhage?

Journal Article Neurology · January 24, 2006 Featured Publication Full text Link to item Cite

Cough and aspiration of food and liquids due to oral-pharyngeal dysphagia: ACCP evidence-based clinical practice guidelines.

Journal Article Chest · January 2006 Featured Publication BACKGROUND: Cough may be an indicator of aspiration due to oral-pharyngeal dysphagia. METHODS: Relevant literature was identified by searching the Communication Sciences and Disorders Dome, the Cumulative Index to Nursing and Allied Health Literature, the ... Full text Link to item Cite

Non-atherosclerotic vascular disease in the young.

Journal Article J Thromb Thrombolysis · October 2005 Featured Publication There are a large variety of non-atherosclerotic causes of ischemic stroke in the young. Arterial dissection, most commonly associated with non-traumatic causes, is among the most common. Both the carotid and vertebrobasilar circulations can be affected. T ... Full text Link to item Cite

Is this patient having a stroke?

Journal Article JAMA · May 18, 2005 Featured Publication CONTEXT: Patients suspected of having a stroke or transient ischemic attack require accurate assessment for appropriate acute treatment and use of secondary preventive interventions. OBJECTIVE: To update a 1994 systematic review of the accuracy and reliabi ... Full text Link to item Cite

Prevention and health services delivery.

Journal Article Stroke · February 2005 Featured Publication Full text Link to item Cite

Management of hallux limitus with distraction of the first metatarsophalangeal joint.

Journal Article J Am Podiatr Med Assoc · 2005 This article describes a joint-preserving and joint-restoring procedure for the management of hallux limitus and hallux rigidus. The procedure uses a minirail external fixator to obtain distraction with or without arthrotomy of the first metatarsophalangea ... Full text Link to item Cite

Neurologists' evaluation and treatment of hyperhomocysteinemia in stroke patients.

Journal Article J Stroke Cerebrovasc Dis · 2005 Featured Publication Observational study data have suggested that neurologists preferentially selected younger patients with generally few traditional stroke risk factors for homocysteine testing. The aim of this study was to corroborate observational data by assessing neurolo ... Full text Link to item Cite

Clinical research in primary stroke prevention: needs, opportunities, and challenges.

Journal Article Neuroepidemiology · 2005 Most ( approximately 70%) of strokes are first-ever strokes, and hence to substantially reduce the neurological burden, primary prevention is crucial. Here, highlights of the National Institute of Neurological Disorders and Stroke workshop "Stroke Risk Ass ... Full text Link to item Cite

Task force 5: Expert testimony and opinions.

Journal Article J Am Coll Cardiol · October 19, 2004 Featured Publication Full text Link to item Cite

ACCF/AHA consensus conference report on professionalism and ethics.

Journal Article Circulation · October 19, 2004 Featured Publication Full text Link to item Cite

Task force 5: Expert testimony and opinions

Journal Article Circulation · October 19, 2004 Full text Cite

Risk of ischemic stroke with tamoxifen treatment for breast cancer: a meta-analysis.

Journal Article Neurology · October 12, 2004 Featured Publication OBJECTIVE: To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data reported in breast cancer trials. BACKGROUND: Tamoxifen increases the risk of venous thromboembolism in women ... Full text Link to item Cite

Susac syndrome with transient inverted vision.

Journal Article Neurology · August 10, 2004 Full text Link to item Cite

Charlson Index comorbidity adjustment for ischemic stroke outcome studies.

Journal Article Stroke · August 2004 Featured Publication BACKGROUND AND PURPOSE: The Charlson Index is commonly used in outcome studies to adjust for patient comorbid conditions, but has not been specifically validated for use in studies of ischemic stroke. The purpose of the present study was to determine wheth ... Full text Link to item Cite

Seizures and epilepsy after ischemic stroke.

Journal Article Stroke · July 2004 Featured Publication BACKGROUND: Although a long-recognized clinical phenomenon, there remain many questions regarding the epidemiology of seizures and epilepsy after ischemic stroke, their effect on outcome, and their treatment. SUMMARY OF REVIEW: Interpretation of the variou ... Full text Link to item Cite

Five keys to reducing secondary stroke risk

Journal Article Emergency Medicine · May 24, 2004 The authors discuss the interventions with proven value against recurrent stroke and stroke subsequent to a transient ischemic attack, emphasizing lifestyle modifications, appropriate treatment of hypertension, indications for anticoagulant therapy, use of ... Cite

Aspirin: it's hard to beat.

Journal Article Neurology · April 13, 2004 Featured Publication Full text Link to item Cite

Statin use and stroke outcomes in the Heart and Estrogen-Progestin Replacement Study (HERS).

Journal Article Neurology · March 23, 2004 Featured Publication The authors investigated the relationship between statin use and the risk of stroke in the Heart and Estrogen-Progestin Replacement Study (HERS). Despite large reductions in relative risk point estimates, statin use was not associated with differences in t ... Full text Link to item Cite

Neurological deficits induced by malathion, DEET, and permethrin, alone or in combination in adult rats.

Journal Article J Toxicol Environ Health A · February 27, 2004 Featured Publication Malathion (O,O-dimethyl-S-[1,2-carbethoxyethyl]phosphorodithionate), DEET (N,N-diethyl-m-toluamide), and permethrin [(+/-)-cis/trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane carboxylic acid (3-phenoxyphenyl) methyl ester] are commonly used pesticid ... Full text Link to item Cite

Neuroprotective therapy for acute ischaemic stroke: down, but not out.

Journal Article Lancet · February 7, 2004 Featured Publication Full text Link to item Cite

Prevention and health services delivery.

Journal Article Stroke · February 2004 Featured Publication Full text Link to item Cite

Co-exposure to pyridostigmine bromide, DEET, and/or permethrin causes sensorimotor deficit and alterations in brain acetylcholinesterase activity.

Journal Article Pharmacol Biochem Behav · February 2004 Featured Publication Military personnel deployed in the Persian Gulf War (PGW) were exposed to a combination of chemicals, including pyridostigmine bromide (PB), DEET, and permethrin. We investigated the dose-response effects of these chemicals, alone or in combination, on the ... Full text Link to item Cite

Blood pressure management in patients with acute ischemic stroke.

Journal Article Hypertension · February 2004 Featured Publication Full text Link to item Cite

Cellular brain ischemia and stroke: Neuroprotection, metabolism, and new strategies for brain recovery

Chapter · January 1, 2004 Each year 4.6 million people die from stroke worldwide and 75% of these cases occur in industrialized countries.1 In the U.S., stroke is the third leading cause of mortality, with 4.7 million survivors, 15 to 30% of whom are left with permanent disabilitie ... Cite

Neurological complications of cardiac procedures

Chapter · January 1, 2004 A variety of procedures have come into common use for the treatment of specific cardiac conditions. Although neurological complications are relatively infrequent, they can be devastating. These complications include acute encephalopathy, longer-term cognit ... Cite

Statewide assessment of hospital-based stroke prevention and treatment services in North Carolina: changes over the last 5 years.

Journal Article Stroke · December 2003 Featured Publication BACKGROUND AND PURPOSE: The first published statewide assessment of stroke prevention and treatment services in the United States was carried out in North Carolina in 1998. The purpose of the present study was to measure changes in these services that may ... Full text Link to item Cite

Stroke location, characterization, severity, and outcome in mitral vs aortic valve endocarditis.

Journal Article Neurology · November 25, 2003 Featured Publication OBJECTIVE: To characterize the incidence and clinical features of patients with infective endocarditis (IE) and stroke. METHODS: The authors reviewed the records of 707 patients diagnosed with definite or possible IE between January 1984 and November 1999. ... Full text Link to item Cite

Extracranial carotid artery stenosis.

Journal Article Stroke · November 2003 Featured Publication BACKGROUND: Carotid endarterectomy is the most common surgical procedure used to treat stenosis of the extracranial precerebral carotid artery. Data from several randomized controlled trials are available to help guide its use in specific patient subgroups ... Full text Link to item Cite

VA Stroke Study: neurologist care is associated with increased testing but improved outcomes.

Journal Article Neurology · September 23, 2003 Featured Publication OBJECTIVE: VA Stroke Study (VASt) data were analyzed to determine whether neurologist management affected the process and outcome of care of patients with ischemic stroke. METHODS: VASt prospectively identified patients with stroke admitted to nine VA hosp ... Full text Link to item Cite

Medicine. Stroke--tPA and the clinic.

Journal Article Science · September 19, 2003 Featured Publication Clinical trial results are not always rapidly incorporated into routine medical practice. This Policy Forum describes a variety of barriers that have impeded the more widespread use of thrombolytic therapy (tPA, tissue plasminogen activator) for selected p ... Full text Link to item Cite

Medicine. Stroke--tPA and the clinic.

Journal Article Science · September 19, 2003 Clinical trial results are not always rapidly incorporated into routine medical practice. This Policy Forum describes a variety of barriers that have impeded the more widespread use of thrombolytic therapy (tPA, tissue plasminogen activator) for selected p ... Cite

Neuropharmacology of TBI-induced plasticity.

Journal Article Brain Inj · August 2003 Featured Publication PRIMARY OBJECTIVE: The purpose of this report is to review both fundamental studies in laboratory animals and preliminary clinical data suggesting that certain drugs may affect behavioural recovery after brain injury. MAIN OUTCOMES AND RESULTS: Laboratory ... Full text Link to item Cite

Sensorimotor deficits and increased brain nicotinic acetylcholine receptors following exposure to chlorpyrifos and/or nicotine in rats.

Journal Article Arch Toxicol · August 2003 Featured Publication Despite well-known adverse effects associated with cigarette smoking, approximately 20% of the US population continues to smoke and many more are exposed to environmental tobacco smoke. Many of the same individuals are also exposed to environmental neuroto ... Full text Link to item Cite

Screening for hypercoagulable syndromes following stroke.

Journal Article Curr Atheroscler Rep · July 2003 Featured Publication Patients with ischemic stroke of unclear etiology are often screened for hypercoagulable syndromes or thrombophilias. These have been recognized to cause venous thrombosis, and include hereditary deficiencies of coagulation factors, genetic mutations, or a ... Full text Link to item Cite

Veterans Administration Acute Stroke (VASt) Study: lack of race/ethnic-based differences in utilization of stroke-related procedures or services.

Journal Article Stroke · April 2003 Featured Publication BACKGROUND AND PURPOSE: Race/ethnic-based disparities in the utilization of health-related services have been reported. Data collected as part of the Veterans Administration Acute Stroke Study (VASt) were analyzed to determine whether similar differences w ... Full text Link to item Cite

Amphetamines and related drugs in motor recovery after stroke.

Journal Article Phys Med Rehabil Clin N Am · February 2003 Featured Publication Studies in laboratory animals indicate that the rate and extent of functional recovery after focal brain injury can be modulated by drugs affecting specific central neurotransmitters. Preliminary clinical studies suggest that similar drug effects may occur ... Full text Link to item Cite

Prevention and health services delivery.

Journal Article Stroke · February 2003 Featured Publication Full text Link to item Cite

Model of recovery of locomotor ability after sensorimotor cortex injury in rats.

Journal Article ILAR J · 2003 Featured Publication Animal models of locomotor recovery after brain injury provide tools for understanding the basic neurobiological processes that may underlie recovery after stroke in humans. Measurement of the ability of rats to traverse a narrow elevated beam has proven t ... Full text Link to item Cite

Pharmacotherapy in stroke rehabilitation.

Journal Article Adv Neurol · 2003 Featured Publication Link to item Cite

Transcranial Doppler monitoring and clinical decision-making after subarachnoid hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · 2003 Featured Publication Our objective was to examine the impact of transcranial Doppler ultrasound (TCD) vasospasm monitoring on clinical decision-making following subarachnoid hemorrhage (SAH). The records of 50 randomly selected patients undergoing serial TCD monitoring followi ... Full text Link to item Cite

Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats.

Journal Article Neurorehabil Neural Repair · December 2002 Featured Publication BACKGROUND: A variety of drugs impair motor recovery after sensorimotor cortex (SMCTX) injury in laboratory animals and may have similar effects in humans. METHODS: Rats (n = 142) underwent unilateral suction-ablation of the hindlimb SMCTX or sham lesion. ... Full text Link to item Cite

Contrast-enhanced magnetic resonance angiography of carotid arteries: utility in routine clinical practice.

Journal Article Stroke · December 2002 Featured Publication BACKGROUND AND PURPOSE: Contrast-enhanced magnetic resonance angiography (CEMRA) is among the newer noninvasive tests used for the evaluation of patients with carotid artery disease. Evidence supporting its utility in routine clinical practice is lacking. ... Full text Link to item Cite

Homocysteine testing in patients with acute ischemic stroke.

Journal Article Neurology · November 26, 2002 Featured Publication OBJECTIVE: To determine pretesting factors associated with elevated total homocysteine (tHcy) levels in a cohort of patients with acute ischemic stroke and to identify patient characteristics associated with physicians' decisions to obtain tHcy levels in r ... Full text Link to item Cite

Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats.

Journal Article Pharmacol Biochem Behav · July 2002 Featured Publication We investigated the effects of uranyl acetate on sensorimotor behavior, generation of nitric oxide and the central cholinergic system of rats. Male Sprague-Dawley rats were treated with intramuscular injection of 0.1 and 1 mg/kg uranyl acetate in water, da ... Full text Link to item Cite

Physician knowledge and practices in the evaluation of coagulopathies in stroke patients.

Journal Article Stroke · April 2002 Featured Publication BACKGROUND AND PURPOSE: Coagulopathies are a rare cause of ischemic stroke. Prior studies demonstrate that current physician test-ordering practices for the evaluation of these conditions in patients with ischemic stroke is not optimal. We sought to determ ... Full text Link to item Cite

Sensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats.

Journal Article Toxicol Sci · March 2002 Featured Publication A myriad of neurological symptoms including muscle and joint pain, ataxia, chronic fatigue, headache, and difficulty in concentration have been reported by Persian Gulf War (PGW) veterans. A large number of these veterans were prophylactically treated with ... Full text Link to item Cite

Patient safety in trials of therapy for acute ischemic stroke.

Journal Article JAMA · February 27, 2002 Featured Publication Full text Link to item Cite

Cor triatriatum sinistrum in children: A congenital cardiac anomaly which is difficult to diagnose

Journal Article Kardiologia Polska · January 1, 2002 Background. Cor triatriatum (CT) is a rare congenital cardiac anomaly which is difficult to diagnose. Aim. To present a large cohort of paediatric patients with CT. Methods. The study group consisted of 15 patients (mean age 3.4 years, range 0.25-12 years) ... Cite

Utility of noninvasive studies in the evaluation of patients with carotid artery disease.

Journal Article Curr Neurol Neurosci Rep · January 2002 Featured Publication Endarterectomy reduces the risk of stroke in selected patients with carotid artery stenosis, and the benefit is related to the degree of stenosis. Although the randomized trials demonstrating this benefit measured the degree of stenosis with conventional c ... Full text Link to item Cite

Telephone assessment of functioning and well-being following stroke: is it feasible?

Journal Article J Stroke Cerebrovasc Dis · 2002 Featured Publication Stroke can affect the physical, emotional, and social aspects of patients' lives. The purpose of this study was to assess the feasibility and psychometric properties of a telephone-administered version of the Health Utilities Index Mark 2 and 3 (HUI2/3). S ... Full text Link to item Cite

Letters to the editor (multiple letters)

Journal Article Toxicological Sciences · January 1, 2002 Full text Cite

Recommendations for improving the quality of care through stroke centers and systems: an examination of stroke center identification options: multidisciplinary consensus recommendations from the Advisory Working Group on Stroke Center Identification Options of the American Stroke Association.

Journal Article Stroke · January 2002 BACKGROUND AND PURPOSE: The American Stroke Association (ASA) assembled a multidisciplinary group of experts to develop recommendations regarding the potential effectiveness of establishing an identification program for stroke centers and systems. "Identif ... Link to item Cite

Low rate of complications of cerebral angiography in routine clinical practice.

Journal Article Neurology · December 11, 2001 Featured Publication OBJECTIVE: The use of cerebral angiography (ANGIO) to select patients for carotid endarterectomy (CEA) has been limited by concern about the risk of complications of the procedure. The authors sought to determine the rate of neurologic complications at bot ... Full text Link to item Cite

Aptiganel hydrochloride in acute ischemic stroke: a randomized controlled trial.

Journal Article JAMA · December 5, 2001 Featured Publication CONTEXT: Tissue plasminogen activator is the only thrombolytic agent approved in the United States for treatment of acute ischemic stroke, and has limitations. Aptiganel hydrochloride is a novel and selective ligand for the ion-channel site of the N-methyl ... Full text Link to item Cite

Improving patient selection for coagulopathy testing in the setting of acute ischemic stroke.

Journal Article Neurology · October 9, 2001 Featured Publication To improve patient selection for specialized coagulation testing in the setting of ischemic stroke, the authors sought to identify factors associated with the presence of hypercoagulable states. Of 208 patients with ischemic stroke tested, undetermined str ... Full text Link to item Cite

Coagulopathies in ischemic stroke [3] (multiple letters)

Journal Article Stroke · September 18, 2001 Cite

Delay between stroke onset and emergency department evaluation.

Journal Article Neuroepidemiology · August 2001 Featured Publication BACKGROUND: Public educational programs have been developed to reduce delays between the onset of ischemic stroke symptoms and emergency department evaluation. An increase in the proportion of patients presenting soon after stroke would reflect the effecti ... Full text Link to item Cite

Medical therapy for acute ischemic stroke.

Journal Article Curr Atheroscler Rep · July 2001 Featured Publication Over the past decade, there has been an explosion in data related to the treatment of patients with acute ischemic stroke. Thrombolytic therapy with intravenous tissue plasminogen activator has revolutionized the approach to stroke treatment. Intra-arteria ... Full text Link to item Cite

Recommendations for clinical trial evaluation of acute stroke therapies.

Journal Article Stroke · July 2001 The development of therapies for acute ischemic stroke has achieved a few notable successes and, unfortunately, many unsuccessful efforts. Many valuable lessons for the future assessment of new acute stroke therapies can be gleaned from the positive and ne ... Full text Link to item Cite

Hormone replacement therapy and ischemic stroke severity in women: a case-control study.

Journal Article Neurology · May 22, 2001 Featured Publication OBJECTIVE: To investigate whether ischemic stroke severity differed among women who were receiving hormone replacement therapy (HRT) as compared with those who were not receiving these drugs. BACKGROUND: Estrogen has a neuroprotective effect in animal mode ... Full text Link to item Cite

Improving the reliability of stroke subgroup classification using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria.

Journal Article Stroke · May 2001 Featured Publication BACKGROUND AND PURPOSE: We sought to improve the reliability of the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification of stroke subtype for retrospective use in clinical, health services, and quality of care outcome studies. The TOAST inv ... Full text Link to item Cite

Clinical carotid endarterectomy decision making: noninvasive vascular imaging versus angiography.

Journal Article Neurology · April 24, 2001 Featured Publication OBJECTIVE: Carotid endarterectomy (CEA) is frequently performed based solely on noninvasive vascular imaging (NVI) results (duplex ultrasound, DU; magnetic resonance angiography, MRA; CT angiography, CTA). The authors determined how often intra-arterial co ... Full text Link to item Cite

Effects of daily dermal application of DEET and epermethrin, alone and in combination, on sensorimotor performance, blood-brain barrier, and blood-testis barrier in rats.

Journal Article J Toxicol Environ Health A · April 6, 2001 Featured Publication DEET and permethrin were implicated in the development of illnesses in some veterans of the Persian Gulf War. This study was designed to investigate the effects of daily dermal application of these chemicals, alone or in combination, on the permeability of ... Full text Link to item Cite

Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination.

Journal Article Toxicol Sci · April 2001 Featured Publication Since their return from Persian Gulf War (PGW), many veterans have complained of symptoms including muscle and joint pain, ataxia, chronic fatigue, headache, and difficulty with concentration. The causes of the symptoms remain unknown. Because these vetera ... Full text Link to item Cite

Use of specialized coagulation testing in the evaluation of patients with acute ischemic stroke.

Journal Article Neurology · March 13, 2001 Featured Publication OBJECTIVE: To investigate the use and appropriateness of specialized coagulation tests in the evaluation of patients with acute ischemic stroke and identify factors that influence test ordering. BACKGROUND: Coagulation abnormalities are a rare but recogniz ... Full text Link to item Cite

Retrospective assessment of initial stroke severity: comparison of the NIH Stroke Scale and the Canadian Neurological Scale.

Journal Article Stroke · March 2001 Featured Publication BACKGROUND AND PURPOSE: The NIH Stroke Scale (NIHSS) and the Canadian Neurological Scale (CNS) have been reported to be useful for the retrospective assessment of initial stroke severity. However, unlike the CNS, the NIHSS requires detailed neurological as ... Full text Link to item Cite

Assessment of aspiration risk in stroke patients with quantification of voluntary cough.

Journal Article Neurology · February 27, 2001 Featured Publication BACKGROUND: Dysphagia and subsequent aspiration are serious complications of acute stroke that may be related to an impaired cough reflex. It was hypothesized that aspirating stroke patients would have impaired objective measures of voluntary cough as comp ... Full text Link to item Cite

Cost implications of specialized coagulation testing for acute ischemic stroke.

Journal Article J Stroke Cerebrovasc Dis · 2001 Featured Publication BACKGROUND AND PURPOSE: Hypercoagulable states are a rare but recognized cause of ischemic stroke. Evaluation for these coagulation disorders is costly, but establishing a diagnosis may lead to a change in treatment. We estimated the incremental cost of sp ... Full text Link to item Cite

Diagnostic testing for coagulopathies in patients with ischemic stroke.

Journal Article Stroke · December 2000 Featured Publication BACKGROUND: Hypercoagulable states are a recognized, albeit uncommon, etiology of ischemic stroke. It is unclear how often the results of specialized coagulation tests affect management. Using data compiled from a systematic review of available studies, we ... Full text Link to item Cite

Stroke in patients with asymptomatic internal-carotid-artery stenosis.

Journal Article N Engl J Med · November 9, 2000 Featured Publication Full text Link to item Cite

New transient ischemic attack and stroke: outpatient management by primary care physicians.

Journal Article Arch Intern Med · October 23, 2000 Featured Publication BACKGROUND: Patients with transient ischemic attack (TIA) or stroke frequently first contact their primary care physician rather than seeking care at a hospital emergency department. The purpose of the present study was to identify a group of patients seen ... Full text Link to item Cite

Rehabilitation and Recovery After Stroke.

Journal Article Curr Treat Options Neurol · July 2000 Featured Publication Many poststroke complications are preventable. There are few data comparing the efficacy of specific, standard physiotherapeutic approaches with each other or with the incidence of spontaneous recovery. More intensive physiotherapeutic approaches may be of ... Full text Link to item Cite

Quality Enhancement Research Initiative in stroke: prevention, treatment, and rehabilitation.

Journal Article Med Care · June 2000 Stroke is the third leading cause of death and a leading cause of adult disability in the United States. Both within and outside of the Veterans Health Administration (VHA), the lack of a systematic approach to stroke prevention and treatment may have cont ... Full text Link to item Cite

Quality of anticoagulation management among patients with atrial fibrillation: results of a review of medical records from 2 communities.

Journal Article Arch Intern Med · April 10, 2000 Featured Publication BACKGROUND: Most treatment of patients at risk for stroke is provided in the ambulatory setting. Although many studies have addressed the proportion of eligible patients with atrial fibrillation (AF) receiving warfarin sodium, few have addressed the qualit ... Full text Link to item Cite

Effects of amphetamines and small related molecules on recovery after stroke in animals and man.

Journal Article Neuropharmacology · March 3, 2000 Featured Publication Drugs modulating the levels of specific central neurotransmitters may influence both the rate and amount of functional recovery after focal brain injuries such as stroke. Because such drugs may be effective long after brain injury, the "therapeutic window" ... Full text Link to item Cite

Novel risk factors for stroke: homocysteine, inflammation, and infection.

Journal Article Curr Atheroscler Rep · March 2000 Featured Publication Recent studies have suggested that the risk of stroke may be increased in patients with several novel predisposing conditions. Although some controversy remains, the evidence supporting an association between moderately elevated levels of homocysteine and ... Full text Link to item Cite

Should antihypertensive therapies be given to patients with acute ischemic stroke?

Journal Article Drug Saf · January 2000 Featured Publication Hypertension is a major risk factor for stroke and many patients with acute stroke have elevated blood pressures. The management of hypertension in the setting of acute ischaemic stroke remains a source of confusion and controversy. Lowering blood pressure ... Full text Link to item Cite

North Carolina stroke prevention and treatment facilities survey. Statewide availability of programs and services.

Journal Article Stroke · January 2000 Featured Publication BACKGROUND/PURPOSE: The aim of this study was to determine the statewide availability of facilities and programs for stroke prevention and treatment to identify underserved regions and target educational efforts. METHODS: A single-page survey was mailed to ... Full text Link to item Cite

Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.

Journal Article Neuroscience · 2000 Featured Publication Motor recovery after unilateral sensorimotor cortex ablation or sham-injury was measured in apolipoprotein E knockout and wild-type mice by testing their abilities to traverse a narrow beam. All mice trained without difficulty. Sham-operated mice performed ... Full text Link to item Cite

Carotid endarterectomy for stroke prevention in older people.

Journal Article Clin Geriatr Med · November 1999 Featured Publication The efficacy of endarterectomy for patients with symptomatic high-grade stenosis of the extracranial carotid artery has been firmly established. Those with asymptomatic carotid disease may also be candidates for the operation. A thorough understanding of t ... Link to item Cite

Clinical stroke trials: guarding against bias.

Journal Article Stroke · June 1999 Featured Publication Full text Link to item Cite

Carotid endarterectomy.

Journal Article N Engl J Med · April 15, 1999 Featured Publication Full text Link to item Cite

Angiographically defined primary angiitis of the CNS: is it really benign?

Journal Article Neurology · April 12, 1999 Featured Publication Link to item Cite

Amphetamine-facilitated poststroke recovery.

Journal Article Stroke · March 1999 Featured Publication Full text Link to item Cite

Evidence-based medicine and stroke.

Journal Article Neuroepidemiology · 1999 Featured Publication The practice of evidence-based medicine requires the interpretation and use of best evidence from a variety of potential sources as it may apply to an individual patient. There are three critical steps in the practice of evidence-based medicine. First, hig ... Full text Link to item Cite

Pharmacological approach to functional reorganization: the role of norepinephrine.

Journal Article Rev Neurol (Paris) · 1999 Featured Publication Pharmacological studies in laboratory animals show that systemically administered drugs that modulate the levels of specific central neurotransmitters can influence post brain injury behavioral recovery. Several lines of evidence support an important role ... Link to item Cite

Age but not sex affects motor recovery after unilateral sensorimotor cortex suction-ablation in the rat.

Journal Article Restor Neurol Neurosci · 1999 Featured Publication Both age and sex can influence recovery after brain injury. To determine the impact of these variables on motor recovery, young (2 month old) and older (5-6 months old) male and female rats were first trained to traverse a narrow elevated beam. Rats then u ... Link to item Cite

Stroke-related knowledge among patients with access to medical care in the stroke belt.

Journal Article J Stroke Cerebrovasc Dis · 1999 Featured Publication North Carolina lies in the country's Stroke Belt, which is a region where cerebrovascular disease is a major public health problem. We performed an open survey of patients residing in a Stroke Belt community who had access to medical care to determine thei ... Full text Link to item Cite

How to recognize neurologic side effects of medications

Journal Article IM - Internal Medicine · January 1, 1999 Cite

North Carolina stroke prevention and treatment facilities survey: rtPA therapy for acute stroke.

Journal Article Stroke · October 1998 Featured Publication BACKGROUND AND PURPOSE: North Carolina is situated in the "stroke belt" region of the United States, an area of the country with a particularly high incidence of cerebrovascular disease. The North Carolina Stroke Prevention and Treatment Facilities Survey ... Full text Link to item Cite

A comprehensive assessment of the cost of multiple sclerosis in the United States.

Journal Article Mult Scler · October 1998 Featured Publication Comprehensive data on the costs of multiple sclerosis is sparse. We conducted a survey of 606 persons with MS who were members of the National Multiple Sclerosis Society to obtain data on their cost of personal health services, other services, equipment, a ... Full text Link to item Cite

Utilities for major stroke: results from a survey of preferences among persons at increased risk for stroke.

Journal Article Am Heart J · October 1998 BACKGROUND: Patient beliefs, values, and preferences are crucial to decisions involving health care. In a large sample of persons at increased risk for stroke, we examined attitudes toward hypothetical major stroke. METHODS AND RESULTS: Respondents were ob ... Full text Link to item Cite

Accuracy of ICD-9-CM coding for the identification of patients with acute ischemic stroke: effect of modifier codes.

Journal Article Stroke · August 1998 Featured Publication BACKGROUND AND PURPOSE: Discharge ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification) codes have been used to identify patients with acute stroke for epidemiological, quality of care, and cost studies. The aim of this s ... Full text Link to item Cite

Potential effects of common drugs on stroke recovery.

Journal Article Arch Neurol · April 1998 Featured Publication Studies in laboratory animals clearly show that the rate and extent of functional recovery after focal brain injury can be modulated by drugs affecting certain neurotransmitters in the central nervous system. Preliminary clinical studies suggest that simil ... Full text Link to item Cite

Multicenter review of preoperative risk factors for endarterectomy for asymptomatic carotid artery stenosis.

Journal Article Stroke · April 1998 Featured Publication BACKGROUND AND PURPOSE: The benefit of carotid endarterectomy is highly dependent on surgical risk. However, little data are available concerning factors affecting the risk of endarterectomy performed for asymptomatic carotid artery stenosis outside the se ... Full text Link to item Cite

Diagnosis of intracranial vasculitis: a multi-disciplinary approach.

Journal Article J Neuropathol Exp Neurol · January 1998 Featured Publication Intracranial vasculitis, or primary angiitis of the central nervous system (PACNS), is an uncommon, often fatal disorder that frequently responds to aggressive immunosuppressive therapy. Magnetic resonance imaging (MRI), cerebral angiography, and brain bio ... Full text Link to item Cite

Physician-reported readiness to change stroke prevention practices.

Journal Article J Stroke Cerebrovasc Dis · 1998 Featured Publication There are a series of possible impediments to the incorporation of new treatment modalities into clinical practice, and any intervention intended to alter practice must consider physicians' motivation and readiness to change. As part of a national survey i ... Full text Link to item Cite

Effects of dorsal noradrenergic bundle lesions on recovery after sensorimotor cortex injury.

Journal Article Pharmacol Biochem Behav · December 1997 Featured Publication Several lines of evidence suggest that the recovery of the ability of rats to traverse a narrow beam after unilateral injury to the sensorimotor cortex is noradrenergically mediated. We tested the hypotheses that the influence of norepinephrine on beam-wal ... Full text Link to item Cite

Influence of projected complication rates on estimated appropriate use rates for carotid endarterectomy. Appropriateness Project Investigators. Academic Medical Center Consortium.

Journal Article Health Serv Res · August 1997 Featured Publication OBJECTIVE: To examine specifically the influence of estimated perioperative mortality and stroke rate on the assessment of appropriateness of carotid endarterectomy. DATA SOURCES/STUDY SETTING: An expert panel convened to rate the appropriateness of a vari ... Link to item Cite

Influence of projected complication rates on estimated appropriate use rates for carotid endarterectomy

Journal Article Health Services Research · August 1, 1997 Objective. To examine specifically the influence of estimated perioperative mortality and stroke rate on the assessment of appropriateness of carotid endarterectomy. Data Sources/Study Setting. An expert panel convened to rate the appropriateness of a vari ... Cite

Retrospective assessment of initial stroke severity with the Canadian Neurological Scale.

Journal Article Stroke · June 1997 Featured Publication BACKGROUND AND PURPOSE: The severity of the initial neurological deficit is a critical determinant of outcome after acute stroke. Retrospective outcome studies are generally limited by a lack of quantitative data relating to this initial stroke severity. W ... Full text Link to item Cite

Complication rates for carotid endarterectomy. A call to action.

Journal Article Stroke · May 1997 Featured Publication Full text Link to item Cite

Knowledge of risk among patients at increased risk for stroke.

Journal Article Stroke · May 1997 Featured Publication BACKGROUND AND PURPOSE: Patients who recognize their increased risk for stroke are more likely to engage in (and comply with) stroke prevention practices than those who do not. We describe perceived risk of stroke among a nationally diverse sample of patie ... Full text Link to item Cite

Primary care physician-reported secondary and tertiary stroke prevention practices. A comparison between the United States and the United Kingdom.

Journal Article Stroke · April 1997 Featured Publication BACKGROUND AND PURPOSE: Stroke is a major healthcare problem in both the United States (US) and the United Kingdom (UK). Little comparative data are available concerning how generalist physicians in the two countries approach the management of patients at ... Full text Link to item Cite

Health status of individuals with mild stroke.

Journal Article Stroke · April 1997 Featured Publication BACKGROUND AND PURPOSE: Diminished quality of life and limitations in higher levels of physical functioning are often underestimated in stroke and are not fully captured by measures such as the Barthel Index and the Rankin Outcome Scale. This study used ad ... Full text Link to item Cite

Influence of common drugs and related factors on stroke outcome.

Journal Article Curr Opin Neurol · February 1997 Featured Publication Laboratory studies show that recovery after brain injury can be influenced by drugs that affect certain central neurotransmitters. The effects of these drugs may be either beneficial or harmful. Although issues related to drug dose, the timing of intervent ... Full text Link to item Cite

Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial.

Journal Article Stroke · February 1997 Featured Publication BACKGROUND AND PURPOSE: The reliability of the National Institutes of Health Stroke Scale (NIHSS) has been established through testing its use in live and videotaped patients. This reliability testing has primarily focused on the use of the scale by neurol ... Full text Link to item Cite

The Bland-White-Garland syndrome - Analysis of 22 cases

Journal Article Kardiologia Polska · January 1, 1997 BACKGROUND: The Bland-White-Garland syndrome is a rare congenital anomaly in which left coronary artery (LCA) originates from the pulmonary mink. It may be complicated by myocardial infarction, left ventricular dilatation end mitral insufficiency. Surgery ... Cite

Prevalence of hyperactive digastric muscles during swallowing as measured by electromyography in patients with myofascial pain dysfunction syndrome.

Journal Article Funct Orthod · 1997 Featured Publication One purpose of this clinical study is to establish a relationship between the hyper activity of the digastric muscles and predisposition of an individual to MPDS (myofacial pain dysfunction syndrome). If a population predisposed to MPD could be identified ... Link to item Cite

Effects of bilateral and unilateral locus coeruleus lesions on beam-walking recovery after subsequent unilateral sensorimotor cortex suction-ablation in the rat.

Journal Article Restor Neurol Neurosci · January 1, 1997 Featured Publication The recovery of beam-walking ability following a unilateral sensorimotor cortex lesion in the rat is hypothesized to be noradrenergically-mediated. We carried out two experiments to further test this hypothesis. In the first experiment, bilateral 6-hydroxy ... Full text Link to item Cite

US National Survey of Physician Practices for the Secondary and Tertiary Prevention of Ischemic Stroke. Medical therapy in patients with carotid artery stenosis.

Journal Article Stroke · September 1996 Featured Publication BACKGROUND AND PURPOSE: Aspirin or other platelet antiaggregants and anticoagulants are commonly used in many types of patients at elevated stroke risk. However, relatively little is known concerning how practicing physicians use these medications in their ... Full text Link to item Cite

Integration of behavioral and relaxation approaches into the treatment of chronic pain and insomnia. NIH Technology Assessment Panel on Integration of Behavioral and Relaxation Approaches into the Treatment of Chronic Pain and Insomnia.

Journal Article JAMA · July 24, 1996 OBJECTIVE: To provide physicians with a responsible assessment of the integration of behavioral and relaxation approaches into the treatment of chronic pain and insomnia. PARTICIPANTS: A nonfederal, nonadvocate, 12-member panel representing the fields of f ... Full text Link to item Cite

US National Survey of Physician Practices for the Secondary and Tertiary Prevention of Ischemic Stroke. Carotid endarterectomy.

Journal Article Stroke · May 1996 Featured Publication BACKGROUND AND PURPOSE: Data from several randomized clinical trials concerning the efficacy of carotid endarterectomy (CE) in patients with symptomatic and asymptomatic stenoses of the extracranial carotid artery are now available. Yet, there are few data ... Full text Link to item Cite

Reply from the Author: Stroke recovery

Journal Article Neurology · January 1, 1996 Full text Cite

Balloon atrioseptostomy in the intensive care unit

Journal Article Kardiologia Polska · January 1, 1996 Balloon atrioseptostomy (BAS) has remained an important palliative procedure in newborns with severe congenital heart defects. In 32 neonates BAS was performed without radiological control in the Intensive Care Unit (ICU) under echocardiographic monitoring ... Cite

Transposition of the great arteries: Comparison of the late clinical outcome following anatomical versus physiological correction

Journal Article Kardiologia Polska · January 1, 1996 The aim of the present study was to compare the late results of two surgical methods used in children with the transposition of the great arteries. In 27 children (group 1) the arterial switch surgery (anatomical correction) was performed and in 17 childre ... Cite

Sacral pseudoradiculopathy due to centrum semiovale stroke.

Journal Article J Stroke Cerebrovasc Dis · 1996 Featured Publication Lesions affecting localized regions of the cerebral cortex may result in pseudoperipheral neurologic deficits. Such deficits have not been reported in association with subcortical lesions. A 60-year-old man with a history of hypertension presented with an ... Full text Link to item Cite

Comparison and meta-analysis of randomized trials of endarterectomy for symptomatic carotid artery stenosis.

Journal Article Neurology · November 1995 Featured Publication OBJECTIVE: Comparison and meta-analysis of randomized trials of carotid endarterectomy for symptomatic stenosis of the extracranial carotid artery. BACKGROUND: Randomized trials (North American Symptomatic Carotid Endarterectomy Trial [NASCET], the Europea ... Full text Link to item Cite

US national survey of physician practices for the secondary and tertiary prevention of ischemic stroke. Design, service availability, and common practices.

Journal Article Stroke · September 1995 Featured Publication BACKGROUND AND PURPOSE: Stroke is largely a preventable disease. However, there are little data available concerning the use of stroke prevention diagnostic and treatment modalities by practicing physicians. These data are critical for the rational allocat ... Full text Link to item Cite

Guidelines on the use of thrombolytic agents in stroke.

Journal Article JAMA · July 19, 1995 Featured Publication Link to item Cite

Prescribing of potentially harmful drugs to patients admitted to hospital after head injury.

Journal Article J Neurol Neurosurg Psychiatry · June 1995 Featured Publication Fundamental studies in laboratory animals show that certain drugs influence behavioural recovery after brain injury. Although some drugs have the potential to enhance recovery, others may be detrimental. The purpose of the present study was to determine ho ... Full text Link to item Cite

Common drugs may influence motor recovery after stroke. The Sygen In Acute Stroke Study Investigators.

Journal Article Neurology · May 1995 Featured Publication Studies in laboratory animals indicate that certain centrally acting drugs (eg, the antihypertensives clonidine and prazosin, neuroleptics and other dopamine receptor antagonists, benzodiazepines, and the anticonvulsants phenytoin and phenobarbital) impair ... Full text Link to item Cite

Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in patients with acute ischemic stroke. Results of a phase IIa randomized trial.

Journal Article Stroke · April 1995 Featured Publication BACKGROUND AND PURPOSE: CGS 19755 is a competitive N-methyl-D-aspartate (NMDA) receptor antagonist that limits neuronal damage in animal stroke models. The objectives of this multicenter (7 centers), randomized, double-blind, placebo-controlled, ascending- ... Full text Link to item Cite

Right vs. left sensorimotor cortex suction-ablation in the rat: no difference in beam-walking recovery.

Journal Article Brain Res · March 13, 1995 Featured Publication The ability of rats to traverse a narrow elevated beam has been used to quantitate recovery of hindlimb motor function after unilateral injury to the sensorimotor cortex. We tested the hypothesis that the rate of spontaneous beam-walking recovery varies wi ... Full text Link to item Cite

Stroke due to recurrent ipsilateral carotid artery dissection in a young adult.

Journal Article Stroke · March 1995 Featured Publication BACKGROUND: Extracranial carotid artery dissection is a well-recognized cause of ischemic stroke. Recurrent carotid artery dissections are infrequent. Recurrent ipsilateral dissection has only rarely been documented and has not been pathologically verified ... Full text Link to item Cite

Occupational impairment and disability among applicants for Social Security disability benefits in Pennsylvania.

Journal Article Am J Public Health · November 1994 OBJECTIVE: The study goal was to assess the extent of workplace-related disease and injury among Social Security Disability Insurance applicants. METHODS: A convenience sample of 240 consecutive applicants to the Pennsylvania Bureau of Disability Determina ... Full text Link to item Cite

Multicenter review of preoperative risk factors for carotid endarterectomy in patients with ipsilateral symptoms.

Journal Article Stroke · June 1994 Featured Publication BACKGROUND AND PURPOSE: Randomized clinical trials have shown that carotid endarterectomy decreases the risk of subsequent stroke in patients with high-grade carotid stenosis and ipsilateral transient ischemic attack or minor stroke. The benefit of surgery ... Full text Link to item Cite

Similar motor recovery of upper and lower extremities after stroke.

Journal Article Stroke · June 1994 Featured Publication BACKGROUND AND PURPOSE: This study examined the validity of the clinical tenet that poststroke recovery of the upper extremity is less rapid and complete than poststroke recovery of the lower extremity. Previous studies comparing upper and lower extremity ... Full text Link to item Cite

Ganglioside GM1 in acute ischemic stroke. The SASS Trial.

Journal Article Stroke · June 1994 BACKGROUND AND PURPOSE: We sought to assess the safety and efficacy of ganglioside GM1 in acute (< or = 48 hours), anterior circulation ischemic stroke. METHODS: We screened more than 5000 patients at 13 centers in a randomized, double-blind, placebo-contr ... Full text Link to item Cite

The rational clinical examination. Clinical assessment of stroke.

Journal Article JAMA · April 13, 1994 Featured Publication Link to item Cite

Response

Journal Article Stroke · January 1, 1994 Cite

Clinical preventive practice.

Journal Article Health Rep · 1994 Featured Publication Link to item Cite

The Stroke P.O.R.T.: secondary and tertiary prevention of ischemic stroke. Stroke Prevention Patient Outcomes Research Team.

Journal Article Health Rep · 1994 Featured Publication The Stroke Prevention Patient Outcomes Research Team (PORT) is a five-year, multidisciplinary project designed to identify, evaluate and disseminate strategies for the secondary and tertiary prevention of ischemic stroke. The project has several major subc ... Link to item Cite

Predicting complications of carotid endarterectomy.

Journal Article Stroke · September 1993 Featured Publication BACKGROUND AND PURPOSE: Carotid endarterectomy has been shown to be beneficial in patients with high-grade carotid stenosis and ipsilateral transient ischemic attack or stroke. This benefit will be realized only if the operation is performed safely. We sou ... Full text Link to item Cite

Rapid reliable measurement of lesion parameters for studies of motor recovery after sensorimotor cortex injury in the rat.

Journal Article J Neurosci Methods · June 1993 Featured Publication Measurement of the ability of rats to traverse a narrow elevated beam has been used to quantitate motor recovery after unilateral injury to the sensorimotor cortex. Lesion extent is an important variable to consider in studies of the effects of drugs on be ... Full text Link to item Cite

Basic and clinical studies of pharmacologic effects on recovery from brain injury.

Journal Article J Neural Transplant Plast · 1993 Featured Publication Investigations in laboratory animals indicate that certain drugs that influence specific neurotransmitters can have profound effects on the recovery process. Even small doses of some drugs given after brain injury facilitate recovery while others are harmf ... Full text Link to item Cite

Acute unilateral sensorimotor cortex injury in the rat blocks d-amphetamine induced norepinephrine release in cerebellum.

Journal Article Restor Neurol Neurosci · January 1, 1993 Featured Publication Pharmacologic studies have implicated norepinephrine in amphetamine-facilitated motor recovery following sensorimotor cortex injury in rats. We studied the acute effects of unilateral sensorimotor cortex ablation on the release of norepinephrine in cerebel ... Full text Link to item Cite

[A case of direct right pulmonary artery-left atrium fistula].

Journal Article Kardiol Pol · November 1992 An unusual case of cyanotic heart disease in a 20-year-old male has been presented. Cyanosis was due to right to left shunt through direct right pulmonary artery--left atrium fistula. After successful operative ligation of the fistula, the patient got rid ... Link to item Cite

[Anatomical correction of transposition of the great arteries in 7 newborn infants].

Journal Article Kardiol Pol · August 1992 In the presented article, the course and results of anatomical correction of transposition of great arteries (TGA) in 7 neonates (2 females and 5 males) with mean body mass of 3250 g and 2 to 5 days old (mean 3 days) are reviewed. Surgery was performed in ... Link to item Cite

Measurement of motor recovery after stroke. Outcome assessment and sample size requirements.

Journal Article Stroke · August 1992 Featured Publication BACKGROUND AND PURPOSE: The purpose of this study was to analyze recovery of motor function in a cohort of patients presenting with an acute occlusion in the carotid distribution. Analysis of recovery patterns is important for estimating patient care needs ... Full text Link to item Cite

Early recurrent ischemic stroke. A case-control study.

Journal Article Stroke · July 1992 Featured Publication BACKGROUND AND PURPOSE: Data concerning potentially treatable risk factors for early recurrent stroke are limited. Therefore, we carried out a retrospective case-control study to identify factors predisposing to early reinfarction. SUMMARY OF REVIEW: We id ... Full text Link to item Cite

Post-lesion administration of the NMDA receptor antagonist MK-801 does not impair motor recovery after unilateral sensorimotor cortex injury in the rat.

Journal Article Brain Res · May 15, 1992 Featured Publication Although treatment with N-methyl-D-aspartate (NMDA) receptor antagonists reduce neuronal loss after cerebral infarction and brain trauma in laboratory animals, there is little data concerning the effects of these drugs on behavioral recovery. Because NMDA ... Full text Link to item Cite

OSHA bloodborne pathogens standard. Implications for the occupational health nurse.

Journal Article AAOHN J · April 1991 The Occupational Safety and Health Administration (OSHA) has promulgated a standard, expected to become mandatory in mid 1991, designed to protect employees from all exposure to blood and other potentially infectious materials. Employers should begin now t ... Link to item Cite

Pharmacologic Modulation of Recovery After Stroke: Clinical Data

Journal Article Neurorehabilitation and Neural Repair · January 1, 1991 Full text Cite

Recurrent transient ischemic attacks and stroke in association with an internal carotid artery web.

Journal Article Stroke · January 1991 Featured Publication Fibromuscular dysplasia is a nonatherosclerotic vascular disease that most commonly affects cervical carotid arteries at the C1-C2 level when cephalic arteries are involved. Several histopathologic and angiographic subtypes of fibromuscular dysplasia exist ... Full text Link to item Cite

Norepinephrine depletion impairs motor recovery following sensorimotor cortex injury in the rat.

Journal Article Restor Neurol Neurosci · January 1, 1991 Featured Publication Beam-walking in the rat provides a method for investigating the effects of drugs on motor recovery following unilateral injury to the sensorimotor cortex. In the present experiment, the impact of norepinephrine depletion on beam-walking recovery was invest ... Full text Link to item Cite

[217] Biochemical receptor studies in stroke (rats, rabbits)

Journal Article Journal of Rehabilitation Research and Development · January 1, 1991 Cite

Pharmacology of recovery after stroke.

Journal Article Stroke · November 1990 Featured Publication Laboratory research during the past decade has begun to provide insights into the neurobiologic basis of functional recovery after brain injury. It is clear that drugs influencing specific neurotransmitters also can influence the recovery process. Some of ... Link to item Cite

Restorative neurology. Drugs and recovery following stroke.

Journal Article Stroke · November 1990 Featured Publication Full text Link to item Cite

Large-dose infusions of heparinoid ORG 10172 in ischemic stroke.

Journal Article Stroke · September 1990 Featured Publication We evaluated the safety and possible efficacy of large doses of the heparinoid ORG 10172 in 57 patients with acute or progressing ischemic stroke. Patients received a loading bolus of the drug followed by a maintenance intravenous infusion for 7 days. The ... Full text Link to item Cite

Influence of lesion size and location on amphetamine-facilitated recovery of beam-walking in rats.

Journal Article Behav Neurosci · April 1990 Featured Publication Amphetamine treatment facilitates recovery of beam-walking in rats with unilateral sensorimotor cortex lesions. Lesion extent was studied in amphetamine- and saline-treated rats selected for rapid and slow recoveries. Lesion volume, lesion depth, and the a ... Full text Link to item Cite

Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat.

Journal Article Brain Res · February 5, 1990 Featured Publication Beam-walking in the rat is a useful model for studying the effects of drugs on motor recovery following brain injury. In the present experiment, the effect of clonidine HCl on beam-walking recovery was investigated. Groups of rats were first trained to tra ... Full text Link to item Cite

Beam-walking in rats: studies towards developing an animal model of functional recovery after brain injury.

Journal Article J Neurosci Methods · February 1990 Featured Publication While it has long been recognized that humans recover function after stroke or head injury, the direct impact of drugs on recovery has only recently received attention. The ability of rats to traverse a narrow, elevated beam has proven to be particularly u ... Full text Link to item Cite

Post-lesion practice and amphetamine-facilitated recovery of beam-walking in the rat.

Journal Article Restor Neurol Neurosci · January 1, 1990 Featured Publication Treatment with amphetamine increases the rate of recovery of beam-walking in rats when administered after a unilateral suction-ablation lesion of the sensorimotor cortex. It is thought that amphetamine treatment must be combined with postlesion practice on ... Full text Link to item Cite

Pharmacology of recovery after stroke

Journal Article Stroke · 1990 Laboratory research during the past decade has begun to provide insights into the neurobiologic basis of functional recovery after brain injury. It is clear that drugs influencing specific neurotransmitters also can influence the recovery process. Some of ... Cite

Pharmacology of recovery after stroke

Conference Stroke · January 1, 1990 Laboratory research during the past decade has begun to provide insights into the neurobiologic basis of functional recovery after brain injury. It is clear that drugs influencing specific neurotransmitters also can influence the recovery process. Some of ... Cite

Interrater reliability of the NIH stroke scale.

Journal Article Arch Neurol · June 1989 Featured Publication The interobserver reliability of a rating scale employed in several multicenter stroke trials was investigated. Twenty patients who had a stroke were rated with this scale by four clinical stroke fellows. Each patient was independently evaluated by one pai ... Full text Link to item Cite

A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke.

Journal Article Neurology · February 1989 Featured Publication An intravenous infusion of a low molecular weight heparinoid, with a reduced risk of hemorrhage, may be an alternative to heparin in the management of acute ischemic stroke. To evaluate this hypothesis, we studied the safety of the heparinoid, ORG 10172, i ... Full text Link to item Cite

A dose escalation study of ORG 10172 (low molecular weight heparinoid) in stroke

Journal Article Neurology · 1989 An intravenous infusion of a low molecular weight heparinoid, with a reduced risk of hemorrhage, may be an alternative to heparin in the management of acute ischemic stroke. To evaluate this hypothesis, we studied the safety of the heparinoid, ORG 10172, i ... Cite

Physician prescribing patterns following hospital admission for ischemic cerebrovascular disease.

Journal Article Neurology · November 1988 Featured Publication Functional recovery after brain injury in laboratory animals is influenced by a variety of drugs. Yet, the impact of currently prescribed drugs on recovery after human stroke remains largely unexplored. From the Duke-VA Stroke Registry, we found 77% of pat ... Full text Link to item Cite

Temporomandibular joint repositioning and exercise performance: a double-blind study.

Journal Article Cranio : the journal of craniomandibular practice · 1985 Cite

Temporomandibular joint repositioning and exercise performance: a double-blind study.

Journal Article Medicine and science in sports and exercise · June 1984 In the present study, the effects of temporomandibular joint (TMJ) repositioning by use of an acrylic appliance on maximum and submaximum physiologic and performance measures were evaluated in seven male and four female volunteers with documented TMJ malal ... Cite

Use of pulse volume plethysmography for TMJ and myofascial pain syndrome.

Journal Article The New York state dental journal · May 1983 Cite

Construction of low-variability litters of preweaning mice.

Journal Article Dev Psychobiol · November 1977 Featured Publication Mouse litter variation at weaning stems from a combination of genetic makeup, intrauterine experience, and postnatal maternal care. The 1st 2 factors may be matched at birth by making up separate litters out of littermate pairs whose birth weights are equa ... Full text Link to item Cite

Salmonella typhimurium SA host specificity system is based on deoxyribonucleic acid-adenine methylation.

Journal Article J Bacteriol · July 1976 We have determined the nature of the deoxyribonucleic acid (DNA) modification governed by the SA host specificity system of Salmonella typhimurium. Two lines of evidence indicate that SA modification is based on methylation of DNA-adenine residues. (i) The ... Full text Link to item Cite